<s>
Seizure-protecting_JJ effects_NN2 of_IO kyotorphin_NN1 and_CC related_JJ peptides_NN2 in_II an_AT1 animal_NN1 model_NN1 of_IO epilepsy_NN1 ._. 
</s>
<s>
In_II one_MC1 long-term_JJ follow-up_JJ study_NN1 ,_, greater_JJR than_CSN 95%_NNU of_IO patients_NN2 with_IW prostate_NN1 cancer_NN1 who_PNQS underwent_VVD surgery_NN1 or_CC received_VVD radiation_NN1 experienced_VVD some_DD sexual_JJ dysfunction_NN1 ,_, and_CC about_RG 50%_NNU reported_JJ urinary_NN1 or_CC bowel_NN1 dysfunction.102_FO Patients_NN2 receiving_VVG hormonal_JJ treatment_NN1 may_VM experience_VVI loss_NN1 of_IO libido_NN1 ,_, hot_JJ flashes_NN2 ,_, night_NNT1 sweats_NN2 ,_, irritability_NN1 ,_, and_CC breast_NN1 development_NN1 ._. 
</s>
<s>
Although_CS the_AT cervix_NN1 may_VM have_VHI appeared_VVN '_NULL normal_JJ '_NULL in_II these_DD2 women_NN2 ,_, a_AT1 shortened_JJ cervical_JJ length_NN1 may_VM have_VHI been_VBN present_JJ ._. 
</s>
<s>
Data_NN are_VBR presented_VVN as_CSA mean_NN1 plus_NN1 and_CC minus_NN1 SD_NN1 and_CC a_AT1 P-value_NN1 of_IO less_DAR than_CSN and_CC equal_JJ to_II 0.05_MC was_VBDZ considered_VVN statistically_RR significant_JJ ._. 
</s>
<s>
This_DD1 dependent_JJ processing_NN1 effect_NN1 of_IO arousal_NN1 on_II valence_NN1 of_IO stimuli_NN2 might_VM explain_VVI the_AT lack_NN1 of_IO effect_NN1 seen_VVN when_CS examining_VVG the_AT dimension_NN1 of_IO arousal_NN1 alone_RR (_( assuming_VVG valence_NN1 levels_NN2 were_VBDR similar_JJ for_IF the_AT three_MC levels_NN2 of_IO arousal_NN1 )_) ._. 
</s>
<s>
In_II31 addition_II32 to_II33 the_AT CT_NN1 scans_NN2 ,_, other_JJ clinical_JJ features_NN2 such_II21 as_II22 cerebrospinal_JJ fluid_NN1 leaks_NN2 and_CC cranial_JJ nerve_NN1 injury_NN1 were_VBDR also_RR considered_VVN indicative_JJ for_IF a_AT1 basal_JJ skull_NN1 fracture_NN1 ._. 
</s>
<s>
Reconstructive_JJ techniques_NN2 ,_, especially_RR flaps_VVZ replacing_VVG the_AT posterior_JJ tongue_NN1 ,_, can_VM compromise_VVI the_AT airway_NN1 even_RR after_II a_AT1 tracheostomy_NN1 is_VBZ allowed_VVN to_TO close_VVI ._. 
</s>
<s>
The_AT levels_NN2 of_IO FA-extractable_JJ Amiux40_FO and_CC Amiux42_FO were_VBDR quantified_VVN by_II C-terminal_JJ specific_JJ sandwich_NN1 ELISAs_NP2 as_CSA described_VVN above_RL ._. 
</s>
<s>
We_PPIS2 ranked_VVD the_AT clinical_JJ diagnosis_NN1 in_II order_NN1 of_IO decreasing_JJ severity_NN1 according_II21 to_II22 Table_NN1 1_MC1 ._. 
</s>
<s>
The_AT regions_NN2 of_IO homozygosity_NN1 are_VBR given_VVN in_II the_AT appendix_NN1 (_( p_ZZ1 11_MC )_) ._. 
</s>
<s>
CEUS_NP1 was_VBDZ performed_VVN using_VVG Sono-Vue_NP1 as_CSA contrast_NN1 agent_NN1 (_( Bracco_NP1 SpA_NN1 ,_, Milan_NP1 ,_, Italy_NP1 )_) ,_, a_AT1 suspension_NN1 of_IO hexafluoride_NN1 gas_NN1 forming_VVG microbubbles_NN2 with_IW a_AT1 diameter_NN1 from_II 0.5_MC up_RG21 to_RG22 1.5_MC micrometer_NN1 ._. 
</s>
<s>
Statistical_JJ Analysis_NN1 Study_NN1 data_NN were_VBDR analyzed_VVN using_VVG both_RR per-protocol_JJ (_( only_RR complete_JJ subject_NN1 data_NN analyzed_VVD )_) and_CC intention-to-treat_NN1 (_( ITT_NP1 )_) analyses_NN2 (_( all_DB subject_JJ data_NN analyzed_VVD with_IW missing_JJ data_NN points_NN2 calculated_VVD using_VVG multiple_JJ imputation_NN1 )_) ._. 
</s>
<s>
Longitudinal_JJ research_NN1 on_II war-affected_JJ youth_NN1 in_II the_AT region_NN1 demonstrates_VVZ high_JJ levels_NN2 of_IO comorbid_JJ mental_JJ health_NN1 problems_NN2 ,_, suggesting_VVG a_AT1 need_NN1 for_IF trauma-informed_NN1 ,_, broad-based_JJ interventions_NN2 ._. 
</s>
<s>
Furthermore_RR ,_, only_RR these_DD2 nine_MC countries_NN2 representing_VVG three_MC continents_NN2 had_VHD data_NN necessary_JJ for_IF this_DD1 analysis_NN1 and_CC there_EX are_VBR large_JJ differences_NN2 in_II place_NN1 and_CC attendance_NN1 at_II birth_NN1 among_II these_DD2 countries_NN2 ._. 
</s>
<s>
In_II contrast_NN1 ,_, the_AT BRUMS_NP2 provides_VVZ a_AT1 score_NN1 range_NN1 from_II 0_MC to_II 16_MC AU_FO ,_, based_VVN on_II subjective_JJ feelings_NN2 of_IO tiredness_NN1 (_( four_MC synonymous_JJ words_NN2 scored_VVN from_II 0_MC to_II 4_MC AU_FO each_DD1 )_) ._. 
</s>
<s>
The_AT authors_NN2 declare_VV0 that_CST they_PPHS2 have_VH0 no_AT conflict_NN1 of_IO interest_NN1 ._. 
</s>
<s>
Together_RL with_IW a_AT1 motor_NN1 examination_NN1 the_AT level_NN1 of_IO completeness_NN1 is_VBZ then_RT classified_VVN with_IW the_AT ASIA_NP1 Impairment_NN1 Scale_NN1 ._. 
</s>
<s>
Conflrmation_NN1 of_IO diagnosis_NN1 Healthy_JJ pancreas_NN1 was_VBDZ assumed_VVN due_JJ to_TO lack_VVI of_IO epigastric_JJ symptoms_NN2 or_CC diarrhea_NN1 ,_, normal_JJ levels_NN2 of_IO lipase_NN1 and_CC normal_JJ transabdominal_JJ ultrasound_NN1 ._. 
</s>
<s>
Oncology_NN1 practitioners_NN2 likely_RR will_VM have_VHI to_TO consider_VVI financial_JJ implications_NN2 when_CS formulating_VVG treatment_NN1 plans_NN2 ._. 
</s>
<s>
Within_II days_NNT2 following_RA intravitreal_JJ injection_NN1 '_NULL fundus_NN1 photography_NN1 shows_VVZ progressive_JJ media_NN haze_NN1 ._. 
</s>
<s>
As_CSA noted_VVN above_RL ,_, 4_MC patients_NN2 were_VBDR classified_VVN due_II21 to_II22 unauthorized_JJ dose_NN1 escalation_NN1 ;_; 4_MC patients_NN2 had_VHD nonprescribed_VVN controlled_VVN or_CC illicit_JJ substances_NN2 on_II UDT_NP1 testing_NN1 (_( B_ZZ1 ,_, C_NP1 :_: opioids_NN2 ;_; D_NP1 :_: cocaine_NN1 and_CC alcohol_NN1 metabolites_NN2 ;_; E_NP1 :_: tetrahydrocannabinol_NN1 )_) ,_, and_CC 1_MC1 patient_NN1 (_( Subject_NN1 I_ZZ1 )_) reported_VVD continued_JJ opioid_JJ use_NN1 despite_II adverse_JJ consequences_NN2 ._. 
</s>
<s>
Name_NN1 :_: Jan_NP1 Van_NP1 Hemelrijck_NP1 ,_, MD_NNA ,_, PhD_NN1 ._. 
</s>
<s>
Ultrasound_VV0 tissue_NN1 characterisation_NN1 ,_, a_AT1 novel_JJ form_NN1 of_IO ultrasound_NN1 ,_, can_VM quantify_VVI the_AT degree_NN1 of_IO disorganisation_NN1 within_II a_AT1 tendon_NN1 and_CC may_VM enhance_VVI clinical_JJ information_NN1 from_II imaging_NN1 (_( Figures_VVZ 3_MC and_CC 4_MC )_) ._. 
</s>
<s>
Chronic_JJ pain_NN1 of_IO any_DD kind_NN1 is_VBZ debilitating_JJ with_IW far_RR reaching_VVG consequences_NN2 on_II the_AT patient_NN1 '_NULL s_ZZ1 life_NN1 ._. 
</s>
<s>
In_II somatic_JJ tissues_NN2 ,_, calcineurin_NN1 is_VBZ composed_VVN of_IO a_AT1 catalytic_JJ subunit_NN1 ,_, encoded_VVN by_II two_MC distinct_JJ genes_NN2 (_( PPP3CA_FO and_CC PPP3CB_FO )_) ,_, and_CC a_AT1 regulatory_JJ subunit_NN1 ,_, encoded_VVN by_II PPP3R1_FO ._. 
</s>
<s>
The_AT calculation_NN1 of_IO the_AT arterial_JJ enhancement_NN1 fraction_NN1 (_( AEF_NP1 )_) ,_, as_CSA introduced_VVN by_II Kim_NP1 et_RA21 al_RA22 ,_, 12_MC allows_VVZ the_AT calculation_NN1 of_IO a_AT1 quantitative_JJ colored_JJ liver_NN1 map_NN1 using_VVG the_AT raw_JJ data_NN of_IO a_AT1 standard_JJ CT_NN1 scan_NN1 with_IW triphasic_JJ acquisition_NN1 (_( unenhanced_JJ ,_, arterial_JJ ,_, and_CC portal_NN1 venous_JJ phase_NN1 )_) ._. 
</s>
<s>
The_AT patients_NN2 in_II the_AT therapy_NN1 group_NN1 received_VVD oral_JJ doxycycline_NN1 at_II a_AT1 dose_NN1 of_IO 100_MC mg_NNU per_II day_NNT1 ._. 
</s>
<s>
In_RR21 addition_RR22 ,_, a_AT1 categorical_JJ irritability_NN1 outcome_NN1 was_VBDZ generated_VVN using_VVG a_AT1 median_JJ split_NN1 into_II high_JJ and_CC low_JJ irritability_NN1 and_CC was_VBDZ used_VVN for_IF purposes_NN2 of_IO illustration_NN1 in_II several_DA2 figures_NN2 ._. 
</s>
<s>
Imagine_VV0 using_VVG bedside_NN1 ultrasound_NN1 to_TO diagnose_VVI pneumonia_NN1 in_II a_AT1 screaming_JJ 1-year-old_JJ or_CC to_TO rule_VVI out_RP an_AT1 elbow_NN1 fracture_NN1 in_II a_AT1 kindergartener_NN1 who_PNQS fell_VVD off_II the_AT monkey_NN1 bars_NN2 ,_, potentially_RR sparing_VVG these_DD2 children_NN2 a_AT1 radiograph_NN1 (_( and_CC sparing_VVG their_APPGE parents_NN2 the_AT cost_NN1 and_CC time_NNT1 it_PPH1 would_VM take_VVI to_TO get_VVI one_MC1 )_) ._. 
</s>
<s>
Moreover_RR ,_, infarcts_NN2 were_VBDR visually_RR identified_VVN and_CC excluded_VVN from_II the_AT WMHs_NP1 ._. 
</s>
<s>
Methods_NN2 '_NULL Using_VVG CHO_NP1 APP75iSW_FO cells_NN2 we_PPIS2 identified_VVD and_CC characterized_VVD effects_NN2 of_IO 2-&lsqb;_( (_( pyridine-2-ylmethyl_NN1 )_) -amino_NN1 &rsqb;_) -phenol_NN1 (_( 2-PMAP_NP1 )_) on_II APP_NP1 steady-state_JJ level_NN1 and_CC AP_NP1 production_NN1 ._. 
</s>
<s>
A_AT1 trauma-informed_JJ approach_NN1 allows_VVZ care_NN1 providers_NN2 to_TO understand_VVI that_CST many_DA2 patients_NN2 and_CC their_APPGE parents_NN2 may_VM have_VHI experienced_VVN prior_JJ PTEs_NN2 and_CC that_CST these_DD2 experiences_NN2 impact_NN1 how_RRQ they_PPHS2 experience_VV0 medical_JJ care_NN1 ._. 
</s>
<s>
One_MC1 rater_NN1 was_VBDZ the_AT nurse_NN1 in_II31 charge_II32 of_II33 the_AT infant_NN1 '_NULL s_ZZ1 care_NN1 while_CS the_AT second_MD rater_NN1 was_VBDZ drawn_VVN from_II the_AT pool_NN1 of_IO recruited_JJ nurses_NN2 ._. 
</s>
<s>
Using_VVG the_AT post-ED_JJ RRT_NP1 as_II a_AT1 trigger_NN1 increased_VVD the_AT cases_NN2 reviewed_VVN by_II 36.5%_FO ._. 
</s>
<s>
In_II the_AT present_JJ study_NN1 ,_, we_PPIS2 investigated_VVD age-related_JJ decline_NN1 in_II duration_NN1 comparison_NN1 on_II a_AT1 millisecond_NNT1 level_NN1 using_VVG the_AT passive_JJ oddball_NN1 task_NN1 to_TO elicit_VVI the_AT mismatch_NN1 negativity_NN1 component_NN1 (_( MMN_NP1 ;_; Naatanen_NP1 et_RA21 al._RA22 ,_, 1978_MC )_) ._. 
</s>
<s>
In_II doing_VDG so_RR ,_, we_PPIS2 created_VVD a_AT1 model_NN1 in_II which_DDQ donor_NN1 DCs_NN2 ,_, presenting_VVG MHC-class_JJ I_ZZ1 molecules_NN2 and_CC OVA_NN2 peptide_NN1 ,_, could_VM be_VBI removed_VVN by_II using_VVG DT_NP1 ,_, following_VVG Act-mOVAxDTR/GFP_NN1 skin_NN1 transplantation_NN1 (_( Figure_NN1 2A_FO )_) ._. 
</s>
<s>
The_AT mice_NN2 were_VBDR then_RT subjected_VVN to_II the_AT elevated_JJ plus_II maze_NN1 and_CC dark/_JJ light_JJ box_NN1 to_TO measure_VVI anxiety-related_JJ behavior_NN1 ._. 
</s>
<s>
Therefore_RR ,_, a_AT1 further_JJR longitudinal_JJ study_NN1 will_VM be_VBI required_VVN to_TO prove_VVI the_AT exact_JJ relationship_NN1 between_II cervical_JJ regeneration_NN1 and_CC pregnancy-related_JJ morbidity_NN1 ._. 
</s>
<s>
In_II our_APPGE hospital_NN1 ,_, Przkora_NP1 et_RA21 al_RA22 ._. 
</s>
<s>
(_( 28_MC )_) compared_VVD cohorts_NN2 of_IO patients_NN2 who_PNQS had_VHD received_VVN SoC_NP1 (_( n_ZZ1 =_FO 11_MC )_) ,_, RET_NP1 (_( n_ZZ1 =_FO 17_MC )_) ,_, long-term_JJ oxandrolone_NN1 treatment_NN1 (_( n_ZZ1 =_FO 9_MC )_) ,_, or_CC both_DB2 RET_VV0 and_CC long-term_JJ oxandrolone_NN1 (_( n_ZZ1 =_FO 14_MC )_) ._. 
</s>
<s>
Here_RL we_PPIS2 record_VV0 ,_, for_IF the_AT first_MD time_NNT1 ,_, spontaneous_JJ seizures_NN2 in_II a_AT1 rat_NN1 model_NN1 of_IO vascular_JJ injury_NN1 and_CC BBB_NP1 breakdown_NN1 ,_, and_CC show_VV0 that_CST local_JJ exposure_NN1 of_IO the_AT cortex_NN1 to_II albumin_NN1 is_VBZ sufficient_JJ to_TO induce_VVI seizures_NN2 ._. 
</s>
<s>
Video_NN1 cassette_NN1 recorders_NN2 had_VHD been_VBN adopted_VVN by_II the_AT majority_NN1 of_IO households_NN2 within_II a_AT1 decade_NNT1 after_II the_AT first_MD VHS_NP1 format_NN1 player_NN1 was_VBDZ introduced_VVN in_II 1976_MC ._. 
</s>
<s>
To_II our_APPGE knowledge_NN1 ,_, there_EX are_VBR no_AT head-to-head_JJ prospective_JJ clinical_JJ trials_NN2 comparing_VVG these_DD2 two_MC ablative_JJ local_JJ treatment_NN1 strategies_NN2 ._. 
</s>
<s>
The_AT recovery_NN1 rate_NN1 for_IF intratympanic_JJ steroid_JJ injection_NN1 has_VHZ been_VBN reported_VVN to_TO be_VBI 61.5-77.3%_FO ._. 
</s>
<s>
Intratympanic_JJ steroid_JJ injection_NN1 has_VHZ advantages_NN2 in_CS21 that_CS22 the_AT concentration_NN1 within_II the_AT perilymph_NN1 is_VBZ higher_JJR than_CSN the_AT administered_JJ dose_NN1 ,_, and_CC side-effects_NN2 as_II31 well_II32 as_II33 complications_NN2 of_IO systemic_JJ administration_NN1 such_II21 as_II22 adrenal_JJ suppression_NN1 or_CC liver_NN1 dysfunction_NN1 rarely_RR develop_VV0 ._. 
</s>
<s>
Furthermore_RR '_NULL LVs_NP1 are_VBR promising_JJ vehicles_NN2 to_TO transfer_VVI genes_NN2 into_II iPSCs_NN2 because_II21 of_II22 their_APPGE stable_NN1 integrating_VVG capability_NN1 ._. 
</s>
<s>
In_II31 accordance_II32 with_II33 the_AT initial_JJ analysis_NN1 ,_, a_AT1 shift_NN1 to_II slower_JJR process_NN1 speeds_VVZ with_IW aging_NN1 was_VBDZ again_RT found_VVN (_( Fig._NN1 3D-F_NP1 )_) ._. 
</s>
<s>
Patients_NN2 in_II the_AT lGBCA_NN1 interval_NN1 received_VVD a_AT1 standardized_JJ application_NN1 of_IO 15_MC or_CC 20_MC mL_NNU (_( 0.5_MC mmol/mL_FU )_) per_II MRI_NP1 ._. 
</s>
<s>
Other_JJ promising_JJ treatment_NN1 approaches_VVZ for_IF BACE1_FO inhibition_NN1 ,_, such_II21 as_II22 anti-BACE1_JJ antibodies_NN2 ,_, 64,65_MC are_VBR in_II preclinical_JJ phases_NN2 and_CC will_VM not_XX be_VBI described_VVN in_II the_AT interest_NN1 of_IO brevity_NN1 ._. 
</s>
<s>
White_JJ cell_NN1 counts_NN2 and_CC neutrophil_VV0 numbers_NN2 after_II adjustment_NN1 for_IF the_AT most_RGT common_JJ confounders_NN2 are_VBR raised_VVN in_II populations_NN2 of_IO frail_JJ older_JJR people_NN (_( Leng_NP1 et_RA21 al._RA22 ,_, 2007_MC ;_; Leng_NP1 et_RA21 al._RA22 ,_, 2009_MC ;_; Collerton_NP1 et_RA21 al._RA22 ,_, 2012_MC )_) ._. 
</s>
<s>
Conclusions_NN2 :_: These_DD2 results_NN2 highlight_VV0 the_AT challenges_NN2 of_IO identifying_VVG nonadherence_NN1 to_II a_AT1 prescription_NN1 regimen_NN1 among_II adolescents_NN2 with_IW chronic_JJ pain_NN1 ._. 
</s>
<s>
Absence_NN1 of_IO Nrf2_FO in_II APP/P1_NP1 mouse_NN1 leads_VVZ to_II autophagy_JJ inhibition_NN1 Mammalian_JJ target_NN1 of_IO rapamycin_NN1 (_( mTOR_NN1 )_) is_VBZ a_AT1 serine/threonine_JJ kinase_NN1 that_CST regulates_VVZ several_DA2 cellular_JJ functions_NN2 including_VVG ,_, but_CCB not_XX limited_VVN ,_, to_II autophagy_NN1 ._. 
</s>
<s>
Oral_JJ glucose_NN1 tolerance_NN1 tests_NN2 Ten_MC children_NN2 with_IW multiple_JJ CMN_NP1 underwent_VVD an_AT1 oral_JJ glucose_NN1 tolerance_NN1 test_NN1 (_( OGTT_NP1 )_) following_VVG the_AT standard_JJ hospital_NN1 protocol_NN1 ._. 
</s>
<s>
In_II GJB2patients_FO an_AT1 abnormal_JJ vestibular_JJ phenotype_NN1 is_VBZ sometimes_RT found_VVN (_( Dodson_NP1 et_RA21 al._RA22 ,_, 2011_MC ;_; Eppsteiner_NP1 et_RA21 al._RA22 ,_, 2011_MC ;_; Kasai_NP1 et_RA21 al._RA22 ,_, 2010_MC ;_; Todt_NP1 et_RA21 al._RA22 ,_, 2005_MC ;_; Zagolski_NP1 ,_, 2007_MC )_) but_CCB in_II most_DAT cases_NN2 it_PPH1 is_VBZ absent_JJ (_( Cohn_NP1 et_RA21 al._RA22 ,_, 1999_MC ;_; Denoyelle_NP1 et_RA21 al._RA22 ,_, 1999_MC ;_; Shinjo_NP1 et_RA21 al._RA22 ,_, 2007_MC )_) ._. 
</s>
<s>
The_AT following_JJ measurements_NN2 were_VBDR done_VDN :_: 3-point-Dixon_NP1 fat-fraction_JJ quantification_NN1 resulting_VVG in_II fat-fraction_JJ maps_NN2 expressed_VVN as_CSA percentage_NN1 fat_NN1 (_( 0-100%_FO )_) ,_, non-fat-suppressed_NN1 T2_FO measurement_NN1 by_II dual-contrast_JJ turbo-spin-echo_JJ imaging_NN1 ,_, and_CC MTR_NP1 imaging_NN1 requiring_VVG two_MC 3D-FLASH_JJ images_NN2 with_IW and_CC without_IW a_AT1 magnetisation_NN1 transfer_NN1 pre-pulse_NN1 with_IW radiofrequency_NN1 field_NN1 (_( B1_FO )_) non-uniformity_JJ correction_NN1 resulting_VVG in_II MTR_NP1 maps_NN2 with_IW values_NN2 expressed_VVN by_II convention_NN1 in_II percentage_NN1 units_NN2 (_( 0-100_MCMC pu_FO )_) .22_MC Sequence_NN1 details_NN2 and_CC variables_NN2 are_VBR listed_VVN in_II the_AT appendix_NN1 ;_; the_AT total_JJ acquisition_NN1 time_NNT1 per_II participant_NN1 per_II visit_NN1 was_VBDZ about_RG 35_MC min_NNU ._. 
</s>
<s>
Activated_JJ RAS_NP2 bindsto_NN1 RAF_NP1 and_CC promotes_VVZ its_APPGE activation_NN1 ._. 
</s>
<s>
Perioperative_JJ complications_NN2 were_VBDR defined_VVN as_CSA surgery-related_JJ events_NN2 occurring_VVG within_II 30_MC days_NNT2 of_IO surgery_NN1 ._. 
</s>
<s>
After_II seeking_VVG parental_JJ permission_NN1 ,_, they_PPHS2 obtained_VVD access_NN1 to_II results_NN2 of_IO standardized_JJ achievement_NN1 testing_NN1 and_CC discovered_VVD 2_MC findings_NN2 of_IO particular_JJ concern_NN1 ._. 
</s>
<s>
HRs_NNU2 were_VBDR combined_VVN using_VVG the_AT fixed-effect_JJ model_NN1 (_( Mantel-Haenzsel_NP1 )_) ._. 
</s>
<s>
The_AT nature_NN1 of_IO cognitive/attentional_JJ impairment_NN1 requires_VVZ discussion_NN1 ._. 
</s>
<s>
Each_DD1 physician_NN1 was_VBDZ provided_VVN a_AT1 set_NN1 of_IO Sony_NP1 MDR-EX38iP_NP1 in-ear_JJ stereo_NN1 headphones_NN2 (_( Sony_NP1 ,_, NewYork_NP1 ,_, New_NP1 York_NP1 )_) and_CC was_VBDZ requested_VVN to_TO set_VVI the_AT audio_JJ playback_NN1 volume_NN1 in_II a_AT1 range_NN1 similar_JJ to_II actual_JJ physical_JJ auscultation_NN1 ._. 
</s>
<s>
Acknowledgments_NN2 This_DD1 paper_NN1 is_VBZ dedicated_VVN to_II the_AT memory_NN1 of_IO Gary_NP1 Whitlock_NP1 ,_, who_PNQS contributed_VVD much_RR to_II developing_VVG the_AT collaboration_NN1 ._. 
</s>
<s>
Patient_JJ reported_JJ duration_NN1 of_IO pain_NN1 condition_NN1 ranged_VVN from_II 0.1_MC to_II 65_MC years_NNT2 and_CC averaged_VVD 9.86_MC years_NNT2 ._. 
</s>
<s>
The_AT primary_JJ endpoint_NN1 was_VBDZ prostate_NN1 cancer-specific_JJ mortality_NN1 ._. 
</s>
<s>
Corresponding_JJ author_NN1 :_: Christopher_NP1 T._NP1 Leffler_NP1 ,_, MD_NNA ,_, MPH_NNU ._. 
</s>
<s>
In_RR21 addition_RR22 ,_, reference_NN1 lists_NN2 of_IO the_AT selected_JJ studies_NN2 were_VBDR checked_VVN for_IF articles_NN2 missed_VVN in_II the_AT initial_JJ search_NN1 ._. 
</s>
<s>
All_DB patients_NN2 suffered_VVN from_II nonfluent_JJ aphasia_NN1 following_VVG the_AT stroke_NN1 ._. 
</s>
<s>
To_II our_APPGE knowledge_NN1 ,_, this_DD1 is_VBZ the_AT first_MD study_NN1 examining_VVG objectively_RR measured_VVN PA_NN1 change_NN1 in_II this_DD1 much_DA1 detail_NN1 over_RG 4_MC years_NNT2 in_II British_JJ adolescents_NN2 ._. 
</s>
<s>
Acknowledgements_NN2 The_AT work_NN1 was_VBDZ supported_VVN by_II the_AT Medical_JJ Research_NN1 Council_NN1 (_( Paul_NP1 Potter_NP1 ,_, Ian_NP1 ._. 
</s>
<s>
Both_DB2 acceleration_NN1 forces_NN2 must_VM be_VBI managed_VVN within_II the_AT same_DA padding_NN1 system_NN1 ._. 
</s>
<s>
SUMMARY_NN1 REMARKS_VVZ Major_JJ burn_NN1 trauma_NN1 is_VBZ unique_JJ in_II31 terms_II32 of_II33 the_AT long-term_JJ deleterious_JJ effects_NN2 it_PPH1 inflicts_VVZ on_II numerous_JJ physiological_JJ systems_NN2 within_II the_AT body_NN1 ._. 
</s>
<s>
In_II separate_JJ encounters_NN2 ,_, each_DD1 physician_NN1 described_VVD both_RR the_AT epidural_NN1 and_CC brachial_JJ plexus_NN1 block_NN1 procedures_NN2 ,_, and_CC each_DD1 patient-participant_NN1 heard_VVD both_DB2 procedures_NN2 described_VVN ._. 
</s>
<s>
Following_VVG these_DD2 guidelines_NN2 from_II the_AT NCAA_NN1 ,_, there_EX is_VBZ some_DD ambiguity_NN1 as_II21 to_II22 whether_CSW a_AT1 student-athlete_NN1 can_VM begin_VVI his/her_APPGE academic_JJ return_NN1 when_CS he/she_PPHS1 tolerates_VVZ cognitive_JJ activity_NN1 without_IW any_DD increase_NN1 in_II concussive_JJ symptoms_NN2 ,_, or_CC if_CS he/she_PPHS1 must_VM be_VBI completely_RR symptom_NN1 free_JJ ._. 
</s>
<s>
Additionally_RR ,_, newly_RR developed_JJ inhibitors_NN2 of_IO the_AT HCV_NP1 enzyme_NN1 may_VM show_VVI different_JJ resistance_NN1 profiles_NN2 for_IF the_AT various_JJ subtypes_NN2 ,_, even_RR within_II one_MC1 HCV_NP1 genotype_NN1 &lsqb;_( 1820_MC &rsqb;_) ._. 
</s>
<s>
Interestingly_RR ,_, and_CC in_II31 support_II32 of_II33 this_DD1 primarily_RR being_VBG a_AT1 prenatal_JJ developmental_JJ abnormality_NN1 ,_, the_AT transplanted_JJ fat_NN1 does_VDZ not_XX appear_VVI to_TO be_VBI affected_VVN by_II the_AT naevus_NN1 ._. 
</s>
<s>
Ultrasound-guided_JJ FNA_NN1 has_VHZ proven_VVN to_TO be_VBI more_RGR efficient_JJ than_CSN conventional_JJ FNA_NN1 ,_, particularly_RR for_IF nodules_NN2 located_VVD deep_RR in_II the_AT thyroid_JJ lobes_NN2 ,_, have_VH0 a_AT1 small_JJ volume_NN1 ,_, or_CC feature_VV0 a_AT1 mixed_JJ solid_JJ cystic_JJ content_NN1 ._. 
</s>
<s>
Wide_JJ local_JJ excision_NN1 and_CC sentinel_VV0 lymph_NN1 node_NN1 biopsy_NN1 (_( SLNB_NP1 )_) were_VBDR performed_VVN and_CC adjuvant_JJ radiation_NN1 therapy_NN1 was_VBDZ deferred_JJ ._. 
</s>
<s>
The_AT tPA_NN1 utilization_NN1 rate_NN1 in_II PSCs_NP2 is_VBZ nearly_RR 3_MC times_NNT2 the_AT national_JJ rate.6_FO However_RR ,_, the_AT PSC_NP1 certification_NN1 program_NN1 currently_RR does_VDZ not_XX include_VVI a_AT1 specific_JJ strategy_NN1 for_IF the_AT 20%_NNU of_IO the_AT US_NP1 population_NN1 that_CST lives_VVZ in_II rural_JJ areas_NN2 ._. 
</s>
<s>
Ophthalmological_JJ examination_NN1 did_VDD not_XX show_VVI Kayser_NP1 Fleischer_NP1 ring_NN1 ._. 
</s>
<s>
Providers_NN2 do_VD0 not_XX always_RR receive_VVI a_AT1 morning_NNT1 or_CC afternoon_NNT1 break_NN1 ,_, but_CCB they_PPHS2 generally_RR do_VD0 ._. 
</s>
<s>
We_PPIS2 intentionally_RR analyzed_VVD measures_NN2 of_IO accuracy_NN1 and_CC agreement_NN1 exclusively_RR based_VVN on_II subgroups_NN2 of_IO nutritional_JJ status_NN1 ,_, rather_II21 than_II22 the_AT population_NN1 as_II a_AT1 whole_NN1 ,_, as_CSA our_APPGE study_NN1 population_NN1 was_VBDZ largely_RR malnourished_JJ and_CC not_XX intended_VVN reflect_VV0 the_AT general_JJ pediatric_JJ population_NN1 ._. 
</s>
<s>
Gestational_JJ age_NN1 was_VBDZ determined_VVN by_II first-trimester_JJ ultrasound_NN1 ._. 
</s>
<s>
The_AT size_NN1 of_IO the_AT cohort_NN1 represents_VVZ one_MC1 of_IO the_AT primary_JJ strengths_NN2 of_IO our_APPGE study_NN1 ._. 
</s>
<s>
Regarding_II the_AT other_JJ groups_NN2 ,_, the_AT decrease_NN1 in_II rER_JJR values_NN2 during_II the_AT second_MD phase_NN1 seems_VVZ systematically_RR slower_JJR with_IW the_AT linear_JJ agents_NN2 than_CSN with_IW 0.1_MC mmol/kg_FU of_IO gadoterate_JJ meglumine_NN1 ._. 
</s>
<s>
Another_DD1 limitation_NN1 is_VBZ reliance_NN1 on_II discharge_NN1 record_NN1 diagnostic_JJ coding_NN1 ._. 
</s>
<s>
This_DD1 has_VHZ led_VVN to_II some_DD criticism_NN1 regarding_II the_AT construct_NN1 of_IO adherence_NN1 as_CSA inherently_RR elusive_JJ ._. 
</s>
<s>
After_CS 1_MC1 minute_NNT1 ,_, the_AT TCI_JJ target_NN1 was_VBDZ increased_VVN to_II 3_MC miug/mL_FU ._. 
</s>
<s>
The_AT eDST_NN1 group_NN1 was_VBDZ also_RR shown_VVN an_AT1 additional_JJ 5-min_JJ overview_NN1 of_IO the_AT use_NN1 of_IO the_AT app_NN1 ._. 
</s>
<s>
Future_JJ Directions_NN2 Mounting_VVG research_NN1 in_II the_AT field_NN1 of_IO sports_NN2 concussion_NN1 biomarkers_NN2 has_VHZ led_VVN to_II a_AT1 greater_JJR understanding_NN1 of_IO the_AT effects_NN2 of_IO brain_NN1 injury_NN1 from_II sports_NN2 ._. 
</s>
<s>
The_AT confronting_VVG subscale_NN1 provides_VVZ a_AT1 measure_NN1 of_IO overactivity_NN1 ,_, whereas_CS the_AT avoidance_NN1 subscale_NN1 provides_VVZ a_AT1 measure_NN1 of_IO avoidance_NN1 of_IO activity_NN1 ._. 
</s>
<s>
The_AT circular_JJ white_JJ target_NN1 was_VBDZ moved_VVN along_II every_AT1 meridian_NN1 (_( periphery_NN1 to_II center_NN1 ;_; speed_NN1 =_FO 2/s_FU )_) ._. 
</s>
<s>
Data_NN Extraction_NN1 A_ZZ1 data_NN extraction_NN1 form_NN1 was_VBDZ created_VVN (_( including_II title_NN1 ,_, author_NN1 ,_, year_NNT1 of_IO publication_NN1 ,_, country_NN1 of_IO origin_NN1 and_CC hospital_NN1 status_NN1 )_) ._. 
</s>
<s>
has_VHZ also_RR been_VBN exploited_VVN to_TO provide_VVI higher_JJR temporal_JJ resolution_NN1 ,_, while_CS preserving_VVG diagnostic_JJ image_NN1 quality_NN1 ,_, in_II dynamic_JJ contrast-enhanced_JJ MRI_NN1 of_IO the_AT prostate_NN1 ._. 
</s>
<s>
To_TO confirm_VVI that_CST these_DD2 pharmacokinetic_JJ measures_NN2 were_VBDR achieved_VVN during_II the_AT study_NN1 ,_, we_PPIS2 measured_VVD plasma_NN1 concentrations_NN2 of_IO drug_NN1 and_CC its_APPGE active_JJ metabolite_NN1 in_II the_AT first_MD cohort_NN1 of_IO eight_MC monkeys_NN2 ._. 
</s>
<s>
They_PPHS2 had_VHD lower_JJR case_NN1 mix_NN1 index_NN1 and_CC comparable_JJ Emergency_NN1 Severity_NN1 Index_NN1 scores_NN2 ._. 
</s>
<s>
Over-expression_NN1 of_IO miR-217_MC in_II younger_JJR HUVECs_NN2 leads_VVZ to_II an_AT1 ageingphenotype_NN1 as_CSA seen_VVN by_II increased_JJ SA-_JJ -Gal_JJ activity_NN1 ,_, decreased_VVD tel-omerase_JJ activity_NN1 and_CC impaired_VVD an_AT1 giogenic_JJ function_NN1 ,_, illustrating_VVG it_PPH1 as_CSA proageing_VVG microRNA_NN1 (_( Menghini_NP1 et_RA21 al._RA22 ,_, 2009_MC )_) ._. 
</s>
<s>
We_PPIS2 hypothesized_VVD that_CST elevated_JJ values_NN2 of_IO NPY_NP1 measured_VVD in_II peripheral_JJ blood_NN1 would_VM be_VBI correlated_VVN to_II the_AT degree_NN1 of_IO angiographic_JJ vasospasm_NN1 and_CC to_TO decrease_VVI in_II global_JJ CBF_NP1 and_CC that_DD1 elevated_JJ levels_NN2 would_VM be_VBI found_VVN in_II patients_NN2 with_IW clinical_JJ manifestations_NN2 of_IO DCI_MC ._. 
</s>
<s>
Therefore_RR ,_, care_NN1 must_VM be_VBI used_VVN in_II estimating_VVG the_AT effects_NN2 ._. 
</s>
<s>
In_II this_DD1 reaction_NN1 ,_, adenosine_VV0 monophosphate_NN1 (_( AMP_NN1 )_) is_VBZ produced_VVN and_CC removed_VVN by_II AMP_NN1 deaminase_NN1 1_MC1 ,_, resulting_VVG in_II the_AT production_NN1 of_IO NH3+_FO and_CC inosine_VV0 monophosphate_NN1 (_( IMP_NP1 )_) ,_, the_AT latter_DA being_NN1 metabolized_VVD to_TO inosine_VVI and_CC then_RT to_TO hypoxanthine_VVI ,_, xanthine_VVI ,_, and_CC uric_JJ acid_NN1 via_II xanthine_NN1 oxidase_NN1 ,_, which_DDQ generates_VVZ reactive_JJ oxygen_NN1 species_NN (_( ROS_NP1 )_) ._. 
</s>
<s>
Trophozoites_NN2 and_CC cysts_NN2 were_VBDR also_RR found_VVN in_II necrotizing_VVG lesions_NN2 in_II pons_NN2 ._. 
</s>
<s>
Microbleeds_NN2 thus_RR appear_VV0 best_RRT suited_VVN to_TO serve_VVI as_II an_AT1 early_JJ phase_NN1 marker_NN1 of_IO therapies_NN2 aimed_VVN at_II reducing_VVG CAA-related_JJ hemorrhagic_JJ events_NN2 ,_, but_CCB require_VV0 careful_JJ methods_NN2 for_IF standardized_JJ detection_NN1 and_CC interpretation_NN1 ._. 
</s>
<s>
The_AT mean_JJ concentration_NN1 of_IO NPY_NN1 that_CST averaged_VVD across_II all_DB days_NNT2 in_II the_AT DCI_MC group_NN1 was_VBDZ 74.83_MC pg/mL_FU (_( 95%_NNU confidence_NN1 interval_NN1 &lsqb;_( CI_FO &rsqb;_) ,_, 61.45-88.20_MCMC )_) and_CC 84.35_MC pg/mL_FU (_( 95%_NNU CI_FO ,_, 76.01-92.68_MCMC )_) in_II the_AT non-DCI_JJ group_NN1 ._. 
</s>
<s>
Summary_NN1 sensitivity_NN1 and_CC specificity_NN1 and_CC differences_NN2 in_II sensitivity_NN1 and_CC specificity_NN1 and_CC positive/negative_JJ predictive_JJ values_NN2 between_II novices_NN2 and_CC experts_NN2 were_VBDR evaluated_VVN using_VVG a_AT1 bivariate_JJ random-effects_NN2 model_NN1 ._. 
</s>
<s>
Finally_RR ,_, dementia_NN1 diagnosis_NN1 and_CC DRS_NP1 total_NN1 at_II baseline_NN1 were_VBDR not_XX significant_JJ moderators_NN2 of_IO depression_NN1 or_CC disability_NN1 outcomes_NN2 ._. 
</s>
<s>
However_RGQV '_NULL mainly_RR eyes_NN2 with_IW dislocation_NN1 grade_NN1 3_MC and_CC substantially_RR compromised_JJ BCVA_NN1 were_VBDR distributed_VVN unequally_RR '_NULL as_CSA can_VM be_VBI seen_VVN from_II Table_NN1 1_MC1 ._. 
</s>
<s>
Surgery_NN1 ._. 
</s>
<s>
Mean_JJ MOPS_NN2 was_VBDZ 3.5_MC ,_, interquartile_JJ range_NN1 2.5_MC -_- 4_MC (_( Table_NN1 1_MC1 )_) ._. 
</s>
<s>
With_IW the_AT advent_NN1 of_IO new_JJ mouse_NN1 models_NN2 to_TO conditionally_RR manipulate_VVI the_AT Cav1_FO gene_NN1 using_VVG Cre/lox_FU technology_NN1 (_( Reagan_NP1 et_RA21 al_RA22 ._. '_NULL 
</s>
<s>
2016_MC ;_; Sethna_NP1 et_RA21 al_RA22 ._. '_NULL 
</s>
<s>
2016_MC )_) '_NULL there_EX are_VBR now_RT unique_JJ opportunities_NN2 to_TO study_VVI cell-specific_JJ caveolin/caveolae_FU functions_VVZ '_NULL in_RR21 vivo_RR22 ._. 
</s>
<s>
Although_CS cases_NN2 of_IO reconstruction_NN1 of_IO the_AT hard_JJ palate_NN1 and_CC maxilla_NN1 by_II an_AT1 osteomyocutaneous_JJ submental_JJ flap_NN1 have_VH0 been_VBN described_VVN ,_, this_DD1 is_VBZ the_AT first_MD case_NN1 demonstrating_VVG the_AT reconstruction_NN1 of_IO the_AT inferior_JJ orbital_JJ rim_NN1 by_II an_AT1 osteomyocutaneous_JJ submental_JJ flap_NN1 ._. 
</s>
<s>
Parallel_JJ imaging_NN1 ,_, as_CSA described_VVN in_II the_AT previous_JJ paragraph_NN1 ,_, thus_RR allows_VVZ increased_JJ imaging_NN1 speed_NN1 ,_, a_AT1 major_JJ reason_NN1 for_IF its_APPGE development_NN1 ._. 
</s>
<s>
Details_NN2 are_VBR included_VVN in_II the_AT Supplemental_JJ Experimental_JJ Procedures_NN2 ._. 
</s>
<s>
Furthermore_RR ,_, potential_JJ group_NN1 differences_NN2 in_II global_JJ social_JJ functioning_NN1 and_CC communication_NN1 at_II baseline_NN1 are_VBR unknown_JJ because_CS the_AT SCQ_NP1 :_: C_NP1 was_VBDZ administered_VVN only_RR at_II 12-month_JJ follow-up_NN1 ._. 
</s>
<s>
For_IF membrane_NN1 proteins_NN2 affinity_NN1 chromatography_NN1 is_VBZ the_AT preferred_JJ mode_NN1 of_IO purification_NN1 ._. 
</s>
<s>
Forty-three_MC papers_NN2 had_VHD a_AT1 response_NN1 rate_NN1 of_IO greater_JJR than_CSN 50%_NNU and_CC gave_VVD sufficient_JJ Glasgow_NP1 Benefit_NN1 Inventory_NN1 total_NN1 and_CC subscales_NN2 for_IF meta-analysis_NN1 ._. 
</s>
<s>
Benzodiazepines_NN2 should_VM be_VBI avoided_VVN because_II21 of_II22 their_APPGE adverse_JJ effects_NN2 ._. 
</s>
<s>
In_II conclusion_NN1 ,_, we_PPIS2 have_VH0 documented_VVN a_AT1 temporal_JJ increase_NN1 in_II preeclampsia_NN1 in_II Washington_NP1 State_NN1 between_II 2000_MC and_CC 2008_MC that_CST occurred_VVD predominantly_RR because_II21 of_II22 an_AT1 increase_NN1 in_II early-onset_JJ disease_NN1 ._. 
</s>
<s>
High_JJ resolution_NN1 microperimetric_JJ assessment_NN1 using_VVG adaptive_JJ optics_NN1 technology_NN1 has_VHZ been_VBN described_VVN ._. 
</s>
<s>
This_DD1 effect_NN1 was_VBDZ strongest_JJT when_CS only_RR one_MC1 anxiety_NN1 disorder_NN1 was_VBDZ present_JJ (_( e.g._REX ,_, an_AT1 84%_NNU response_NN1 rate_NN1 compared_VVN with_IW a_AT1 53%_NNU response_NN1 rate_NN1 for_IF intensive_JJ psychotherapy_NN1 versus_II collaborative_JJ care_NN1 )_) ;_; with_IW two_MC or_CC more_DAR anxiety_NN1 disorders_NN2 ,_, the_AT advantage_NN1 of_IO intensive_JJ psychotherapy_NN1 was_VBDZ attenuated_VVN to_II a_AT1 very_RG small_JJ effect_NN1 size_NN1 (_( i.e._REX ,_, number_NN1 needed_VVN to_II treat=12.5_FO )_) ._. 
</s>
<s>
An_AT1 index_NN1 visit_NN1 was_VBDZ defined_VVN as_II the_AT first_MD ED_NN1 visit_NN1 (_( regardless_RR of_IO disposition_NN1 )_) for_IF a_AT1 unique_JJ patient_NN1 or_CC any_DD successive_JJ visits_NN2 in_II which_DDQ the_AT patient_NN1 had_VHD no_AT prior_JJ visit_NN1 or_CC hospitalization_NN1 during_II the_AT preceding_JJ 30_MC days_NNT2 ._. 
</s>
<s>
By_II reflecting_VVG a_AT1 larger_JJR proportion_NN1 of_IO the_AT incident_NN1 US_NP1 beam_NN1 ,_, echogenic_JJ needles_NN2 have_VH0 been_VBN shown_VVN to_TO improve_VVI needle_NN1 visibility_NN1 in_II phantoms_NN2 and_CC cadavers_NN2 ,_, particularly_RR in_II deeper_JJR blocks_NN2 requiring_VVG steeper_JJR needle_NN1 trajectories_NN2 ,_, although_CS evidence_NN1 of_IO a_AT1 clinical_JJ benefit_NN1 is_VBZ scant_JJ at_RR21 present_RR22 ._. 
</s>
<s>
External_JJ genital_JJ examination_NN1 At_II the_AT least_RRT ,_, the_AT physical_JJ examination_NN1 includes_VVZ the_AT steps_NN2 of_IO comprehensive_JJ internal_JJ and_CC external_JJ genital_JJ examination_NN1 used_VVN in_II adult_NN1 and_CC adolescent/pediatric_JJ gynecologic_JJ prac-tice120-122_MC ;_; therefore_RR ,_, it_PPH1 requires_VVZ an_AT1 examiner_NN1 skilled_JJ in_II genitopelvic_JJ examination_NN1 and_CC procedures_NN2 ._. 
</s>
<s>
In_II this_DD1 study_NN1 ,_, we_PPIS2 analyzed_VVD the_AT interest_NN1 of_IO controlling_VVG body_NN1 orientation_NN1 while_CS stroke_NN1 patients_NN2 estimate_VV0 VV_NP1 ._. 
</s>
<s>
We_PPIS2 averaged_VVD two_MC non-consecutive_JJ trials_NN2 of_IO 15_MC LEPs_NN2 ,_, with_IW a_AT1 break_NN1 of_IO two_MC minutes_NNT2 between_II each_DD1 trial_NN1 ._. 
</s>
<s>
Another_DD1 limitation_NN1 of_IO MR-based_JJ attenuation_NN1 correction_NN1 methods_NN2 is_VBZ truncation_NN1 due_II21 to_II22 the_AT smaller_JJR field_NN1 of_IO view_NN1 (_( FOV_NP1 )_) of_IO MR_NNB scanners_NN2 ._. 
</s>
<s>
Murine_JJ rods_NN2 have_VH0 inverted_JJ heterochromatin_NN1 organization_NN1 '_NULL i.e._REX contain_VV0 a_AT1 single_JJ large_JJ chromocenter_VV0 in_II the_AT middle_NN1 of_IO the_AT nucleus_NN1 (_( Solovei_NP1 et_RA21 al_RA22 ._. '_NULL 
</s>
<s>
2009_MC ;_; Solovei_NP1 et_RA21 al_RA22 ._. '_NULL 
</s>
<s>
2013_MC )_) ._. 
</s>
<s>
The_AT same_DA was_VBDZ true_JJ for_IF patients_NN2 showing_VVG signs_NN2 of_IO a_AT1 Balint-Holmes_NP1 syndrome_NN1 ,_, who_PNQS also_RR gave_VVD an_AT1 imprecise_JJ or_CC incorrect_JJ reason_NN1 for_IF their_APPGE visual_JJ impairments_NN2 in_II the_AT CVSQ_NP1 ._. 
</s>
<s>
A_AT1 total_NN1 of_IO 796_MC patients_NN2 were_VBDR included_VVN ._. 
</s>
<s>
This_DD1 was_VBDZ shown_VVN in_II the_AT NAWM_NP1 ,_, WMH_NP1 ,_, and_CC CGM_NP1 ,_, supporting_VVG the_AT generalized_JJ nature_NN1 of_IO cSVD_NNU ._. 
</s>
<s>
The_AT 2_MC operation_NN1 methods_NN2 to_TO be_VBI compared_VVN differed_VVN in_II duration_NN1 and_CC perioperative_JJ complications_NN2 ._. 
</s>
<s>
Withdrawal_NN1 assessment_NN1 occurs_VVZ one_MC1 or_CC more_DAR times_NNT2 per_II day_NNT1 during_II the_AT opioid_JJ taper_NN1 period_NN1 and_CC for_IF several_DA2 days_NNT2 following_RA taper_NN1 completion_NN1 ._. 
</s>
<s>
Assessment_NN1 of_IO Heterogeneity_NP1 &lsqb;_( chi_NN1 &rsqb;_) 2_MC test_NN1 and_CC f2_FO test_NN1 were_VBDR used_VVN for_IF testing_VVG the_AT heterogeneity_NN1 between_II studies_NN2 ._. 
</s>
<s>
Additionally_RR ,_, the_AT Intergroup_JJ Melanoma_NP1 Surgical_JJ Trial4_FO of_IO patients_NN2 randomly_RR assigned_VVN to_II either_RR a_AT1 2_MC cm_NNU or_CC 4_MC cm_NNU excision_NN1 margin_NN1 for_IF trunk_NN1 and_CC extremity_NN1 melanomas_NN2 with_IW Breslow_NP1 thickness_NN1 1-4_MCMC mm_NNU (_( median_NN1 1.96_MC mm_NNU )_) showed_VVD a_AT1 non-significant_JJ difference_NN1 (_( p=0.07_FO )_) in_II 10-year_JJ disease-specific_JJ survival_NN1 between_II groups_NN2 (_( 70%_NNU for_IF the_AT 2_MC cm_NNU group_NN1 and_CC 77%_NNU for_IF the_AT 4_MC cm_NNU group_NN1 )_) ._. 
</s>
<s>
The_AT order_NN1 of_IO experimental_JJ trials_NN2 was_VBDZ randomized_VVN and_CC counter-balanced_VVN ._. 
</s>
<s>
Examples_NN2 of_IO lower-extremity_JJ use_NN1 are_VBR foot_NN1 and_CC ankle_NN1 surgeries_NN2 ,_, anterior_JJ cruciate_NN1 ligament_NN1 (_( ACL_NP1 )_) reconstruction_NN1 ,_, meniscal_JJ repair_NN1 ,_, open_JJ reduction_NN1 internal_JJ fixation_NN1 (_( ORIF_NP1 )_) of_IO fractures_NN2 ,_, and_CC TKA_NP1 ._. 
</s>
<s>
All_DB included_VVD studies_NN2 used_VVD a_AT1 study_NN1 design_NN1 in_II which_DDQ patients_NN2 with_IW a_AT1 history_NN1 of_IO ocular_JJ Inflammation_NN1 (_( iritis_NN1 or_CC uveitis_NN1 )_) had_VHD been_VBN excluded_VVN from_II the_AT study_NN1 ._. 
</s>
<s>
However_RR ,_, we_PPIS2 face_VV0 the_AT challenge_NN1 that_CST in_RR21 vitro_RR22 biochemical_JJ assays_NN2 are_VBR predominantly_RR based_VVN on_II phosphorylated_JJ and_CC activated_VVN kinases_NN2 ._. 
</s>
<s>
The_AT miu_NN1 rate_NN1 constants_NN2 were_VBDR 0.107_MC hour-1_MC1 for_IF gadoterate_JJ meglumine_NN1 at_II 0.1_MC mmol/kg_FU ,_, 0.007_MC and_CC 0.020_MC hour_NNT1 '_NULL 1_MC1 for_IF gadodiamide_NN1 at_II 0.1_MC and_CC 0.3_MC mmol/kg_FU ,_, 0.029_MC and_CC 0.027_MC hour_NNT1 '_NULL 1_MC1 for_IF gadoxetate_NN1 disodium_NN1 at_II 0.2_MC and_CC 0.5_MC mmol/kg_FU ,_, and_CC 0.018_MC and_CC 0.017_MC hour_NNT1 '_NULL 1_MC1 for_IF Dy-EOB-DTPA_NP1 at_II 0.25_MC and_CC 0.5_MC mmol/kg_FU ._. 
</s>
<s>
Many_DA2 of_IO the_AT mechanisms_NN2 underlying_VVG the_AT relationships_NN2 between_II exercise_NN1 and_CC health_NN1 are_VBR well_RR characterized_VVN ,_, and_CC there_EX are_VBR reasonably_RR clear_JJ exercise_NN1 targets_NN2 and_CC expected_JJ dose_NN1 response_NN1 relationships_NN2 ._. 
</s>
<s>
Meanwhile_RR ,_, Cx36-mediated_JJ neuronal_JJ oscillations_NN2 in_II the_AT gamma_NN1 frequency_NN1 range_NN1 (_( 30_MC to_II 80_MC Hz_NNU )_) (_( n_ZZ1 =_FO 7_MC to_II 8_MC )_) and_CC the_AT neuronal_JJ synaptic_JJ transmission_NN1 (_( n_ZZ1 =_FO 13_MC to_II 19_MC )_) were_VBDR also_RR enhanced_VVN ._. 
</s>
<s>
Global_JJ FCI_NN1 refers_VVZ to_II the_AT average_JJ FCI_JJ absolute_JJ values_NN2 across_II all_DB values_NN2 in_II the_AT matrix_NN1 (_( matrix_NN1 diagonal_JJ excluded_JJ )_) ,_, and_CC allows_VVZ us_PPIO2 to_TO quantify_VVI variation_NN1 in_II FCI_NP1 at_II the_AT global_JJ level_NN1 within_II the_AT entire_JJ bilateral_JJ language_NN1 template_NN1 ._. 
</s>
<s>
We_PPIS2 used_VVD 3_MC data_NN files_NN2 :_: the_AT registry_NN1 of_IO beneficiaries_NN2 ,_, the_AT registry_NN1 of_IO Catastrophic_JJ Illness_NN1 Patient_NN1 Database_NN1 (_( CIPD_NP1 )_) ,_, and_CC all_DB inpatient_NN1 and_CC ambulatory_JJ care_NN1 records_NN2 for_IF cancer_NN1 care_NN1 ._. 
</s>
<s>
A_AT1 full_JJ description_NN1 of_IO which_DDQ sources_NN2 contributed_VVN to_II each_DD1 of_IO the_AT 15_MC CNVs_NP1 analysed_VVD is_VBZ provided_VVN in_II the_AT Supplementary_JJ Material_NN1 ;_; Supplementary_JJ Table_NN1 S3_FO ._. 
</s>
<s>
This_DD1 revealed_VVD that_DD1 mutant_NN1 collagen_NN1 directly_RR reduced_VVN replicative_JJ lifespan_NN1 and_CC increased_JJ stress-induced_JJ SA-BGal_JJ activity_NN1 ,_, p16_FO INK4A_FO expression_NN1 ,_, and_CC p21_FO CIP1_FO expression_NN1 ._. 
</s>
<s>
Another_DD1 factor_NN1 affecting_VVG the_AT quality_NN1 of_IO data_NN may_VM be_VBI the_AT poor_JJ 5-year_JJ survival_NN1 rates_NN2 for_IF patients_NN2 who_PNQS develop_VV0 hypopharyngeal_JJ cancer_NN1 :_: long-term_JJ outcomes_NN2 can_VM not_XX be_VBI ascertained_VVN for_IF a_AT1 large_JJ proportion_NN1 of_IO patients_NN2 who_PNQS require_VV0 PL_NN1 ._. 
</s>
<s>
The_AT ANOVA_NP1 revealed_VVD significant_JJ main_JJ effects_NN2 of_IO skin_NN1 type_NN1 (_( simultaneous_JJ 2PD_FO ,_, F114_FO =_FO 46.3_MC ,_, p_NNU less_DAR than_CSN 0.0001_MC ;_; successive_JJ 2PD_FO ,_, F19_FO =_FO 146.98_MC ,_, p_NNU less_DAR than_CSN 0.0001_MC )_) and_CC modality_NN1 (_( simultaneous_JJ 2PD_FO ,_, F114_FO =_FO 8.3_MC ,_, p_ZZ1 =_FO 0.012_MC ;_; successive_JJ 2PD_FO ,_, F19_FO =_FO 21.61_MC ,_, p_ZZ1 =_FO 0.001_MC )_) ._. 
</s>
<s>
We_PPIS2 did_VDD not_XX find_VVI a_AT1 disproportionate_JJ number_NN1 of_IO inpatient_NN1 diagnoses_VVZ that_CST would_VM absolutely_RR prohibit_VVI tPA_NN1 use_NN1 ;_; however_RR ,_, comorbid_JJ disease_NN1 severity_NN1 ,_, prestroke_VV0 disability_NN1 ,_, life_NN1 expectancy_NN1 ,_, or_CC other_JJ factors_NN2 that_CST result_VV0 in_II appropriate_JJ tPA_NN1 contraindication_NN1 may_VM vary_VVI in_II rural_JJ vs_II urban_JJ populations_NN2 ,_, even_RR after_II accounting_VVG for_IF baseline_NN1 sociodemographic_JJ differences_NN2 and_CC standard_JJ comorbidity_NN1 scoring_VVG in_II our_APPGE study_NN1 ._. 
</s>
<s>
Specifically_RR ,_, the_AT mean_JJ deviations_NN2 from_II the_AT spiral_JJ ganglion_NN1 estimate_NN1 were_VBDR 29.04_MC semitones_NN2 (_( SE_NP1 :_: 8.5_MC )_) in_II the_AT basal_JJ region_NN1 ,_, 16.32_MC semitones_NN2 (_( SE_NP1 :_: 2.54_MC )_) in_II the_AT middle_JJ region_NN1 ,_, and_CC 4.99_MC semitones_NN2 (_( SE_NP1 :_: 6.47_MC )_) in_II the_AT apical_JJ region_NN1 ._. 
</s>
<s>
It_PPH1 could_VM be_VBI speculated_VVN that_CST the_AT deficit_NN1 in_II dopaminergic_JJ D1/D5_JJ receptor-mediated_JJ signaling_NN1 in_II aging_NN1 could_VM affect_VVI transcription_NN1 and_CC translation_NN1 of_IO BDNF_NP1 causing_VVG the_AT memory_NN1 deficits_NN2 ._. 
</s>
<s>
In_II conclusion_NN1 ,_, the_AT literature_NN1 does_VDZ not_XX support_VVI the_AT hypothesis_NN1 that_CST training_NN1 for_IF muscle_NN1 hypertrophy_NN1 requires_VVZ shorter_JJR rest_NN1 intervals_NN2 than_CSN training_NN1 for_IF strength_NN1 development_NN1 or_CC that_DD1 predetermined_JJ rest_NN1 intervals_NN2 are_VBR preferable_JJ to_II auto-regulated_JJ rest_NN1 periods_NN2 in_II this_DD1 regard_NN1 ._. 
</s>
<s>
Ethics_NN committees_NN2 at_II each_DD1 center_NN1 approved_VVD the_AT study_NN1 and_CC participants_NN2 provided_CS written_VVN informed_JJ consent_NN1 ._. 
</s>
<s>
Competing_JJ interests_NN2 :_: The_AT funding_NN1 organization(s)_NN2 played_VVD no_AT role_NN1 in_II the_AT study_NN1 design_NN1 ;_; in_II the_AT collection_NN1 ,_, analysis_NN1 ,_, and_CC interpretation_NN1 of_IO data_NN ;_; in_II the_AT writing_NN1 of_IO the_AT report_NN1 ;_; or_CC in_II the_AT decision_NN1 to_TO submit_VVI the_AT report_NN1 for_IF publication_NN1 ._. 
</s>
<s>
I._NP1 A._NP1 is_VBZ a_AT1 Howard_NP1 Hughes_NP1 Medical_JJ Institute_NN1 Early_JJ Career_NN1 Scientist_NN1 ._. 
</s>
<s>
Additionally_RR ,_, when_CS neuronal_JJ death_NN1 occurs_VVZ it_PPH1 may_VM in_II turn_VVI cause_VV0 a_AT1 decreased_JJ level_NN1 of_IO endogenous_JJ KTP_NP1 in_II brain_NN1 which_DDQ further_JJR impacts_NN2 on_II chronic_JJ pain_NN1 and_CC impairment_NN1 of_IO NO_AT production_NN1 ._. 
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<s>
We_PPIS2 excluded_VVD studies_NN2 of_IO real-time_JJ ultrasound-guided_JJ neuraxial_JJ blocks_NN2 as_II31 well_II32 as_II33 those_DD2 related_VVN to_II interventional_JJ pain_NN1 procedures_NN2 on_II the_AT spine_NN1 ._. 
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<s>
The_AT reproducibility_NN1 and_CC validity_NN1 of_IO this_DD1 procedure_NN1 for_IF the_AT knee_NN1 extensors_NN2 has_VHZ been_VBN previously_RR established_VVN ._. 
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<s>
The_AT attached_JJ Figure_NN1 1_MC1 describes_VVZ six_MC hypothetical_JJ patients_NN2 and_CC applies_VVZ to_II all_DB cancers_NN2 of_IO different_JJ disease_NN1 biology_NN1 and_CC dynamics_NN ._. 
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<s>
They_PPHS2 have_VH0 hypothesized_VVN that_CST hs-cTn_JJ use_NN1 could_VM decrease_VVI specificity_NN1 and_CC lead_VVI to_II more_DAR patients_NN2 with_IW diagnostic_JJ and_CC therapeutic_JJ dilemmas_NN2 ._. 
</s>
<s>
Both_DB2 groups_NN2 used_VVD KR_NP1 similarly_RR as_CSA indicated_VVN by_II the_AT overall_JJ increase_NN1 in_II velocity_NN1 (_( Figures_VVZ 3A_FO and_CC 3C_FO )_) ._. 
</s>
<s>
However_RR ,_, Collal_NP1 r/r_ZZ1 mice_NN2 displayed_VVD several_DA2 features_NN2 of_IO premature_JJ aging_NN1 ._. 
</s>
<s>
The_AT mechanisms_NN2 underlying_VVG the_AT hepatic_JJ 5alpha-reductase_JJ deficiency_NN1 among_II AIP_NP1 patients_NN2 remain_VV0 obscure_JJ ._. 
</s>
<s>
In_II newly_RR diagnosed_VVD MM_NNU and_CC in_II patients_NN2 relapsing_VVG following_JJ treatment_NN1 discontinuation_NN1 ,_, the_AT predominating_JJ tumor_NN1 cells_NN2 are_VBR Xbp1s+_FO plasma_NN1 cells_NN2 or_CC plasmablasts_NN2 (_( Figures_VVZ 6_MC ,_, 7A_FO ,_, and_CC 7D_NNU )_) ,_, although_CS progenitor_NN1 subpopulations_NN2 including_II CD20_FO ._. 
</s>
<s>
This_DD1 circadian_JJ rhythm_NN1 also_RR lasted_VVD at_RR21 least_RR22 up_II21 to_II22 day_NNT1 14_MC (_( ZT4_FO versus_II ZT16_FO :_: 10.14_MC plus_II and_CC minus_II 1.94_MC vs_II 15.03_MC plus_II and_CC minus_II 1.32_MC ;_; P_NP1 less_DAR than_CSN 0.001_MC ;_; Fig._NN1 1B_FO )_) ._. 
</s>
<s>
Rather_RR ,_, the_AT Alu-related_JJ transcripts_NN2 found_VVN in_II HeLa_NP1 cells_NN2 are_VBR transcribed_VVN primarily_RR by_II RNA_NN1 Pol_NP1 II_MC ,_, reflecting_VVG the_AT fact_NN1 that_CST many_DA2 A_ZZ1 !_! u_ZZ1 elements_NN2 are_VBR embedded_VVN within_II Pol_NP1 II_MC transcription_NN1 units_NN2 ._. 
</s>
<s>
Fig_NN1 ._. 
</s>
<s>
S3_FO MDT-15_MC is_VBZ required_VVN to_TO upregulate_VVI SKN-1_MC1 targets_NN2 upon_II loss_NN1 of_IO wdr-23_MC ._. 
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<s>
In_II this_DD1 respect_NN1 ,_, several_DA2 observations_NN2 should_VM be_VBI taken_VVN into_II account_NN1 ._. 
</s>
<s>
There_EX were_VBDR no_AT reported_JJ adverse_JJ effects_NN2 of_IO vitamin_NN1 C_ZZ1 supplementation_NN1 ._. 
</s>
<s>
Whether_CSW this_DD1 holds_VVZ true_RR given_VVN the_AT distribution_NN1 of_IO where_RRQ stroke_NN1 patients_NN2 are_VBR treated_VVN is_VBZ unknown_JJ ._. 
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<s>
Their_APPGE study_NN1 reports_VVZ that_CST the_AT desired_JJ BCI_NP1 accuracy_NN1 for_IF people_NN with_IW ALS_NP2 is_VBZ at_RR21 least_RR22 90%_NNU ,_, but_CCB accuracies_NN2 reported_VVN in_II the_AT literature_NN1 are_VBR usually_RR lower_JJR ._. 
</s>
<s>
To_TO determine_VVI whether_CSW sleep_NN1 pressure_NN1 is_VBZ dissipated_VVN under_II propofol_NN1 anesthesia_NN1 ,_, we_PPIS2 subjected_VVD flies_NN2 to_II SD_NP1 for_IF 10_MC h_ZZ1 from_II ZT_NP1 14_MC to_II 24_MC and_CC individually_RR transferred_VVN them_PPHO2 to_II activity_NN1 tubes_NN2 containing_VVG either_RR 1.0_MC mM_NNU propofol_NN1 or_CC an_AT1 equivalent_JJ concentration_NN1 of_IO vehicle_NN1 for_IF 6_MC h_ZZ1 from_II ZT_NP1 0_MC to_II 6_MC ._. 
</s>
<s>
MACE_NP1 occurred_VVD in_II 20/259_MF (_( 7.7%_FO )_) patients_NN2 in_II the_AT main_JJ cohort:there_FO were_VBDR no_AT deaths_NN2 ,_, 14_MC patients_NN2 had_VHD MI_NP1 ,_, and_CC 6_MC patients_NN2 had_VHD coronary_JJ revascularization_NN1 without_IW MI_NP1 ._. 
</s>
<s>
The_AT AEF_NN1 thus_RR allows_VVZ not_XX only_RR to_TO detect_VVI lesions_NN2 that_CST have_VH0 been_VBN overlooked_VVN in_II the_AT conventional_JJ readout_NN1 but_CCB also_RR to_TO raise_VVI the_AT sensitivity_NN1 by_II including_VVG HCC_NP1 lesions_NN2 with_IW weak_JJ arterial_JJ enhancement_NN1 and/or_CC uncertain_JJ washout_NN1 without_IW losing_VVG the_AT high_JJ specificity_NN1 of_IO 96%_NNU to_II 98%_NNU ._. 
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<s>
All_DB the_AT SNPs_NP2 are_VBR checked_VVN for_IF Hardy_NP1 -_- Weinberg_NP1 equilibrium_NN1 (_( HWE_NP1 )_) by_II the_AT exact_JJ test_NN1 ._. 
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<s>
Several_DA2 groups_NN2 have_VH0 investigated_VVN whether_CSW chronobiologic_JJ treatments_NN2 can_VM improve_VVI depressive_NN1 symptoms_NN2 in_II older_JJR adults_NN2 ._. 
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<s>
The_AT current_JJ evidence_NN1 suggests_VVZ that_DD1 TOP_NN1 should_VM be_VBI the_AT preferred_JJ method_NN1 of_IO speech_NN1 rehabilitation_NN1 ._. 
</s>
<s>
The_AT mean_JJ age_NN1 of_IO those_DD2 who_PNQS did_VDD and_CC did_VDD not_XX stutter_VVI was_VBDZ 22.6_MC (_( SD_NP1 =_FO 3.1_MC )_) and_CC 22.7_MC (_( SD_NP1 =_FO 3.4_MC )_) years_NNT2 old_JJ respectively_RR ._. 
</s>
<s>
RESULTS_NN2 Participants_NN2 Fifty-eight_MC patients_NN2 were_VBDR consented_VVN for_IF UDT_NP1 ,_, and_CC 50_MC were_VBDR able_JK to_TO provide_VVI a_AT1 specimen_NN1 ._. 
</s>
<s>
Although_CS opium_NN1 had_VHD been_VBN known_VVN for_IF centuries_NNT2 to_TO relieve_VVI pain_NN1 and_CC provide_VVI some_DD surgical_JJ analgesia_NN1 ,_, Boyle_NP1 focused_VVD on_II it_PPH1 as_CSA poison_NN1 ,_, perhaps_RR because_CS his_APPGE interest_NN1 was_VBDZ more_RGR chemical_JJ than_CSN medical_JJ ,_, and_CC because_CS opium_NN1 was_VBDZ known_VVN to_TO kill_VVI :_: '_NULL we_PPIS2 have_VH0 more_DAR than_CSN once_RR given_VVN to_II a_AT1 Dog_NN1 ,_, without_IW much_RR harming_VVG him_PPHO1 ,_, such_DA a_AT1 quantity_NN1 of_IO Opium_NN1 ,_, as_CSA would_VM probably_RR have_VHI suffic_JJ '_NULL d_ZZ1 to_TO have_VHI killJd_NN1 several_DA2 Men_NN2 ,_, Several_DA2 pages_NN2 of_IO his_APPGE essay_NN1 were_VBDR dedicated_VVN to_II the_AT question_NN1 of_IO how_RRQ opium_NN1 might_VM best_RRT be_VBI formulated_VVN and_CC prepared_VVN with_IW alcohol_NN1 to_TO form_VVI various_JJ kinds_NN2 of_IO laudenum_NN1 ,_, some_DD including_II saffron_NN1 and_CC vinegar_NN1 ._. 
</s>
<s>
Conclusion_NN1 :_: No_AT connection_NN1 between_II allergy_NN1 to_TO propofol_VVI and_CC allergy_NN1 to_II egg_NN1 ,_, soy_JJ or_CC peanut_NN1 was_VBDZ found_VVN ._. 
</s>
<s>
In_BCL21 order_BCL22 to_TO provide_VVI multiple_JJ methods_NN2 for_IF comparison_NN1 across_II studies_NN2 ,_, several_DA2 statistics_NN were_VBDR computed_VVN to_TO describe_VVI analyte_NN1 variation_NN1 ._. 
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<s>
By_II assuming_VVG leadership_NN1 and_CC responsibility_NN1 for_IF the_AT stewardship_NN1 of_IO our_APPGE health_NN1 care_NN1 resources_NN2 ,_, they_PPHS2 have_VH0 an_AT1 opportunity_NN1 to_TO preserve_VVI their_APPGE autonomy_NN1 and_CC ensure_VVI that_CST hospitalized_VVD children_NN2 receive_VV0 the_AT highest_JJT quality_NN1 care_NN1 ._. 
</s>
<s>
To_TO assess_VVI fidelity_NN1 ,_, group_NN1 leaders_NN2 documented_VVD session_NNT1 activities_NN2 (_( eg_REX ,_, review_NN1 of_IO homework_NN1 and_CC video_NN1 vignettes_NN2 discussed_VVN )_) after_CS each_DD1 session_NNT1 using_VVG the_AT IY_NP1 program_NN1 '_NULL s_ZZ1 Leader_NN1 '_NULL s_ZZ1 Process_VV0 Checklist_NN1 ._. 
</s>
<s>
After_CS the_AT radical_JJ maxillectomy_NN1 ,_, the_AT upper_JJ border_NN1 of_IO the_AT submental_JJ flap_NN1 was_VBDZ marked_VVN at_II the_AT inferior_JJ border_NN1 of_IO the_AT mandibular_JJ arch_NN1 ._. 
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<s>
Two_MC other_JJ major_JJ signs_NN2 to_TO affirm_VVI the_AT diagnosis_NN1 of_IO HCC_NP1 beneath_II the_AT perfusion_NN1 characteristics_NN2 are_VBR the_AT presence_NN1 of_IO a_AT1 capsule_NN1 and_CC threshold_NN1 growth_NN1 between_II 2_MC imaging_JJ studies_NN2 ._. 
</s>
<s>
Jeffrey_NP1 Sapyta_NP1 ,_, PhD_NNA ,_, Duke_NN1 University_NN1 Medical_JJ Center_NN1 ,_, Durham_NP1 ,_, NC_NP1 ._. 
</s>
<s>
The_AT prevalence_NN1 of_IO migraine_NN1 was_VBDZ higher_JJR among_II people_NN with_IW bipolar_JJ disorder_NN1 type_NN1 II_MC (_( 54.17%_FO ,_, 95%_NNU CI_FO 31.52_MC to_II 75.95_MC )_) compared_VVN with_IW bipolar_JJ disorder_NN1 type_NN1 I_ZZ1 (_( 32.7%_FO ,_, 95%_NNU CI_FO 18.16_MC to_II 49.19_MC )_) .17_MC Bipolar_JJ disorder_NN1 comorbidity_NN1 with_IW migraine_NN1 seems_VVZ to_TO be_VBI a_AT1 subtype_NN1 of_IO bipolar_JJ disorder_NN1 with_IW an_AT1 unstable_JJ rapid_JJ cycling_NN1 course_NN1 ,_, an_AT1 increased_JJ prevalence_NN1 of_IO comorbid_JJ panic_NN1 attacks_NN2 ,_, an_AT1 earlier_JJR age_NN1 of_IO onset_NN1 and_CC increased_JJ prevalence_NN1 in_II women.18_FO ,_, 19_MC Bipolar_JJ disorder_NN1 and_CC migraine_VV0 share_VV0 similar_JJ features_NN2 ._. 
</s>
<s>
Because_CS standardized_JJ stroke_NN1 protocols_NN2 are_VBR generally_RR not_XX tailored_VVN to_II the_AT demonstration_NN1 of_IO venous_JJ vessels_NN2 ,_, the_AT confirmation_NN1 or_CC exclusion_NN1 of_IO CVST_NP1 is_VBZ frequently_RR not_XX possible_JJ in_II these_DD2 examinations_NN2 ._. 
</s>
<s>
Representative_JJ MRI_JJ images_NN2 (_( axial_JJ resolution_NN1 23.4_MC mm_NNU )_) of_IO three_MC c_ZZ1 ratory_JJ models_NN2 acquired_VVD using_VVG established_JJ protocols_NN2 (_( Berkowitz_NP1 et_RA21 al._RA22 ,_, 2014_MC ;_; Bissig_NP1 et_RA21 al._RA22 ,_, 2013_MC )_) ;_; the_AT images_NN2 are_VBR proportionately_RR sized_VVN based_VVN on_II ocular_JJ anatomy.2009a_FO ,_, 2010_MC ,_, 2012a_FO ,_, 2006_MC ,_, 2007d_NNU ;_; Bissig_NP1 and_CC Berkowitz_NP1 ,_, 2011_MC )_) ._. 
</s>
<s>
Though_CS the_AT parents_NN2 love_VV0 their_APPGE child_NN1 ,_, they_PPHS2 gradually_RR lack_VV0 patience_NN1 ,_, acceptance_NN1 ,_, understanding_VVG ,_, resistance_NN1 and_CC willingness_NN1 to_TO spend_VVI time_NNT1 together_RL (_( Farnik_NP1 et_RA21 al._RA22 ,_, 2010_MC ;_; Miller_NP1 ,_, 2009_MC )_) ._. 
</s>
<s>
Provenance_NN1 and_CC peer_VV0 review_VV0 Not_XX commissioned_VVN ;_; externally_RR peer_VV0 reviewed_VVN ._. 
</s>
<s>
In_II 2011_MC ,_, the_AT National_JJ Lung_NN1 Screening_NN1 cer_NN1 therapeutics_NN1 ._. 
</s>
<s>
The_AT serum_NN1 potassium_NN1 report_NN1 was_VBDZ 2.0_MC mmol/L_FU ._. 
</s>
<s>
With_IW administration_NN1 potassium_NN1 (_( 160_MC meq_JJ intravenous_JJ over_RG 24_MC h_ZZ1 followed_VVN by_II 60_MC meq_JJ per_II day_NNT1 in_II three_MC divided_JJ doses_NN2 orally_RR in_II form_NN1 of_IO potassium_NN1 chloride_NN1 )_) ,_, the_AT patient_NN1 showed_VVD dramatic_JJ clinical_JJ improvement_NN1 ._. 
</s>
<s>
We_PPIS2 confirmed_VVD these_DD2 projections_NN2 using_VVG a_AT1 retrograde_NN1 tracer_NN1 ._. 
</s>
<s>
Modified_VVN from_II Marc_NP1 et_RA21 al_RA22 ._. 
</s>
<s>
(_( 2013_MC )_) ,_, The_AT New_JJ Visual_JJ Neurosciences_NP2 ,_, in_II press_NN1 ,_, by_II permission_NN1 of_IO the_AT authors_NN2 ._. 
</s>
<s>
We_PPIS2 firstly_RR used_VVD the_AT Genevar_NN1 expression_NN1 database_NN1 ,_, consisting_VVG of_IO 75_MC lymphoblastoid_JJ cell_NN1 lines_NN2 from_II healthy_JJ European_JJ individuals_NN2 ,_, 40_MC and_CC found_VVN rs2709373_FO and_CC rs2551949_FO were_VBDR significantly_RR associated_VVN with_IW CREB1_FO expression_NN1 (_( rs2709373_FO ,_, P_ZZ1 =_FO 2.4_MC x_ZZ1 10-3_MCMC ;_; rs2551949_FO ,_, P_ZZ1 =_FO 5.0_MC x_ZZ1 10-4_MCMC ,_, probe_VV0 ID_NN1 :_: ILMN2334242_FO ;_; Figure_NN1 3a_FO )_) ,_, with_IW the_AT risk_NN1 alleles_NN2 having_VHG higher_JJR expression_NN1 ._. 
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<s>
A_AT1 decrease_NN1 in_II endotoxin_NN1 could_VM theoretically_RR reduce_VVI the_AT activation_NN1 of_IO systemic_JJ proinflammatory_JJ mediators_NN2 such_II21 as_II22 TNF-a_NP1 and_CC NF-kB_NN1 resulting_VVG in_II an_AT1 overall_JJ decrease_NN1 in_II adipose_VV0 tissue_NN1 and_CC systemic_JJ inflammation_NN1 ._. 
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<s>
Impaired_JJ maturation_NN1 of_IO proNGF_NN1 caused_VVN by_II the_AT oxidative_JJ milieu_NN1 of_IO the_AT diabetic_JJ retina_NN1 results_NN2 in_II increased_JJ expression_NN1 of_IO proNGF_NN1 ,_, with_IW a_AT1 corresponding_JJ decrease_NN1 in_II NGF_NP1 (_( Mysona_NP1 et_RA21 al._RA22 ,_, 2014_MC )_) ._. 
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<s>
OBJECTIVE_JJ To_TO test_VVI whether_CSW CSF_NP1 NFL_NP1 concentration_NN1 is_VBZ associated_VVN with_IW cognitive_JJ decline_NN1 and_CC imaging_VVG evidence_NN1 of_IO neurodegeneration_NN1 and_CC white_JJ matter_NN1 change_NN1 in_II AD.DESIGN_NP1 ,_, SETTING_VVG ,_, AND_CC PARTICIPANTS_NN2 A_ZZ1 commercially_RR available_JJ immunoassay_NN1 was_VBDZ used_VVN to_TO analyze_VVI CSF_NP1 NFL_NP1 concentration_NN1 in_II a_AT1 cohort_NN1 of_IO patients_NN2 with_IW AD_RA (_( n_ZZ1 =_FO 95_MC )_) or_CC mild_JJ cognitive_JJ impairment_NN1 (_( MCI_MC )_) (_( n_ZZ1 =_FO 192_MC )_) and_CC in_II cognitively_RR normal_JJ individuals_NN2 (_( n_ZZ1 =_FO 110_MC )_) from_II the_AT Alzheimer_NP1 '_NULL s_ZZ1 Disease_NN1 Neuroimaging_VVG Initiative_NN1 ._. 
</s>
<s>
Focus_VV0 on_II BrM_NP1 proved_VVD fruitful_JJ ,_, because_CS it_PPH1 is_VBZ the_AT compartment_NN1 for_IF AMD-specific_JJ lesions_NN2 (_( drusen_NN1 and_CC BLinD_JJ )_) ,_, thus_RR imparting_VVG great_JJ potential_NN1 for_IF direct_JJ involvement_NN1 in_II lesion_NN1 biogenesis_NN1 ._. 
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<s>
Women_NN2 were_VBDR initially_RR classified_VVN using_VVG information_NN1 provided_VVN at_II recruitment_NN1 ,_, and_CC those_DD2 who_PNQS provided_VVD updated_JJ information_NN1 on_II HT_NN1 use_NN1 on_II the_AT second_MD study_NN1 questionnaire_NN1 (_( on_II average_NN1 3_MC years_NNT2 after_II recruitment_NN1 )_) were_VBDR then_RT reclassified_VVN using_VVG this_DD1 updated_JJ information_NN1 ._. 
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<s>
Scapula_JJ position_NN1 has_VHZ been_VBN shown_VVN to_TO contribute_VVI to_II subacromial_JJ impingement_NN1 and_CC should_VM therefore_RR be_VBI assessed_VVN to_TO determine_VVI resting_NN1 position_NN1 and_CC mobility_NN1 ._. 
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<s>
This_DD1 is_VBZ achieved_VVN by_II defining_VVG the_AT target_NN1 deletion_NN1 space_NN1 through_II careful_JJ choice_NN1 of_IO primer_NN1 locations_NN2 and_CC the_AT restriction_NN1 enzyme_NN1 ._. 
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<s>
Carotid_JJ imaging_NN1 at_II 7_MC T_ZZ1 has_VHZ attracted_VVN substantial_JJ attention_NN1 ,_, given_VVN the_AT importance_NN1 ofspatial_JJ resolution_NN1 in_II evaluating_VVG the_AT carotid_JJ wall_NN1 and_CC atherosclerotic_JJ disease.435_FO Other_JJ specialty_NN1 areas_NN2 within_II the_AT CNS_NP1 where_CS ultra-high_JJ field_NN1 MR_NNB could_VM easily_RR surpass_VVI 3_MC T_ZZ1 in_II31 terms_II32 of_II33 diagnostic_JJ efficacy_NN1 include_VV0 the_AT orbit_NN1 ,_, sella_NN1 ,_, and_CC internal_JJ auditory_JJ canal_NN1 ._. 
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<s>
The_AT ability_NN1 to_TO exchange_VVI ,_, aggregate_NN1 ,_, and_CC apply_VVI information_NN1 is_VBZ critical_JJ to_TO advance_VVI biomedical_JJ research_NN1 and_CC to_TO support_VVI the_AT learning_NN1 health_NN1 care_NN1 enterprise_NN1 ._. 
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<s>
It_PPH1 has_VHZ also_RR been_VBN demonstrated_VVN as_CSA useful_JJ in_II identifying_VVG high-risk_JJ septic_JJ patients_NN2 in_II the_AT ED_NP1 ._. 
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<s>
It_PPH1 was_VBDZ least_RRT in_II group_NN1 K_ZZ1 and_CC was_VBDZ comparable_JJ to_II group_NN1 D_ZZ1 except_CS at_II 6_MC hours_NNT2 (_( Table_NN1 3_MC )_) ._. 
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<s>
Implications_NN2 for_IF function_NN1 Recognizing_VVG the_AT limitations_NN2 of_IO room-temperature_JJ recordings_NN2 from_II immature_JJ ,_, excised_VVD cochlear_JJ tissue_NN1 ,_, nonetheless_RR it_PPH1 is_VBZ worth_II considering_VVG the_AT implications_NN2 of_IO these_DD2 results_NN2 ._. 
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<s>
Some_DD evidence_NN1 suggests_VVZ that_CST biphosphonates_NN2 might_VM improve_VVI survival_NN1 ._. 
</s>
<s>
Both_RR early_JJ onset_NN1 presentations_NN2 in_II infancy_NN1 and_CC late_JJ onset_NN1 manifestations_NN2 in_II adults_NN2 >_FO 70_MC years_NNT2 are_VBR now_RT well_RR recognized_VVN ._. 
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<s>
There_EX was_VBDZ no_AT high-dose_JJ hook_NN1 effect_NN1 up_RG21 to_RG22 13_MC ,_, 000_MC ng/mL_FU AMH_NN1 ._. 
</s>
<s>
Therefore_RR ,_, the_AT overall_JJ benefit_NN1 of_IO tPA_NN1 likely_RR will_VM outweigh_VVI any_DD risk_NN1 for_IF excess_NN1 bleeding_RG associated_JJ with_IW antiplatelet_NN1 therapy_NN1 ._. 
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<s>
No_AT relevant_JJ conflicts_NN2 of_IO interest_NN1 to_TO disclose_VVI ._. 
</s>
<s>
These_DD2 mice_NN2 with_IW poor_JJ performance_NN1 were_VBDR the_AT oldest_JJT mice_NN2 (_( 10_MC month_NNT1 old_JJ )_) in_II both_DB2 genotype_NN1 groups_NN2 ._. 
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<s>
It_PPH1 is_VBZ well_RR recognized_VVN that_CST non-cardiac_JJ surgery_NN1 in_II patients_NN2 with_IW previous_JJ PCI_NP1 is_VBZ associated_VVN with_IW excessive_JJ cardiac_JJ events_NN2 ._. 
</s>
<s>
A_AT1 preplanned_JJ subgroup_NN1 analysis_NN1 that_CST examined_VVD visual_JJ outcomes_NN2 as_II a_AT1 function_NN1 of_IO duration_NN1 of_IO DME_NN1 at_II randomization_NN1 (_( above_RL or_CC below_II the_AT median_JJ duration_NN1 )_) revealed_VVD that_CST the_AT treatment_NN1 effect_NN1 resided_VVD primarily_RR in_II patients_NN2 with_IW chronic_JJ DME_NN1 ._. 
</s>
<s>
Carolinas_NP2 Medical_JJ Center_NN1 ,_, Charlotte_NP1 ,_, North_ND1 Carolina_NP1 :_: J._NP1 Bernard_NP1 ,_, S._NP1 Dibert_NP1 ,_, J._NP1 Story_NN1 ,_, J._NP1 Martin_NP1 ,_, and_CC M.Price_NP1 ._. 
</s>
<s>
To_TO demonstrate_VVI the_AT utility_NN1 and_CC sensitivity_NN1 of_IO this_DD1 assay_NN1 ,_, we_PPIS2 analyzed_VVD deletion_NN1 loads_NN2 within_II the_AT mitochondrial_JJ genome_NN1 of_IO human_JJ brain_NN1 samples_NN2 ._. 
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<s>
A_AT1 neural_JJ network_NN1 can_VM be_VBI thought_VVN of_IO as_II a_AT1 small_JJ machine_NN1 capable_JJ of_IO learning_NN1 ._. 
</s>
<s>
We_PPIS2 review_VV0 a_AT1 range_NN1 of_IO potential_JJ outcome_NN1 markers_NN2 for_IF CAA_NP1 against_II the_AT ideal_JJ criteria_NN2 of_IO being_VBG clinically_RR meaningful_JJ ,_, closely_RR reflective_JJ of_IO biological_JJ progression_NN1 ,_, efficient_JJ for_IF smaller/shorter_JJR trials_NN2 ,_, reliably_RR measurable_JJ ,_, and_CC cost_VV0 effective_JJ ._. 
</s>
<s>
The_AT animal_NN1 was_VBDZ then_RT returned_VVN to_II its_APPGE home_NN1 cage_NN1 for_IF seven_MC days_NNT2 survival_NN1 time_NNT1 ._. 
</s>
<s>
Two-by-two_MC tables_NN2 were_VBDR used_VVN to_TO determine_VVI sensitivity_NN1 ,_, specificities_NN2 ,_, positive_JJ and_CC negative_JJ likelihood_NN1 ratios_NN2 ,_, and_CC agreement_NN1 between_II Ottawa_NP1 3DY_FO Scale_NN1 scores_NN2 and_CC Animal_NN1 Fluency_NN1 Test_NN1 scores_NN2 and_CC MiniMental_JJ State_NN1 Examination_NN1 results_NN2 at_II predetermined_JJ cutoffs_NN2 ._. 
</s>
<s>
First_MD ,_, it_PPH1 is_VBZ difficult_JJ to_TO draw_VVI conclusions_NN2 regarding_II device_NN1 performance_NN1 in_II individual_JJ patients_NN2 using_VVG the_AT geometric_JJ mean_NN1 of_IO 37_MC patients_NN2 whose_DDQGE urinary_JJ hCG_NNU concentrations_NN2 demonstrated_VVN such_DA a_AT1 large_JJ standard_JJ deviation_NN1 ._. 
</s>
<s>
The_AT C-arm_NN1 (_( MultiDiagnost_NP1 Eleva_NP1 ;_; Philips_NP1 Medical_JJ Systems_NN2 ,_, Nederland_NP1 B.V._NP1 ,_, Holland_NP1 )_) was_VBDZ rotated_VVN until_CS the_AT superior_JJ and_CC inferior_JJ vertebral_JJ plate_NN1 were_VBDR aligned_VVN and_CC angled_VVN at_II approximately_RR 45_MC degrees_NN2 in_II the_AT oblique_JJ view_NN1 ,_, or_CC until_CS the_AT upper_JJ tip_NN1 of_IO the_AT target_NN1 superior_JJ articular_JJ process_NN1 was_VBDZ located_VVN at_II the_AT midpoint_NN1 of_IO the_AT vertebral_JJ body_NN1 ._. 
</s>
<s>
The_AT suppression_NN1 of_IO various_JJ activity-associated_JJ genes_NN2 could_VM stabilize_VVI the_AT neuromuscular_JJ junction_NN1 and_CC inhibit_VVI reinnervation_NN1 in_II the_AT MuRF1_FO KO_NN1 mice_NN2 during_II this_DD1 time_NNT1 of_IO motoneuron_NN1 loss_NN1 and_CC synapse_VV0 remodeling_VVG ._. 
</s>
<s>
Data_NN Analyses_VVZ Previous_JJ studies_NN2 testing_VVG the_AT concurrent_JJ validity_NN1 of_IO neonatal_JJ pain_NN1 scales_NN2 have_VH0 evidenced_VVN large_JJ effect_NN1 sizes_NN2 ._. 
</s>
<s>
As_II a_AT1 proxy_NN1 for_IF measuring_VVG switching_NN1 to_II less_RGR expensive_JJ clinicians_NN2 ,_, HOPD_NP1 utilization_NN1 was_VBDZ examined_VVN ._. 
</s>
<s>
The_AT most_RGT clinically_RR serious_JJ event_NN1 was_VBDZ 1_MC1 case_NN1 of_IO endophthalmitis_NN1 ._. 
</s>
<s>
Ventricle_NN1 reduction_NN1 was_VBDZ counted_VVN as_CSA agreement_NN1 because_CS enlargement_NN1 of_IO ventricles_NN2 can_VM often_RR resolve_VVI spontaneously_RR during_II pregnancy_NN1 ._. 
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<s>
An_AT1 increase_NN1 in_II the_AT number_NN1 of_IO GABAA_NN1 receptors_NN2 is_VBZ predicted_VVN to_TO enhance_VVI the_AT behavioral_JJ neurodepressive_JJ properties_NN2 of_IO general_JJ anesthetics_NN2 ._. 
</s>
<s>
Hypotension_NN1 necessitating_VVG changes_NN2 in_II analgesic_NN1 therapy_NN1 (_( either_RR holding_VVG or_CC dose_NN1 adjustment_NN1 )_) occurred_VVD in_RP approximately_RR 25%_NNU of_IO patients_NN2 on_II POD1_FO and_CC approximately_RR 10%_NNU of_IO patients_NN2 on_II POD2_FO in_II the_AT epidural_JJ analgesia_NN1 cohort_NN1 ;_; it_PPH1 was_VBDZ virtually_RR eliminated_VVN in_II the_AT intravenous_JJ lidocaine_NN1 group_NN1 ._. 
</s>
<s>
Several_DA2 clinical_JJ studies_NN2 have_VH0 shown_VVN DEX_VV0 to_TO be_VBI a_AT1 useful_JJ sedative_JJ drug_NN1 for_IF conscious_JJ sedation_NN1 during_II awake_JJ craniotomy_NN1 ,_, but_CCB the_AT sedative_NN1 and_CC analgesic_NN1 effects_NN2 of_IO an_AT1 intraoperative_JJ infusion_NN1 of_IO DEX_NN1 after_II craniotomy_NN1 have_VH0 not_XX been_VBN reported_VVN ._. 
</s>
<s>
A_AT1 review_NN1 team_NN1 ,_, including_II co-coordinators_NN2 and_CC staff_NN specifically_RR trained_VVN in_II the_AT A-6_MC Method_NN1 application_NN1 ,_, conducted_VVD the_AT systematic_JJ review_NN1 ._. 
</s>
<s>
No_NN1 IS_VBZ in_II31 accordance_II32 with_II33 the_AT International_JJ Federation_NN1 of_IO Clinical_JJ Chemistry_NN1 is_VBZ currently_RR available_JJ ._. 
</s>
<s>
Very_RG recently_RR ,_, two_MC reverse_JJ endophenotype_NN1 studies_NN2 have_VH0 examined_VVN the_AT ability_NN1 of_IO schizophrenia_NN1 polygenic_JJ risk_NN1 scores_NN2 to_TO predict_VVI cognitive_JJ abilities_NN2 in_II independent_JJ cohorts.11,12_FO Both_DB2 studies_NN2 draw_VV0 from_II the_AT work_NN1 of_IO the_AT Psychiatric_JJ GWAS_NN2 Consortium_NN1 on_II Schizophrenia_NN1 (_( PGC-SCZ_NP1 )_) ,_, a_AT1 large-scale_JJ mega-analytic_JJ GWAS_NN2 of_IO 17_MC Caucasian_JJ cohorts_NN2 encompassing_VVG greater_JJR than_CSN 9000_MC SCZ_NP1 cases_NN2 and_CC greater_JJR than_CSN 12,000_MC controls.13_FO In_II one_MC1 study12_FO ,_, polygenic_JJ risk_NN1 scores_NN2 for_IF SCZ_NP1 were_VBDR significantly_RR associated_VVN with_IW IQ_NN1 in_II a_AT1 cohort_NN1 of_IO patients_NN2 with_IW SCZ_NP1 and_CC controls_NN2 ,_, but_CCB these_DD2 associations_NN2 were_VBDR not_XX observed_VVN in_II the_AT smaller_JJR (_( n=322_FO )_) healthy_JJ cohort_NN1 alone_RR ._. 
</s>
<s>
It_PPH1 may_VM be_VBI that_DD1 ,_, with_IW sufficient_JJ samples_NN2 sizes_NN2 ,_, associations_NN2 of_IO SCN2A_FO SNPs_NP2 with_IW the_AT schizophrenia_NN1 diagnosis_NN1 will_VM emerge_VVI ._. 
</s>
<s>
The_AT median_JJ creatinine_NN1 for_IF the_AT CNDR_NP1 machine_NN1 was_VBDZ 0.72_MC mg/dL_FU with_IW an_AT1 interquartile_JJ range_NN1 of_IO 0.61_MC to_II 0.90_MC mg/dL_FU ._. 
</s>
<s>
Median_JJ intra-individual_JJ creatinine_NN1 results_NN2 obtained_VVN with_IW the_AT StatSensor_NP1 Xpress_NP1 device_NN1 were_VBDR on_II the_AT average_NN1 0.32_MC mg/dL_FU higher_JJR than_CSN the_AT CNDR_NP1 results_NN2 with_IW the_AT magnitude_NN1 of_IO difference_NN1 greater_JJR for_IF higher_JJR creatinine_NN1 concentrations_NN2 ._. 
</s>
<s>
Functional_JJ tests_NN2 are_VBR recommended_VVN to_TO assess_VVI more_RGR complex_JJ activities_NN2 of_IO daily_JJ living_NN1 and_CC sport_NN1 in_II those_DD2 with_IW or_CC at_II risk_NN1 of_IO degenerative_JJ knee_NN1 disease_NN1 (_( 11,21_MC )_) ._. 
</s>
<s>
Two_MC different_JJ kinds_NN2 of_IO tourniquet_NN1 cuff_NN1 were_VBDR used_VVN in_II the_AT study_NN1 ._. 
</s>
<s>
Although_CS linear_JJ radiolabeled_JJ Ac-&lsqb;Nle4_NN1 ,_, D-Phe7_NN1 &rsqb;_) -a-MSH_NP1 (_( NDP_NP1 )_) peptide_NN1 analogues_NN2 were_VBDR engineered_VVN for_IF increased_JJ stability_NN1 in_RR21 vivo_RR22 ,_, they_PPHS2 have_VH0 suffered_VVN from_II moderate_JJ tumor_NN1 uptake_NN1 and_CC poor_JJ tumor_NN1 retention_NN1 ._. 
</s>
<s>
These_DD2 assumptions_NN2 have_VH0 been_VBN tested_VVN and_CC will_VM be_VBI discussed_VVN under_II the_AT following_JJ 3_MC headings:1.Direct_FO Electrode_NN1 Stimulation_NN1 Studies_NN2 ;_; 2_MC ._. 
</s>
<s>
Two-Dimensional_JJ Screen-based_JJ Studies_NN2 ;_; and3.Three-Dimensional_JJ Object_NN1 Recognition_NN1 Study.3.2.1.1_FO ._. 
</s>
<s>
Prenatal_NP1 ,_, infant_NN1 ,_, childhood_NN1 predictors_NN2 of_IO adult_NN1 obesity_NN1 Prenatal_JJ risk_NN1 factors_NN2 are_VBR associated_VVN with_IW increased_JJ risk_NN1 for_IF obesity_NN1 later_RRR in_II life_NN1 (_( Fig._NN1 1_MC1 )_) ._. 
</s>
<s>
Laufs_NN2 and_CC colleagues_NN2 reported_VVD increased_JJ circulating_NN1 EPC_NP1 levels_NN2 after_II training_NN1 with_IW 30_MC min_NNU of_IO moderate_JJ exercise_NN1 (_( 80_MC -_- 100%_NNU velocity_NN1 of_IO the_AT individuals_NN2 '_NULL AT_II )_) but_CCB not_XX after_II short_JJ term_NN1 (_( 10_MC min_NNU )_) of_IO running_VVG in_II healthy_JJ subjects_NN2 ._. 
</s>
<s>
Factors_NN2 constraining_VVG the_AT benefit_NN1 to_II speech_NN1 understanding_NN1 of_IO combining_VVG information_NN1 from_II low-frequency_JJ hearing_NN1 and_CC a_AT1 cochlear_JJ implant_NN1 Michael_NP1 F._NP1 Dorman_NP1 ,_, Sarah_NP1 Cook_NP1 ,_, Tony_NP1 Spahr_NP1 ,_, Ting_NN1 Zhang_NN1 ,_, Louise_NP1 Loiselle_NP1 ,_, David_NP1 Schramm_NP1 ,_, JoAnne_NP1 Whittingham_NP1 ,_, and_CC Rene_NP1 Gifford_NP1 Arizona_NP1 State_NN1 University_NN1 Department_NN1 of_IO Speech_NN1 and_CC Hearing_VVG Science_NN1 Tempe_NP1 ,_, AZ_NP1 ._. 
</s>
<s>
Equally_RR important_JJ '_NULL scientists_NN2 '_NULL engineers_NN2 and_CC device_NN1 manufacturers_NN2 must_VM implement_VVI device_NN1 parameters_NN2 that_CST provide_VV0 a_AT1 fair_JJ balance_NN1 of_IO subjectivity_NN1 and_CC objectivity_NN1 for_IF the_AT clinician_NN1 to_TO make_VVI an_AT1 educated_JJ diagnosis_NN1 ._. 
</s>
<s>
Between-group_JJ demographic_JJ imbalances_NN2 in_II the_AT follow-up_JJ sample_NN1 were_VBDR adjusted_VVN for_IF in_II the_AT analysis_NN1 ._. 
</s>
<s>
In_RR21 addition_RR22 ,_, FC_NP1 diet_NN1 treatment_NN1 for_IF 6_MC weeks_NNT2 significantly_RR increased_VVD the_AT levels_NN2 of_IO choline_NN1 acetyltransferase_NN1 (_( ChAT_NN1 )_) and_CC the_AT presynaptic_JJ and_CC postsynaptic_JJ markers_NN2 Synapsin-1_MC1 and_CC PSD-95_MC ,_, respectively_RR ,_, while_CS decreasing_JJ levels_NN2 of_IO Nogo-A_NP1 ,_, a_AT1 neurite_NN1 outgrowth_NN1 inhibitor_NN1 ._. 
</s>
<s>
Effects_NN2 of_IO 2_MC different_JJ swallowing_JJ exercise_NN1 regimens_NN2 during_II organ-preservation_JJ therapies_NN2 for_IF head_NN1 and_CC neck_NN1 cancers_NN2 on_II swallowing_VVG function_NN1 Aneesha_NP1 Virani_NP1 ,_, PhD_NNA ,_, CCC-SLP_NP1 ,_, Melda_NP1 Kunduk_NP1 ,_, PhD_NNA ,_, CCC-SLP_NP1 ,_, Daniel_NP1 S._NP1 Fink_NP1 ,_, MD_NNA ,_, Andrew_NP1 J._NP1 McWhorter_NP1 ,_, MID_JJ Department_NN1 of_IO Communication_NN1 Sciences_NN2 and_CC Disorders_NN2 ,_, Louisiana_NP1 State_NN1 University_NN1 ,_, Baton_NP1 Rouge_NP1 ,_, Louisiana_NP1 ,_, 0ur_FO Lady_NN1 of_IO the_AT Lake_NNL1 Voice_NP1 Center_NN1 ,_, Baton_NP1 Rouge_NP1 ,_, Louisiana_NP1 ,_, Department_NN1 of_IO Otolaryngology-Head_NN1 and_CC Neck_NN1 Surgery_NN1 ,_, Louisiana_NP1 State_NN1 University_NN1 Health_NN1 Sciences_NN2 Center_NN1 ,_, New_NP1 Orleans_NP1 ,_, Louisiana_NP1 Corresponding_JJ author_NN1 :_: M._NN1 Kunduk_NN1 ,_, Department_NN1 of_IO Communication_NN1 Sciences_NN2 and_CC Disorders_NN2 ,_, Louisiana_NP1 State_NN1 University_NN1 ,_, 64_MC Hatcher_NP1 Hall_NN1 ,_, Baton_NP1 Rouge_NP1 ,_, LA_NP1 70803_MC ._. 
</s>
<s>
Discussion_NN1 :_: Results_NN2 of_IO this_DD1 study_NN1 provided_CS initial_JJ support_NN1 for_IF the_AT new_JJ FIT_JJ Teens_NN2 program_NN1 ._. 
</s>
<s>
Depression_NN1 was_VBDZ found_VVN to_TO be_VBI significantly_RR correlated_VVN with_IW mental_JJ health_NN1 services_NN2 use_VV0 (_( r=0.29_FO ,_, p=0.001_FO )_) ,_, self-administration_NN1 of_IO psychotropic_JJ medication_NN1 (_( r=0.45_FO ,_, p_NNU less_DAR than_CSN 0.001_MC )_) ,_, anxiety_NN1 (_( r=_FO 0.43_MC ,_, p_NNU less_DAR than_CSN 0.001_MC )_) ,_, burnout_NN1 (_( r=0.72_FO ,_, p_NNU less_DAR than_CSN 0.001_MC )_) ,_, and_CC drug_NN1 abuse_NN1 (_( r=0.25_FO ,_, p=0.007_FO )_) ._. 
</s>
<s>
The_AT safety_NN1 profile_NN1 of_IO the_AT DEX_NN1 implant_NN1 in_II this_DD1 study_NN1 was_VBDZ better_RRR than_CSN the_AT reported_JJ safety_NN1 profile_NN1 of_IO other_JJ intraocular_JJ corticosteroids_NN2 in_II patients_NN2 with_IW DME_NP1 ._. 
</s>
<s>
This_DD1 risk_NN1 ,_, however_RR ,_, is_VBZ extremely_RR small_JJ ,_, projected_VVN as_CSA one_MC1 additional_JJ missed_JJ ciTBI_NN2 for_IF every_AT1 4000_MC children_NN2 evaluated_VVN for_IF minor_JJ head_NN1 trauma_NN1 ._. 
</s>
<s>
The_AT studies_NN2 were_VBDR compliant_JJ with_IW the_AT rules_NN2 and_CC regulations_NN2 under_II the_AT Health_NN1 Insurance_NN1 Portability_NN1 and_CC Accountability_NN1 Act_NN1 of_IO 1996_MC ._. 
</s>
<s>
For_IF the_AT specific_JJ outcome_NN1 of_IO performance_NN1 time_NNT1 ,_, the_AT study_NN1 was_VBDZ classified_VVN as_CSA supportive_JJ for_IF US_PPIO2 only_RR if_CS it_PPH1 was_VBDZ directly_RR stated_VVN that_CST US_NP1 scan_NN1 time_NNT1 was_VBDZ included_VVN in_II block_NN1 performance_NN1 time_NNT1 ._. 
</s>
<s>
B_ZZ1 cell_NN1 depletion_NN1 by_II rituximab_NN1 is_VBZ thought_VVN to_TO occur_VVI through_II several_DA2 potential_JJ mechanisms_NN2 ._. 
</s>
<s>
Thoracic_JJ epidural_JJ anaesthesia_NN1 (_( TEA_NN1 )_) has_VHZ emerged_VVN as_II the_AT gold_NN1 standard_NN1 for_IF post-thoracotomy_JJ pain_NN1 control_NN1 ._. 
</s>
<s>
Therefore_RR ,_, the_AT Warburg_NP1 effect_NN1 functions_NN2 as_II the_AT metabolic_JJ foundation_NN1 of_IO oncogenic_JJ growth_NN1 ,_, tumor_NN1 progression_NN1 ,_, and_CC tumor_NN1 resistance_NN1 to_II treatment_NN1 ._. 
</s>
<s>
Note_VV0 that_CST fitted_JJ responses_NN2 were_VBDR necessary_JJ for_IF cross-condition_JJ comparisons_NN2 ,_, given_CS21 that_CS22 the_AT sampled_JJ time_NNT1 points_NN2 were_VBDR not_XX identical_JJ across_II the_AT different_JJ stimuli_NN2 (_( see_VV0 Table_NN1 1_MC1 )_) ._. 
</s>
<s>
In_II conclusion_NN1 ,_, in_II our_APPGE cohort_NN1 of_IO overall_JJ healthy_JJ subjects_NN2 ,_, self-reported_NN1 snoring_VVG and_CC sleep_VV0 apnoea_NN1 are_VBR independently_RR associated_VVN with_IW a_AT1 higher_JJR PVW_NP1 ,_, and_CC AIx_NP1 is_VBZ statistically_RR significantly_RR higher_JJR in_II snorers_NN2 with_IW or_CC without_IW sleep_NN1 apnoea_NN1 than_CSN in_II non-snorers_NN2 ._. 
</s>
<s>
Therefore_RR ,_, the_AT 5-5(2s)ping_NN1 and_CC 5-5(4s)ping_JJ aHDRs_NN2 were_VBDR augmented_VVN by_II appending_VVG the_AT initial_JJ portion_NN1 of_IO aHDR_NN1 of_IO the_AT 5ping_FO prior_II21 to_II22 the_AT first_MD acquired_JJ data_NN point_NN1 (_( i._MC e._ZZ1 ,_, 4_MC or_CC 6s_MC2 post-onset_NN1 )_) ,_, with_IW a_AT1 smooth_JJ combination_NN1 achieved_VVN using_VVG a_AT1 3rd_MD order_NN1 polynomial_NN1 fit_NN1 ._. 
</s>
<s>
When_CS analyzing_VVG the_AT need_NN1 for_IF transplantation_NN1 in_II patients_NN2 with_IW keratitis_NN1 of_IO viral_JJ origin_NN1 and_CC with_IW central_JJ neovascularization_NN1 ,_, results_NN2 showed_VVD that_DD1 aganirsen_NN1 treatment_NN1 significantly_RR decreased_VVD the_AT need_NN1 for_IF transplantation_NN1 at_II both_RR day_NNT1 90_MC (_( nominal_JJ P_ZZ1 value_NN1 =0.048_FO ,_, data_NN not_XX shown_VVN )_) and_CC day_NNT1 180_MC (_( nominal_JJ P_ZZ1 value_NN1 =0.048_FO ,_, Fisher_NP1 exact_JJ test_NN1 )_) (_( Table_NN1 6_MC )_) ._. 
</s>
<s>
Risk_NN1 of_IO Graft_NN1 Rejection_NN1 ._. 
</s>
<s>
There_EX is_VBZ indeed_RR evidence_NN1 of_IO increased_JJ levels_NN2 of_IO muscle_NN1 ADP_NN1 and_CC plasma_NN1 NH3+and_FO hypoxanthine_VV0 during_II exercise_NN1 in_II McArdle_NP1 disease_NN1 patients_NN2 compared_VVN with_IW non-patients_NN2 ,_, suggesting_VVG high_JJ oxidative_JJ stress_NN1 in_II their_APPGE skeletal_JJ muscles_NN2 ._. 
</s>
<s>
Seventeen_MC HCC_NP1 lesions_NN2 larger_JJR than_CSN 2_MC cm_NNU were_VBDR treated_VVN with_IW TACE_NP1 before_II the_AT CT_NN1 acquisitions_NN2 ,_, whereas_CS 10_MC of_IO the_AT lesions_NN2 larger_JJR than_CSN 2_MC cm_NNU were_VBDR not_XX treated_VVN with_IW TACE_NP1 before_II the_AT CT_NN1 acquisition_NN1 and_CC the_AT liver_NN1 transplantation_NN1 ._. 
</s>
<s>
Further_JJR accumulation_NN1 of_IO cases_NN2 and_CC longer_JJR follow-up_NN1 are_VBR warranted_VVN to_TO elucidate_VVI the_AT ability_NN1 of_IO this_DD1 method_NN1 to_TO predict_VVI prognosis_NN1 ._. 
</s>
<s>
Indeed_RR ,_, as_CSA Riskin_NP1 et_RA21 al_RA22 pointed_VVD out_RP ,_, "_" most_DAT surgeons_NN2 innovate_VV0 on_II a_AT1 daily_JJ basis_NN1 ,_, tailoring_VVG therapies_NN2 and_CC operations_NN2 to_II the_AT intrinsic_JJ uniqueness_NN1 of_IO every_AT1 patient_NN1 and_CC their_APPGE disease_NN1 ._. "_" 
</s>
<s>
All_DB experiments_NN2 used_VVD the_AT uterus_NN1 as_II a_AT1 positive_JJ control_NN1 ._. 
</s>
<s>
Cancer_NN1 diagnoses_NN2 are_VBR reported_VVN to_II local_JJ cancer_NN1 registries_NN2 from_II multiple_JJ sources_NN2 ,_, including_II local_JJ hospitals_NN2 and_CC community_NN1 health_NN1 centers_NN2 as_II31 well_II32 as_II33 the_AT Urban_JJ Resident_JJ Basic_JJ Medical_JJ Insurance_NN1 program_NN1 and_CC the_AT New_JJ Rural_JJ Cooperative_JJ Medical_JJ Scheme_NN1 ._. 
</s>
<s>
As_CSA respiratory_JJ motion_NN1 artifacts_NN2 are_VBR problematic_JJ when_CS generating_VVG pixelwise_JJ parameter_NN1 maps_NN2 ,_, the_AT motion_NN1 insensitive_JJ technique_NN1 used_VVN in_II this_DD1 study_NN1 might_VM be_VBI a_AT1 valuable_JJ tool_NN1 to_TO achieve_VVI valid_JJ and_CC reproducible_JJ parameter_NN1 maps_NN2 ._. 
</s>
<s>
These_DD2 studies_NN2 were_VBDR sham_NN1 controlled_VVN for_IF the_AT first_MD 2_MC years_NNT2 ;_; in_II the_AT third_MD year_NNT1 ,_, patients_NN2 in_II the_AT sham_NN1 group_NN1 could_VM cross_VVI over_RP to_TO receive_VVI ranibizumab_NN1 0_MC ._. 
</s>
<s>
The_AT purpose_NN1 of_IO this_DD1 statement_NN1 is_VBZ to_TO further_RRR define_VVI and_CC discuss_VVI the_AT status_NN1 of_IO off-label_JJ use_NN1 of_IO medications_NN2 in_II children_NN2 ._. 
</s>
<s>
Although_CS it_PPH1 is_VBZ not_XX clear_RR why_RRQ this_DD1 side_NN1 effect_NN1 occurred_VVD ,_, the_AT rapid_JJ development_NN1 of_IO behavioral_JJ changes_NN2 in_II these_DD2 children_NN2 suggests_VVZ that_CST it_PPH1 may_VM have_VHI been_VBN due_II21 to_II22 an_AT1 increase_NN1 in_II CNS_NP1 dopamine_NN1 secondary_NN1 to_II increased_JJ 5MTHF_FO or_CC tetrahydrobiopterin_NN1 in_II the_AT CNS_NP1 ,_, which_DDQ then_RT may_VM have_VHI reduced_VVN the_AT dopamine_NN1 receptor-blocking_NN1 effect_NN1 of_IO risperidone_NN1 ._. 
</s>
<s>
Methods_NN2 :_: In_II this_DD1 population-based_NN1 ,_, retrospective_JJ ,_, cohort_NN1 study_NN1 ,_, we_PPIS2 identified_VVD all_DB adult_JJ patients_NN2 who_PNQS were_VBDR discharged_VVN from_II an_AT1 emergency_NN1 department_NN1 in_II Ontario_NP1 ,_, Canada_NP1 ,_, between_II 2006_MC and_CC 2011_MC ,_, with_IW a_AT1 primary_JJ diagnosis_NN1 of_IO a_AT1 peripheral_JJ vestibular_JJ disorder_NN1 ._. 
</s>
<s>
A_AT1 schematic_JJ overview_NN1 is_VBZ shown_VVN in_II Figure_NN1 1_MC1 ._. 
</s>
<s>
CAF_NP1 was_VBDZ the_AT only_JJ parameter_NN1 significantly_RR predicting_VVG dPr_NNU (_( HR=1.005_NP1 ;_; Table_NN1 3_MC )_) ,_, whereas_CS creatinine_NN1 ,_, BUN_NN1 and_CC eGFR_NN1 failed_VVD to_TO predict_VVI this_DD1 endpoint_NN1 ._. 
</s>
<s>
Materials_NN2 and_CC methods_NN2 The_AT analyzer_NN1 and_CC the_AT reagents_NN2 used_VVN for_IF this_DD1 evaluation_NN1 have_VH0 been_VBN provided_VVN by_II Bio-Rad_NP1 Laboratories_NN2 (_( Hercules_NP1 ,_, CA_NP1 ,_, USA_NP1 )_) and_CC have_VH0 been_VBN used_VVN according_II21 to_II22 manufacturer_NN1 '_NULL s_ZZ1 instructions_NN2 ._. 
</s>
<s>
These_DD2 fibroblastic_JJ cells_NN2 secrete_VV0 numerous_JJ cytokines_NN2 and_CC growth_NN1 factors_NN2 ,_, including_II insulin-like_JJ growth_NN1 factor_NN1 1_MC1 (_( IGF-1_MC1 )_) ,_, interleukin-6_MC (_( IL-6_MC )_) ,_, prostaglandin_NN1 E2_FO (_( PGE2_FO )_) ,_, and_CC transforming_VVG growth_NN1 factor-&lsqb;beta&rsqb;_NN1 (_( TGF-&lsqb;beta&rsqb;_NN1 )_) ._. 
</s>
<s>
Figure_VV0 1_MC1 is_VBZ from_II a_AT1 child_NN1 who_PNQS at_II 10_MC years_NNT2 of_IO age_NN1 sustained_VVD a_AT1 mTBI_NN2 (_( GCS=15_FO )_) without_IW documented_JJ loss_NN1 of_IO consciousness_NN1 (_( LOC_NP1 )_) as_II the_AT result_NN1 of_IO a_AT1 bicycle_NN1 accident_NN1 ._. 
</s>
<s>
In_II conclusion_NN1 ,_, our_APPGE study_NN1 showed_VVD group_NN1 differences_NN2 in_II central_JJ speech-sound_NN1 discrimination_NN1 between_II CWS_NP1 and_CC TDC_NP1 using_VVG the_AT multi-feature_JJ MMN_NP1 paradigm_NN1 involving_VVG several_DA2 different_JJ deviant_JJ types_NN2 ._. 
</s>
<s>
Although_CS the_AT pathogenic_JJ mechanisms_NN2 and_CC data_NN reviewed_VVD here_RL focus_VV0 specifically_RR on_II CAA_NP1 ,_, many_DA2 of_IO the_AT considerations_NN2 and_CC findings_NN2 can_VM be_VBI generalized_VVN to_II all_DB forms_NN2 of_IO cerebral_JJ small_JJ vessel_NN1 disease_NN1 associated_VVN with_IW vascular_JJ cognitive_JJ impairment_NN1 (_( VCI_NP1 )_) ._. 
</s>
<s>
However_RR ,_, recent_JJ studies_NN2 in_II both_RR adults_NN2 and_CC children_NN2 report_VV0 poor_JJ US_NP1 accuracy_NN1 for_IF differentiating_VVG perforated_JJ from_II nonperforated_JJ appendicitis_NN1 ,_, with_IW published_JJ sensitivities_NN2 ranging_VVG from_II 23%_NNU to_II 48%_NNU and_CC specificities_NN2 ranging_VVG from_II 93%_NNU to_II 100%_NNU ._. 
</s>
<s>
However_RR ,_, where_CS a_AT1 financial_JJ penalty_NN1 was_VBDZ rendered_VVN ,_, the_AT findings_NN2 were_VBDR quite_RG similar_JJ ,_, averaging_VVG 1.5_MC to_II 2.5_MC million_NNO dollars_NNU2 per_II case_NN1 with_IW the_AT highest_JJT penalties_NN2 associated_VVN with_IW cases_NN2 involving_VVG anoxic_JJ brain_NN1 injury_NN1 ._. 
</s>
<s>
A_AT1 pathologist_NN1 has_VHZ a_AT1 limited_JJ ability_NN1 to_TO distinguish_VVI among_II these_DD2 diagnoses_NN2 '_NULL but_CCB transcriptomics_NN2 can_VM potentially_RR provide_VVI a_AT1 more_RGR precise_JJ differential_NN1 (_( Yeremenko_NP1 et_RA21 al_RA22 ._. '_NULL 
</s>
<s>
2013_MC )_) ._. 
</s>
<s>
One_MC1 member_NN1 of_IO the_AT panel_NN1 has_VHZ served_VVN in_II guideline_NN1 development_NN1 and_CC as_II a_AT1 member_NN1 of_IO the_AT National_JJ Quality_NN1 Forum_NN1 Neurology_NN1 measures_NN2 group_NN1 (_( W.G.B._NP1 )_) ,_, and_CC another_DD1 member_NN1 has_VHZ been_VBN involved_JJ in_II national_JJ stroke_NN1 quality_NN1 improvement_NN1 efforts_NN2 through_II the_AT AHA_UH ,_, including_VVG Get_VV0 With_IW the_AT Guidelines_NN2 -_- Stroke_VV0 (_( M.J.R._NP1 )_) ._. 
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<s>
Sample_NN1 size_NN1 for_IF the_AT EPC_NP1 analysis_NN1 was_VBDZ calculated_VVN using_VVG the_AT short-term_JJ effect_NN1 of_IO exercise_NN1 on_II EPC_NP1 release_NN1 10_MC min_NNU after_II a_AT1 symptom-limited_JJ dynamic_JJ exercise_NN1 test_NN1 in_II volunteers_NN2 ._. 
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<s>
However_RR ,_, in_II patients_NN2 presenting_VVG with_IW expiratory_JJ flow_NN1 limitation_NN1 ,_, external_JJ PEEP_NN1 will_VM not_XX lower_VVI the_AT expiratory_JJ driving_JJ pressure_NN1 until_CS the_AT level_NN1 of_IO external_JJ PEEP_NN1 exceeds_VVZ the_AT level_NN1 of_IO auto-PEEP_NN1 by_II a_AT1 ratio_NN1 of_IO 50_MC to_II 75%_NNU ._. 
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External_JJ PEEP_NN1 was_VBDZ variable_JJ in_II our_APPGE study_NN1 ._. 
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<s>
There_EX were_VBDR some_DD older_JJR mice_NN2 that_CST did_VDD not_XX perform_VVI as_II31 well_II32 as_II33 most_DAT of_IO the_AT younger_JJR mice_NN2 ,_, but_CCB this_DD1 also_RR did_VDD not_XX differ_VVI between_II genotypes_NN2 (_( 1/3_MF for_IF each_DD1 )_) ._. 
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<s>
A_AT1 scleral_JJ triangular_JJ flap_NN1 was_VBDZ made_VVN behind_II the_AT limbus_NN1 corresponding_VVG to_II the_AT superior_JJ haptic_JJ location_NN1 '_NULL followed_VVN by_II a_AT1 limbal_JJ incision_NN1 approximately_RR 180_MC apart_RL ._. 
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<s>
So_RG far_RR ,_, GRASP_NN1 has_VHZ been_VBN successfully_RR applied_VVN in_II the_AT liver_NN1 and_CC the_AT prostate_NN1 ._. 
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<s>
Lesions_NN2 were_VBDR only_RR considered_VVN to_TO be_VBI eligible_JJ to_TO be_VBI upgraded_VVN by_II the_AT given_JJ proposed_JJ adjustment_NN1 when_RRQ not_XX already_RR being_VBG upgraded_VVN by_II the_AT existing_JJ decision_NN1 rules_NN2 (_( eg_REX ,_, a_AT1 PZ_NP1 lesion_NN1 being_VBG upgraded_VVN from_II category_NN1 3_MC to_II 4_MC due_II21 to_II22 DCE_NP1 score_NN1 of_IO positive_JJ or_CC a_AT1 lesion_NN1 in_II either_DD1 zone_NN1 being_VBG upgraded_VVN from_II category_NN1 4_MC to_II 5_MC due_II21 to_II22 definite_JJ extra-prostatic_JJ extension_NN1 was_VBDZ not_XX considered_VVN to_TO be_VBI eligible_JJ to_TO be_VBI upgraded_VVN on_II the_AT basis_NN1 of_IO proposed_JJ adjustments_NN2 to_II the_AT decision_NN1 rules_NN2 )_) ._. 
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<s>
Another_DD1 possibility_NN1 is_VBZ that_CST the_AT severity_NN1 of_IO diverticulitis_NN1 has_VHZ been_VBN increasing_VVG ,_, and_CC surgeons_NN2 may_VM be_VBI performing_VVG more_RGR elective_JJ procedures_NN2 on_II patients_NN2 with_IW more_RGR complicated_JJ disease_NN1 ._. 
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<s>
The_AT FAF_NN1 images_NN2 show_VV0 a_AT1 progressive_JJ loss_NN1 of_IO RPE_NP1 even_RR after_II the_AT drug_NN1 is_VBZ stopped_VVN ,_, and_CC this_DD1 loss_NN1 can_VM spread_VVI toward_II the_AT outer_JJ reaches_NN2 of_IO the_AT macula_NN1 ._. 
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<s>
These_DD2 considerations_NN2 provide_VV0 a_AT1 rationale_NN1 for_IF focusing_VVG on_II the_AT evaluation_NN1 of_IO anti-oxidant_JJ therapy_NN1 on_II rod_NN1 cells_NN2 in_RR21 vivo_RR22 ._. 
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<s>
Transcranial_JJ magnetic_JJ stimulation_NN1 (_( TMS_NP1 )_) has_VHZ been_VBN successfully_RR used_VVN to_TO demonstrate_VVI the_AT presence_NN1 of_IO supraspinal_JJ fatigue_NN1 across_II a_AT1 range_NN1 of_IO exercise_NN1 paradigms_NN2 ._. 
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<s>
Previous_JJ work_NN1 suggests_VVZ that_CST there_EX are_VBR two_MC kinds_NN2 of_IO gap_NN1 junction_NN1 hexamers_NN2 (_( two_MC hexamers_NN2 from_II each_DD1 cell_NN1 dock_NN1 to_TO form_VVI a_AT1 gap_NN1 junction_NN1 )_) ,_, homomeric_JJ (_( composed_VVN of_IO same_DA connexin_NN1 subtypes_VVZ in_II the_AT same_DA junctional_JJ plaque_NN1 )_) and_CC heteromeric_JJ (_( composed_VVN of_IO different_JJ connexin_NN1 subtypes_VVZ in_II the_AT same_DA plaque_NN1 )_) (_( Koval_NP1 et_RA21 al._RA22 ,_, 2014_MC )_) ._. 
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<s>
The_AT median_NN1 (_( IQR_NP1 )_) duration_NN1 of_IO the_AT epidural_JJ administration_NN1 was_VBDZ 19_MC hours_NNT2 (_( 18_MC '_NULL 20_MC hours_NNT2 )_) and_CC was_VBDZ not_XX different_JJ between_II high_JJ and_CC low_JJ spread_NN1 groups_NN2 (_( P_ZZ1 =_FO 0.50_MC )_) ._. 
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<s>
The_AT present_JJ study_NN1 demonstrates_VVZ that_CST this_DD1 technique_NN1 is_VBZ feasible_JJ in_II patients_NN2 with_IW established_JJ cirrhosis_NN1 and_CC provides_VVZ a_AT1 practical_JJ alternative_NN1 to_II the_AT challenges_NN2 of_IO measuring_VVG proper_JJ HA_UH flow_NN1 and_CC TLBF_NP1 using_VVG direct_JJ PCMRI_NN2 ._. 
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<s>
In_II31 addition_II32 to_II33 subtle_JJ structural_JJ abnormalities_NN2 ,_, application_NN1 of_IO functional_JJ MRI_JJ methods_NN2 have_VH0 shown_VVN differences_NN2 in_II functional_JJ connectivity_NN1 with_IW the_AT basal_JJ ganglia_NN2 network_NN1 ,_, the_AT default-mode_JJ network_NN1 and_CC the_AT sensorimotor_NN1 resting_NN1 state_NN1 network_NN1 ,_, between_II patients_NN2 with_IW PD_NP1 and_CC healthy_JJ controls_NN2 ,_, some_DD of_IO which_DDQ are_VBR influenced_VVN by_II dopaminergic_JJ medication_NN1 (_( see_VV0 online_RR supplementary_JJ material_NN1 for_IF examples_NN2 of_IO studies_NN2 )_) ._. 
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<s>
Owing_II21 to_II22 the_AT small_JJ sample_NN1 sizes_NN2 ,_, stratification_NN1 with_IW a_AT1 propensity_NN1 score_NN1 is_VBZ not_XX possible_JJ in_II this_DD1 analysis_NN1 and_CC hence_RR no_AT adjustment_NN1 for_IF covariates_NN2 was_VBDZ performed_VVN ._. 
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<s>
The_AT layout_NN1 of_IO this_DD1 design_NN1 is_VBZ shown_VVN in_II Figure_NN1 1_MC1 ._. 
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<s>
Expression_NN1 of_IO the_AT full_JJ length_NN1 APP_NN1 was_VBDZ densitometrically_RR quantified_VVN on_II Western_JJ immunoblots_NN2 developed_VVD using_VVG 6E10_FO mAb_NN1 while_CS expression_NN1 of_IO APP_NP1 CTFs_NP1 on_II those_DD2 developed_VVN using_VVG A163_FO pAb_NN1 ._. 
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<s>
It_PPH1 is_VBZ sporadic_JJ in_II 95%_NNU of_IO cases_NN2 and_CC mainly_RR associated_VVN not_XX only_RR with_IW autoimmune_NN1 thyrotoxicosis_NN1 (_( Graves_NN2 disease_NN1 )_) but_CCB also_RR with_IW thyroid_JJ stimulating_JJ hormone-secreting_JJ pituitary_JJ tumors_NN2 ,_, amiodarone-induced_JJ thyrotoxicosis_NN1 ,_, lymphocytic_JJ thyroiditis_NN1 ,_, etc_RA ._. 
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<s>
This_DD1 resulted_VVD in_II an_AT1 80%_NNU power_NN1 ._. 
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<s>
Results_NN2 Between_II Oct_NPM1 20_MC ,_, 2003_MC ,_, and_CC Aug_NPM1 15_MC ,_, 2007_MC ,_, 2273_MC men_NN2 were_VBDR screened_VVN for_IF the_AT study_NN1 ,_, and_CC 1071_MC were_VBDR randomly_RR allocated_VVN to_II one_MC1 of_IO the_AT four_MC treatment_NN1 groups_NN2 (_( figure_NN1 1_MC1 )_) ._. 
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<s>
We_PPIS2 report_VV0 hazard_NN1 ratios_NN2 (_( HRs_NNU2 )_) and_CC 95%_NNU CIs_NN2 as_II a_AT1 measure_NN1 of_IO association_NN1 for_IF time_NNT1 to_II event_NN1 data_NN and_CC C-Sta-tistics_NP1 (_( area_NN1 under_II the_AT curve_NN1 &lsqb;_( AUC_NP1 &rsqb;_) )_) as_II a_AT1 measure_NN1 of_IO discrimination_NN1 ._. 
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<s>
We_PPIS2 performed_VVD additional_JJ posthoc_NN1 analyses_VVZ on_II the_AT MMSE_NN1 and_CC IMCT_VV0 cognitive_JJ functional_JJ tests_NN2 ._. 
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<s>
We_PPIS2 estimated_VVD the_AT crude_JJ OR_CC and_CC 95%_NNU CI_NN1 for_IF the_AT association_NN1 between_II microcephaly_NN1 and_CC laboratory_NN1 confirmation_NN1 of_IO Zika_NP1 virus_NN1 infection_NN1 ,_, considering_CS the_AT results_NN2 in_II serum_NN1 or_CC cerebrospinal_JJ fluid_NN1 and_CC the_AT results_NN2 in_II serum_NN1 alone_RR ,_, overall_JJ and_CC separately_RR for_IF cases_NN2 with_IW and_CC without_IW radiological_JJ evidence_NN1 of_IO brain_NN1 abnormalities_NN2 ._. 
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<s>
Ideally_RR ,_, especially_RR in_II a_AT1 collegiate_JJ setting_NN1 ,_, a_AT1 certified_JJ athletic_JJ trainer_NN1 will_VM be_VBI available_JJ to_TO oversee_VVI each_DD1 step_NN1 of_IO the_AT RTP_NP1 process_NN1 ._. 
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<s>
Although_CS widely_RR employed_VVN in_II clinical_JJ practice_NN1 ,_, the_AT current_JJ physiotherapeutic_JJ approach_NN1 for_IF patients_NN2 with_IW community-acquired_JJ pneumonia_NN1 ,_, which_DDQ focuses_VVZ on_II airway_NN1 clearance_NN1 ,_, is_VBZ not_XX supported_VVN by_II evidence_NN1 and_CC the_AT main_JJ guidelines_NN2 for_IF the_AT management_NN1 of_IO this_DD1 condition_NN1 do_VD0 not_XX recommend_VVI it_PPH1 ._. 
</s>
<s>
Nonparsimonious_JJ logistic_JJ regression_NN1 models_NN2 were_VBDR created_VVN by_II forcing_VVG and/or_CC exchanging_VVG additional_JJ variables_NN2 into_II the_AT models_NN2 as_II31 well_II32 as_II33 by_II altering_VVG the_AT variable_JJ structures_NN2 for_IF blood_NN1 loss_NN1 and_CC operative_JJ duration_NN1 ,_, in_II an_AT1 attempt_NN1 to_TO diminish_VVI associations_NN2 between_II anesthesia_NN1 providers_NN2 and_CC major_JJ complication_NN1 with_IW alternative_JJ adjustment_NN1 ._. 
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<s>
Address_NN1 correspondence_NN1 to_II R.C.O._NP1 (_( email_NN1 :_: )_) ._. 
</s>
<s>
The_AT chi-square_JJ test_NN1 of_IO model_NN1 (_( x2_FO ;_; p_ZZ1 >_FO .05_MC )_) allowed_VVD for_IF an_AT1 overall_JJ indication_NN1 of_IO good_JJ model_NN1 fit_NN1 ._. 
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<s>
Trends_NN2 were_VBDR tested_VVN by_II adding_VVG the_AT categorical_JJ exposure_NN1 variables_NN2 into_II the_AT model_NN1 as_CSA continuous_JJ ._. 
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<s>
The_AT "_" not_XX missing_VVG completely_RR at_RR21 random_RR22 "_" (_( NOMCAR_NP1 )_) option_NN1 in_II SAS_NP1 was_VBDZ used_VVN for_IF variance_NN1 estimation_NN1 ._. 
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<s>
Due_II21 to_II22 these_DD2 challenges_NN2 of_IO performing_VVG clinical_JJ trials_NN2 in_II infants_NN2 ,_, few_DA2 labeling_JJ changes_NN2 have_VH0 included_VVN infant-specific_JJ information_NN1 ._. 
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<s>
This_DD1 article_NN1 makes_VVZ an_AT1 important_JJ contribution_NN1 to_II trauma_NN1 research_NN1 and_CC health_NN1 policy_NN1 by_II addressing_VVG the_AT question_NN1 ,_, Can_VM we_PPIS2 potentially_RR save_VVI money_NN1 in_II trauma_NN1 systems_NN2 without_IW compromising_VVG outcomes_NN2 by_II redirecting_VVG patients_NN2 with_IW minor_JJ to_TO moderate_VVI injuries_NN2 away_II21 from_II22 major_JJ trauma_NN1 centers_NN2 ?_? 
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<s>
Multisite_NN1 compliance_NN1 and_CC logistics_NN1 were_VBDR regulated_VVN in_II the_AT Department_NN1 of_IO Anesthesiology_NN1 at_II Vanderbilt_NP1 University_NN1 ._. 
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<s>
This_DD1 meta-analysis_NN1 reports_VVZ that_CST the_AT superior_JJ frontal_JJ gyrus_NN1 shows_VVZ increased_JJ activation_NN1 in_II depressed_JJ patients_NN2 as_II31 well_II32 as_II33 enhanced_JJ activation_NN1 in_II31 response_II32 to_II33 positive_JJ emotional_JJ stimuli_NN2 and_CC decreased_JJ activation_NN1 in_II31 response_II32 to_II33 negative_JJ emotional_JJ stimuli_NN2 ._. 
</s>
<s>
The_AT mouse_NN1 melanopsin_NN1 open_JJ reading_NN1 frame_NN1 was_VBDZ cloned_VVN into_II a_AT1 bicistronic_JJ expression_NN1 vector_NN1 (_( pIRES2-EGFP_NP1 )_) ._. 
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<s>
However_RR ,_, given_VVN the_AT increased_JJ risk_NN1 of_IO body_NN1 fluid_NN1 exposure_NN1 ,_, obstetric_JJ units_NN2 caring_VVG for_IF patients_NN2 with_IW Ebola_NP1 virus_NN1 disease_NN1 should_VM employ_VVI additional_JJ personal_JJ protective_JJ equipment_NN1 ,_, such_II21 as_II22 shoe_NN1 covers_NN2 ,_, double_JJ gloves_NN2 ,_, and_CC leg_NN1 covers_NN2 ._. 
</s>
<s>
Analyzing_VVG these_DD2 lesions_NN2 with_IW spectral_JJ domain_NN1 optical_JJ coherence_NN1 tomography_NN1 (_( SD-OCT_NPM1 )_) ,_, Zweifel_NP1 et_RA21 al_RA22 ._. 
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<s>
(_( 2010_MC )_) found_VVD that_CST they_PPHS2 are_VBR localized_VVN between_II the_AT RPE_NN1 and_CC the_AT inner_JJ segment/outer_FU segment_NN1 boundary_NN1 (_( now_RT referred_VVN to_II as_II the_AT "_" inner_JJ segment_NN1 ellipsoid_NN1 (_( ISe_NP1 )_) band_NN1 "_" )_) and_CC referred_VVN to_II reticular_JJ lesions_NN2 as_CSA "_" subretinal_JJ drusenoid_JJ deposits_NN2 "_" (_( SDD_NP1 )_) ._. 
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<s>
The_AT H1_FO haplotype_NN1 has_VHZ consistently_RR been_VBN associated_VVN with_IW 4-repeat_JJ tauopathies_NN2 including_II PSP_NP1 (_( Baker_NP1 et_RA21 al._RA22 ,_, 1999_MC )_) and_CC CBD_NN1 (_( Di_NP1 Maria_NP1 et_RA21 al._RA22 ,_, 2000_MC )_) relative_II21 to_II22 controls_NN2 ,_, though_CS we_PPIS2 are_VBR unaware_JJ of_IO a_AT1 direct_JJ comparison_NN1 between_II FTLD-tau_NN1 and_CC FTLD-TDP_NN1 that_CST evaluated_VVD the_AT specificity_NN1 of_IO this_DD1 haplotype_NN1 ._. 
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<s>
The_AT Houston_NP1 CARES_VVZ registry_NN1 has_VHZ been_VBN independently_RR evaluated_VVN and_CC was_VBDZ shown_VVN to_TO have_VHI captured_VVN every_AT1 9-1-1_MCMC OHCA_NN1 event_NN1 between_II 2007_MC and_CC 2009.14_MC However_RR ,_, the_AT accuracy_NN1 of_IO data_NN entry_NN1 has_VHZ not_XX been_VBN assessed_VVN or_CC verified_VVD ._. 
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<s>
In_RR21 addition_RR22 ,_, exercise_VV0 tolerance_NN1 during_II M->S_FO was_VBDZ extended_VVN by_II 22%_NNU after_II NO3-_NN1 compared_VVN with_IW placebo_NN1 ingestion_NN1 ._. 
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<s>
These_DD2 data_NN are_VBR the_AT first_MD to_TO show_VVI that_DD1 transmetallation_NN1 may_VM occur_VVI in_II patients_NN2 without_IW renal_JJ insufficiency_NN1 ,_, but_CCB in_II a_AT1 nonplasma_NN1 slowly_RR equilibrating_VVG compartment_NN1 ._. 
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<s>
We_PPIS2 have_VH0 been_VBN writing_VVG sentences_NN2 like_II this_DD1 for_IF years_NNT2 ,_, thus_RR suggesting_VVG that_CST the_AT advances_NN2 in_II this_DD1 field_NN1 have_VH0 not_XX been_VBN sufficient_JJ to_TO achieve_VVI a_AT1 significant_JJ clinical_JJ impact_NN1 on_II the_AT disease_NN1 ._. 
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<s>
In_II summary_NN1 ,_, 14,541_MC women_NN2 were_VBDR enrolled_VVN ,_, provided_CS21 that_CS22 they_PPHS2 were_VBDR resident_JJ in_II Avon_NP1 while_CS pregnant_JJ and_CC had_VHD an_AT1 expected_JJ delivery_NN1 date_NN1 between_II April_NPM1 1_MC1 ,_, 1991_MC and_CC December_NPM1 31_MC ,_, 1992_MC ._. 
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<s>
The_AT interviews_NN2 were_VBDR conducted_VVN by_II 2_MC authors_NN2 (_( Manisha_NP1 Verma_NP1 and_CC Mona_NP1 Sarfaty_NP1 )_) and_CC were_VBDR tailored_VVN to_II individual_JJ programs_NN2 to_TO collect_VVI information_NN1 that_CST was_VBDZ not_XX found_VVN in_II the_AT available_JJ publications_NN2 ._. 
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<s>
A_AT1 grade_NN1 2_MC antrum_NN1 correlates_VVZ with_IW higher_JJR than_CSN baseline_NN1 gastric_JJ volume_NN1 and_CC is_VBZ uncommon_JJ in_II fasted_JJ subjects_NN2 0_MC ._. 
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<s>
Muscle_NN1 RING_NN1 Finger_NN1 1_MC1 (_( MuRF1_FO )_) ,_, a_AT1 muscle-specific_JJ E3_FO ubiquitin_NN1 ligase_NN1 ,_, is_VBZ believed_VVN to_TO mediate_VVI muscle_NN1 atrophy_NN1 through_II the_AT ubiquitin_NN1 proteasome_JJ system_NN1 (_( UPS_NN2 )_) ._. 
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<s>
Participants_NN2 wore_VVD an_AT1 ABP_NN1 cuff_NN1 from_II 0800_MC h_ZZ1 until_CS 2200_MC h_ZZ1 on_II all_DB conditions_NN2 ._. 
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<s>
All_DB women_NN2 who_PNQS tested_VVD positive_JJ for_IF fFN_NNU in_II the_AT study_NN1 (_( n_ZZ1 =_FO 11_MC )_) received_VVD tocolytic_JJ therapy_NN1 with_IW oral_JJ nifedipine_NN1 ._. 
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<s>
It_PPH1 has_VHZ been_VBN well-documented_JJ that_CST comparable_JJ voice_NN1 outcomes_NN2 can_VM be_VBI achieved_VVN in_II these_DD2 patients_NN2 who_PNQS then_RT underwent_VVD either_RR primary_JJ or_CC secondary_JJ TEP.As_NP1 available_JJ technology_NN1 has_VHZ improved_VVN ,_, secondary_JJ TEP_NN1 placement_NN1 in_II the_AT office_NN1 has_VHZ become_VVN an_AT1 accepted_JJ technique_NN1 with_IW outcomes_NN2 comparable_JJ to_II primary_JJ TEP_NN1 or_CC traditional_JJ secondary_JJ TEP_NN1 under_II rigid_JJ endoscopic_JJ guidance_NN1 ._. 
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<s>
The_AT sex_NN1 differences_NN2 in_II both_DB2 the_AT timing_NN1 and_CC the_AT magnitude_NN1 of_IO declines_VVZ in_II lung_NN1 cancer_NN1 mortality_NN1 are_VBR because_II21 of_II22 sex_NN1 differences_NN2 in_II the_AT time_NNT1 course_NN1 of_IO cigarette_NN1 marketing_NN1 ,_, use_VV0 ,_, and_CC cessation.11_FO Tobacco_NN1 use_NN1 has_VHZ been_VBN on_II the_AT decline_NN1 in_II the_AT United_NP1 States_NP1 since_CS the_AT 1960s_MC2 ,_, but_CCB the_AT trajectory_NN1 of_IO downward_JJ trends_NN2 in_II cigarette_NN1 smoking_NN1 slowed_VVN in_II the_AT 1990s_MC2 ,_, now_RT leaving_VVG about_II 1_MC1 of_IO every_AT1 6_MC American_JJ adults_NN2 as_CSA regular_JJ cigarette_NN1 smokers_NN2 ._. 
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<s>
The_AT 55_MC 003_MC regions_NN2 can_VM be_VBI identified_VVN on_II the_AT array_NN1 form_VV0 the_AT background_NN1 list_NN1 from_II which_DDQ DMRs_NP1 were_VBDR generated_VVN ._. 
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<s>
Separation_NN1 of_IO the_AT discs_NN2 from_II the_AT plasma_NN1 membrane_NN1 combined_VVN with_IW immunogold_NN1 electron_NN1 microscopy_NN1 (_( EM_FU )_) showed_VVD that_CST this_DD1 protein_NN1 localized_VVD to_II the_AT rims_NN2 and_CC incisures_NN2 of_IO the_AT flattened_JJ OS_NP2 discs_NN2 (_( Molday_NP1 et_RA21 al._RA22 ,_, 1987_MC )_) ._. 
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<s>
Maintaining_VVG the_AT trunk_NN1 upright_RL enhances_VVZ the_AT validity_NN1 of_IO VV_NP1 orientation_NN1 ,_, and_CC maintaining_VVG the_AT head_NN1 upright_RL enhances_VVZ the_AT validity_NN1 of_IO within-subject_NN1 variability_NN1 ._. 
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<s>
Although_CS the_AT standard_NN1 of_IO care_NN1 may_VM have_VHI changed_VVN during_II the_AT last_MD 13_MC years_NNT2 ,_, barring_VVG direct_JJ comparison_NN1 ,_, all_DB subjects_NN2 in_II both_DB2 experimental_JJ and_CC control_NN1 groups_NN2 for_IF all_DB 3_MC recent_JJ trials_NN2 received_VVD early_RR intravenous_JJ fluid_NN1 and_CC antibiotics_NN2 ._. 
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<s>
Because_II21 of_II22 the_AT rarity_NN1 of_IO the_AT tumor_NN1 ,_, there_EX is_VBZ no_AT consensus_NN1 for_IF its_APPGE proper_JJ diagnosis_NN1 and_CC treatment_NN1 ._. 
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<s>
Of_IO the_AT 940_MC patients_NN2 ,_, 249_MC were_VBDR excluded_VVN for_IF subgroup_NN1 analysis_NN1 :_: 241_MC patients_NN2 did_VDD not_XX attend_VVI all_DB tumour_NN1 assessments_NN2 ,_, or_CC had_VHD results_NN2 where_CS it_PPH1 was_VBDZ not_XX possible_JJ to_TO determine_VVI response_NN1 status_NN1 ,_, and_CC eight_MC patients_NN2 had_VHD salvage_NN1 treatment_NN1 before_II the_AT third_MD assessment_NN1 ._. 
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<s>
The_AT patient_JJ satisfaction_NN1 score_NN1 was_VBDZ recorded_VVN in_II only_RR 59_MC patients_NN2 in_II the_AT placebo_NN1 group_NN1 and_CC 52_MC patients_NN2 in_II the_AT ropivacaine_NN1 group_NN1 :_: there_EX was_VBDZ no_AT significant_JJ difference_NN1 in_II the_AT patient_JJ satisfaction_NN1 score_NN1 between_II the_AT 2_MC groups_NN2 (_( 9_MC plus_II and_CC minus_II 1_MC1 vs_II 9_MC plus_II and_CC minus_II 1_MC1 ;_; P_ZZ1 =_FO 0.70_MC )_) ._. 
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<s>
Independently_RR of_IO comorbidities_NN2 ,_, hs-cTnT_JJ concentration_NN1 increases_VVZ exponentially_RR with_IW age_NN1 after_II 65_MC years_NNT2 ._. 
</s>
<s>
These_DD2 molecules_NN2 were_VBDR selected_VVN because_CS they_PPHS2 are_VBR involved_JJ in_II inflammation_NN1 and_CC have_VH0 been_VBN associated_VVN with_IW decreased_JJ survival_NN1 and_CC recovery_NN1 in_II prior_JJ studies_NN2 ._. 
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<s>
Randomisation_NN1 was_VBDZ checked_VVN on_II baseline_NN1 characteristics_NN2 ._. 
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<s>
Study_NN1 objectives_NN2 are_VBR to_TO evaluate_VVI the_AT association_NN1 between_II OSA_NP1 and_CC biomarkers_NN2 ,_, and_CC to_TO test_VVI the_AT hypothesis_NN1 that_CST a_AT1 combination_NN1 of_IO markers_NN2 may_VM be_VBI useful_JJ in_II screening_VVG for_IF OSA_NN1 ._. 
</s>
<s>
Materials_NN2 and_CC Methods_NN2 Subjects_NN2 Sixteen_MC male_JJ ,_, 4-week_JJ old_JJ albino_NN1 Dunkin-Hartley_NP1 guinea_NN1 pigs_NN2 were_VBDR purchased_VVN from_II Charles_NP1 River_NNL1 Laboratories_NN2 (_( Wilmington_NP1 ,_, MA_NNA )_) ._. 
</s>
<s>
Mary_NP1 T._NP1 Roth_NP1 ,_, Pharm.D._NP1 ,_, M.H.S.From_NP1 the_AT Department_NN1 of_IO Psychiatry_NP1 (_( LCW_NP1 )_) ,_, UNC_NP1 School_NN1 of_IO Medicine_NN1 ,_, University_NN1 of_IO North_ND1 Carolina_NP1 at_II Chapel_NP1 Hill_NNL1 ,_, Chapel_NP1 Hill_NNL1 ,_, NC_NP1 ;_; Division_NN1 of_IO General_JJ Medicine_NN1 and_CC Clinical_JJ Epidemiology_NN1 ,_, UNC_NP1 School_NN1 of_IO Medicine_NN1 ,_, and_CC Department_NN1 of_IO Biostatistics_NP1 (_( DAE_NP1 )_) ,_, UNC_NP1 Gillings_NP1 School_NN1 of_IO Public_JJ Health_NN1 ,_, University_NN1 of_IO North_ND1 Carolina_NP1 at_II Chapel_NP1 Hill_NNL1 ,_, Chapel_NP1 Hill_NNL1 ,_, NC_NP1 ;_; Division_NN1 of_IO Pharmacy_NP1 Practice_NN1 and_CC Experiential_JJ Education_NN1 (_( JLI_NP1 )_) ,_, UNC_NP1 Eshelman_NP1 School_NN1 of_IO Pharmacy_NP1 ,_, University_NN1 of_IO North_ND1 Carolina_NP1 at_II Chapel_NP1 Hill_NNL1 ,_, Chapel_NP1 Hill_NNL1 ,_, NC_NP1 ;_; Division_NN1 of_IO General_JJ Medicine_NN1 and_CC Clinical_JJ Epidemiology_NN1 (_( CLL_NP1 )_) ,_, UNC_NP1 School_NN1 of_IO Medicine_NN1 ,_, University_NN1 of_IO North_ND1 Carolina_NP1 at_II Chapel_NP1 Hill_NNL1 ,_, Chapel_NP1 Hill_NNL1 ,_, NC_NP1 ;_; Department_NN1 of_IO Pharmacy_NP1 Care_NN1 Systems_NN2 (_( RH_FO )_) ,_, Harrison_NP1 School_NN1 of_IO Pharmacy_NP1 ,_, Auburn_JJ University_NN1 ,_, Auburn_JJ ,_, AL_FW ;_; Department_NN1 of_IO Health_NN1 Policy_NN1 and_CC Management_NN1 ,_, UNC_NP1 Gillings_NP1 School_NN1 of_IO Global_JJ Public_JJ Health_NN1 ,_, University_NN1 of_IO North_ND1 Carolina_NP1 at_II Chapel_NP1 Hill_NNL1 School_NN1 ,_, Chapel_NP1 Hill_NNL1 ,_, NC_NP1 ;_; Center_NN1 for_IF Health_NN1 Services_NN2 Research_NN1 (_( MW_NNU )_) ,_, Durham_NP1 Veterans_NN2 Affairs_NN2 Medical_JJ Center_NN1 ,_, Durham_NP1 ,_, NC_NP1 ;_; and_CC Division_NN1 of_IO Pharmaceutical_JJ Outcomes_NN2 and_CC Policy_NN1 (_( MTR_NP1 )_) ,_, UNC_NP1 Eshelman_NP1 School_NN1 of_IO Pharmacy_NP1 ,_, University_NN1 of_IO North_ND1 Carolina_NP1 at_II Chapel_NP1 Hill_NNL1 ,_, Chapel_NP1 Hill_NNL1 ,_, NC_NP1 ._. 
</s>
<s>
A_AT1 small_JJ study_NN1 of_IO 11_MC participants_NN2 with_IW CAA-related_JJ ICH_FW and_CC 13_MC matched_JJ healthy_JJ controls_NN2 found_VVN reduced_VVD FA_NP1 in_II the_AT temporal_JJ white_JJ matter_NN1 (_( inferior_JJ longitudinal_JJ and_CC occipital_JJ fasciculi_NN2 ,_, 17%_NNU reduction_NN1 )_) and_CC splenium_NN1 of_IO the_AT corpus_NN1 callosum_NN1 (_( 15%_NNU reduction_NN1 )_) as_II31 well_II32 as_II33 increased_JJ FA_NP1 of_IO lower_JJR magnitude_NN1 in_II deep_JJ grey_JJ matter_NN1 structures_NN2 ._. 
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<s>
Actually_RR ,_, there_EX are_VBR no_AT validated_JJ reference_NN1 controls_VVZ for_IF the_AT analysis_NN1 of_IO the_AT expression_NN1 of_IO miRNAs_NN2 in_II PCa_NP1 ,_, showing_VVG the_AT published_JJ studies_NN2 contradictory_JJ results_NN2 ._. 
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<s>
After_II washing_VVG the_AT strips_NN2 ,_, (_( BCIP_NP1 )_) -nitroblue_JJ tetrazolium_NN1 chromogen_NN1 (_( substrate_NN1 )_) reacted_VVD with_IW the_AT conjugate_NN1 ,_, forming_VVG the_AT purple/brown_JJ visible_JJ line_NN1 patterns_NN2 ._. 
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<s>
Sarcopenia_NN1 is_VBZ a_AT1 component_NN1 of_IO frailty_NN1 ,_, which_DDQ is_VBZ the_AT status_NN1 of_IO decreased_JJ physical_JJ and_CC cognitive_JJ reserve_NN1 leading_VVG to_II an_AT1 increased_JJ vulnerability_NN1 to_II stressors_NN2 ._. 
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<s>
While_NNT1 of_IO interest_NN1 to_II clinicians_NN2 to_TO guide_VVI the_AT treatment_NN1 required_VVN ,_, the_AT need_NN1 for_IF further_JJR treatment_NN1 of_IO infected_JJ skin_NN1 requiring_VVG more_DAR hospital_NN1 visits_NN2 and_CC time_NNT1 off_II work_NN1 or_CC revision_NN1 surgery_NN1 is_VBZ of_IO greater_JJR importance_NN1 to_II patients_NN2 ._. 
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<s>
The_AT grafts_NN2 were_VBDR observed_VVN every_AT1 day_NNT1 afterwards_RT and_CC considered_VVN rejected_VVN when_CS no_AT viable_JJ skin_NN1 remained_VVD ._. 
</s>
<s>
The_AT conservative_JJ variance_NN1 analysis_NN1 allowed_VVN for_IF correlation_NN1 of_IO individuals_NN2 within_II randomisation_NN1 clusters_NN2 but_CCB not_XX between_II clusters_NN2 ,_, and_CC used_VVD the_AT Huber-White_JJ information_NN1 sandwich_NN1 method_NN1 to_TO estimate_VVI variance_NN1 ._. 
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<s>
The_AT purpose_NN1 of_IO this_DD1 study_NN1 was_VBDZ to_TO determine_VVI whether_CSW a_AT1 locomotor_NN1 adaptation_NN1 that_CST requires_VVZ overcoming_VVG a_AT1 novel_JJ swing-phase_JJ resistance_NN1 is_VBZ impaired_VVN in_II persons_NN2 with_IW chronic_JJ stroke_NN1 and_CC hemiparesis_NN1 ._. 
</s>
<s>
While_CS confirmation_NN1 in_II a_AT1 larger_JJR cohort_NN1 is_VBZ needed_VVN ,_, our_APPGE data_NN suggests_VVZ that_CST the_AT HEART_NN1 Pathway_NN1 may_VM be_VBI utilized_VVN without_IW modification_NN1 in_II places_NN2 where_RRQ hs-cTnI_NN2 assays_NN2 are_VBR already_RR available_JJ and_CC when_CS they_PPHS2 become_VV0 available_JJ in_II the_AT U.S._NP1 Abstract_JJ IMPORTANCE-Executive_NN1 dysfunction_NN1 after_II traumatic_JJ brain_NN1 injury_NN1 (_( TBI_NP1 )_) in_II children_NN2 is_VBZ common_JJ and_CC leads_VVZ to_II significant_JJ short-_JJ and_CC long-term_JJ problems_NN2 in_II functioning_VVG across_RP multiple_JJ settings_NN2 ._. 
</s>
<s>
VOIs_NP1 were_VBDR located_VVN in_II the_AT midbrain_NN1 (_( 8.7E-02_MC ;_; Figure_NN1 2_MC ._. 
</s>
<s>
B_ZZ1 )_) and_CC in_II the_AT right_JJ superior_JJ longitudinal_JJ fasciculus_NN1 (_( -4.7E-02_MC ;_; SLF_NP1 ;_; Figure_NN1 2_MC ._. 
</s>
<s>
A_ZZ1 )_) ._. 
</s>
<s>
Plantar_NN1 flexor_NN1 muscles_NN2 of_IO rats_NN2 in_II a_AT1 supine_JJ position_NN1 were_VBDR stimulated_VVN (_( 3_MC Hz_NNU ;_; pulse_NN1 duration_NN1 :_: 220_MC ls_NNU2 )_) directly_RR with_IW transcutaneous_JJ surface_NN1 electrodes_NN2 located_VVN at_II the_AT knee_NN1 and_CC heel_NN1 levels_NN2 (_( Arsac_NP1 et_RA21 al._RA22 ,_, 2008_MC )_) ._. 
</s>
<s>
Individuals_NN2 with_IW other_JJ risks_NN2 for_IF neuropathy_NN1 (_( eg_REX ,_, alcoholism_NN1 ,_, vitamin_NN1 B12_FO deficiency_NN1 ,_, chemotherapy_NN1 )_) were_VBDR excluded_VVN ._. 
</s>
<s>
There_EX was_VBDZ a_AT1 significant_JJ decline_NN1 with_IW age_NN1 in_II the_AT intensity_NN1 of_IO Otx2_FO mRNA_NN1 expression_NN1 across_II all_DB regions_NN2 examined_VVD ,_, and_CC in_II the_AT SNC_NP1 and_CC VTA_NP1 expression_NN1 was_VBDZ reduced_VVN to_II below_II average_NN1 by_II early_JJ middle_JJ age_NN1 ._. 
</s>
<s>
Statistical_JJ analysis_NN1 All_DB analyses_NN2 were_VBDR by_II intention_NN1 to_TO treat_VVI based_VVN on_II the_AT randomised_JJ treatment_NN1 allocation_NN1 ._. 
</s>
<s>
The_AT gold_NN1 standard_NN1 for_IF diagnosis_NN1 is_VBZ currently_RR based_VVN upon_II overnight_JJ polysomnography_NN1 (_( sleep_VV0 study_NN1 )_) ,_, and_CC patients_NN2 are_VBR often_RR not_XX referred_VVN for_IF this_DD1 definitive_JJ testing_NN1 ._. 
</s>
<s>
The_AT case-control_JJ study_NN1 will_VM continue_VVI to_TO investigate_VVI the_AT current_JJ and_CC alternative_JJ hypotheses_NN2 as_II31 well_II32 as_II33 the_AT role_NN1 of_IO cofactors_NN2 ,_, and_CC provide_VV0 final_JJ estimates_NN2 ._. 
</s>
<s>
For_IF antigen_NN1 retrieval_NN1 ,_, the_AT slides_NN2 were_VBDR heated_VVN at_II 98_MC ._. 
</s>
<s>
C_NP1 in_II an_AT1 EDTA_NN1 buffer_NN1 (_( pH_NN1 8.0_MC ;_; Shanghai_NP1 Sun_NN1 BioTech_NP1 Co_NP1 ,_, Shanghai_NP1 ,_, China_NP1 )_) for_IF a_AT1 total_NN1 of_IO 20_MC minutes_NNT2 for_IF staining_VVG for_IF CD31_FO ,_, ADRB2_FO ,_, p-CREB_NP1 ,_, ADRA1_FO ,_, and_CC ADRA2_FO ,_, or_CC citrate_JJ buffer_NN1 (_( pH6.0_FO )_) for_IF a_AT1 total_NN1 of_IO 30_MC minutes_NNT2 for_IF staining_VVG for_IF PCNA_NP1 ,_, VEGF_NP1 ,_, ADRB1_FO ,_, and_CC ADRB3_FO and_CC then_RT cooled_VVD naturally_RR to_II the_AT room_NN1 temperature_NN1 ._. 
</s>
<s>
In_II31 light_II32 of_II33 the_AT supposed_JJ failures_NN2 of_IO cortectomies_NN2 or_CC thala-motomies_NN2 to_TO relieve_VVI phantom_JJ percepts_NN2 and_CC pain_NN1 ,_, Melzack_NP1 proposed_VVD that_CST the_AT anatomical_JJ substrate_NN1 of_IO the_AT physical_JJ self_NN1 is_VBZ a_AT1 network_NN1 of_IO neurons_NN2 that_CST extends_VVZ throughout_II widespread_JJ areas_NN2 of_IO the_AT brain_NN1 (_( Neuromatrix_NP1 )_) ._. 
</s>
<s>
When_CS we_PPIS2 used_VVD more_DAR than_CSN 400_MC datapoints_VVZ to_TO estimate_VVI the_AT regression_NN1 coefficients_NN2 ,_, the_AT regressions_NN2 also_RR included_VVN regional_JJ random_JJ effects_NN2 ._. 
</s>
<s>
Specific_JJ conditional_NN1 Sox2_FO deletion_NN1 induces_VVZ a_AT1 rapid_JJ loss_NN1 of_IO Nestin+_FO NPCs_NP1 and_CC a_AT1 decline_NN1 in_II dentate_NN1 cell_NN1 proliferation_NN1 ,_, substantiating_VVG the_AT crucial_JJ role_NN1 of_IO Sox2_FO in_II maintaining_VVG undifferentiated_JJ NPCs_NP1 and_CC hence_RR neurogenesis_NN1 in_II the_AT adult_NN1 hippocampus_NN1 (_( Favaro_NP1 et_RA21 al._RA22 ,_, 2009_MC ;_; Ferri_NP1 et_RA21 al._RA22 ,_, 2004_MC )_) ._. 
</s>
<s>
In_II places_NN2 such_II21 as_II22 Kenya_NP1 or_CC Pakistan_NP1 ,_, food_NN1 expenditures_NN2 consume_VV0 on_II average_NN1 almost_RR one-half_MF of_IO the_AT disposable_JJ income_NN1 ._. 
</s>
<s>
Prostate_NN1 mpMRI_NN2 is_VBZ being_VBG used_VVN not_XX only_RR to_TO localize_VVI and_CC stage_NN1 prostate_NN1 cancer_NN1 but_CCB also_RR to_TO establish_VVI candidates_NN2 for_IF AS_II ._. 
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<s>
Three_MC patients_NN2 ,_, all_DB of_IO whom_PNQO had_VHD had_VHN seizure_NN1 activity_NN1 in_II the_AT ICU_NN1 before_II enrollment_NN1 in_II the_AT trial_NN1 ,_, had_VHD seizures_NN2 during_II an_AT1 episode_NN1 of_IO hypoglycemia_NN1 ._. 
</s>
<s>
On_II the_AT basis_NN1 of_IO formal_JJ review_NN1 of_IO the_AT emerging_JJ literature_NN1 ,_, the_AT ACS_NN2 will_VM determine_VVI the_AT need_NN1 to_TO update_VVI on_II a_AT1 regular_JJ basis_NN1 ._. 
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<s>
R.A._NP1 and_CC M.L._NNU are_VBR employees_NN2 of_IO Philips_NP1 ._. 
</s>
<s>
Conflicts_NN2 of_IO interest_NN1 :_: There_EX are_VBR no_AT conflicts_NN2 of_IO interest_NN1 to_TO report_VVI ._. 
</s>
<s>
The_AT test_NN1 measures_NN2 sensitivity_NN1 to_II an_AT1 achromatic_JJ ,_, briefly_RR presented_VVN stimulus_NN1 that_CST is_VBZ non-selective_JJ for_IF pre-cortical_JJ visual_JJ pathways_NN2 (_( Swanson_NP1 et_RA21 al_RA22 ._. 
</s>
<s>
,_, 2011_MC )_) ._. 
</s>
<s>
Rehabilitative_JJ training_NN1 (_( RT_NP1 )_) reduces_VVZ impairments_NN2 but_CCB is_VBZ often_RR insufficient_JJ to_TO restore_VVI normal_JJ functionality_NN1 ._. 
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<s>
While_CS the_AT resulting_JJ increase_NN1 in_II Erk_NP1 activity_NN1 was_VBDZ minor_JJ ,_, it_PPH1 was_VBDZ sufficient_JJ to_TO significantly_RR reduce_VVI colony_NN1 forming_VVG capacity_NN1 of_IO the_AT two_MC pre-B_JJ ALL_DB cases_NN2 (_( Figures_VVZ 3G_NNU and_CC 3H_FO )_) ._. 
</s>
<s>
Deviation_NN1 from_II rate_NN1 control_NN1 was_VBDZ largely_RR a_AT1 result_NN1 of_IO drug_NN1 ineffectiveness_NN1 ,_, whereas_CS amiodarone_NN1 was_VBDZ discontinued_VVN mostly_RR due_II21 to_II22 drug-related_JJ toxic_JJ effects_NN2 ._. 
</s>
<s>
Two_MC authors_NN2 (_( J.R.I._NP1 and_CC A.C.K._NP1 )_) independently_RR undertook_VVD study_NN1 selection_NN1 and_CC no_AT language_NN1 restrictions_NN2 were_VBDR applied_VVN ._. 
</s>
<s>
Nested_JJ networks_NN2 :_: In_II any_DD network_NN1 architecture_NN1 ,_, there_EX are_VBR two_MC kinds_NN2 of_IO nesting_NN1 :_: hierarchical_JJ and_CC simple_JJ ._. 
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<s>
International_JJ guidelines_NN2 recommend_VV0 the_AT assessment_NN1 of_IO functional_JJ CAD_NN1 severity_NN1 before_II revascularization_NN1 ._. 
</s>
<s>
Neuropathic_JJ animals_NN2 received_VVN Drp1_FO AS_CSA or_CC MM-ODN_NN1 at_II day_NNT1 12_MC to_II 14_MC after_CS gp120_FO ._. 
</s>
<s>
The_AT reoperation_NN1 rate_NN1 was_VBDZ significantly_RR lower_JJR in_II both_DB2 univariate_VV0 and_CC multivariable_JJ analysis_NN1 with_IW adjustable_JJ sutures_NN2 (_( multivariable_JJ odds_NN2 ratio_NN1 ,_, OR_CC 0.69_MC ,_, 95%_NNU confidence_NN1 interval_NN1 ,_, CI_NP1 ,_, 0.52_MC to_II 0.91_MC ,_, p=0.02_FO )_) ,_, in_II younger_JJR patients_NN2 (_( age_NN1 18_MC to_II 39_MC )_) ,_, with_IW monocular_JJ deviations_NN2 ,_, with_IW unilateral_JJ surgery_NN1 on_II two_MC horizontal_JJ muscles_NN2 ,_, and_CC with_IW surgery_NN1 not_XX defined_VVN as_CSA complex_JJ (_( Tables_NN2 2_MC and_CC 3_MC )_) ._. 
</s>
<s>
In_II a_AT1 secondary_JJ analysis_NN1 which_DDQ counted_VVD only_RR horizontal_JJ muscle_NN1 surgeries_NN2 as_CSA reoperations_NN2 ,_, 280_MC patients_NN2 (_( 6.4%_FO )_) had_VHD a_AT1 reoperation_NN1 by_II one_MC1 year_NNT1 ._. 
</s>
<s>
Occludins_NN2 are_VBR integral_JJ membrane_NN1 proteins_NN2 crucial_JJ for_IF tight_JJ junctions_NN2 ,_, and_CC the_AT cadherins_NN2 are_VBR involved_JJ in_II cell-to-cell_JJ adhesion_NN1 as_II31 well_II32 as_II33 communication_NN1 ._. 
</s>
<s>
In_RR21 addition_RR22 ,_, the_AT need_NN1 for_IF EBP_NP1 was_VBDZ significantly_RR reduced_VVN from_II 52%_NNU to_II 20%_NNU and_CC even_RR more_RRR when_CS intrathecal_JJ saline_JJ infusion_NN1 was_VBDZ added_VVN to_II the_AT intrathecal_JJ catheter_NN1 (_( 52%-8%_FO )_) ._. 
</s>
<s>
Conclusion_NN1 In_II community-dwelling_JJ persons_NN2 aged_VVN at_RR21 least_RR22 75_MC years_NNT2 with_IW no_AT comorbid_JJ depressive_NN1 symptoms_NN2 or_CC cognitive_JJ impairment_NN1 ,_, apathy_NN1 as_II a_AT1 syndrome_NN1 in_II its_APPGE own_DA right_NN1 frequently_RR occurred_VVD in_RP over_RG 7%_NNU ._. 
</s>
<s>
The_AT matrix_NN1 size_NN1 was_VBDZ 104_MC x_ZZ1 106_MC after_II zero-filling_NN1 and_CC SENSE_NN1 reconstruction_NN1 ,_, resulting_VVG in_II reconstructed_JJ image_NN1 size_NN1 of_IO 224_MC x_ZZ1 224_MC pixels_NN2 with_IW pixel_NN1 size_NN1 of_IO 1.65_MC x_ZZ1 1.65_MC mm2_FO ._. 
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<s>
To_TO investigate_VVI the_AT mechanism_NN1 of_IO action_NN1 ,_, CD4+_FO T_ZZ1 cells_NN2 were_VBDR coincubated_VVN with_IW CD19+-CD24hiCD38hi_FO B_ZZ1 cells_NN2 ,_, in_II the_AT presence_NN1 of_IO human_NN1 IL-10_MC neutralizing_NN1 antibody_NN1 (_( IL-10_MC mAb_NN1 )_) or_CC isotype_VV0 control_NN1 (_( Fig._NN1 4a_FO )_) ._. 
</s>
<s>
Exact_JJ numbers_NN2 are_VBR 971_MC pre-radiotherapy_JJ plus_II 85_MC baseline_NN1 for_IF overall_JJ bowel_NN1 bother_VV0 ;_; 969_MC plus_II 84_MC for_IF overall_JJ urinary_JJ bother_NN1 (_( per_II treatment_NN1 group_NN1 shown_VVN in_II appendix_NN1 p_ZZ1 14_MC )_) ._. 
</s>
<s>
Our_APPGE results_NN2 add_VV0 to_II the_AT growing_JJ body_NN1 of_IO evidence_NN1 that_CST acute_JJ injuries_NN2 in_II older_JJR adults_NN2 can_VM have_VHI a_AT1 substantial_JJ negative_JJ effect_NN1 on_II important_JJ longterm_JJ pain_NN1 and_CC health_NN1 outcomes_NN2 and_CC extend_VV0 these_DD2 findings_NN2 to_II a_AT1 population_NN1 of_IO independently_RR living_VVG older_JJR adults_NN2 whom_PNQO most_DAT clinicians_NN2 would_VM regard_VVI as_CSA lacking_VVG injuries_NN2 likely_JJ to_TO have_VHI long-term_JJ consequences_NN2 ._. 
</s>
<s>
In_II31 terms_II32 of_II33 supervision_NN1 and_CC autonomy_NN1 ,_, we_PPIS2 excluded_VVD respondents_NN2 who_PNQS graduated_VVD more_DAR than_CSN 10_MC years_NNT2 ago_RA (_( when_CS most_DAT programs_NN2 were_VBDR not_XX accredited_VVN and_CC training_NN1 was_VBDZ inherently_RR different_JJ )_) ._. 
</s>
<s>
HEK_VV0 cells_NN2 were_VBDR then_RT immunolabeled_VVN with_IW an_AT1 Alexa_NP1 Fluor_NP1 594_MC secondary_JJ antibody_NN1 against_II human_JJ IgG_NN1 (_( 1:1,000_MC )_) ._. 
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<s>
The_AT method_NN1 robustness_NN1 and_CC specificity_NN1 was_VBDZ tested_VVN in_II more_DAR than_CSN three-hundred_MC samples_NN2 over_RG two_MC years_NNT2 :_: invalid_JJ IR_NN1 or_CC altered_JJ peak_NN1 shape_NN1 were_VBDR observed_VVN in_II less_DAR than_CSN 5%_NNU of_IO the_AT samples_NN2 ._. 
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<s>
IgG4_FO is_VBZ the_AT least_RGT common_JJ of_IO all_DB four_MC isoforms_NN2 of_IO IgG_NN1 ._. 
</s>
<s>
Since_CS it_PPH1 does_VDZ not_XX bind_VVI complement_NN1 '_NULL some_DD believe_VV0 that_CST its_APPGE primary_JJ function_NN1 is_VBZ anti-inflammatory_JJ (_( Rispens_NP1 et_RA21 al_RA22 ._. '_NULL 
</s>
<s>
2009_MC )_) ._. 
</s>
<s>
By_II using_VVG different_JJ ophthalmologists_NN2 working_VVG at_II different_JJ units_NN2 ,_, the_AT results_NN2 of_IO the_AT study_NN1 are_VBR more_RGR likely_JJ to_TO be_VBI generalizable_JJ than_CSN results_NN2 from_II studies_NN2 performed_VVN in_II a_AT1 single_JJ unit_NN1 ._. 
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<s>
The_AT ImagingDMD_NP1 study_NN1 is_VBZ supported_VVN by_II the_AT National_JJ Institute_NN1 of_IO Arthritis_NP1 and_CC Musculoskeletal_NP1 and_CC Skin_NN1 Diseases_NN2 and_CC the_AT National_JJ Institute_NN1 of_IO Neurological_JJ Disorders_NN2 and_CC Stroke_NN1 (_( RO1AR056973/R01AR065943_NP1 )_) ._. 
</s>
<s>
This_DD1 dimension_NN1 intersects_VVZ with_IW patient_JJ Theme_NN1 1_MC1 :_: threats_NN2 to_II trustworthiness_NN1 and_CC iatrogenic_JJ suffering_NN1 ._. 
</s>
<s>
For_IF the_AT CLOZUK_NN1 sample_NN1 we_PPIS2 thank_VV0 Novartis_NN1 for_IF their_APPGE guidance_NN1 and_CC co-operation_NN1 ._. 
</s>
<s>
In_II the_AT present_JJ study_NN1 ,_, an_AT1 attempt_NN1 was_VBDZ made_VVN to_TO relate_VVI sirtuins_NN2 to_II a_AT1 major_JJ geriatric_JJ syndrome_NN1 that_CST is_VBZ frailty_NN1 ._. 
</s>
<s>
Such_DA a_AT1 dependency_NN1 was_VBDZ evident_JJ in_II the_AT current_JJ study_NN1 ,_, with_IW an_AT1 overestimation_NN1 of_IO the_AT iodine_NN1 content_NN1 in_II the_AT iodine-calcium_JJ mixtures_NN2 at_II both_RR DSCT_NP1 and_CC RSCT_NP1 ._. 
</s>
<s>
The_AT increase_NN1 in_II response_NN1 and_CC progression-free_JJ survival_NN1 in_II the_AT cediranib_NN1 group_NN1 was_VBDZ achieved_VVN with_IW an_AT1 increase_NN1 in_II neutropenia_NN1 ,_, febrile_JJ neutropenia_NN1 ,_, diarrhoea_NN1 ,_, and_CC hypertension_NN1 ._. 
</s>
<s>
Inter-rater_JJ reliability_NN1 as_CSA indicated_VVN by_II intraclass_NN1 correlation_NN1 (_( ICC_NP1 )_) was_VBDZ .978_MC with_IW a_AT1 95%_NNU confidence_NN1 interval_NN1 of_IO .401-.999_MCMC ._. 
</s>
<s>
But_CCB despite_II convincing_JJ functional_JJ abnormalities_NN2 in_II the_AT dopamine_NN1 system_NN1 as_CSA measured_VVN by_II imaging_VVG methods_NN2 in_II disorders_NN2 such_II21 as_II22 schizophrenia_NN1 ,_, there_EX is_VBZ little_DA1 evidence_NN1 for_IF static_JJ abnormalities_NN2 in_II the_AT dopamine_NN1 system_NN1 from_II postmortem_NN1 or_CC genetic_JJ studies_NN2 ._. 
</s>
<s>
Statistical_JJ and_CC permutation_NN1 analysis_NN1 Areas_NN2 are_VBR approximated_VVN using_VVG trapezoidal_JJ numerical_JJ integration_NN1 ._. 
</s>
<s>
Others_NN2 have_VH0 used_VVN the_AT ED_NP1 to_TO identify_VVI ill_JJ and_CC injured_JJ young_JJ adult_NN1 patients_NN2 with_IW hazardous_JJ alcohol_NN1 use_NN1 and_CC deliver_VV0 a_AT1 text_NN1 message_NN1 intervention_NN1 for_IF alcohol_NN1 reduction31_FO ._. 
</s>
<s>
The_AT P3a_FO component_NN1 The_AT mean_JJ amplitudes_NN2 from_II the_AT P3a_FO time_NNT1 window_NN1 were_VBDR submitted_VVN to_II a_AT1 three-factor_JJ ANOVA_NN1 5_MC for_IF the_AT anterior-posterior_NN1 pooling_VVG dimension_NN1 and_CC to_II ANOVA_NP1 6_MC for_IF the_AT lateral_JJ one_MC1 ._. 
</s>
<s>
Basically_RR ,_, this_DD1 is_VBZ ideal_JJ crash_NN1 energy_NN1 management_NN1 where_CS deformation_NN1 occurs_VVZ in_II the_AT padded_JJ lining_NN1 ._. 
</s>
<s>
Patients_NN2 were_VBDR censored_VVN at_II the_AT time_NNT1 they_PPHS2 last_VV0 reported_JJ outcomes_NN2 in_II the_AT long-term_JJ follow-up_JJ system_NN1 ._. 
</s>
<s>
Increasing_JJ urge_NN1 was_VBDZ associated_VVN with_IW greater_JJR urgency_NN1 incontinent_JJ participant_NN1 than_CSN control_NN1 activation_NN1 of_IO the_AT interoceptive_JJ network_NN1 and_CC activation_NN1 in_II networks_NN2 that_CST are_VBR determinants_NN2 of_IO self-awareness_NN1 (_( default_NN1 mode_NN1 network_NN1 )_) and_CC of_IO response_NN1 to_II unexpected_JJ external_JJ stimuli_NN2 (_( ventral_JJ attention_NN1 network_NN1 )_) ._. 
</s>
<s>
A_AT1 concern_NN1 with_IW providing_VVG RFN_NP1 therapy_NN1 to_II patients_NN2 with_IW pedicle_NN1 screw_NN1 hardware_NN1 is_VBZ the_AT potential_NN1 for_IF heat_NN1 transmission_NN1 from_II the_AT radiofrequency_NN1 (_( RF_NP1 )_) probe_VV0 through_II the_AT pedicle_NN1 screw_NN1 to_II the_AT surrounding_JJ bony_JJ or_CC soft_JJ tissues_NN2 ._. 
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<s>
For_REX21 example_REX22 ,_, if_CS an_AT1 elective_JJ surgical_JJ procedure_NN1 is_VBZ planned_VVN (_( e.g._REX diagnostic_JJ knee_NN1 arthroscopy_NN1 )_) ,_, the_AT presence_NN1 of_IO solid_JJ food_NN1 in_II the_AT stomach_NN1 will_VM likely_RR result_VVI in_II deferral_NN1 of_IO the_AT surgical_JJ timing_NN1 ._. 
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<s>
On_II the_AT other_JJ hand_NN1 ,_, an_AT1 unhealthy_JJ aging_JJ course_NN1 is_VBZ associated_VVN with_IW several_DA2 comorbid_JJ diseases_NN2 ,_, diminished_VVD quality_NN1 of_IO life_NN1 ,_, and_CC increased_JJ mortality_NN1 risk_NN1 (_( Sodergren_NP1 ,_, 2013_MC )_) ._. 
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<s>
He_PPHS1 presented_VVD to_II dermatologists_NN2 at_II 1_MC1 year_NNT1 of_IO age_NN1 with_IW ulcerating_VVG lesions_NN2 of_IO the_AT ear_NN1 helices_NN2 ,_, which_DDQ were_VBDR exacerbated_VVN by_II cold_JJ and_CC healed_VVN with_IW scarring_VVG ._. 
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<s>
Thus_RR ,_, investigators_NN2 have_VH0 been_VBN seeking_VVG alternatives_NN2 for_IF the_AT non-invasive_JJ prenatal_JJ detection_NN1 of_IO aneuploidy_NN1 ._. 
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<s>
Hypoxia_NP1 occurred_VVD in_II 40.2_MC per_II 1,000_MC sedations_NN2 (_( 95%_NNU CI_FO =_FO 32.5_MC to_II 47.9_MC )_) ;_; vomiting_VVG ,_, 16.4_MC per_II 1,000_MC sedations_NN2 (_( 95%_NNU CI_FO =_FO 9.7_MC to_II 23.0_MC )_) ;_; hypotension_NN1 ,_, 15.2_MC per_II 1,000_MC sedations_NN2 (_( 95%_NNU CI_FO =_FO 10.7_MC to_II 19.7_MC )_) ;_; and_CC apnea_NN1 12.4_MC per_II 1,000_MC (_( 95%_NNU CI_FO =_FO 7.9_MC to_II 16.9_MC )_) ._. 
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<s>
Methylation_NN1 of_IO lysine_NN1 27_MC on_II histone_NN1 H3_FO (_( H3K27me3_FO )_) by_II EZH2_FO imposes_VVZ gene_NN1 silencing_VVG in_RR21 part_RR22 by_II triggering_VVG recruitment_NN1 of_IO PRC1_NP1 (_( Cao_NP1 et_RA21 al._RA22 ,_, 2002_MC ;_; Min_NNU et_RA21 al._RA22 ,_, 2003_MC )_) and_CC histone_NN1 deacetylases_NN2 (_( HDACs_NP2 )_) ._. 
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<s>
Based_VVN on_II the_AT absence_NN1 in_II controls_NN2 ,_, the_AT conservation_NN1 of_IO H50_FO ,_, and_CC the_AT predicted_JJ and_CC observed_VVD functional_JJ effects_NN2 affecting_VVG copper_NN1 coordination_NN1 ,_, p.H50Q_FO was_VBDZ regarded_VVN as_II a_AT1 pathogenic_JJ mutation_NN1 ._. 
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<s>
Data_NN were_VBDR expressed_VVN as_CSA means_VVZ plus_II and_CC minus_II SD_NP1 unless_CS otherwise_RR specified_VVN ._. 
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<s>
In_II these_DD2 patients_NN2 ,_, although_CS overall_JJ improvement_NN1 in_II BCVA_NP1 was_VBDZ observed_VVN at_II month_NNT1 12_MC ,_, the_AT gain_NN1 was_VBDZ significantly_RR lower_JJR than_CSN that_DD1 observed_VVD in_II patients_NN2 receiving_VVG rani-bizumab_NN1 throughout_II the_AT study.10_FO A_ZZ1 VA_FW loss_NN1 of_IO 15_MC letters_NN2 or_CC more_RRR at_II month_NNT1 12_MC was_VBDZ reported_VVN in_II a_AT1 higher_JJR percentage_NN1 (_( 5.9%_FO )_) of_IO patients_NN2 in_II the_AT CRYSTAL_NN1 study_NN1 than_CSN in_II the_AT CRUISE_NN1 study_NN1 (_( 2.3%_FO )_) ,_, 10_MC possibly_RR related_VVN to_II the_AT differences_NN2 in_II the_AT patient_JJ population_NN1 ._. 
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<s>
Data_NN Analysis_NN1 Data_NN were_VBDR collected_VVN by_II a_AT1 trained_JJ research_NN1 associate_NN1 and_CC then_RT entered_VVN into_II a_AT1 Microsoft_NP1 Excel_VV0 database_NN1 ._. 
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<s>
Key_JJ Words_NN2 :_: Ecological_JJ Momentary_JJ Assessment_NN1 ,_, physical_JJ activity_NN1 ,_, sedentary_JJ behavior_NN1 ,_, methods_NN2 ,_, health_NN1 behavior_NN1 theory_NN1 ,_, intraindividual_JJ variability_NN1 ,_, multilevel_VV0 modeling_VVG INTRODUCTION_NN1 Physical_JJ activity_NN1 reduces_VVZ risks_NN2 of_IO many_DA2 serious_JJ health_NN1 conditions_NN2 ,_, including_II coronary_JJ heart_NN1 disease_NN1 ,_, type_NN1 2_MC diabetes_NN1 ,_, and_CC breast_NN1 and_CC colon_NN1 cancers_NN2 (_( 20_MC )_) ._. 
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<s>
The_AT efficient_JJ transfer_NN1 of_IO these_DD2 three_MC items_NN2 represents_VVZ one_MC1 of_IO the_AT major_JJ hurdles_NN2 to_TO overcome_VVI in_RP in_RR21 vivo_RR22 retinal_JJ genome_NN1 editing_NN1 '_NULL and_CC the_AT choice_NN1 of_IO an_AT1 optimal_JJ vector_NN1 system_NN1 is_VBZ crucial_JJ ._. 
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<s>
The_AT ethnic_JJ disparity_NN1 in_II gastric_JJ cancer_NN1 is_VBZ driven_VVN wholly_RR by_II distal_JJ tumors_NN2 ,_, for_IF which_DDQ the_AT incidence_NN1 rate_NN1 is_VBZ 6.2_MC (_( per_II 100,000_MC population_NN1 )_) in_II His-panics_NN2 compared_VVN with_IW 2.2_MC in_II NHWs.10_FO Indeed_RR ,_, the_AT rate_NN1 for_IF proximal_JJ tumors_NN2 is_VBZ lower_JJR in_II Hispanics_NP1 (_( 1.5_MC per_II 100,000_MC population_NN1 )_) than_CSN in_II NHWs_NP1 (_( 2.2_MC )_) ._. 
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<s>
This_DD1 study_NN1 was_VBDZ reviewed_VVN and_CC approved_VVN by_II the_AT appropriate_JJ institutions_NN2 ,_, and_CC was_VBDZ conducted_VVN in_II31 accordance_II32 with_II33 the_AT Declaration_NN1 of_IO Helsinki_NP1 and_CC good_JJ clinical_JJ practice_NN1 guidelines_NN2 ._. 
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<s>
Interestingly_RR ,_, conditional_JJ knockout_NN1 studies_NN2 suggest_VV0 that_CST VEGFR2_FO signalling_VVG in_II RGCs_NP1 is_VBZ not_XX required_VVN for_IF retinal_JJ morphogenesis_NN1 (_( Okabe_NP1 et_RA21 al._RA22 ,_, 2014_MC )_) ,_, while_CS VEGFR2_FO is_VBZ instead_RR required_VVN for_IF the_AT survival_NN1 of_IO Muller_NP1 glia_NN1 ,_, which_DDQ are_VBR in_II turn_NN1 essential_JJ for_IF the_AT viability_NN1 of_IO adult_JJ retinal_JJ neurons_NN2 in_II a_AT1 model_NN1 of_IO diabetic_JJ retinopathy_NN1 (_( Fu_NP1 et_RA21 al_RA22 ._. 
</s>
<s>
Diabetes_NN1 2015_MC )_) ._. 
</s>
<s>
Roger_NP1 stated_VVD that_CST opening_VVG up_RP can_VM be_VBI viewed_VVN as_II a_AT1 sign_NN1 of_IO weakness_NN1 ._. 
</s>
<s>
The_AT distribution_NN1 of_IO the_AT assigned_JJ PI-RADS_NN2 V2_FO categories_NN2 was_VBDZ computed_VVN ,_, as_CSA were_VBDR the_AT frequency_NN1 of_IO tumors_NN2 and_CC of_IO GS_NP1 greater_JJR than_CSN and_CC equal_JJ to_II 7_MC tumors_NN2 for_IF each_DD1 category_NN1 ,_, overall_JJ and_CC separately_RR in_II the_AT PZ_NP1 and_CC TZ_NP1 ._. 
</s>
<s>
Moreover_RR ,_, sirolimus_NN1 appears_VVZ to_TO enhance_VVI T_ZZ1 regulatory_JJ cell_NN1 function_NN1 in_II humans_NN2 ,_, which_DDQ may_VM have_VHI both_DB2 beneficial_JJ and_CC harmful_JJ effects_NN2 on_II immune_JJ function_NN1 ._. 
</s>
<s>
Despite_II substantial_JJ improvement_NN1 of_IO immunosuppressive_JJ therapy_NN1 ,_, delayed_VVD graft_NN1 function_NN1 and_CC allograft_VV0 rejection_NN1 remain_VV0 major_JJ problems_NN2 limiting_VVG long-term_JJ graft_NN1 function_NN1 and_CC graft_VV0 survival_NN1 ._. 
</s>
<s>
Discussion_NN1 In_II the_AT ARTemis_NP1 study_NN1 ,_, the_AT addition_NN1 of_IO short_JJ course_NN1 bevacizumab_NN1 to_II standard_JJ neoadjuvant_JJ anthracycline_NN1 and_CC taxane-based_JJ chemotherapy_NN1 in_II HER2-negative_JJ ,_, early_JJ breast_NN1 cancer_NN1 ,_, was_VBDZ associated_VVN with_IW a_AT1 significant_JJ improvement_NN1 in_II the_AT proportion_NN1 of_IO patients_NN2 achieving_VVG a_AT1 pathological_JJ complete_JJ response_NN1 ._. 
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<s>
There_EX was_VBDZ added_VVN diagnostic_JJ value_NN1 in_II 21%_NNU of_IO patients_NN2 with_IW CDT-VIBE_NP1 ._. 
</s>
<s>
To_II our_APPGE knowledge_NN1 the_AT impact_NN1 of_IO EM_FU residents_NN2 on_II attending_VVG physicians_NN2 '_NULL ability_NN1 to_TO produce_VVI and_CC bill_NN1 for_IF RVUs_NP1 has_VHZ not_XX yet_RR been_VBN studied_VVN ._. 
</s>
<s>
Postoperative_JJ radiotherapy_NN1 seems_VVZ to_TO significantly_RR improve_VVI local_JJ control_NN1 ._. 
</s>
<s>
No_AT differences_NN2 between_II the_AT two_MC margin_NN1 widths_NN2 were_VBDR noted_VVN regarding_II the_AT cumulative_JJ incidence_NN1 of_IO death_NN1 due_II21 to_II22 other_JJ causes_NN2 (_( figure_NN1 4_MC ;_; point_NN1 estimates_NN2 of_IO cumulative_JJ incidence_NN1 at_II 8.8_MC years_NNT2 were_VBDR 14.5%_FO &lsqb;_( 95%_NNU CI_NN1 10.1-20.6_MCMC &rsqb;_) in_II the_AT 1_MC1 cm_NNU margin_NN1 group_NN1 ,_, 18.2%_FO &lsqb;_( 13.6-24.0_MCMC &rsqb;_) in_II the_AT 3_MC cm_NNU group_NN1 )_) ._. 
</s>
<s>
In_II unadjusted_JJ analysis_NN1 ,_, RRS_NP2 implementation_NN1 was_VBDZ associated_VVN with_IW a_AT1 reduction_NN1 in_II the_AT proportion_NN1 of_IO unplanned_JJ transfers_NN2 requiring_VVG vasopressors_NN2 in_II the_AT first_MD 1_MC1 hour_NNT1 following_VVG transfer_NN1 but_CCB not_XX in_II the_AT first_MD 12_MC hours_NNT2 (_( Table_NN1 2_MC )_) ._. 
</s>
<s>
The_AT DNA_NN1 hypomethylation_NN1 of_IO the_AT signature_NN1 set_NN1 identified_VVN in_II SCLC_NP1 lines_NN2 correctly_RR predicted_VVN sensitivity_NN1 to_II LSD1_FO inhibition_NN1 in_II primary_JJ SCLC_NP1 ,_, further_RRR strengthening_VVG the_AT rationale_NN1 for_IF clinical_JJ application_NN1 to_TO identify_VVI SCLC_NP1 patients_NN2 most_RGT likely_JJ to_TO respond_VVI to_II GSK2879552_FO treatment_NN1 ._. 
</s>
<s>
However_RR ,_, as_CSA previously_RR demonstrated_VVN by_II Sharrock_NP1 et_RA21 al_RA22 ._. 
</s>
<s>
epinephrine_NN1 in_II the_AT dose_NN1 range_NN1 used_VVN in_II the_AT present_JJ investigation_NN1 augments_VVZ CO_FO during_II HEA_NP1 ._. 
</s>
<s>
In_II this_DD1 instance_NN1 '_NULL direct_JJ activation_NN1 of_IO the_AT gp130_FO receptor_NN1 subunit_NN1 would_VM be_VBI favourable_JJ and_CC the_AT designer_NN1 hIL-6_MC '_NULL that_CST consists_VVZ of_IO the_AT covalently_RR linked_VVN bioactive_JJ parts_NN2 of_IO IL-6_MC and_CC soluble_JJ IL-6a_FO '_NULL does_VDZ exactly_RR this_DD1 (_( Peters_VVZ et_RA21 al_RA22 ._. '_NULL 
</s>
<s>
1998_MC )_) ._. 
</s>
<s>
Similar_JJ to_II the_AT genetic_JJ study_NN1 ,_, we_PPIS2 observed_VVD that_CST 3xTg_FO mice_NN2 receiving_VVG the_AT active_JJ drug_NN1 had_VHD a_AT1 significant_JJ amelioration_NN1 of_IO their_APPGE working_JJ memory_NN1 and_CC conditioning_JJ learning_NN1 ._. 
</s>
<s>
Application_NN1 of_IO AMH_NP1 measurement_NN1 onto_II an_AT1 automated_JJ immunoassay_NN1 platform_NN1 is_VBZ a_AT1 major_JJ step_NN1 forward_RL to_TO allow_VVI rapid_JJ access_NN1 of_IO an_AT1 AMH_NN1 assay_NN1 to_II health_NN1 care_NN1 providers_NN2 and_CC adopting_VVG its_APPGE measurement_NN1 into_II daily_JJ clinical_JJ practice_NN1 ._. 
</s>
<s>
Stephen_NP1 C_NP1 Pflugfelder_NP1 has_VHZ the_AT following_JJ financial_JJ disclosures_NN2 :_: Consulting_JJ and_CC research_NN1 funding_NN1 from_II Allergan_NP1 ,_, and_CC research_NN1 funding_NN1 from_II Bausch_NP1 and_CC Lomb_NP1 ._. 
</s>
<s>
After_CS emergence_NN1 ,_, 19%_NNU of_IO the_AT patients_NN2 (_( 10/53_MF )_) complained_VVD of_IO moderate_JJ pain_NN1 at_II the_AT site_NN1 of_IO skin_NN1 incision_NN1 ._. 
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<s>
In_RR21 addition_RR22 ,_, the_AT average_JJ cell_NN1 diameter_NN1 in_II the_AT control_NN1 obtained_VVN in_II our_APPGE study_NN1 ,_, 11.8_MC pm_RA ,_, is_VBZ within_II the_AT reported_JJ range_NN1 of_IO 10-12_MCMC pm_RA ,_, 18-21_MCMC and_CC the_AT basal_JJ cell_NN1 density_NN1 of_IO the_AT limbus_NN1 in_II our_APPGE normal_JJ control_NN1 is_VBZ also_RR comparable_JJ to_II those_DD2 previously_RR published_VVN ._. 
</s>
<s>
Two_MC main_JJ DECT_NN1 implementations_NN2 are_VBR currently_RR available_JJ commercially_RR ,_, rapid_JJ kVp-switching_JJ CT_NN1 (_( RSCT_NP1 )_) ,_, where_CS a_AT1 single_JJ x-ray_JJ source_NN1 alternately_RR pulses_NN2 between_II low_JJ and_CC high_JJ tube_NN1 potentials_NN2 during_II a_AT1 single_JJ gantry_NN1 rotation_NN1 ,_, and_CC dual-source_JJ CT_NN1 (_( DSCT_NP1 )_) where_RRQ two_MC x-ray_JJ sources_NN2 offset_VVN by_II 90_MC degrees_NN2 operate_VV0 at_II different_JJ tube_NN1 potentials_NN2 ._. 
</s>
<s>
The_AT method_NN1 predicted_VVD some_DD genes_NN2 that_CST have_VH0 been_VBN already_RR studied_VVN and_CC others_NN2 less_RRR known_VVN in_II31 relation_II32 to_II33 PCa_NP1 ._. 
</s>
<s>
A_AT1 beneficial_JJ intervention_NN1 for_IF alleviating_VVG exercise_NN1 intolerance_NN1 symptoms_NN2 and_CC '_NULL protecting_VVG '_NULL the_AT muscle_NN1 from_II rhabdo-myolysis_JJ risk_NN1 consists_VVZ of_IO ensuring_VVG that_DD1 sufficient_JJ blood_NN1 glucose_NN1 (_( derived_VVN from_II high_JJ hepatic_JJ glycogen_NN1 stores_NN2 )_) is_VBZ constantly_RR made_VVN available_JJ to_II patients_NN2 '_NULL muscles_NN2 during_II the_AT daytime_NNT1 ._. 
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<s>
During_II his_APPGE inaugural_JJ speech_NN1 "_" Mind_VV0 the_AT Gap_NN1 ,_, "_" Dr_NNB Stapleton_NP1 set_VVD the_AT stage_NN1 for_IF why_RRQ these_DD2 efforts_NN2 are_VBR important_JJ and_CC tied_VVN to_II achieving_VVG excellence_NN1 in_II a_AT1 changing_JJ world_NN1 ._. 
</s>
<s>
Patients_NN2 with_IW impaired_JJ ability_NN1 to_TO perform_VVI activities_NN2 of_IO daily_JJ living_NN1 should_VM be_VBI referred_VVN to_II a_AT1 rehabilitation_NN1 specialist_NN1 ._. 
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<s>
Gestational_JJ timing_NN1 of_IO infection_NN1 was_VBDZ unknown_JJ for_IF 2_MC of_IO the_AT 26_MC fetuses_NN2 or_CC infants_NN2 with_IW birth_NN1 defects_NN2 and_CC 27_MC of_IO the_AT total_JJ completed_JJ pregnancies_NN2 ._. 
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<s>
Regarding_II intraoperative_JJ details_NN2 ,_, degree_NN1 of_IO wound_NN1 contamination_NN1 and_CC length_NN1 of_IO fascial_JJ incision_NN1 are_VBR typically_RR known_VVN before_II surgery_NN1 and_CC their_APPGE inclusion_NN1 would_VM enhance_VVI the_AT risk_NN1 model_NN1 ._. 
</s>
<s>
The_AT increase_NN1 was_VBDZ statistically_RR significantly_RR until_CS 6_MC months_NNT2 but_CCB no_AT further_JJR increase_NN1 was_VBDZ observed_VVN from_II 6_MC to_II 12_MC months_NNT2 ._. 
</s>
<s>
In_II31 line_II32 with_II33 this_DD1 evidence_NN1 ,_, the_AT Eastern_JJ Association_NN1 for_IF the_AT Surgery_NN1 of_IO Trauma_NN1 (_( EAST_ND1 )_) practice_NN1 management_NN1 guidelines_NN2 advocate_VV0 limited_JJ prehospital_JJ IVF_NN1 resuscitation.32_FO In_II the_AT absence_NN1 of_IO conclusive_JJ patient-specific_JJ guidelines_NN2 ,_, prehospital_JJ IVF_NN1 administration_NN1 should_VM not_XX be_VBI a_AT1 justification_NN1 for_IF delaying_VVG transport_NN1 of_IO the_AT injured_JJ patient_NN1 to_II a_AT1 definitive_JJ care_NN1 facility_NN1 ._. 
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<s>
In_II the_AT United_NP1 States_NP1 alone_RR the_AT population_NN1 growth_NN1 of_IO people_NN aged_VVN above_II 65_MC years_NNT2 was_VBDZ 15.1%_FO between_II 2000_MC and_CC 2010_MC ,_, although_CS the_AT general_JJ population_NN1 grew_VVD only_RR by_II 9.7%_FO during_II the_AT same_DA time_NNT1 interval_NN1 (_( Vigen_NP1 et_RA21 al._RA22 ,_, 2012_MC )_) ._. 
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<s>
Administrative_JJ ,_, technical_JJ ,_, or_CC material_NN1 support_NN1 :_: David_NP1 ,_, Morgan_NP1 ,_, Frissa_NP1 ,_, Glahn_NP1 ,_, Hatch_NP1 ,_, Hotopf_NP1 ._. 
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<s>
Not_XX adjusting_VVG for_IF obstetric_JJ complications_NN2 among_II women_NN2 giving_VVG birth_NN1 in_II facilities_NN2 could_VM therefore_RR lead_VVI to_II incorrect_JJ conclusions_NN2 on_II the_AT effects_NN2 of_IO facility_NN1 birth_NN1 on_II newborn_JJ mortality_NN1 ._. 
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<s>
Funding_NN1 :_: This_DD1 study_NN1 was_VBDZ financially_RR supported_VVN by_II National_JJ Health_NN1 and_CC Medical_JJ Research_NN1 Council_NN1 (_( practitioner_NN1 fellowship_NN1 1080518_MC ,_, project_NN1 grants_VVZ 1083539_MC and_CC 1032484_MC and_CC centre_NN1 for_IF research_NN1 excellence_NN1 1001216_MC )_) ,_, and_CC University_NN1 of_IO Melbourne_NP1 Research_NN1 Fellowship_NN1 ._. 
</s>
<s>
Another_DD1 study_NN1 ,_, however_RR ,_, using_VVG a_AT1 slightly_RR younger_JJR cohort_NN1 with_IW mean_JJ age_NN1 of_IO 54.2_MC years_NNT2 (_( compared_VVN with_IW 61_MC years_NNT2 in_II the_AT previous_JJ study_NN1 )_) failed_VVD to_TO show_VVI significant_JJ evidence_NN1 for_IF an_AT1 association_NN1 between_II duration_NN1 of_IO delirium_NN1 and_CC cognitive_JJ decline_NN1 ._. 
</s>
<s>
The_AT majority_NN1 of_IO patients_NN2 was_VBDZ transfused_VVN intraoperatively_RR ;_; however_RR ,_, 2_MC of_IO the_AT 51_MC transfused_JJ patients_NN2 received_VVD blood_NN1 products_NN2 postoperatively_RR ._. 
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<s>
Acknowledgments_NP1 :_: The_AT authors_NN2 thank_VV0 Patrizio_NP1 Pasqual-etti_NP1 ,_, PhD_NNA who_PNQS wrote_VVD the_AT statistical_JJ results_NN2 of_IO current_JJ investigation_NN1 and_CC Valentine_NP1 Negrouk_NP1 ,_, PhD_NNA for_CS precision_NN1 test_NN1 replication_NN1 and_CC measurements_NN2 of_IO non-Cp_NP1 Cu_FO in_II healthy_JJ US_NP1 subjects_NN2 at_II IGEA_NP1 Research_NN1 Corporation_NN1 ,_, Miami_NP1 ,_, FL_NNU ,_, USA_NP1 ._. 
</s>
<s>
This_DD1 mistake_NN1 in_II the_AT initial_JJ classification_NN1 of_IO p53_FO was_VBDZ the_AT result_NN1 of_IO a_AT1 simple_JJ error_NN1 ;_; the_AT TP53_FO gene_NN1 that_CST had_VHD been_VBN cloned_VVN and_CC used_VVN in_II the_AT initial_JJ experiments_NN2 encoded_VVD a_AT1 mutant_NN1 version_NN1 of_IO the_AT wild-type_JJ gene_NN1 ._. 
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<s>
Changes_NN2 in_II male_NN1 and_CC female_JJ BMI_NN2 were_VBDR weakly_RR correlated_VVN across_II countries_NN2 ._. 
</s>
<s>
The_AT clinical_JJ significance_NN1 of_IO this_DD1 difference_NN1 is_VBZ underscored_VVN by_II results_NN2 of_IO the_AT Early_JJ Manifest_JJ Glaucoma_NN1 Trial_NN1 ,_, which_DDQ found_VVD that_CST in_II patients_NN2 with_IW OAG_NP1 ,_, each_DD1 millimeter_NN1 of_IO mercury_NN1 of_IO IOP_NP1 reduction_NN1 from_II baseline_NN1 at_II the_AT first_MD follow-up_JJ visit_NN1 (_( 3_MC months_NNT2 )_) was_VBDZ associated_VVN with_IW an_AT1 approximately_RR 10%_NNU reduction_NN1 in_II progression_NN1 of_IO visual_JJ field_NN1 loss.9_FO More_RRR recently_RR ,_, Heijl29_FO suggested_VVD a_AT1 19%_NNU reduction_NN1 in_II the_AT risk_NN1 of_IO visual_JJ field_NN1 progression_NN1 for_IF every_AT1 1_MC1 mmHg_NNU IOP_NN1 reduction_NN1 on_II the_AT basis_NN1 of_IO a_AT1 review_NN1 of_IO data_NN from_II the_AT UK_NP1 Glaucoma_NP1 Treatment_NN1 Study_NN1 evaluating_VVG the_AT effect_NN1 of_IO latanoprost_NN1 0.005%_FO compared_VVN with_IW vehicle_NN1 in_II patients_NN2 with_IW OAG.11,29_FO Results_NN2 of_IO secondary_JJ efficacy_NN1 end_NN1 points_NN2 were_VBDR consistent_JJ with_IW the_AT primary_JJ outcome_NN1 measures_NN2 ._. 
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<s>
For_IF the_AT majority_NN1 of_IO subunits_NN2 (_( 4_MC of_IO 6_MC )_) ,_, proteolytic_JJ activity_NN1 was_VBDZ significantly_RR higher_JJR in_II the_AT old_JJ KO_NN1 than_CSN WT_NN1 mice_NN2 ._. 
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<s>
This_DD1 awareness_NN1 may_VM have_VHI engaged_VVN them_PPHO2 to_TO use_VVI more_RGR cognitive_JJ effort45_FO and_CC better_JJR motor_NN1 planning_VVG to_TO increase_VVI the_AT essential_JJ ranges_NN2 of_IO arm_NN1 motion_NN1 required_VVN for_IF successful_JJ pointing_JJ ._. 
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<s>
The_AT diagnostic_JJ criteria_NN2 for_IF CRPS_NP1 was_VBDZ not_XX reported_VVN ._. 
</s>
<s>
With_IW the_AT exception_NN1 of_IO cerebrovascular_JJ events_NN2 ,_, the_AT incidence_NN1 of_IO all_DB other_JJ MACCE_NN1 increased_VVN as_CSA preoperative_JJ eGFR_NN1 decreased_VVN (_( Table_NN1 3_MC )_) ._. 
</s>
<s>
These_DD2 responses_NN2 of_IO ketamine_NN1 are_VBR mediated_VVN centrally_RR and_CC the_AT use_NN1 of_IO a_AT1 centrally_RR depressant_JJ agent_NN1 such_II21 as_II22 benzodiazepines_NN2 can_VM blunt_JJ this_DD1 effect_NN1 ._. 
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<s>
In_II the_AT current_JJ report_NN1 ,_, there_EX were_VBDR no_AT reports_NN2 of_IO birth_NN1 defects_NN2 among_II fetuses_NN2 or_CC infants_NN2 with_IW prenatal_JJ exposure_NN1 to_II Zika_NP1 virus_NN1 infection_NN1 only_RR in_II the_AT second_MD trimester_NN1 (_( 0%_NNU ;_; 95%_NNU CI_FO ,_, 0%-5%_FO )_) or_CC third_MD trimester_NN1 (_( 0%_NNU ;_; 95%_NNU CI_FO ,_, 0%-11%_FO )_) ;_; however_RR ,_, the_AT confidence_NN1 intervals_NN2 demonstrated_VVD the_AT imprecision_NN1 of_IO these_DD2 estimates_NN2 based_VVN on_II current_JJ data_NN ._. 
</s>
<s>
Author_NN1 contributions_NN2 :_: Guarantors_NN2 of_IO integrity_NN1 of_IO entire_JJ study_NN1 ,_, B.B.B._NP1 ,_, P.A.B._NP1 ;_; study_VV0 concepts/study_FU design_NN1 or_CC data_NN acquisition_NN1 or_CC data_NN analysis/_NN1 interpretation_NN1 ,_, B.B.B._NP1 ,_, P.A.B._NP1 ;_; manuscript_NN1 drafting_NN1 or_CC manuscript_NN1 revision_NN1 for_IF important_JJ intellectual_JJ content_NN1 ,_, B.B.B._NP1 ,_, P.A.B._NP1 ;_; approval_NN1 of_IO final_JJ version_NN1 of_IO submitted_JJ manuscript_NN1 ,_, B.B.B._NP1 ,_, P.A.B._NP1 ;_; agrees_VVZ to_TO ensure_VVI any_DD questions_NN2 related_VVN to_II the_AT work_NN1 are_VBR appropriately_RR resolved_VVN ,_, B.B.B._NP1 ,_, P.A.B._NP1 ;_; literature_NN1 research_NN1 ,_, B.B.B._NP1 ,_, P.A.B._NP1 ;_; statistical_JJ analysis_NN1 ,_, B.B.B._NP1 ,_, P.A.B._NP1 ;_; and_CC manuscript_NN1 editing_NN1 ,_, B.B.B._NP1 ,_, PA.B_NP1 ._. 
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Conflicts_NN2 of_IO interest_NN1 are_VBR listed_VVN at_II the_AT end_NN1 of_IO this_DD1 article_NN1 ._. 
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HAVS_NN2 immediate_JJ angiogram_NN1 occlusion_NN1 rate_NN1 Of_IO the_AT 268_MC sessions_NNT2 performed_VVD ,_, 214_MC sessions_NNT2 of_IO shunts_NN2 embolization_NN1 were_VBDR performed_VVN ._. 
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A_AT1 second_MD question_NN1 in_II the_AT post-eConsult_JJ survey_NN1 asked_VVD primary_JJ care_NN1 providers_NN2 to_TO evaluate_VVI the_AT value_NN1 of_IO the_AT eConsult_NN1 for_IF the_AT patient_NN1 ._. 
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Of_IO the_AT 277_MC operations_NN2 observed_VVD ,_, 124_MC (_( 44.8%_FO )_) included_VVD 1_MC1 or_CC more_DAR ME_NN1 and/or_CC ADE_NP1 ._. 
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Oliver_NP1 C._NP1 Dziemba_NP1 receives_VVZ financial_JJ support_NN1 for_IF research_NN1 projects_NN2 from_II Cochlear_JJ Deutschland_NP1 GmbH_NP1 &;_NULL Co_NP1 ._. 
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KG_NNU ._. 
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Similarly_RR ,_, Schlüter_NP1 et_RA21 al_RA22 ._. 
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(_( 2003_MC )_) also_RR reported_VVN that_CST Sncaknockout_VV0 mice_NN2 showed_VVD a_AT1 partial_JJ protection_NN1 against_II MPTP_NP1 toxicity_NN1 and_CC were_VBDR slightly_RR more_RGR sensitive_JJ to_TO methamphetamine_VVI ,_, different_JJ from_II mice_NN2 carrying_VVG the_AT spontaneous_JJ deletion_NN1 of_IO the_AT Snca_NP1 gene_NN1 ,_, and_CC demonstrated_VVD that_CST the_AT -synuclein_JJ proteins_NN2 may_VM have_VHI no_AT major_JJ role_NN1 in_II MPTP_NP1 toxicity_NN1 which_DDQ is_VBZ different_JJ from_II studies_NN2 by_II Richfieldet_NP1 al_NP1 ._. 
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(_( 2002_MC )_) ,_, but_CCB can_VM influence_VVI MPTP_NP1 toxicity_NN1 on_II some_DD genetic_JJ backgrounds_NN2 ._. 
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An_AT1 older_JJR study_NN1 at_II AUBMC_NP1 revealed_VVD 80_MC %_NNU burnout_NN1 in_II at_RR21 least_RR22 one_MC1 domain_NN1 on_II the_AT MBI_NN1 ._. 
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African_JJ Americans_NN2 had_VHD the_AT lowest_JJT prevalence_NN1 of_IO comorbidity_NN1 ,_, and_CC non-Hispanic_JJ whites_NN2 had_VHD the_AT highest_JJT ._. 
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A_AT1 deeper_JJR understanding_NN1 of_IO the_AT upstream_JJ contribution_NN1 to_II these_DD2 risk_VV0 factors_NN2 provides_VVZ the_AT opportunity_NN1 to_TO develop_VVI more_RGR effective_JJ interventions_NN2 and_CC reduce_VVI health_NN1 disparities_NN2 ._. 
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Finally_RR ,_, we_PPIS2 show_VV0 recent_JJ evidence_NN1 in_II31 support_II32 of_II33 the_AT hypothesis_NN1 that_CST the_AT combination_NN1 of_IO acute_JJ and_CC long-term_JJ interventions_NN2 might_VM maximize_VVI the_AT effects_NN2 of_IO cardiovascular_JJ exercise_NN1 on_II human_JJ memory_NN1 ._. 
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The_AT molecular_JJ genetic_JJ bases_NN2 of_IO T-ALL_JJ are_VBR well_RR characterized_VVN (_( Van_NP1 Vlier-berghe_NP1 and_CC Ferrando_NP1 ,_, 2012_MC )_) ,_, yet_RR this_DD1 knowledge_NN1 has_VHZ not_XX translated_VVN into_II targeted_JJ therapies_NN2 ._. 
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Negative_JJ predictive_JJ value_NN1 (_( NPV_NP1 )_) :_: the_AT probability_NN1 that_CST a_AT1 person_NN1 does_VDZ not_XX have_VHI the_AT condition_NN1 when_CS a_AT1 negative_JJ test_NN1 result_NN1 is_VBZ observed_VVN ._. 
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All_DB variables_NN2 were_VBDR forced_VVN into_II the_AT multivariable_JJ models_NN2 using_VVG enter_VV0 method_NN1 ,_, which_DDQ was_VBDZ used_VVN to_TO fit_VVI the_AT multivariable_JJ model_NN1 (_( IBM_NP1 SPSS_NP1 version_NN1 22.0_MC ;_; IBM_NP1 Inc._JJ ,_, USA_NP1 )_) ._. 
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JW_NP1 and_CC SWC_NP1 did_VDD SNP_NP1 array_NN1 data_NN analysis_NN1 ._. 
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The_AT associations_NN2 with_IW composite_JJ morbidity_NN1 ,_, mechanical_JJ ventilation_NN1 ,_, and_CC severe_JJ brain_NN1 injury_NN1 (_( which_DDQ were_VBDR observed_VVN in_II the_AT overall_JJ SGA_NN1 group_NN1 )_) were_VBDR not_XX statistically_RR significant_JJ ._. 
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Next_MD ,_, we_PPIS2 will_VM compare_VVI the_AT patterns_NN2 of_IO HC_NP1 loss_NN1 we_PPIS2 observed_VVD in_II sound_JJ exposed_JJ animals_NN2 to_II that_DD1 observed_VVD by_II other_JJ investigators_NN2 ._. 
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Sex_NN1 differences_NN2 in_II the_AT timing_NN1 of_IO onset_NN1 ,_, prevalence_NN1 ,_, and_CC clinical_JJ course_NN1 of_IO neuropsychiatric_JJ and_CC substance_NN1 use_NN1 disorders_NN2 provide_VV0 clues_NN2 to_II the_AT underlying_JJ pathophysiology_NN1 of_IO these_DD2 disorders_NN2 ._. 
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Comparison_NN1 with_IW other_JJ studies_NN2 is_VBZ not_XX straightforward_JJ as_CSA many_DA2 authors_NN2 referred_VVD the_AT transit_NN1 times_NNT2 to_II the_AT absolute_JJ injection_NN1 time_NNT1 ,_, 16,39_MC whereas_CS we_PPIS2 focused_VVD on_II relative_JJ transit_NN1 time_NNT1 between_II RV_NP1 and_CC LV_MC Comparison_NN1 of_IO the_AT Method_NN1 With_IW the_AT Literature_NN1 The_AT adopted_JJ MR_NNB sequence_NN1 and_CC small_JJ dose_NN1 of_IO contrast_NN1 agent_NN1 ensures_VVZ the_AT linearity_NN1 of_IO the_AT contrast_NN1 agent/MR_FU signal_NN1 relationship_NN1 ,_, a_AT1 prerequisite_NN1 for_IF indicator_NN1 dilution_NN1 parameter_NN1 estimate.20Approaches_FO based_VVN only_RR on_II contrast_NN1 agent_NN1 arrival_NN1 time_NNT1 do_VD0 not_XX take_VVI into_II account_NN1 statistical_JJ aspects_NN2 of_IO the_AT contrast_NN1 agent_NN1 transport_NN1 kinetic_JJ :_: they_PPHS2 neglect_VV0 the_AT multipath_NN1 trajectory_NN1 of_IO the_AT indicator_NN1 transport40_FO introducing_VVG a_AT1 bias_NN1 toward_II the_AT shortest_JJT path_NN1 ;_; by_II relying_VVG on_II a_AT1 threshold_NN1 for_IF defining_VVG the_AT indicator_NN1 arrival_NN1 ,_, and_CC on_II only_RR 1_MC1 point_NN1 on_II the_AT time-enhancement_JJ curve_NN1 ,_, they_PPHS2 are_VBR more_RGR susceptible_JJ to_II noise_NN1 in_II the_AT image_NN1 acquisition_NN1 ._. 
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Many_DA2 diagnostic_JJ tests_NN2 appear_VV0 to_TO have_VHI specificity_NN1 until_CS they_PPHS2 are_VBR tested_VVN using_VVG diseases_NN2 that_CST can_VM be_VBI clinically_RR difficult_JJ to_TO differentiate_VVI ._. 
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Fig._NN1 1_MC1 illustrates_VVZ the_AT LA_NP1 trajectories_NN2 for_IF the_AT 6-syllable_JJ simple_JJ nonword_NN1 ,_, /m_FU ?_? btaibapotiba/_NN1 from_II Sessions_NNT2 1_MC1 and_CC 2_MC for_IF a_AT1 control_NN1 participant_NN1 (_( upper_JJ half_NN1 )_) and_CC an_AT1 AWS_NN2 (_( lower_JJR half_NN1 )_) ._. 
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Major_JJ funding_NN1 was_VBDZ also_RR provided_VVN by_II the_AT National_JJ Institute_NN1 on_II Alcohol_NN1 Abuse_NN1 and_CC Alcoholism_NN1 ,_, the_AT National_JJ Institutes_NN2 of_IO Health_NN1 (_( NIH_NP1 )_) Office_NN1 of_IO Behavioral_NP1 and_CC Social_JJ Sciences_NN2 Research_VV0 ,_, the_AT NIH_NN1 Substance_NN1 Abuse_NN1 and_CC Mental_JJ Health_NN1 Services_NN2 Administration_NN1 (_( Center_NN1 for_IF Mental_JJ Health_NN1 Services_NN2 ,_, Center_NN1 for_IF Substance_NN1 Abuse_NN1 Prevention_NN1 ,_, and_CC Center_NN1 for_IF Substance_NN1 Abuse_NN1 Treatment_NN1 )_) ,_, the_AT National_JJ Institute_NN1 on_II Minority_NN1 Health_NN1 and_CC Health_NN1 Disparities_NN2 ,_, the_AT Centers_NN2 for_IF Disease_NN1 Control_NN1 and_CC Prevention_NN1 (_( National_JJ Center_NN1 for_IF Injury_NN1 Prevention_NN1 and_CC Control_NN1 and_CC National_JJ Center_NN1 for_CS HIV/AIDS_FU ,_, Viral_JJ Hepatitis_NN1 ,_, STD_NN1 ,_, and_CC TB_NN1 Prevention_NN1 )_) ,_, the_AT NIH_NN1 Office_NN1 of_IO Research_NN1 on_II Women_NN2 '_NULL s_ZZ1 Health_NN1 ,_, the_AT NIH_NN1 Office_NN1 of_IO Rare_JJ Diseases_NN2 ,_, the_AT Department_NN1 of_IO Labor_NN1 ,_, the_AT Department_NN1 of_IO Housing_NN1 and_CC Urban_JJ Development_NN1 ,_, the_AT William_NP1 T._NP1 Grant_NP1 Foundation_NN1 ,_, and_CC the_AT Robert_NP1 Wood_NP1 Johnson_NP1 Foundation_NN1 ._. 
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Increased_JJ permeability_NN1 values_NN2 have_VH0 been_VBN reported_VVN in_II presumably_RR normal_JJ brain_NN1 tissue_NN1 as_CSA well.27,31,32_FO This_DD1 observation_NN1 was_VBDZ attributed_VVN to_II image_NN1 noise_NN1 or_CC the_AT vicinity_NN1 to_II blood_NN1 vessels_NN2 carrying_VVG CA_NP1 ._. 
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Analysis_NN1 of_IO the_AT isometric_JJ twitch_NN1 revealed_VVD a_AT1 slowing_NN1 of_IO both_DB2 time-to-peak_JJ tension_NN1 and_CC half_DB relaxation_NN1 time_NNT1 in_II both_RR WT_NN1 and_CC KO_NN1 mice_NN2 (_( Table_NN1 S1_FO )_) ._. 
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All_DB experts_NN2 regularly_RR performed_VVD UGRA_NP1 procedures_NN2 and_CC were_VBDR in_II31 charge_II32 of_II33 the_AT UGRA_NN1 education_NN1 for_IF residents_NN2 ._. 
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No_AT wonder_NN1 ,_, then_RT ,_, that_DD1 consciousness_NN1 has_VHZ come_VVN to_TO be_VBI seen_VVN as_CSA fragile_JJ ._. 
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Items_NN2 collapse_VV0 into_II five_MC primary_JJ scales_NN2 that_CST assess_VV0 subjective_JJ ratings_NN2 of_IO current_JJ compared_VVN with_IW past_JJ memory_NN1 functioning_VVG (_( retrospective_JJ functioning_NN1 )_) ;_; how_RGQ often_RR problems_NN2 arise_VV0 in_II specific_JJ memory_NN1 situations_NN2 (_( frequency_NN1 of_IO forgetting_VVG )_) ;_; how_RGQ often_RR memory_NN1 problems_NN2 occur_VV0 while_CS reading_VVG books_NN2 and_CC newspapers_NN2 (_( forgetting_VVG when_CS reading_VVG )_) ;_; skill_NN1 at_II recalling_VVG past_JJ events_NN2 (_( past_JJ events_NN2 )_) ;_; and_CC how_RGQ often_RR external_JJ memory_NN1 aids_NN2 are_VBR relied_VVN upon_II to_TO aid_VVI memory_NN1 (_( mnemonics_NN2 usage_NN1 )_) ._. 
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For_IF many_DA2 of_IO the_AT cases_NN2 in_II which_DDQ ARIA-E_NP1 and_CC ARIA-H_NP1 occurred_VVD in_II the_AT same_DA general_JJ region_NN1 ,_, the_AT abnormalities_NN2 appeared_VVD at_II different_JJ times_NNT2 ,_, were_VBDR accompanied_VVN by_II a_AT1 finding_NN1 in_II another_DD1 brain_NN1 region_NN1 ,_, or_CC both_DB2 ._. 
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The_AT expected_JJ value_NN1 of_IO the_AT EF_NN1 measures_NN2 was_VBDZ calculated_VVN using_VVG formulas_NN2 obtained_VVN by_II polynomial_NN1 regressions_NN2 between_II the_AT measures_NN2 of_IO the_AT EF_NN1 tasks_NN2 and_CC age_NN1 in_II the_AT control_NN1 group_NN1 ._. 
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The_AT STARD13_FO gene_NN1 has_VHZ moreover_RR been_VBN associated_VVN (_( P_ZZ1 less_RRR than_CSN 1_MC1 x_ZZ1 10-5_MCMC )_) with_IW plasma_NN1 levels_NN2 of_IO amyloid_JJ beta_NN1 peptides_NN2 that_CST ,_, among_II other_JJ things_NN2 ,_, play_VV0 a_AT1 role_NN1 in_II Alzheimer_NP1 '_NULL s_ZZ1 disease_NN1 and_CC hypertension_NN1 (_( Chouraki_NP1 et_RA21 al._RA22 ,_, 2014_MC )_) ._. 
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The_AT cause_NN1 and_CC number_NN1 of_IO TIPS_NN2 revisions_NN2 during_II the_AT study_NN1 period_NN1 were_VBDR noted_VVN for_IF each_DD1 patient_NN1 ._. 
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Figures_NN2 2C_FO to_II 2D_NNU show_VV0 average_JJ CoO_NN1 differences_NN2 (_( pure_JJ spatial_JJ measure_NN1 )_) and_CC interlimb_VV0 phasing_VVG (_( pure_JJ temporal_JJ measure_NN1 )_) for_IF all_DB groups_NN2 and_CC testing_VVG periods_NN2 ._. 
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The_AT questionnaires_NN2 require_VV0 approximately_RR 20_MC minutes_NNT2 completing_VVG and_CC most_DAT were_VBDR administered_VVN via_II computer_NN1 tablet_NN1 ,_, which_DDQ minimizes_VVZ data_NN entry_NN1 error_NN1 ._. 
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Finally_RR ,_, although_CS the_AT gender_NN1 discrimination_NN1 data_NN indicated_VVD that_CST the_AT participants_NN2 with_IW CD_NN1 attended_VVN to_II the_AT facial_JJ stimuli_NN2 ,_, their_APPGE eye-scanning_JJ patterns_NN2 may_VM have_VHI differed_VVN from_II those_DD2 of_IO healthy_JJ controls_NN2 ._. 
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Similarly_RR ,_, as_CSA reported_VVN by_II researchers_NN2 investigating_VVG performance_NN1 outcomes_NN2 for_IF CI-SSD_JJ recipients_NN2 ,_, hearing_VVG performance_NN1 progress_NN1 is_VBZ observed_VVN to_TO be_VBI a_AT1 function_NN1 of_IO postimplant_NN1 listening_NN1 experience_NN1 ,_, especially_RR for_IF speech_NN1 tests_NN2 performed_VVD in_RP spatially_RR separated_JJ signal_NN1 and_CC noise_NN1 conditions_NN2 (_( Arndt_NP1 et_RA21 al._RA22 ,_, 2011c_FO ;_; Hassepass_NP1 et_RA21 al._RA22 ,_, 2013_MC ;_; Mertens_NP1 et_RA21 al._RA22 ,_, 2017_MC ;_; Rahne_NP1 and_CC Plontke_NP1 ,_, 2016_MC )_) ._. 
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Interestingly_RR ,_, the_AT time_NNT1 needed_VVN to_TO complete_VVI the_AT test_NN1 was_VBDZ 1.6_MC ±_FO 3.0%_FO shorter_JJR when_CS the_AT women_NN2 volleyball_NN1 players_NN2 ingested_VVD the_AT caffeinated_JJ energy_NN1 drink_NN1 ._. 
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Nonetheless_RR ,_, further_JJR validation_NN1 of_IO the_AT VNS_NP1 is_VBZ required_VVN ,_, using_VVG genuine_JJ clinical_JJ pre-_JJ and_CC post-treatment_JJ images_NN2 ._. 
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The_AT presence_NN1 of_IO a_AT1 measureable_JJ amount_NN1 of_IO smooth_JJ muscle_NN1 as_CSA identified_VVN by_II smooth_JJ muscle_NN1 alpha-actin_NN1 ,_, calponin-1_MC1 ,_, and_CC SM-22alpha_NN1 in_II the_AT cervix_NN1 at_II day_NNT1 20_MC of_IO a_AT1 21_MC day_NNT1 gestation_NN1 period_NN1 is_VBZ sufficient_JJ proof_NN1 of_IO the_AT hypothesis_NN1 that_CST smooth_JJ muscle_NN1 persists_VVZ through_II pregnancy_NN1 ._. 
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Conclusion_NN1 :_: Fibrosis_NP1 is_VBZ independently_RR associated_VVN with_IW the_AT MR_NNB viscoelastic_NN1 parameters_NN2 and_CC is_VBZ less_RGR associated_JJ with_IW the_AT diffusion_NN1 parameters_NN2 than_CSN is_VBZ steatosis_NN1 ._. 
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Current_JJ national_JJ priorities_NN2 of_IO quality_NN1 improvement_NN1 ,_, fiscal_JJ responsibility_NN1 ,_, and_CC the_AT need_NN1 for_IF medical_JJ advancement_NN1 demand_VV0 that_CST we_PPIS2 confront_VV0 the_AT needs_NN2 of_IO the_AT new_JJ pediatric_JJ population_NN1 and_CC its_APPGE workforce_NN1 and_CC use_VV0 the_AT brightest_JJT minds_NN2 from_II all_DB to_TO succeed_VVI ._. 
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Incidences_NN2 of_IO major_JJ bleeding_JJ in_II the_AT first_MD 30_MC days_NNT2 in_II other_JJ risk_NN1 categories_NN2 and_CC in_II the_AT enoxaparin/VKA_NN1 group_NN1 are_VBR given_VVN in_II Table_NN1 3_MC ._. 
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The_AT oxygen_NN1 fraction_NN1 ,_, tidal_JJ volume_NN1 ,_, and_CC respiratory_JJ rate_NN1 were_VBDR maintained_VVN unchanged_JJ for_IF the_AT entire_JJ study_NN1 ._. 
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It_PPH1 has_VHZ been_VBN shown_VVN that_CST these_DD2 methods_NN2 are_VBR able_JK to_TO detect_VVI complete_JJ deficiency_NN1 but_CCB fail_VV0 to_TO detect_VVI partial_JJ deficient_JJ cases_NN2 ._. 
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Although_CS more_DAR experiences_NN2 are_VBR required_VVN to_TO evaluate_VVI long-term_JJ efficacy_NN1 and_CC cost-effectiveness_NN1 ,_, ultrasound-guided_JJ core_NN1 biopsy_NN1 is_VBZ a_AT1 convenient_JJ office-based_JJ procedure_NN1 for_IF both_DB2 new_JJ and_CC previously_RR treated_VVN cases_NN2 ,_, especially_RR helpful_JJ for_IF those_DD2 patients_NN2 who_PNQS are_VBR vulnerable_JJ to_II current_JJ sampling_NN1 methods_NN2 ._. 
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Simple_JJ visual_JJ hallucinations_NN2 were_VBDR reported_VVN more_RGR often_RR than_CSN complex_JJ ones_NN2 and_CC noncolored_VVD more_RGR often_RR than_CSN colored_JJ visual_JJ hallucinations_NN2 ._. 
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In_II 89.2%_FO of_IO the_AT patients_NN2 ,_, the_AT contrast_NN1 agent_NN1 was_VBDZ injected_VVN automatically_RR and_CC in_II 10.8%_FO of_IO the_AT patients_NN2 ,_, manually_RR ._. 
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The_AT quality_NN1 of_IO anesthesia_NN1 was_VBDZ considered_VVN satisfactory_JJ when_CS the_AT ocular_JJ mobility_NN1 evaluation_NN1 score_NN1 at_II 10_MC minutes_NNT2 was_VBDZ less_DAR than_CSN 4_MC ._. 
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One_MC1 of_IO the_AT most_RGT obvious_JJ gaps_NN2 in_II the_AT literature_NN1 to_II date_NN1 is_VBZ the_AT lack_NN1 of_IO research_NN1 regarding_II social_JJ anxiety_NN1 disorder_NN1 among_II children_NN2 and_CC adolescents_NN2 who_PNQS stutter_VV0 ._. 
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The_AT genotype_NN1 frequencies_NN2 for_IF the_AT three_MC examined_JJ genotypes_NN2 did_VDD not_XX differ_VVI significantly_RR from_II Hardy-Weinberg_NP1 equilibrium_NN1 :_: BDNFrs6265_FO (_( x2_FO =_FO 0.837_MC ,_, p_ZZ1 =_FO 0.36_MC )_) ,_, COMTrs4680_FO (_( x2_FO =_FO 2.786_MC ,_, p_ZZ1 =_FO 0.10_MC )_) ,_, and_CC APOE_VV0 rs7412_FO ,_, rs429358_FO (_( x2_FO =_FO 0.545_MC ,_, p_ZZ1 =_FO 0.909_MC )_) or_CC among_II any_DD baseline_NN1 characteristics_NN2 ._. 
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Participants_NN2 subsequently_RR responded_VVN in_II written_JJ form_NN1 to_II five_MC questions_NN2 ._. 
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This_DD1 is_VBZ the_AT first_MD evidence_NN1 suggesting_VVG that_DD1 risk_NN1 alleles_NN2 for_IF BD_NP1 in_II CREB1_FO arose_VVD in_II Europeans_NN2 through_II genetic_JJ hitchhiking_NN1 due_II21 to_II22 natural_JJ selection_NN1 on_II its_APPGE neighboring_JJ gene_NN1 ._. 
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Time_NNT1 to_TO complete_VVI Stage_NN1 1_MC1 has_VHZ been_VBN used_VVN as_II an_AT1 outcome_NN1 measure_NN1 or_CC a_AT1 target_NN1 for_IF regression_NN1 modeling_VVG in_II many_DA2 research_NN1 studies_NN2 into_II the_AT Lidcombe_NP1 Program_NN1 (_( e.g._REX ,_, Kingston_NP1 et_RA21 al._RA22 ,_, 2003_MC ;_; Koushik_NP1 et_RA21 al._RA22 ,_, 2011_MC ;_; Lewis_NP1 et_RA21 al._RA22 ,_, 2008_MC )_) due_II21 to_II22 its_APPGE documentation_NN1 of_IO the_AT time_NNT1 commitment_NN1 required_VVN from_II the_AT SLP_NP1 ,_, parent_NN1 and_CC child_NN1 to_TO obtain_VVI extremely_RR low_RR stuttering_VVG levels_NN2 ._. 
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The_AT accuracy_NN1 of_IO the_AT method_NN1 was_VBDZ assessed_VVN by_II comparing_VVG the_AT HbA1c_FO results_NN2 obtained_VVD using_VVG D-100TM_JJ system_NN1 in_II 10_MC samples_NN2 deriving_VVG from_II an_AT1 external_JJ quality_NN1 assurance_NN1 scheme_NN1 with_IW IFCC-assigned_JJ values_NN2 (_( Table_NN1 2_MC )_) ._. 
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These_DD2 values_NN2 are_VBR clearly_RR below_II the_AT mean_JJ incidence_NN1 of_IO 32_MC and_CC 21%_NNU for_IF nausea_NN1 and_CC vomiting_VVG ,_, respectively_RR ,_, which_DDQ have_VH0 been_VBN reported_VVN in_II a_AT1 2005_MC published_JJ meta-analysis_NN1 on_II adverse_JJ events_NN2 of_IO PCA_NN1 ._. 
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Thomsen_NP1 et_NP1 al.reported_NNU no_AT significant_JJ change_NN1 in_II tinnitus_NN1 in_II the_AT two_MC groups_NN2 ._. 
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Historically_RR understudied_JJ ,_, cholesterol_NN1 in_II the_AT retina_NN1 is_VBZ receiving_VVG more_DAR attention_NN1 now_RT because_II21 of_II22 genetic_JJ studies_NN2 showing_VVG that_CST several_DA2 cholesterol-related_JJ genes_NN2 are_VBR risk_NN1 factors_NN2 for_IF age-related_JJ macular_JJ degeneration_NN1 (_( AMD_NP1 )_) and_CC because_II21 of_II22 eye_NN1 pathology_NN1 studies_NN2 showing_VVG high_JJ cholesterol_NN1 content_NN1 of_IO drusen_NN1 ,_, aging_VVG Bruch_NP1 '_NULL s_ZZ1 membrane_NN1 ,_, and_CC newly_RR found_VVN subretinal_JJ lesions_NN2 ._. 
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Pulse_NN1 sequences_NN2 included_VVD axial_JJ turbo_NN1 spin-echo_JJ T2-weighted_JJ imaging_NN1 (_( repetition_NN1 time_NNT1 msec/echo_NN1 time_NNT1 msec_NN1 ,_, 4000-4960/105_MCMC ;_; section_NN1 thickness_NN1 ,_, 3_MC mm_NNU ;_; field_NN1 of_IO view_NN1 ,_, 180_MC X_ZZ1 180_MC mm_NNU ;_; matrix_NN1 ,_, 256_MC X_ZZ1 256_MC ;_; parallel_RR imaging_VVG factor_NN1 ,_, two_MC ;_; three_MC signals_NN2 acquired_VVN )_) and_CC single-shot_JJ echo-planar_JJ DWI_NN2 (_( 4100/86_MF ;_; section_NN1 thickness_NN1 ,_, 3_MC mm_NNU ;_; field_NN1 of_IO view_NN1 ,_, 200_MC X_ZZ1 200_MC ;_; matrix_NN1 ,_, 100_MC X_ZZ1 100_MC ;_; parallel_RR imaging_VVG factor_NN1 ,_, two_MC ;_; 10_MC signals_NN2 acquired_VVN ;_; b_ZZ1 values_NN2 ,_, 50_MC and_CC 1000_MC sec/mm2_FU )_) with_IW inline_NN1 reconstruction_NN1 via_II a_AT1 monoexponential_JJ fit_NN1 of_IO the_AT apparent_JJ diffusion_NN1 coefficient_NN1 map_NN1 and_CC a_AT1 calculated_JJ high-b-value_JJ image_NN1 set_VVN at_II a_AT1 b_ZZ1 value_NN1 of_IO 1500_MC sec/mm2_FU ._. 
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Brain_NN1 was_VBDZ removed_VVN ,_, gently_RR rinsed_VVN in_II cold_NN1 0.9%_FO PBS_NP1 and_CC immediately_RR dissected_VVN in_II two_MC halves_NN2 ._. 
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In_II Tetrahymena_NP1 ,_, histamine_NN1 can_VM stimulate_VVI a_AT1 number_NN1 of_IO cell_NN1 functions_NN2 ,_, including_II phagocytosis_NN1 ,_, chemosensory_JJ behavior_NN1 ,_, glucose_NN1 uptake_NN1 ,_, and_CC cell_NN1 division_NN1 via_II histamine_NN1 H1_FO and_CC H2_FO receptor_NN1 activation_NN1 (_( 7,17_MC )_) ._. 
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Duloxetine_NN1 specifically_RR improved_VVN physical_JJ comfort_NN1 ,_, independence_NN1 ,_, emotional_JJ ,_, and_CC pain_NN1 subcomponents_NN2 in_II the_AT quality_NN1 of_IO recovery_NN1 score_NN1 ._. 
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Sentara_NP1 Northern_JJ Virginia_NP1 Medical_JJ Center_NN1 ,_, Woodbridge_NP1 ,_, Virginia_NP1 :_: J._NP1 Agola_NP1 ,_, R._NP1 Zweifler_NP1 ,_, J._NP1 Rathbun_NP1 ,_, S._NP1 Cummings_NP1 ,_, P._NP1 Hollsten_NP1 ,_, and_CC S._NP1 Bright_NP1 ._. 
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<s>
The_AT subjects_NN2 underwent_VVD a_AT1 general_JJ medical_JJ examination_NN1 ,_, as_II31 well_II32 as_II33 a_AT1 clinical_JJ anamnesis_NN1 ,_, to_TO rule_VVI out_RP the_AT presence_NN1 of_IO any_DD cardi-ologic_JJ symptoms_NN2 contraindicating_VVG exercise_NN1 ,_, or_CC the_AT presence_NN1 of_IO reduced_JJ effort_NN1 tolerance_NN1 ._. 
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<s>
Jameson_NN1 and_CC Longo_NP1 define_VV0 precision_NN1 medicine_NN1 as_CSA "_" treatments_NN2 targeted_VVN to_II the_AT needs_NN2 of_IO individual_JJ patients_NN2 on_II the_AT basis_NN1 of_IO genetic_JJ '_NULL biomarker_NN1 '_NULL phenotypic_JJ or_CC psychosocial_JJ characteristics_NN2 that_CST distinguish_VV0 a_AT1 given_JJ patient_NN1 from_II other_JJ patients_NN2 with_IW similar_JJ clinical_JJ presentations_NN2 "_" (_( Jameson_NP1 and_CC Longo_NP1 '_NULL 2015_MC )_) ._. 
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<s>
We_PPIS2 used_VVD this_DD1 percentage_NN1 as_II a_AT1 measure_NN1 of_IO age-related_JJ GMD_NP1 decline_NN1 and_CC found_VVD that_CST the_AT areas_NN2 most_RGT sensitive_JJ to_II GMD_NP1 decreases_NN2 were_VBDR the_AT left_JJ IFG_NN1 triangularis_NN1 (_( 64%_NNU )_) and_CC bilateral_JJ IFG_NN1 opercularis_NN1 (_( left_VVN :_: 67%_NNU ;_; right_RR :_: 80%_NNU )_) ._. 
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This_DD1 problem_NN1 is_VBZ illustrated_VVN by_II the_AT reported_JJ incidence_NN1 of_IO the_AT outcome_NN1 (_( 0.2_MC and_CC 2.3%_FO ,_, respectively_RR )_) ,_, which_DDQ was_VBDZ much_RR lower_JJR than_CSN reported_VVN in_II other_JJ studies_NN2 ._. 
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Almost_RR half_DB of_IO the_AT patient_JJ participants_NN2 had_VHD a_AT1 personal_JJ or_CC family_NN1 history_NN1 of_IO drug_NN1 use_NN1 or_CC of_IO mental_JJ health_NN1 problems_NN2 ,_, or_CC both_RR ,_, which_DDQ over-represents_VVZ the_AT typical_JJ rate_NN1 estimated_VVN in_II individuals_NN2 with_IW chronic_JJ pain_NN1 ._. 
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Despite_II these_DD2 findings_NN2 ,_, the_AT amount_NN1 and_CC intensity_NN1 of_IO locomotor_NN1 practice_NN1 observed_VVN during_II inpatient_NN1 rehabilitation_NN1 of_IO individuals_NN2 poststroke_VV0 remain_VV0 limited_JJ ._. 
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<s>
Our_APPGE results_NN2 suggest_VV0 that_CST at_II low_JJ levels_NN2 of_IO screen-detected_JJ DCIS_NN1 ,_, up_RG21 to_RG22 1_MC1 ._. 
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5_MC per_II 1000_MC ,_, a_AT1 reduction_NN1 of_IO one_MC1 invasive_JJ interval_NN1 cancer_NN1 is_VBZ observed_VVN per_II 1_MC1 ._. 
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<s>
Dr._NNB Chan_NP1 and_CC colleagues_NN2 performed_VVD a_AT1 single-center_NN1 ,_, prospective_JJ cohort_NN1 study_NN1 of_IO adult_NN1 patients_NN2 with_IW cancer_NN1 who_PNQS had_VHD solid_JJ tumors_NN2 or_CC lymphoma_NN1 ,_, had_VHD received_VVN chemotherapy_NN1 ,_, and_CC developed_VVN FN_NP1 between_II January_NPM1 2009_MC and_CC January_NPM1 2012_MC ._. 
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<s>
The_AT injected_JJ activity_NN1 ,_, specific_JJ activity_NN1 ,_, and_CC injected_VVD mass_JJ dose_NN1 of_IO both_DB2 radioligands_NN2 were_VBDR similar_JJ for_IF monkeys_NN2 that_CST were_VBDR administered_VVN either_RR placebo_NN1 or_CC fluoxetine_NN1 (_( see_VV0 Table_NN1 S1_FO in_II the_AT online_JJ data_NN supplement_VV0 )_) ._. 
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<s>
Calculation_NN1 of_IO Binding_JJ Potential_NN1 (_( BPNd_NP1 )_) Using_VVG a_AT1 Reference_NN1 Tissue_NN1 Model_NN1 Binding_JJ potential_NN1 (_( BPNd_NP1 )_) ,_, which_DDQ is_VBZ the_AT ratio_NN1 at_II equilibrium_NN1 of_IO specific_JJ binding_NN1 to_II nondisplaceable_JJ uptake_NN1 in_II the_AT brain_NN1 ,_, was_VBDZ used_JJ to_II measure_NN1 receptor_NN1 density_NN1 ._. 
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<s>
In_II the_AT early_JJ group_NN1 ,_, RRT_NP1 was_VBDZ started_VVN after_II serum_NN1 creatinine_NN1 exceeded_VVD 7_MC mg/dL_FU or_CC serum_NN1 urea_NN1 exceeded_VVD 25_MC mmol/L_FU regardless_RR of_IO other_JJ AKI_JJ complications_NN2 ._. 
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The_AT cancer_NN1 profile_NN1 in_II US_NP1 Hispanics_NP1 reflects_VVZ the_AT risk_NN1 in_II immigrant_JJ countries_NN2 of_IO origin_NN1 ._. 
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The_AT 12-_NN1 and_CC 18-month_JJ assessments_NN2 measured_VVD the_AT maintenance_NN1 of_IO effects_NN2 over_II time_NNT1 ._. 
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<s>
As_CSA disease_NN1 management_NN1 becomes_VVZ increasingly_RR complex_JJ ,_, bringing_VVG together_RL a_AT1 group_NN1 of_IO experts_NN2 ,_, all_DB of_IO whom_PNQO can_VM independently_RR contribute_VVI to_II a_AT1 diagnosis_NN1 and_CC suggested_JJ treatment_NN1 strategy_NN1 is_VBZ important_JJ ._. 
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<s>
Student_NN1 '_NULL s_ZZ1 t-test_JJ or_CC one-way_JJ anova_NN1 was_VBDZ used_VVN for_IF comparing_VVG mean_JJ data_NN from_II separate_JJ experiments_NN2 ._. 
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<s>
The_AT effect_NN1 of_IO the_AT CPT_NP1 and_CC exercise_VV0 conditions_NN2 on_II pain_NN1 sensitivity_NN1 parameters_NN2 was_VBDZ analyzed_VVN using_VVG a_AT1 3-way_JJ RM-ANOVA_NN1 with_IW factor_NN1 condition_NN1 (_( the_AT CPT_NP1 ,_, bicycling_VVG ,_, and_CC isometric_JJ contractions_NN2 )_) and_CC time_NNT1 (_( before_RT ,_, immediately_RR after_CS ,_, and_CC 15_MC min_NNU after_II )_) as_CSA repeated_VVN measures_NN2 and_CC pain_NN1 sensitivity_NN1 group_NN1 as_II the_AT group_NN1 factor_NN1 ._. 
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AM_VBM treatment_NN1 also_RR significantly_RR increased_VVD the_AT number_NN1 of_IO capillaries_NN2 in_II ischemic_JJ limbs_NN2 ._. 
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<s>
Further_JJR studies_NN2 are_VBR needed_VVN to_TO evaluate_VVI the_AT number_NN1 of_IO TACE_NP1 procedures_NN2 needed_VVN before_II this_DD1 therapy_NN1 is_VBZ abandoned_VVN in_II patients_NN2 with_IW NELM_NP1 who_PNQS are_VBR nonresponders_NN2 ._. 
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<s>
Table_NN1 2_MC shows_VVZ the_AT level_NN1 of_IO pain_NN1 that_CST patients_NN2 experienced_VVN and_CC their_APPGE ability_NN1 to_TO undertake_VVI certain_JJ activities_NN2 at_II 10_MC days_NNT2 ,_, 6_MC weeks_NNT2 ,_, 3_MC months_NNT2 ,_, and_CC 12_MC months_NNT2 ._. 
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<s>
Repanshek_NP1 suggested_VVD that_CST in_II an_AT1 ideal_JJ world_NN1 ,_, a_AT1 secondary_JJ analysis_NN1 of_IO both_RR respondents_NN2 and_CC nonrespondents_NN2 to_II the_AT Press_NN1 Ganey_NP1 survey_NN1 should_VM be_VBI conducted_VVN to_TO determine_VVI their_APPGE demographic_JJ ,_, patient_JJ profile_NN1 ,_, and_CC satisfaction_NN1 differences_NN2 ._. 
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<s>
The_AT '_NULL high_JJ avoidance_NN1 ,_, low_JJ overactivity_NN1 '_NULL subgroup_NN1 were_VBDR the_AT group_NN1 most_RGT likely_JJ to_TO report_VVI difficulties_NN2 (_( OR=5.10_FO ,_, P=0.003_FO ;_; 95%_NNU CI_FO ,_, 0.56-2.70_MCMC )_) ,_, followed_VVN by_II the_AT '_NULL high_JJ avoidance_NN1 ,_, high_JJ overactivity_NN1 '_NULL subgroup_NN1 (_( OR=3.70_FO ,_, P=0.009_FO ;_; 95%_NNU CI_FO ,_, 0.33-2.3_MCMC )_) ,_, then_RT the_AT '_NULL high_JJ overactivity_NN1 ,_, low_JJ avoidance_NN1 '_NULL subgroup_NN1 (_( OR=2.99_FO ,_, P=0.03_FO ;_; 95%_NNU CI_FO ,_, 0.08-2.11_MCMC )_) ._. 
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<s>
For_IF each_DD1 major_JJ cause_NN1 of_IO death_NN1 ,_, BMI_NP1 was_VBDZ non-linearly_RR associated_VVN with_IW mortality_NN1 in_II each_DD1 major_JJ region_NN1 we_PPIS2 studied_VVD (_( appendix_NN1 pp_NNU2 27-29_MCMC ,_, 41_MC ,_, 42_MC )_) ._. 
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<s>
A_ZZ1 shortened_VVD CSP_NP1 indicates_VVZ a_AT1 dysfunction_NN1 in_II the_AT inhibitory_JJ mechanisms_NN2 ,_, in_II essence_NN1 '_NULL too_RG little_DA1 '_NULL inhibition_NN1 ._. 
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<s>
Enhanced_JJ MITF_NN1 expression_NN1 is_VBZ linked_VVN to_II innate_JJ resistance_NN1 ,_, and_CC increased_JJ MITF_NN1 expression_NN1 as_II31 well_II32 as_II33 MITF_NP1 amplification_NN1 isfound_NN1 in_II some_DD progressed_VVD melanomas_NN2 (_( Gopal_NP1 et_RA21 al._RA22 ,_, 2014_MC ;_; Ji_NP1 et_RA21 al._RA22 ,_, 2015_MC ;_; Muller_NP1 et_RA21 al._RA22 ,_, 2014_MC ;_; Van_NP1 Allen_NP1 et_RA21 al._RA22 ,_, 2014_MC )_) ._. 
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<s>
BD_NP1 samples_NN2 were_VBDR excluded_VVN if_CS any_DD of_IO the_AT following_JJ QC_NN1 statistics_NN constituted_VVD an_AT1 outlier_JJR within_II their_APPGE source_NN1 data_NN set_VV0 :_: Log_VV0 R_ZZ1 ratios_NN2 s.d._NNU ,_, B-allele_JJ frequency_NN1 drift_NN1 ,_, wave_NN1 factor_NN1 and_CC total_JJ number_NN1 of_IO CNVs_NP1 ._. 
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Needle_NN1 Tip_NN1 Interpretation_NN1 Accurate_JJ and_CC reliable_JJ presentation_NN1 of_IO the_AT needle_NN1 tip_NN1 by_II the_AT US_NP1 machine_NN1 is_VBZ only_RR useful_JJ if_CS the_AT needle_NN1 tip_NN1 can_VM be_VBI interpreted_VVN as_CSA such_DA by_II the_AT provider_NN1 ._. 
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<s>
The_AT views_NN2 expressed_VVN are_VBR those_DD2 of_IO the_AT authors_NN2 and_CC not_XX necessarily_RR those_DD2 of_IO the_AT National_JJ Health_NN1 Service_NN1 ,_, NIHR_NP1 ,_, or_CC UK_NP1 Department_NN1 of_IO Health_NN1 ._. 
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<s>
The_AT evaluation_NN1 questionnaire_NN1 consisted_VVN of6questions_FO ,_, 3_MC of_IO which_DDQ were_VBDR used_VVN to_TO obtain_VVI background_NN1 information_NN1 regarding_II age_NN1 ,_, sex_NN1 ,_, diagnosis_NN1 ._. 
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<s>
The_AT mean_JJ duration_NN1 of_IO DME_NN1 before_II study_NN1 entry_NN1 was_VBDZ 24.9_MC months_NNT2 (_( median_NN1 ,_, 16_MC )_) ._. 
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However_RR ,_, the_AT statistical_JJ heterogeneity_NN1 suggested_VVD that_CST reasonable_JJ cautions_NN2 could_VM be_VBI taken_VVN with_IW the_AT numerical_JJ value_NN1 of_IO HR_NNU ._. 
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<s>
Written_VVN informed_JJ consent_NN1 was_VBDZ obtained_VVN from_II all_DB study_NN1 participants_NN2 ._. 
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<s>
Other_JJ applications_NN2 ,_, such_II21 as_II22 machine-learning_JJ algorithms_NN2 for_IF predicting_VVG pneumonia_NN1 mortality_NN1 and_CC presence_NN1 of_IO myocardial_JJ infarction_NN1 ,_, have_VH0 also_RR been_VBN developed_VVN ._. 
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<s>
Adequate_JJ diuresis_NN1 together_RL with_IW no_AT need_NN1 for_IF renal-replacement_JJ therapy_NN1 were_VBDR observed_VVN earlier_RRR in_II the_AT delayed-strategy_JJ group_NN1 than_CSN in_II the_AT early-strategy_JJ group_NN1 (_( P_NNU less_DAR than_CSN 0.001_MC )_) (_( Fig._NN1 2_MC )_) ._. 
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<s>
To_TO confirm_VVI that_CST the_AT dVMAT_NN1 weak_JJ expressor_NN1 would_VM respond_VVI to_II drugs_NN2 that_CST act_VV0 presynaptically_RR ,_, we_PPIS2 used_VVD amphetamine_NN1 ,_, which_DDQ promotes_VVZ the_AT presynaptic_JJ release_NN1 of_IO monoamines_NN2 in_II both_DB2 mammals_NN2 (_( 10_MC )_) and_CC flies_NN2 (_( 16_MC )_) ._. 
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These_DD2 results_NN2 agree_VV0 with_IW studies_NN2 showing_VVG increased_JJ vascular_JJ permeability_NN1 in_II non-barrier_JJ endothelium_NN1 from_II Cav-1-/-_FU mice_NN2 (_( Schubert_NP1 et_RA21 al_RA22 ._. '_NULL 
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2002_MC )_) ._. 
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<s>
Moreover_RR ,_, excessive_JJ weight_NN1 loss_NN1 in_II a_AT1 short_JJ period_NN1 of_IO time_NNT1 was_VBDZ discouraged_VVN ,_, since_CS such_DA a_AT1 reduction_NN1 in_II weight_NN1 has_VHZ been_VBN reported_VVN to_TO have_VHI a_AT1 negative_JJ effect_NN1 on_II the_AT outcome_NN1 of_IO assisted_JJ reproductive_JJ technology_NN1 and_CC to_TO be_VBI associated_VVN with_IW an_AT1 increased_JJ risk_NN1 of_IO adverse_JJ pregnancy_NN1 outcomes_NN2 such_II21 as_II22 low_JJ birth_NN1 weight_NN1 or_CC miscarriage_NN1 ._. 
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Electrodes_NN2 were_VBDR implanted_VVN 10_MC days_NNT2 prior_II21 to_II22 RT_NP1 (_( to_TO ensure_VVI their_APPGE viability_NN1 )_) ._. 
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A_AT1 clinical_JJ diagnostic_JJ trial_NN1 is_VBZ required_VVN to_TO test_VVI this_DD1 model_NN1 on_II a_AT1 larger_JJR population_NN1 to_TO confirm_VVI these_DD2 findings_NN2 and_CC to_TO further_RRR refine_VVI the_AT predictive_JJ values_NN2 ._. 
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<s>
The_AT PFS_NP1 rates_NN2 of_IO the_AT 113_MC patients_NN2 were_VBDR 58.4%_FO ,_, 31.9%_FO ,_, and_CC 7.1%_FO at_II 3-month_NNT1 ,_, 6-month_JJ ,_, and_CC 12-month_JJ ,_, respectively_RR ._. 
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Financial_JJ cost_NN1 of_IO Meniett_NP1 device_NN1 The_AT cost_NN1 ofusing_VVG the_AT Meniett_NP1 device_NN1 in_II the_AT UK_NP1 is_VBZ GBP2000_FO and_CC in_II North_ND1 America_NP1 is_VBZ approximately_RR $2500_NNU ._. 
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Pharmacokinetic_JJ Modeling_NN1 and_CC Simulation_NN1 The_AT pharmacokinetic_JJ analysis_NN1 of_IO hydromorphone_NN1 has_VHZ been_VBN reported_VVN previously_RR ._. 
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This_DD1 makes_VVZ it_PPH1 very_RG unlikely_JJ that_CST the_AT obesity_NN1 epidemic_NN1 is_VBZ caused_VVN by_II environ-mental_JJ changes_NN2 that_CST affect_VV0 certain_JJ sociodemographic_JJ sub-groups_NN2 disproportionally_RR ._. 
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That_DD1 said_VVD ,_, children_NN2 who_PNQS do_VD0 not_XX stutter_VVI had_VHD a_AT1 higher_JJR mean_JJ score_NN1 on_II subsection_NN1 IB_NN1 (_( indicating_VVG less_DAR knowledge_NN1 of_IO stuttering_VVG )_) in_II31 comparison_II32 with_II33 children_NN2 who_PNQS stutter_VV0 ._. 
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Fortunately_RR ,_, Liu_NP1 et_NP1 al1_FO found_VVD no_AT episodes_NN2 of_IO cardiac_JJ arrest_NN1 related_VVD to_TO LAST_VVI ._. 
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However_RR ,_, other_JJ studies_NN2 on_II NMDAR_NP1 binding_NN1 have_VH0 reported_VVN an_AT1 increase_NN1 ,_, or_CC no_AT change_NN1 in_II NMDAR_NP1 binding_VVG in_II the_AT brains_NN2 of_IO people_NN with_IW schizophrenia_NN1 ._. 
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As_CSA skeletal_JJ muscles_NN2 contract_NN1 ,_, the_AT elevation_NN1 in_II extravascular_JJ pressure_NN1 causes_VVZ compression_NN1 or_CC distortion_NN1 of_IO the_AT resistance_NN1 vessels_NN2 ,_, thus_RR exposing_VVG the_AT erythrocytes_NN2 to_II even_RR greater_JJR mechanical_JJ stress_NN1 during_II exercise_NN1 ._. 
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<s>
During_II the_AT initial_NN1 two_MC sessions_NNT2 ,_, situations_NN2 or_CC problems_NN2 that_CST trigger_VV0 negative_JJ emotions_NN2 or_CC inhibit_VV0 positive_JJ emotions_NN2 (_( e.g._REX lack_NN1 of_IO pleasurable_JJ activities_NN2 )_) are_VBR identified_VVN ._. 
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<s>
Participants_NN2 were_VBDR recruited_VVN from_II the_AT dermatology_NN1 department_NN1 of_IO a_AT1 regional_JJ teaching_NN1 hospital_NN1 in_II the_AT U.K._NP1 Migraine_NP1 studies_NN2 demonstrate_VV0 abnormal_JJ function_NN1 ,_, structure_NN1 and_CC connectivity_NN1 of_IO brain_NN1 regions_NN2 that_CST play_VV0 important_JJ roles_NN2 in_II determining_VVG emotional_JJ responses_NN2 to_II pain_NN1 and_CC to_II other_JJ sensory_JJ stimuli_NN2 ,_, and_CC in_II determining_VVG general_JJ affect_NN1 and_CC mood_NN1 ._. 
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Recent_JJ evidence_NN1 demonstrated_VVD that_CST social_JJ distress_NN1 may_VM have_VHI an_AT1 impact_NN1 on_II pain_NN1 ._. 
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<s>
Nonetheless_RR ,_, our_APPGE study_NN1 was_VBDZ able_JK to_TO report_VVI discharge_NN1 destination_NN1 ,_, ambulatory_JJ status_NN1 ,_, and_CC mRS_NNU scores_NN2 ,_, which_DDQ have_VH0 strong_JJ associations_NN2 with_IW long-term_JJ functional_JJ outcomes_NN2 at_II 90_MC days.39_FO Last_MD ,_, the_AT GWTG-Stroke_JJ registry_NN1 is_VBZ a_AT1 voluntary_JJ program_NN1 ._. 
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<s>
This_DD1 result_NN1 is_VBZ remarkable_JJ with_II31 respect_II32 to_II33 the_AT comparable_JJ low_JJ sensitivity_NN1 of_IO confrontation_NN1 visual_JJ field_NN1 tests_NN2 frequently_RR used_VVN in_II clinical_JJ diagnostic_JJ settings_NN2 ._. 
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One_MC1 route_NN1 to_II pathobiology_NN1 insight_NN1 is_VBZ to_TO ask_VVI if_CSW aging_JJ retina_NN1 reveals_VVZ biologic_JJ processes_NN2 that_CST serve_VV0 as_RG anatomical_JJ ,_, physiological_JJ ,_, and_CC molecular_JJ predictors_NN2 for_IF disease_NN1 initiation_NN1 and_CC advancement_NN1 ._. 
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Nonvolume_VV0 quality_NN1 metrics_NN1 of_IO training_NN1 must_VM be_VBI defined_VVN and_CC measured_VVN ._. 
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The_AT images_NN2 are_VBR then_RT registered_VVN to_II sub-pixel_JJ accuracy_NN1 using_VVG a_AT1 12-dimensional_JJ mapping_NN1 that_CST accounts_VVZ for_IF the_AT unknown_JJ retinal_JJ curvature_NN1 and_CC camera_NN1 parameters_NN2 ._. 
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In_II31 addition_II32 to_II33 NSCLC_NP1 cell_NN1 lines_NN2 ,_, BDA-366_MC also_RR efficiently_RR suppressed_VVN growth_NN1 of_IO SCLC_NP1 cell_NN1 lines_NN2 (_( Figure_NN1 1_MC1 )_) ._. 
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In_II wild-type_JJ livers_NN2 ,_, NEMO_NP1 prevents_VVZ hepatocyte_NN1 apoptosis_NN1 by_II inhibiting_VVG the_AT formation_NN1 of_IO the_AT death-inducing_JJ RIPK1/FADD/Caspase-8_NN1 signaling_VVG complex_NN1 (_( complex_JJ IIb_NP1 )_) ._. 
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To_TO verify_VVI this_DD1 hypothesis_NN1 ,_, we_PPIS2 further_RRR examined_VVD the_AT mRNA_NN1 and_CC protein_NN1 levels_NN2 of_IO IL-1miu_NN1 in_II A172_FO cells_NN2 treated_VVN with_IW NS398_FO (_( 50_MC mium_NN1 )_) ._. 
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<s>
Cerebral_JJ ischemia_NN1 triggers_VVZ reactive_JJ astrogliosis_NN1 ,_, a_AT1 condition_NN1 characterized_VVN by_II an_AT1 increase_NN1 of_IO GFAP_NN1 levels_NN2 in_II astrocytes_NN2 (_( Farkas_NN2 et_RA21 al._RA22 ,_, 2007_MC )_) ._. 
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Age_VV0 at_RR21 least_RR22 18_MC years_NNT2 and_CC evidence_NN1 of_IO elevated_JJ NT-proBNP_JJ value_NN1 ,_, either_RR before_CS or_CC soon_RR after_II surgery_NN1 ,_, were_VBDR the_AT only_JJ inclusion_NN1 criteria_NN2 ._. 
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In_II the_AT present_JJ study_NN1 ,_, the_AT evaluation_NN1 of_IO anesthesia_NN1 quality_NN1 was_VBDZ performed_VVN by_II a_AT1 single_JJ author_NN1 (_( H.M.C._NP1 )_) who_PNQS had_VHD no_AT prior_JJ information_NN1 about_II the_AT CT_NN1 results_NN2 for_IF the_AT needle_NN1 path_NN1 or_CC the_AT anesthetic_JJ dispersion_NN1 ,_, at_RR21 least_RR22 reducing_VVG this_DD1 potential_JJ bias_NN1 inclusion_NN1 ._. 
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The_AT construction_NN1 techniques_NN2 of_IO fluting_VVG the_AT plastic_NN1 ,_, however_RR ,_, does_VDZ help_VVI to_TO promote_VVI strength_NN1 along_II the_AT ridge_NN1 ._. 
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Among_II the_AT remaining_JJ 721_MC cases_NN2 ,_, 285_MC patients_NN2 did_VDD not_XX meet_VVI our_APPGE diagnostic_JJ criteria_NN2 of_IO PD_NP1 and_CC were_VBDR not_XX counted_VVN as_CSA cases_NN2 ._. 
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<s>
A_AT1 population-based_JJ study_NN1 of_IO babies_NN2 who_PNQS were_VBDR exposed_VVN to_II antiepileptic_JJ drugs_NN2 (_( AEDs_NP2 )_) in_II utero_NN1 revealed_VVD impairment_NN1 of_IO fine_JJ motor_NN1 and_CC social_JJ skills_NN2 as_RG early_RR as_CSA 6_MC months_NNT2 of_IO age_NN1 ._. 
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<s>
Longer_JJR follow-up_NN1 of_IO up_RG21 to_RG22 4.8_MC years_NNT2 was_VBDZ carried_VVN out_RP via_II telephone_NN1 consultation_NN1 and_CC checking_VVG medical_JJ records_NN2 to_TO ascertain_VVI whether_CSW there_EX was_VBDZ any_DD further_JJR deterioration_NN1 in_II hearing_NN1 or_CC consultations_NN2 regarding_II this_DD1 ._. 
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<s>
Transcranial_JJ Direct_JJ Current_JJ Stimulation-Transcranial_JJ direct_JJ current_JJ stimulation_NN1 (_( tDCS_NNU )_) involves_VVZ an_AT1 energy_NN1 source_NN1 that_CST delivers_VVZ constant_JJ ,_, weak_JJ (_( typically_RR less_DAR than_CSN 1_MC1 mA_NN1 )_) electrical_JJ current_JJ through_II scalp_NN1 electrodes_NN2 ._. 
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<s>
While_CS previous_JJ studies_NN2 have_VH0 determined_VVN that_CST the_AT Hippo_NN1 kinases_NN2 MST1/2_FU and_CC LATS1/2_FU are_VBR downregulated_VVN and_CC YAP_NN1 is_VBZ upregulated_JJ inasubset_NN1 of_IO primaryhuman_NN1 prostate_NN1 cancers_NN2 (_( Cinaret_VV0 al._NNU ,_, 2007_MC ;_; Steinhardt_NP1 et_RA21 al._RA22 ,_, 2008_MC ;_; Zhao_NP1 et_RA21 al._RA22 ,_, 2012_MC )_) ,_, the_AT causes_NN2 and_CC consequences_NN2 of_IO YAP1_FO activation_NN1 have_VH0 not_XX been_VBN defined_VVN ,_, nor_CC have_VH0 causal_JJ roles_NN2 for_IF Hippo_NN1 signaling_VVG in_II the_AT genesis_NN1 of_IO prostate_NN1 cancer_NN1 been_VBN established_VVN ._. 
</s>
<s>
Four_MC weeks_NNT2 after_II cataract_NN1 surgery_NN1 culture-positive_JJ Streptococcus_NN1 pneumoniae_NN2 endophthalmitis_NN1 developed_VVD ,_, leading_VVG to_II rapid_JJ corneal_JJ perforation_NN1 and_CC subsequent_JJ evisceration_NN1 ._. 
</s>
<s>
Smokers_NN2 with_IW expired_JJ air_NN1 CO_FO levels_NN2 greater_JJR than_CSN and_CC less_DAR than_CSN 30_MC ppm_NNU (_( the_AT median_NN1 CO_FO for_IF all_DB subjects_NN2 )_) were_VBDR assigned_VVN to_II 42_MC mg/24_FU h_ZZ1 and_CC 21_MC mg/24_FU h_ZZ1 nicotine_NN1 patch_NN1 doses_NN2 ,_, respectively_RR (_( GlaxoSmithKline_NP1 )_) ._. 
</s>
<s>
Guided_VVN by_II previous_JJ literature_NN1 ,_, the_AT association_NN1 between_II 12_MC co-morbidities_NN2 and_CC the_AT outcome_NN1 was_VBDZ assessed_VVN in_II univariable_JJ models_NN2 ._. 
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<s>
In_II an_AT1 exploratory_JJ analysis_NN1 of_IO a_AT1 predefined_JJ subgroup_NN1 of_IO 502_MC patients_NN2 with_IW poor_JJ prognosis_NN1 disease_NN1 ,_, 332_MC (_( 66%_NNU )_) died_VVD (_( 174_MC in_II the_AT standard_JJ chemotherapy_NN1 group_NN1 and_CC 158_MC in_II the_AT bevacizumab_NN1 group_NN1 )_) ,_, and_CC a_AT1 significant_JJ difference_NN1 in_II overall_JJ survival_NN1 was_VBDZ noted_VVN between_II women_NN2 who_PNQS received_VVD bevacizumab_NN1 plus_II chemotherapy_NN1 and_CC those_DD2 who_PNQS received_VVD chemotherapy_NN1 alone_RR (_( restricted_JJ mean_JJ survival_NN1 time_NNT1 34.5_MC months_NNT2 &lsqb;_( 95%_NNU CI_FO 32*0_FO '_NULL 37*0_FO &rsqb;_) with_IW standard_JJ chemotherapy_NN1 vs_II 39.3_MC months_NNT2 &lsqb;_( 37*0_FO '_NULL 41*7_FO &rsqb;_) with_IW bevacizumab_NN1 ;_; log-rank_NN1 p=0*03_FO )_) ._. 
</s>
<s>
There_EX was_VBDZ a_AT1 difference_NN1 in_II number_NN1 of_IO patients_NN2 with_IW a_AT1 suprapubic_JJ urinary_JJ catheter_NN1 (_( Table_NN1 3_MC )_) ,_, and_CC overall_RR 15.8%_FO of_IO the_AT patients_NN2 in_II the_AT lavage_NN1 group_NN1 did_VDD not_XX need_VVI a_AT1 urinary_JJ catheter_NN1 compared_VVN to_II no_AT patients_NN2 in_II the_AT Hartmann_NP1 '_NULL s_ZZ1 group_NN1 (_( P_ZZ1 =_FO 0.025_MC )_) ._. 
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<s>
Role_NN1 of_IO the_AT Sponsor_NN1 :_: The_AT funding_NN1 agency_NN1 had_VHD no_AT role_NN1 in_II the_AT design_NN1 and_CC conduct_NN1 of_IO the_AT study_NN1 ;_; collection_NN1 ,_, management_NN1 ,_, analysis_NN1 ,_, or_CC interpretation_NN1 of_IO the_AT data_NN ;_; preparation_NN1 ,_, review_NN1 ,_, or_CC approval_NN1 of_IO the_AT manuscript_NN1 ;_; and_CC decision_NN1 to_TO submit_VVI the_AT manuscript_NN1 for_IF publication_NN1 ._. 
</s>
<s>
This_DD1 suggests_VVZ that_CST these_DD2 loci_NN2 are_VBR responsible_JJ at_RR21 least_RR22 in_RR21 part_RR22 for_IF the_AT initiation_NN1 of_IO OAG_NP1 ,_, consistent_JJ with_IW their_APPGE role_NN1 in_II determination_NN1 of_IO these_DD2 risk_VV0 factor_NN1 traits_NN2 ,_, which_DDQ are_VBR themselves_PPX2 predictive_JJ for_IF OAG_NN1 development_NN1 ._. 
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<s>
Lack_NN1 of_IO functional_JJ MTP_NP1 and_CC apoB_NN1 is_VBZ the_AT basis_NN1 of_IO abetalipoproteinemia_NN1 and_CC hypobetalipoproteinemia_NN1 ,_, respectively_RR ,_, two_MC rare_JJ inherited_JJ disorders_NN2 that_CST include_VV0 pigmentary_JJ retinopathies_NN2 ,_, historically_RR attributed_VVN to_II impaired_JJ dietary_JJ delivery_NN1 of_IO lipophilic_JJ vitamins_NN2 by_II plasma_NN1 apoB-containing_NN1 lipoproteins_NN2 but_CCB not_XX reversible_JJ by_II long-term_JJ supplementation_NN1 (_( Chowers_NP1 et_RA21 al._RA22 ,_, 2001_MC )_) ._. 
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<s>
Respiratory_JJ inductance_NN1 plethysmography_NN1 (_( RIP_NP1 )_) permits_VVZ measurement_NN1 of_IO respiratory_JJ motion_NN1 in_II clinical_JJ settings_NN2 not_XX conducive_JJ to_II spirometry_NN1 ,_, but_CCB correlation_NN1 of_IO RIP_NP1 volume_NN1 changes_NN2 and_CC spirometer_JJR flow_NN1 in_II the_AT time_NNT1 domain_NN1 is_VBZ degraded_VVN by_II the_AT development_NN1 of_IO paradoxical_JJ breathing_NN1 ._. 
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<s>
The_AT RV_NP1 threshold_NN1 used_VVD ,_, albeit_CS prespecified_VVN ,_, was_VBDZ arbitrarily_RR chosen_VVN ,_, and_CC a_AT1 post_JJ21 hoc_JJ22 sensitivity_NN1 analysis_NN1 (_( eTable_JJ 8_MC in_II Supplement_NN1 2_MC )_) indicated_VVD that_CST 200%_NNU predicted_VVN may_VM be_VBI a_AT1 more_RGR sensitive_JJ response_NN1 threshold_NN1 ._. 
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<s>
The_AT data_NN we_PPIS2 present_VV0 add_VV0 a_AT1 new_JJ contribution_NN1 to_II this_DD1 discussion_NN1 ,_, and_CC lend_VV0 support_NN1 to_II the_AT concepts_NN2 put_VV0 forth_RR by_II Bohne_NP1 and_CC Harding_NP1 in_II their_APPGE chinchilla_NN1 model_NN1 of_IO noise_NN1 exposure_NN1 ._. 
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<s>
This_DD1 risk_NN1 is_VBZ amplified_VVN by_II the_AT short_JJ range_NN1 of_IO the_AT strontium_NN1 p_ZZ1 particles_NN2 in_II tissue_NN1 ,_, 5_MC compounded_VVD by_II the_AT fact_NN1 that_CST surgeons_NN2 may_VM hold_VVI the_AT probe_NN1 away_II21 from_II22 the_AT retinal_JJ surface_NN1 to_TO reduce_VVI the_AT risk_NN1 of_IO trauma_NN1 ._. 
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<s>
Phase_NN1 II_MC research_NN1 is_VBZ also_RR recommended_VVN ,_, to_TO continue_VVI exploration_NN1 of_IO the_AT viability_NN1 of_IO the_AT Lidcombe_NP1 Program_NN1 for_IF Chinese-Malaysian_JJ families_NN2 and_CC to_TO estimate_VVI the_AT proportion_NN1 of_IO those_DD2 who_PNQS will_VM respond_VVI to_II the_AT treatment_NN1 ._. 
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<s>
In_RR21 addition_RR22 ,_, the_AT cortical_JJ silent_JJ period_NN1 has_VHZ consistently_RR been_VBN shown_VVN to_TO lengthen_VVI during_II sustained_JJ isolated_JJ muscle_NN1 exercise_NN1 ,_, including_VVG for_IF knee_NN1 extensor_NN1 contractions_NN2 but_CCB recovery_NN1 on_II exercise_NN1 cessation_NN1 is_VBZ rapid_JJ ._. 
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<s>
The_AT review_NN1 concluded_VVD that_CST if_CS acute_JJ systemic_JJ factors_NN2 are_VBR in_II fact_NN1 involved_JJ in_II the_AT post-exercise_JJ hypertrophic_JJ response_NN1 ,_, the_AT overall_JJ magnitude_NN1 of_IO the_AT effect_NN1 would_VM be_VBI of_IO small_JJ consequence_NN1 ._. 
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<s>
Trainers_NN2 tracked_VVD participants_NN2 '_NULL ability_NN1 and_CC comfort_VV0 completing_VVG exercises_NN2 during_II each_DD1 session_NNT1 as_CSA 1_MC1 indicator_NN1 of_IO tolerability_NN1 ._. 
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<s>
Conflict_NN1 of_IO Interest_NN1 :_: The_AT results_NN2 of_IO the_AT present_JJ study_NN1 do_VD0 not_XX constitute_VVI endorsement_NN1 by_II ACSM_NP1 ._. 
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<s>
After_CS completion_NN1 of_IO the_AT experiments_NN2 ,_, the_AT chronically_RR instrumented_VVD dogs_NN2 were_VBDR maintained_VVN for_IF the_AT rest_NN1 of_IO their_APPGE lives_NN2 in_II the_AT animal_NN1 research_NN1 facility_NN1 of_IO our_APPGE institution_NN1 ,_, for_IF use_NN1 in_II other_JJ experiments_NN2 until_CS they_PPHS2 died_VVD of_IO natural_JJ causes_NN2 ._. 
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<s>
The_AT increasing_JJ ADCTE_NN1 with_IW increasing_VVG T2_FO relaxation_NN1 times_NNT2 can_VM also_RR be_VBI detected_VVN in_II the_AT calculated_JJ effect_NN1 sizes_NN2 ._. 
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<s>
All_DB patients_NN2 underwent_VVD autopsy_NN1 for_IF analysis_NN1 of_IO tissue_NN1 response_NN1 to_II implantation_NN1 and_CC for_IF the_AT identification_NN1 of_IO the_AT continued_JJ presence_NN1 of_IO the_AT transplanted_JJ cells_NN2 within_II the_AT spinal_JJ cord_NN1 ._. 
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<s>
Results_NN2 :_: A_AT1 total_NN1 of_IO 177_MC returned_VVD complete_JJ data_NN sets_NN2 ._. 
</s>
<s>
The_AT problem_NN1 can_VM be_VBI exacerbated_VVN in_II patient_JJ populations_NN2 that_CST have_VH0 inferior_JJ fixation_NN1 ability_NN1 ._. 
</s>
<s>
At_II the_AT last_MD BCH_NP1 follow-up_JJ visit_NN1 ,_, 11_MC (_( 6.6%_FO )_) of_IO 166_MC patients_NN2 who_PNQS had_VHD a_AT1 lumbar_NN1 herniation_NN1 and_CC radiculopathy_NN1 were_VBDR receiving_VVG opioids_NN2 ._. 
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<s>
Dexmedetomidine_VV0 also_RR decreases_VVZ HR_NNU and_CC blood_NN1 pressure_NN1 in_II a_AT1 dose-dependent_JJ manner_NN1 ._. 
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<s>
The_AT discrepancy_NN1 between_II the_AT findings_NN2 may_VM be_VBI due_II21 to_II22 the_AT anatomical_JJ specificity_NN1 and/or_CC method_NN1 of_IO analysis_NN1 used_VVN in_II the_AT studies_NN2 (_( i.e._REX differences_NN2 in_II splice_NN1 variants_NN2 amplified_VVN by_II the_AT different_JJ primers_NN2 of_IO different_JJ groups_NN2 )_) ._. 
</s>
<s>
The_AT most_RGT important_JJ reason_NN1 that_CST this_DD1 study_NN1 used_VVD duct-to-mucosa_JJ PJ_NP1 was_VBDZ to_TO decompress_VVI the_AT main_JJ pancreatic_JJ duct_NN1 and_CC reduce_VVI pancreatic_JJ juice_NN1 leakage_NN1 from_II the_AT branch_NN1 pancreatic_JJ duct_NN1 ._. 
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<s>
Endothelial_JJ Dysfunction_NN1 in_II Advanced_JJ CKD_NP1 :_: Evidence_NN1 for_IF a_AT1 "_" Uremi_NN1 Switch_VV0 "_" The_AT stimulus_NN1 for_IF decreased_JJ L-arginine_JJ transport_NN1 seems_VVZ to_TO be_VBI related_VVN to_II an_AT1 increase_NN1 in_II circulating_VVG urea_NN1 and_CC other_JJ uremic_JJ toxins_NN2 that_CST occurs_VVZ with_IW CKD_NP1 ._. 
</s>
<s>
The_AT assumption_NN1 of_IO proportional_JJ odds_NN2 was_VBDZ assessed_VVN with_IW the_AT score_NN1 test_NN1 and_CC was_VBDZ valid_JJ (_( p_NNU greater_JJR than_CSN 0.3_MC )_) for_IF all_DB analyses_NN2 ._. 
</s>
<s>
Subsequent_JJ model_NN1 trimming_NN1 eliminated_VVD all_DB terms_NN2 that_CST included_VVD severity_NN1 ,_, indicating_VVG that_DD1 severity_NN1 did_VDD not_XX have_VHI main_JJ or_CC moderation_NN1 effects_NN2 on_II the_AT maintenance_NN1 of_IO treatment_NN1 effects_NN2 ._. 
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<s>
EHS_NN2 provided_VVD the_AT number_NN1 of_IO hours_NNT2 worked_VVN by_II EM_FU residents_NN2 and_CC the_AT operating_NN1 costs_NN2 of_IO the_AT residency_NN1 program_NN1 ._. 
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<s>
In_II the_AT last_MD two_MC decades_NNT2 ,_, a_AT1 number_NN1 of_IO studies_NN2 have_VH0 been_VBN published_VVN on_II the_AT prognostic_JJ value_NN1 of_IO MRI_NN2 in_II acute_JJ hamstring_NN1 injuries_NN2 that_CST reported_VVD multiple_JJ findings_NN2 as_CSA indicators_NN2 for_IF the_AT time_NNT1 to_II RTP_NP1 ,_, but_CCB the_AT large_JJ variation_NN1 of_IO the_AT time_NNT1 to_II RTP_NP1 from_II 1_MC1 day_NNT1 all_DB the_AT way_NN1 up_RG21 to_RG22 104_MC weeks_NNT2 makes_VVZ estimating_VVG the_AT prognosis_NN1 a_AT1 challenge_NN1 ._. 
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<s>
Supplementary_JJ Material_NN1 Refer_VV0 to_II Web_NN1 version_NN1 on_II PubMed_JJ Central_JJ for_IF supplementary_JJ material_NN1 ._. 
</s>
<s>
Specific_JJ survey_NN1 content_NN1 is_VBZ found_VVN in_II Tables_NN2 1-6_MCMC ,_, and_CC distribution_NN1 methods_NN2 are_VBR detailed_VVN below_RL for_IF each_DD1 of_IO the_AT six_MC groups_NN2 ._. 
</s>
<s>
At_II the_AT discretion_NN1 of_IO the_AT investigator_NN1 ,_, this_DD1 could_VM be_VBI extended_VVN to_II 60_MC (_( plus_NN1 and_CC minus7_FO )_) days_NNT2 or_CC 90_MC (_( plus_NN1 and_CC minus7_FO )_) days_NNT2 for_IF patients_NN2 who_PNQS did_VDD not_XX receive_VVI treatment_NN1 ._. 
</s>
<s>
It_PPH1 is_VBZ often_RR associated_VVN with_IW severe_JJ pain_NN1 and_CC may_VM be_VBI associated_VVN with_IW sight-threatening_NN1 complications.4_FO Non-infectious_JJ or_CC autoimmune_NN1 scleritis_NN1 is_VBZ thought_VVN to_TO arise_VVI from_II immune-mediated_JJ mechanisms_NN2 that_CST are_VBR not_XX well_RR understood_VVN ._. 
</s>
<s>
The_AT PRISM_NN1 III-12_MC scores_NN2 were_VBDR available_JJ in_II 1558_MC (_( 86%_NNU )_) of_IO the_AT transfers_NN2 ;_; the_AT median_JJ preimplementation_NN1 score_NN1 was_VBDZ 2_MC ,_, and_CC the_AT median_JJ postimplementation_NN1 score_NN1 was_VBDZ 0_MC (_( Table_NN1 1_MC1 )_) ._. 
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<s>
Although_CS this_DD1 limitation_NN1 for_IF big_JJ data_NN may_VM be_VBI overcome_VVN in_II the_AT future_NN1 ,_, caution_NN1 is_VBZ warranted_VVN because_CS conflicting_JJ results_NN2 between_II nonexperimental_JJ methods_NN2 and_CC randomized_VVD controlled_JJ trials_NN2 are_VBR common_JJ ._. 
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<s>
Barriers_NN2 to_II routine_NN1 integration_NN1 of_IO trauma-informed_JJ approaches_NN2 into_II pediatric_JJ medicine_NN1 include_VV0 a_AT1 lack_NN1 of_IO available_JJ training_NN1 and_CC unclear_JJ best_JJT practice_NN1 guidelines_NN2 ._. 
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<s>
The_AT CBFVmean_NN1 at_II baseline_NN1 and_CC at_II 3_MC HEA_NN1 intervals_NN2 during_II surgery_NN1 was_VBDZ 46_MC plus_II and_CC minus_II 12_MC (_( SD_NP1 )_) ,_, 45_MC plus_II and_CC minus_II 12_MC ,_, 47_MC plus_II and_CC minus_II 14_MC ,_, and_CC 47_MC plus_II and_CC minus_II 14_MC cm_NNU s-1_FO ,_, respectively_RR ._. 
</s>
<s>
All_DB animals_NN2 were_VBDR placed_VVN inside_II a_AT1 custom-made_JJ restraint_NN1 tube_NN1 that_CST was_VBDZ modified_VVN for_IF guinea_NN1 pigs_NN2 (_( Snyder_NP1 and_CC Salvi_NP1 ,_, 1994_MC )_) ._. 
</s>
<s>
AuthorAffiliations_NP1 :_: DukeClinical_JJ Research_NN1 Institute_NN1 ,_, Durham_NP1 ,_, North_ND1 Carolina_NP1 (_( Xian_JJ ,_, Grau-Sepulveda_NP1 ,_, Hernandez_NP1 ,_, Thomas_NP1 ,_, Webb_NP1 ,_, Bettger_NP1 ,_, Peterson_NP1 )_) ;_; medical_JJ student_NN1 at_II University_NN1 of_IO North_ND1 Carolina_NP1 School_NN1 of_IO Medicine_NN1 ,_, Chapel_NP1 Hill_NNL1 (_( Federspiel_NP1 )_) ;_; currently_RR with_IW Department_NN1 of_IO Gynecology_NP1 and_CC Obstetrics_NN1 ,_, Johns_NP1 Hopkins_NP1 School_NN1 ofMedicine_NN1 ,_, Baltimore_NP1 ,_, Maryland_NP1 (_( Federspiel_NP1 )_) ;_; Division_NN1 of_IO Neurology_NP1 ,_, Massachusetts_NP1 General_JJ Hospital_NN1 ,_, Boston_NP1 (_( Schwamm_NP1 )_) ;_; Brigham_NP1 and_CC Women_NN2 '_NULL s_ZZ1 Hospital_NN1 Heart_NN1 and_CC Vascular_JJ Center_NN1 and_CC Harvard_NP1 Medical_JJ School_NN1 ,_, Boston_NP1 ,_, Massachusetts_NP1 (_( Bhatt_NP1 )_) ;_; Department_NN1 ofClinical_JJ Neurosciences_NP2 ,_, University_NN1 ofCalgary_NN1 ,_, Calgary_NP1 ,_, Alberta_NP1 ,_, Canada_NP1 (_( Smith_NP1 )_) ;_; Hotchkiss_NP1 Brain_NN1 lnstitute_NN1 ,_, University_NN1 of_IO Calgary_NP1 ,_, Calgary_NP1 ,_, Alberta_NP1 ,_, Canada_NP1 (_( Smith_NP1 )_) ;_; Department_NN1 of_IO Epidemiology_NP1 ,_, Michigan_NP1 State_NN1 University_NN1 ,_, East_ND1 Lansing_NP1 (_( Reeves_NP1 )_) ;_; Department_NN1 of_IO Neurology_NP1 ,_, Duke_NN1 University_NN1 Medical_JJ Center_NN1 ,_, Durham_NP1 ,_, North_ND1 Carolina_NP1 (_( Laskowitz_NP1 )_) ;_; Division_NN1 of_IO Cardiology_NP1 ,_, University_NN1 of_IO California_NP1 ,_, Los_NP1 Angeles_NP1 (_( Fonarow_NP1 )_) ._. 
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<s>
Inflammation_NN1 ,_, evaluated_VVN as_II the_AT number_NN1 of_IO cells_NN2 and_CC flare_NN1 by_II laser_NN1 photometry_NN1 ,_, was_VBDZ less_RRR pronounced_VVN in_II the_AT NSAID_JJ group_NN1 after_II 1_MC1 week_NNT1 of_IO treatment_NN1 ._. 
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<s>
Respondents_NN2 were_VBDR asked_VVN to_TO evaluate_VVI the_AT survey-items_NN2 on_II a_AT1 Likert-type_JJ scale_NN1 ,_, with_IW gradual_JJ increase_NN1 in_II strength_NN1 of_IO agreement_NN1 from_II 1_MC1 to_II 5_MC ._. 
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<s>
Overall_JJ curriculum_NN1 satisfaction_NN1 for_IF all_DB trainees_NN2 ranged_VVN from_II 3.6-4.6_MCMC &lsqb;_( mean=_FO 4.1_MC ,_, Standard_JJ Deviation_NN1 (_( SD_NP1 )_) =_FO 0.3_MC &rsqb;_) ._. 
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<s>
The_AT sections_NN2 were_VBDR incubated_VVN with_IW polyclonal_JJ antibody_NN1 anti-BMP-4_JJ (_( Novocastra_NP1 ,_, Newcastle_NP1 ,_, UK_NP1 )_) and_CC monoclonal_JJ antibody_NN1 anti-MMP-13_JJ (_( Santa_NP1 Cruz_NP1 Biotechnology_NN1 ,_, Santa_NP1 Cruz_NP1 ,_, CA_NP1 )_) ._. 
</s>
<s>
Among_II them_PPHO2 ,_, 141_MC peptides_NN2 contained_VVD at_RR21 least_RR22 one_MC1 acidic_JJ residue_NN1 surrounding_VVG the_AT phosphorylated_JJ Tyr_NN1 ,_, and_CC were_VBDR ,_, therefore_RR ,_, considered_VVD potential_JJ substrates_NN2 for_IF SYK_NP1 (_( Xue_NP1 et_RA21 al._RA22 ,_, 2012_MC ,_, 2013_MC )_) ._. 
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<s>
To_TO define_VVI normal_JJ weight_NN1 ,_, overweight_JJ and_CC obesity_NN1 ,_, we_PPIS2 used_VVD BMI_JJ cut-points_NN2 25.0_MC and_CC 30.0kg/m2_FU respectively_RR ._. 
</s>
<s>
Iron_NN1 toxicity_NN1 Bound_VVD iron_NN1 is_VBZ considered_VVN '_NULL safe_JJ ,_, '_NULL but_CCB free_JJ iron_NN1 is_VBZ more_RGR likely_JJ to_TO exchange_VVI electrons_NN2 with_IW nearby_JJ molecules_NN2 and_CC produce_VVI free_JJ radicals_NN2 ._. 
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<s>
Second_MD ,_, the_AT previously_RR anoxic_JJ cells_NN2 and_CC tissues_NN2 are_VBR now_RT exposed_VVN to_II oxygen_NN1 ,_, which_DDQ can_VM lead_VVI to_II oxidative_JJ damage_NN1 in_II myocytes_NN2 by_II promoting_VVG formation_NN1 of_IO ROS_NP1 generation_NN1 (_( 18_MC )_) ._. 
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<s>
Under_II basal_JJ conditions_NN2 ,_, most_DAT of_IO the_AT oxygen_NN1 entering_VVG cells_NN2 are_VBR reduced_VVN to_II molecular_JJ water_NN1 in_II the_AT mitochondrial_JJ matrix_NN1 ._. 
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<s>
Pain_NN1 burden_NN1 and_CC oral_JJ opioid_JJ consumption_NN1 were_VBDR also_RR increased_VVN in_II subjects_NN2 who_PNQS demonstrated_VVD a_AT1 high_JJ sensory_JJ spread_NN1 after_II the_AT test_NN1 dose_NN1 ._. 
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<s>
Importantly_RR ,_, western_JJ blot_NN1 analysis_NN1 and_CC tumor_NN1 staining_VVG revealed_JJ ERK_NN1 target_NN1 inhibition_NN1 ,_, as_CSA measured_VVN by_II decreases_NN2 in_II pERK_NN1 ,_, pRSK_NNU ,_, pS6_FO ,_, and_CC p4E-BP1_JJ levels_NN2 (_( Figures_VVZ S6J_FO and_CC S6K_FO )_) ._. 
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<s>
Outcome_NN1 Measures_VVZ Relevant_JJ full-text_JJ articles_NN2 were_VBDR separated_VVN into_II type_NN1 of_IO regional_JJ anesthesia_NN1 (_( peripheral_JJ or_CC neuraxial_JJ blockade_NN1 )_) and_CC subsequently_RR reviewed_VVN ._. 
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<s>
He_PPHS1 was_VBDZ started_VVN on_II levodopa/carbidopa_NN1 110_MC mg_NNU twice_RR daily_RR 2_MC years_NNT2 after_II diagnosis_NN1 ._. 
</s>
<s>
In_II prediction_NN1 dichotomizing_VVG continuous_JJ predictors_NN2 is_VBZ arguable_JJ ,_, because_II21 of_II22 a_AT1 loss_NN1 of_IO information_NN1 &lsqb;_( 12_MC &rsqb;_) ._. 
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<s>
Further_RRR ,_, plasma_NN1 biomarker_NN1 concentrations_NN2 were_VBDR not_XX measured_VVN in_II all_DB patients_NN2 enrolled_VVN in_II the_AT primary_JJ study_NN1 due_II21 to_II22 logistic_JJ issues_NN2 ._. 
</s>
<s>
This_DD1 parity_NN1 is_VBZ observed_VVN only_RR if_CS ,_, in_II the_AT noise-exposure_JJ model_NN1 ,_, OHC_NP1 function_NN1 has_VHZ returned_VVN to_II normal_JJ ,_, as_CSA evidenced_VVN by_II full_JJ recovery_NN1 of_IO otoacoustic_JJ emission_NN1 thresholds_NN2 and_CC suprathreshold_VV0 response_NN1 amplitudes_NN2 ._. 
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<s>
However_RR ,_, most_DAT (_( 85_MC '_NULL 95%_NNU )_) cases_NN2 of_IO diabetes_NN1 in_II adults_NN2 are_VBR type_NN1 2,50_MC ,_, 52_MC so_RR the_AT observed_JJ rise_NN1 in_II diabetes_NN1 prevalence_NN1 in_II adults_NN2 is_VBZ quite_RG likely_JJ due_II21 to_II22 increases_NN2 in_II type_NN1 2_MC diabetes_NN1 ._. 
</s>
<s>
Lidcombe_VV0 Program_NN1 was_VBDZ introduced_VVN at_II Week_NNT1 16_MC in_II English_NN1 till_II Week_NNT1 23_MC ._. 
</s>
<s>
The_AT intervention_NN1 proved_VVD feasible_JJ in_II the_AT psychiatric_JJ clinic_NN1 ._. 
</s>
<s>
Early-life_JJ IQ_NN1 also_RR influenced_VVN WMH_NP1 in_II later_JJR life_NN1 ._. 
</s>
<s>
Our_APPGE current_JJ studies_NN2 provide_VV0 the_AT key_NN1 in_RR21 vivo_RR22 experimental_JJ evidence_NN1 demonstrating_VVG the_AT requirement_NN1 of_IO KDM4C_FO for_IF cancer_NN1 development_NN1 and_CC its_APPGE functional_JJ crosstalk_NN1 with_IW PRMT1_FO in_II the_AT establishment_NN1 of_IO histone_NN1 codes_NN2 for_IF transcriptional_JJ deregulation_NN1 in_II AML_NP1 ._. 
</s>
<s>
All_DB predictor_NN1 variables_NN2 were_VBDR entered_VVN into_II the_AT regression_NN1 in_II a_AT1 single_JJ step_NN1 because_CS filtering_VVG variables_NN2 based_VVN on_II unadjusted_JJ P_ZZ1 values_NN2 consumes_VVZ degrees_NN2 of_IO freedom_NN1 and_CC can_VM lead_VVI to_II an_AT1 overfitted_JJ model_NN1 ._. 
</s>
<s>
KPNC_NP1 is_VBZ the_AT pioneer_NN1 in_II leading_JJ initiatives_NN2 to_TO launch_VVI population-based_JJ approaches_NN2 for_IF CRC_NP1 screening_NN1 ,_, followed_VVN by_II similar_JJ efforts_NN2 by_II Kaiser_NN1 in_II Southern_JJ California_NP1 ._. 
</s>
<s>
Initially_RR ,_, the_AT program_NN1 included_VVD one_MC1 group_NN1 face-to-face_JJ information_NN1 session_NNT1 plus_II a_AT1 program_NN1 handbook_NN1 ._. 
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<s>
Our_APPGE study_NN1 measured_VVD psychological_JJ and_CC functional_JJ outcomes_NN2 through_II a_AT1 variety_NN1 of_IO tests_NN2 ._. 
</s>
<s>
As_II the_AT expansion_NN1 progressed_VVD ,_, it_PPH1 became_VVD clear_JJ that_CST efforts_NN2 to_TO initiate_VVI treatment_NN1 at_II the_AT primary-care_JJ level_NN1 were_VBDR also_RR needed_VVN ;_; by_II the_AT time_NNT1 women_NN2 reached_VVD the_AT hospital_NN1 ,_, the_AT condition_NN1 had_VHD often_RR progressed_VVN past_II the_AT point_NN1 of_IO effective_JJ treatment_NN1 ._. 
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<s>
RESULTS_NN2 ASD_VV0 is_VBZ not_XX associated_VVN with_IW systemic_JJ differences_NN2 in_II global_JJ DNA_NN1 methylation_NN1 As_CSA expected_VVN ,_, within-twin_NN1 patterns_NN2 of_IO DNA_NN1 methylation_NN1 were_VBDR highly_RR correlated_VVN across_II all_DB MZ_NP1 twin_NN1 pairs_NN2 (_( average_JJ within-twin_NN1 r_ZZ1 across_II all_DB probes_NN2 =_FO 0.99_MC )_) ,_, indicating_VVG that_DD1 ASD_NN1 and_CC related_JJ traits_NN2 are_VBR not_XX associated_VVN with_IW systemic_JJ changes_NN2 in_II epigenetic_JJ programming_NN1 ._. 
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<s>
METHODS_NN2 Participants_NN2 Table_NN1 1_MC1 provides_VVZ descriptive_JJ characteristics_NN2 of_IO participants_NN2 from_II both_DB2 studies_NN2 ._. 
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<s>
No_AT significant_JJ differences_NN2 in_II the_AT mean_JJ limbal_JJ basal_JJ cell_NN1 density_NN1 were_VBDR found_VVN among_II different_JJ stages_NN2 ._. 
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<s>
In_II the_AT sensitivity_NN1 analysis_NN1 limiting_VVG the_AT reports_NN2 to_II completed_JJ pregnancies_NN2 with_IW symptom_NN1 onset_NN1 or_CC exposure_NN1 exclusively_RR during_II the_AT first_MD trimester_NN1 (_( or_CC first_MD trimester_NN1 and_CC periconceptional_JJ period_NN1 )_) and_CC an_AT1 EDD_NN1 from_II April_NPM1 2016_MC through_II August_NPM1 2016_MC ,_, the_AT proportion_NN1 with_IW birth_NN1 defects_NN2 was_VBDZ comparable_JJ with_IW the_AT overall_JJ analysis_NN1 ,_, with_IW 7_MC fetuses_NN2 or_CC infants_NN2 presenting_VVG with_IW birth_NN1 defects_NN2 among_II 49_MC completed_JJ pregnancies_NN2 (_( 14%_NNU ;_; 95%_NNU CI_FO ,_, 7%-27%_FO )_) ,_, comparable_JJ with_IW the_AT 11%_NNU observed_VVN in_II the_AT primary_JJ analysis_NN1 ._. 
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<s>
Computer-aided_JJ detection_NN1 (_( CAD_NN1 )_) has_VHZ been_VBN developed_VVN to_TO improve_VVI detection_NN1 of_IO pulmonary_JJ nodules_NN2 and_CC numerous_JJ previous_JJ studies_NN2 in_II standard_JJ dose_NN1 CT_NN1 showed_VVD that_DD1 CAD_NN1 used_VVN as_II a_AT1 second_MD reader_NN1 significantly_RR improved_JJ detection_NN1 rate_NN1 of_IO pulmonary_JJ nodules_NN2 ._. 
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<s>
Subsequent_JJ analysis_NN1 showed_VVD that_CST 76.9%_FO of_IO the_AT statements_NN2 of_IO the_AT AWNS_NP2 were_VBDR classified_VVN as_CSA neutral_JJ while_CS fewer_DAR statements_NN2 of_IO the_AT AWS_NP2 were_VBDR classified_VVN as_CSA neutral_JJ both_RR prior_II21 to_II22 (_( 72.5%_FO )_) and_CC following_VVG therapy_NN1 (_( 68.6%_FO )_) ._. 
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<s>
Because_CS the_AT impact_NN1 of_IO the_AT dramatic_JJ changes_NN2 in_II US_NP1 demographics_NN1 is_VBZ manifesting_VVG first_MD in_II the_AT pediatric_JJ population_NN1 ,_, we_PPIS2 must_VM lead_VVI the_AT medical_JJ profession_NN1 in_II creating_VVG a_AT1 national_JJ strategy_NN1 to_TO address_VVI organizational_JJ change_NN1 in_II the_AT academic_JJ and_CC practice_NN1 work-force_NN1 and_CC thus_RR ensure_VV0 the_AT best_JJT health_NN1 outcomes_NN2 in_II the_AT 21st_MD century_NNT1 ._. 
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<s>
This_DD1 is_VBZ consistent_JJ with_IW past_JJ research_NN1 that_CST has_VHZ found_VVN the_AT experience_NN1 of_IO MS_NN1 pain_NN1 may_VM be_VBI buffered_VVN by_II social_JJ factors_NN2 ,_, such_II21 as_II22 perceived_JJ support.42_FO The_AT current_JJ results_NN2 suggest_VV0 that_CST potentially_RR increasing_JJ social_JJ support_NN1 may_VM be_VBI a_AT1 critical_JJ treatment_NN1 target_NN1 in_II improving_JJ pain_NN1 ,_, psychological_JJ ,_, and_CC physical_JJ functioning_NN1 in_II the_AT context_NN1 of_IO MS_NN1 ._. 
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<s>
Sample_NN1 sizes_NN2 were_VBDR small_JJ (_( range_NN1 11_MC -_- 108_MC )_) ._. 
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<s>
The_AT assessment_NN1 of_IO thoracic_JJ fluid_NN1 volumes_NN2 is_VBZ crucial_JJ for_IF the_AT diagnosis_NN1 ,_, management_NN1 ,_, and_CC stratification_NN1 and_CC follow-up_NN1 of_IO heart_NN1 failure_NN1 (_( HF_NP1 )_) patients_NN2 ._. 
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<s>
One_MC1 study_NN1 reported_VVD a_AT1 higher_JJR incidence_NN1 of_IO nuisance_NN1 adverse_JJ effects_NN2 (_( not_XX leading_VVG to_II treatment_NN1 discontinuation_NN1 )_) with_IW FAEs_NN2 compared_VVN with_IW placebo_NN1 (_( RR_NP1 4.72_MC ,_, 95%_NNU CI_NN1 2.45-9.08_MCMC ;_; 99_MC participants_NN2 ;_; moderate-quality_JJ evidence_NN1 )_) ,_, affecting_VVG 76%_NNU of_IO participants_NN2 given_VVN FAEs_NN2 (_( n_ZZ1 =_FO 49_MC )_) and_CC 16%_NNU of_IO the_AT placebo_NN1 group_NN1 (_( n_ZZ1 =_FO 50_MC )_) ,_, representing_VVG a_AT1 number_NN1 needed_VVD to_TO treat_VVI to_TO harm_VVI of_IO 2_MC ._. 
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<s>
The_AT net_JJ effect_NN1 is_VBZ to_TO promote_VVI inflammation_NN1 and_CC type_NN1 I_ZZ1 choroidal_JJ neovascularization_NN1 in_II a_AT1 narrow_JJ cleavage_NN1 plane_NN1 between_II the_AT RPE_NN1 basal_JJ lamina_NN1 and_CC the_AT inner_JJ collagenous_JJ layer_NN1 of_IO BrM_NP1 ,_, as_CSA proposed_VVN early_RR (_( Spaide_NP1 et_RA21 al._RA22 ,_, 2003_MC )_) ._. 
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<s>
Of_IO the_AT 14_MC serious_JJ adverse_JJ events_NN2 that_CST occurred_VVD in_II the_AT rivastigmine_NN1 group_NN1 ,_, only_RR two_MC were_VBDR assessed_VVN as_CSA being_VBG probably_RR or_CC definitely_RR related_VVN to_II the_AT treatment_NN1 ,_, both_DB2 of_IO which_DDQ were_VBDR worsening_JJ of_IO parkinsonism_NN1 ._. 
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<s>
Lipopolysaccharide_VV0 alone_RR also_RR reduced_VVD the_AT freezing_JJ scores_NN2 (_( F_ZZ1 (_( 1_MC1 65_MC )_) =_FO 20.56_MC ,_, n_ZZ1 =_FO 10_MC or_CC 11_MC ,_, P_NNU less_DAR than_CSN 0.0001_MC ,_, two-way_JJ ANOVA_NN1 ;_; fig._NN1 6D_NNU )_) ._. 
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<s>
Randomization_NN1 and_CC Interventions_NN2 Patients_NN2 were_VBDR randomized_VVN in_II a_AT1 1:1_MC ratio_NN1 to_II 1_MC1 of_IO the_AT 2_MC treatment_NN1 groups_NN2 using_VVG a_AT1 computerized_JJ system_NN1 ._. 
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<s>
Each_DD1 volleyball_NN1 team_NN1 was_VBDZ represented_VVN on_II court_NN1 by_II a_AT1 setter_NN1 ,_, two_MC receivers_NN2 ,_, two_MC middles_NN2 and_CC the_AT opposite_JJ while_CS the_AT libero_NN1 substituted_VVN for_IF middle_JJ players_NN2 when_CS they_PPHS2 were_VBDR positioned_VVN in_II backcourt_NN1 or_CC in_II defensive_JJ positions_NN2 ._. 
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<s>
It_PPH1 is_VBZ important_JJ to_TO identify_VVI each_DD1 team_NN1 member_NN1 '_NULL s_ZZ1 role_NN1 in_II the_AT transition_NN1 to_TO help_VVI the_AT child_NN1 to_TO begin_VVI to_TO take_VVI on_RP a_AT1 more_RGR independent_JJ role_NN1 in_II his_APPGE or_CC her_APPGE health_NN1 care_NN1 ._. 
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<s>
A_AT1 meta-analysis_NN1 examined_VVD the_AT relationship_NN1 between_II antidepressant_JJ response_NN1 and_CC neuropsychological_JJ test_NN1 performance_NN1 among_II depressed_JJ adults_NN2 ._. 
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<s>
Here_RL we_PPIS2 report_VV0 a_AT1 family_NN1 comprising_VVG three_MC affected_JJ individuals_NN2 who_PNQS harbour_VV0 a_AT1 heterozygous_JJ IFIH1_FO mutation_NN1 ,_, variably_RR expressing_VVG a_AT1 skin_NN1 and_CC a_AT1 neurological_JJ phenotype_NN1 ._. 
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<s>
As_CSA in_II the_AT previous_JJ figure_NN1 ,_, image_NN1 quality_NN1 and_CC SNR_NP1 are_VBR essentially_RR equivalent_JJ ,_, with_IW a_AT1 reduction_NN1 in_II scan_NN1 time_NNT1 from_II 7:14_MC to_II 3:48_MC min:s_FO ._. 
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<s>
The_AT scan_NN1 time_NNT1 with_IW SMS_NP1 is_VBZ sufficiently_RR short_JJ to_TO make_VVI such_DA a_AT1 high_JJ spatial_JJ resolution_NN1 acquisition_NN1 (_( with_IW a_AT1 0.4_MC x_ZZ1 0.4_MC mm2_FO pixel_NN1 )_) clinically_RR feasible_JJ ._. 
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<s>
Voxel-based_JJ morphometric_JJ (_( VBM_NP1 )_) analysis_NN1 was_VBDZ performed_VVN to_TO explore_VVI the_AT brain_NN1 regions_NN2 where_RRQ atrophy_NN1 might_VM be_VBI associated_VVN with_IW the_AT declines_VVZ of_IO the_AT core_NN1 EF_NN1 components_NN2 in_II patients_NN2 with_IW aMCI_NN2 ,_, which_DDQ was_VBDZ the_AT main_JJ aim_NN1 of_IO this_DD1 study_NN1 ._. 
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<s>
However_RR ,_, the_AT main_JJ effect_NN1 of_IO disclosure_NN1 should_VM not_XX affect_VVI the_AT expression_NN1 of_IO the_AT observed_JJ interaction_NN1 effect_NN1 of_IO genotype_NN1 by_II disclosure_NN1 status_NN1 ,_, since_CS performance_NN1 on_II the_AT memory_NN1 test_NN1 was_VBDZ not_XX near_II floor_NN1 or_CC ceiling_NN1 levels_NN2 in_II any_DD of_IO the_AT four_MC groups_NN2 ._. 
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<s>
We_PPIS2 demonstrated_VVD that_CST the_AT longevity_NN1 effect_NN1 of_IO IGF-1R+/-_FU mutation_NN1 on_II 129/SvPas_FU genetic_JJ background_NN1 is_VBZ sexually_RR dimorphic_JJ ,_, because_CS lifespan_NN1 was_VBDZ extended_VVN by_II 33%_NNU in_II females_NN2 ,_, while_CS the_AT effect_NN1 was_VBDZ not_XX significant_JJ in_II males_NN2 (_( Holzenberger_NP1 et_RA21 al._RA22 ,_, 2003_MC )_) ._. 
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<s>
Although_CS further_JJR research_NN1 is_VBZ required_VVN ,_, initial_JJ observations_NN2 support_VV0 an_AT1 ergogenic_JJ effect_NN1 after_II short-term_JJ NO3-supplementation_NN1 in_II moderately_RR trained_VVN team-sport_JJ athletes_NN2 ,_, but_CCB not_XX necessarily_RR after_II acute_JJ NO3-_JJ ingestion_NN1 and/or_CC when_RRQ elite_NN1 endurance_NN1 athletes_NN2 complete_VV0 short-duration_JJ high-intensity_JJ intermittent_JJ exercise_NN1 ._. 
</s>
<s>
However_RR ,_, age_NN1 did_VDD correlate_VVI with_IW white_JJ matter_NN1 microstructure_NN1 ,_, with_IW higher_JJR FA_NP1 and_CC lower_JJR MD_NN1 and_CC RD_NN1 with_IW increasing_JJ age_NN1 ._. 
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<s>
Semen_NN1 quality_NN1 was_VBDZ assessed_VVN by_II sperm_NN concentration_NN1 ,_, motility_NN1 ,_, morphology_NN1 and_CC total_JJ sperm_NN count_VV0 ._. 
</s>
<s>
Earlier_JJR studies_NN2 conducted_VVN on_II CHAMP_NN1 population_NN1 assessed_VVN the_AT SIRT1_FO expression_NN1 in_II SK_NP1 Hep1_FO cells_NN2 grown_VVN in_II the_AT presence_NN1 of_IO serum_NN1 samples_NN2 obtained_VVN from_II frail_JJ or_CC nonfrail_VV0 individuals_NN2 and_CC found_VVD there_EX was_VBDZ no_AT association_NN1 between_II frailty_NN1 and_CC SIRT1_FO expression_NN1 in_II cells_NN2 ._. 
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<s>
Hence_RR ,_, this_DD1 issue_NN1 needs_VVZ to_TO be_VBI further_RRR investigated_VVN ,_, preferentially_RR with_IW full-length_JJ melanopsins_NN2 in_II an_AT1 artificial_JJ membrane_NN1 ,_, as_II31 well_II32 as_II33 in_JJ21 vivo_JJ22 ._. 
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<s>
There_EX are_VBR ,_, however_RR ,_, limited_JJ prospective_JJ studies_NN2 examining_VVG whether_CSW HPV_NP1 is_VBZ found_VVN in_II other_JJ clinical_JJ conditions_NN2 (_( ie_REX ,_, branchial_JJ cleft_JJ cysts_NN2 ,_, benign_JJ lymph_NN1 nodes_NN2 ,_, or_CC in_II metastasis_NN1 from_II HNSCC_NP1 )_) ,_, other_II21 than_II22 tonsillar_JJ SCC_NP1 or_CC BOT_NP1 SCC_NP1 ._. 
</s>
<s>
As_II a_AT1 result_NN1 ,_, an_AT1 ANCOVA_NN1 was_VBDZ conducted_VVN with_IW age_NN1 (_( masseter_NN1 and_CC FDI_NP1 )_) and_CC symptom_NN1 duration_NN1 (_( FDI_NP1 )_) as_CSA covariates_VVZ ._. 
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<s>
OPPORTUNITIES_NN2 IN_II EMERGENCY_NN1 CARE_VV0 Nowhere_RL is_VBZ the_AT need_NN1 to_TO explore_VVI the_AT value_NN1 of_IO new-wave_JJ predictive_JJ analytics_NN2 more_RGR evident_JJ than_CSN in_II high-flow_NN1 ,_, acute_JJ care_NN1 settings_NN2 such_II21 as_II22 the_AT ED_NP1 ._. 
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<s>
Further_JJR support_NN1 was_VBDZ received_VVN through_II the_AT Intramural_JJ Research_NN1 Program_NN1 of_IO the_AT Eunice_NP1 Kennedy_NP1 Shriver_NP1 National_JJ Institute_NN1 of_IO Child_NN1 Health_NN1 and_CC Human_JJ Development_NN1 (_( Contract_NN1 N01HD33348_FO )_) ._. 
</s>
<s>
More_DAR falls_NN2 will_VM be_VBI associated_VVN with_IW a_AT1 proportional_JJ increase_NN1 in_II fall-related_JJ morbidity_NN1 and_CC mortality_NN1 secondary_NN1 to_II injury_NN1 ._. 
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<s>
The_AT closed_JJ society_NN1 where_RRQ terrorists_NN2 are_VBR indoctrinated_VVN is_VBZ the_AT very_JJ heart_NN1 of_IO their_APPGE dehumanization_NN1 ._. 
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<s>
Sociodemographic_JJ marginalization_NN1 and_CC psychosocial_JJ deprivation_NN1 have_VH0 been_VBN associated_VVN with_IW earlier_JJR diagnosis_NN1 of_IO GDM_NP1 ,_, higher_JJR plasma_NN1 glucose_NN1 level_NN1 at_II diagnosis_NN1 ,_, and_CC need_VV0 for_IF insulin_NN1 therapy_NN1 ._. 
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<s>
Therefore_RR ,_, it_PPH1 would_VM be_VBI unlikely_JJ for_IF headgear_NN1 to_TO have_VHI a_AT1 clinically_RR relevant_JJ effect_NN1 for_IF these_DD2 types_NN2 of_IO impacts_NN2 ._. 
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<s>
In_II both_DB2 groups_NN2 ,_, high-degree_JJ hubs_NN2 in_II bilateral_JJ precuneus_NN ,_, superior_JJ frontal_JJ cortex_NN1 ,_, superior_JJ parietal_JJ cortex_NN1 ,_, and_CC insula_NN1 composed_VVD a_AT1 rich_JJ club_NN1 ,_, but_CCB the_AT density_NN1 of_IO connections_NN2 between_II rich_JJ club_NN1 nodes_NN2 was_VBDZ significantly_RR and_CC specifically_RR reduced_VVN in_II the_AT patient_JJ group_NN1 ._. 
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<s>
Because_CS the_AT CI_NN1 is_VBZ influenced_VVN by_II the_AT sample_NN1 size_NN1 ,_, it_PPH1 is_VBZ anticipated_VVN that_CST in_II a_AT1 larger_JJR ,_, adequately_RR powered_JJ phase_NN1 III_MC study_NN1 ofsimilar_JJ design_NN1 the_AT noninferiority_NN1 margin_NN1 would_VM be_VBI met_VVN in_II most_DAT time_VV0 points_NN2 for_IF the_AT traditional_JJ IOP_NN1 assessments_NN2 within_II the_AT first_MD 12weeks_FO ._. 
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<s>
One_MC1 possibility_NN1 is_VBZ that_CST Cav-1_MC1 deficiency_NN1 alters_VVZ the_AT ionic_JJ milieu_NN1 surrounding_VVG photoreceptors_NN2 '_NULL in_RR21 situ_RR22 ._. 
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<s>
The_AT most_RGT relevant_JJ studies_NN2 in_II Europe_NP1 dealing_VVG with_IW AADD_NN1 in_II patients_NN2 of_IO any_DD age_NN1 such_II21 as_II22 that_DD1 of_IO Douma_NP1 et_RA21 al_RA22 ._. 
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<s>
&lsqb;_( 14_MC &rsqb;_) ,_, comprising_VVG three_MC cohorts_NN2 ,_, as_II31 well_II32 as_II33 the_AT validation_NN1 prospective_JJ study_NN1 reported_VVN by_II Righini_NP1 et_RA21 al_RA22 ._. 
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<s>
&lsqb;_( 15_MC &rsqb;_) ,_, show_VV0 a_AT1 clinical_JJ usefulness_NN1 with_IW the_AT use_NN1 of_IO AADD_NN1 of_IO 42_MC ,_, 51_MC ,_, 40_MC and_CC 39.8_MC %_NNU ,_, respectively_RR ,_, among_II patients_NN2 with_IW non-high_JJ PTP_NP1 of_IO PE_NN1 ._. 
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<s>
But_CCB there_EX were_VBDR no_AT such_DA complications_NN2 recorded_VVN in_II group_NN1 M_NN1 as_II31 well_II32 as_II33 group_NN1 S._NP1 Maxillary_NP1 block_NN1 is_VBZ now_RT used_VVN commonly_RR in_II dental_JJ offices_NN2 for_IF various_JJ dental_JJ procedures_NN2 ._. 
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<s>
Focus_NN1 was_VBDZ placed_VVN on_II the_AT right_JJ arm_NN1 muscles_NN2 ,_, based_VVN on_II data_NN from_II Shan_NP1 et_RA21 al_RA22 ._. 
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<s>
(_( 32_MC )_) indicating_VVG that_DD1 right_NN1 (_( bowing_VVG )_) arm_NN1 movements_NN2 have_VH0 the_AT largest_JJT amplitudes_NN2 and_CC velocity_NN1 during_II violin_NN1 performance_NN1 ._. 
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<s>
If_CS data_NN were_VBDR still_RR missing_VVG after_II attempting_VVG to_TO contact_VVI the_AT author_NN1 ,_, we_PPIS2 classified_VVD the_AT study_NN1 as_CSA unclear_JJ ._. 
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<s>
The_AT effectiveness_NN1 of_IO ustekinumab_NN1 for_IF reducing_VVG inflammation_NN1 in_II BSCR_NP1 remains_VVZ to_TO be_VBI determined_VVN '_NULL but_CCB there_EX is_VBZ an_AT1 upcoming_JJ phase_NN1 1_MC1 and_CC 2_MC study_NN1 for_IF the_AT use_NN1 of_IO ustekinumab_NN1 in_II uveitis_NN1 that_CST is_VBZ expected_VVN to_TO be_VBI completed_VVN in_II June_NPM1 2015_MC (_( Clinical-Trials.gov_NP1 Identifier_NN1 :_: NCT01647152_FO )_) ._. 
</s>
<s>
ERG_NP1 Interacts_VVZ with_IW TEAD-Occupied_JJ Chromatin_NN1 Regions_NN2 ,_, Increases_VVZ Histone_NP1 Acetylation_NN1 ,_, and_CC Promotes_VVZ YAP1-Dependent_JJ Transcription_NN1 Since_CS ERG_NP1 and_CC YAP1_FO both_DB2 localize_VV0 to_II the_AT nucleus_NN1 (_( Figures_VVZ 1L_NNU ,_, 3G_NNU ,_, and_CC 3H_FO )_) ,_, we_PPIS2 hypothesized_VVD that_CST ERG_VV0 directly_RR binds_VVZ and_CC activates_VVZ YAP1_FO target_NN1 genes_NN2 ._. 
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<s>
Second_MD '_NULL GPA_NP1 '_NULL TED_NP1 '_NULL and_CC sarcoidosis_NN1 in_II the_AT orbit_NN1 show_VV0 distinctive_JJ molecular_JJ signatures_NN2 (_( Rosenbaum_NP1 et_RA21 al_RA22 ._. '_NULL 
</s>
<s>
2015c_FO )_) ._. 
</s>
<s>
Correspondence:Prof_FO ._. 
</s>
<s>
Richard_NP1 G._NP1 Weleber_NP1 ,_, Oregon_NP1 Retinal_NP1 Degeneration_NN1 Center_NN1 ,_, Casey_NP1 Eye_NP1 Institute_NN1 ,_, Oregon_NP1 Health_NN1 &;_NULL Science_NN1 University_NN1 ,_, 3375_MC SW_ND1 Terwilliger_NP1 Boulevard_NP1 ,_, Portland_NP1 ,_, OR_CC 97239-4197_MCMC ._. 
</s>
<s>
A_AT1 small_JJ but_CCB growing_JJ body_NN1 of_IO evidence_NN1 indicates_VVZ that_CST caveolae_NN2 are_VBR also_RR involved_JJ in_II pathogen_NN1 uptake_NN1 and_CC inflammatory_JJ responses_NN2 at_II the_AT ocular_JJ surface_NN1 ._. 
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<s>
The_AT main_JJ reason_NN1 was_VBDZ that_CST the_AT attending_VVG anesthesiologists_NN2 have_VH0 13_MC to_II 15_MC years_NNT2 of_IO clinical_JJ experience_NN1 and_CC were_VBDR familiar_JJ with_IW the_AT pharmacological_JJ characteristics_NN2 of_IO propofol_NN1 ,_, remifentanil_VV0 ,_, and_CC DEX_NP1 ._. 
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<s>
The_AT study_NN1 is_VBZ registered_VVN at_II clinicaltrials.gov_NNU (_( NCT01326169_FO )_) ._. 
</s>
<s>
Selection_NN1 of_IO Participants_NN2 Research_VV0 Assistants_NN2 (_( RAs_NP2 )_) were_VBDR assigned_VVN to_II shifts_NN2 that_CST covered_VVD all_DB days_NNT2 of_IO the_AT week_NNT1 and_CC all_DB time_NNT1 periods_NN2 at_II both_DB2 EDs_NN2 ._. 
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<s>
The_AT duration_NN1 of_IO general_JJ anesthesia_NN1 (_( 5_MC vs_II 71_MC min_NNU ,_, P_NNU less_DAR than_CSN .001_MC )_) and_CC time_NNT1 in_II the_AT post-anesthesia_JJ care_NN1 unit_NN1 (_( 37_MC vs_II 93_MC min_NNU ,_, P_NNU less_DAR than_CSN .001_MC )_) were_VBDR significantly_RR shorter_JJR in_II the_AT chemodenervation_NN1 group_NN1 ._. 
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<s>
Much_DA1 of_IO our_APPGE understanding_NN1 of_IO this_DD1 communication_NN1 ,_, the_AT subject_NN1 of_IO the_AT field_NN1 of_IO psychoneuroimmunology_NN1 (_( PNI_NP1 )_) ,_, comes_VVZ from_II both_DB2 experimental_JJ animal_NN1 manipulations_NN2 and_CC clinical_JJ observations_NN2 that_CST demonstrate_VV0 that_CST a_AT1 wide_JJ variety_NN1 of_IO psychological_JJ ,_, physical_JJ or_CC physiological_JJ stressors_NN2 can_VM affect_VVI innate_JJ and_CC adaptive_JJ immune_JJ function_NN1 as_CSA examined_VVN either_RR in_JJ21 vivo_JJ22 or_CC in_RR21 vitro_RR22 ._. 
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<s>
To_TO complicate_VVI things_NN2 further_RRR ,_, optimal_JJ values_NN2 can_VM be_VBI substantially_RR different_JJ between_II methods_NN2 ,_, and_CC values_NN2 apply_VV0 only_RR for_IF the_AT specific_JJ application_NN1 in_II which_DDQ they_PPHS2 have_VH0 been_VBN used_VVN and_CC optimized_JJ ._. 
</s>
<s>
Although_CS another_DD1 relevant_JJ gene_NN1 ,_, theFOXO3A_FO ,_, has_VHZ been_VBN replicated_VVN in_II several_DA2 candidate_NN1 gene_NN1 studies_NN2 (_( Anselmi_NP1 et_RA21 al._RA22 ,_, 2009_MC ;_; Dumer_NP1 et_RA21 al._RA22 ,_, 2014_MC ;_; Flachsbart_NP1 et_RA21 al._RA22 ,_, 2009_MC ;_; Willcox_NP1 et_RA21 al._RA22 ,_, 2008_MC )_) ,_, no_AT consistency_NN1 for_IF it_PPH1 has_VHZ been_VBN obtained_VVN in_II the_AT GWAS_NP2 ._. 
</s>
<s>
For_IF the_AT noninferiority_NN1 outcome_NN1 ,_, a_AT1 2-sided_JJ test_NN1 at_II the_AT 0.05_MC significance_NN1 level_NN1 is_VBZ equivalent_JJ to_II a_AT1 1-sided_JJ test_NN1 at_II the_AT 0.025_MC significance_NN1 level_NN1 ._. 
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<s>
Seven_MC neurological_JJ issues_NN2 described_VVN during_II the_AT 30_MC days_NNT2 after_II GBCA_NP1 administration_NN1 included_VVD migraine_NN1 headache_NN1 ,_, loss_NN1 of_IO consciousness_NN1 ,_, memory_NN1 loss_NN1 (_( 2_MC patients_NN2 )_) ,_, falling_VVG ,_, lightheadedness_NN1 ,_, and_CC ataxia_NN1 were_VBDR also_RR present_JJ before_II GBCA_NP1 exposure_NN1 ._. 
</s>
<s>
The_AT association_NN1 between_II CSF_NP1 AB_FO and_CC CAA_NP1 disease_NN1 progression_NN1 has_VHZ yet_RR to_TO be_VBI explored_VVN ;_; by_II analogy_NN1 to_II AD_RA ,_, 93_MC one_MC1 might_VM expect_VVI the_AT reductions_NN2 in_II CSF_NP1 AB_FO in_II CAA_NP1 to_TO correlate_VVI inversely_RR with_IW ,_, and_CC carry_VVI roughly_RR the_AT same_DA information_NN1 as_CSA ,_, amyloid_JJ burden_NN1 in_II CAA_NP1 measured_VVD by_II PiB-PET_NN1 ._. 
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<s>
Stuttering_VVG severity_NN1 was_VBDZ higher_JJR in_II English_NN1 (_( her_APPGE less_RGR proficient_JJ language_NN1 )_) than_CSN in_II Mandarin_NN1 ._. 
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<s>
Five_MC studies_NN2 concluded_VVD that_CST there_EX were_VBDR no_AT differences_NN2 between_II nerve_NN1 localization_NN1 techniques_NN2 ._. 
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<s>
The_AT StatSensor_NP1 Xpress_NP1 (_( http_NNU :_: statsensor-creatinine/_NN1 )_) measurement_NN1 was_VBDZ performed_VVN in_II duplicate_NN1 using_VVG capillary_JJ blood_NN1 from_II the_AT same_DA finger_NN1 stick_NN1 ._. 
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<s>
Matching_JJ GP_NN1 records_NN2 to_II practice_NN1 records_NN2 resulted_VVN in_II 3227_MC letters_NN2 being_VBG issued_VVN ._. 
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<s>
This_DD1 finding_NN1 may_VM be_VBI the_AT result_NN1 of_IO heterogeneity_NN1 between_II studies_NN2 measuring_VVG control_NN1 beliefs_NN2 ;_; with_IW 3_MC different_JJ constructs_NN2 of_IO control_NN1 (_( ie_REX ,_, Locus_NN1 of_IO Control_NN1 ,_, perceived_VVD control_NN1 of_IO managing_JJ pain_NN1 ,_, perceived_VVD control_NN1 of_IO treatment_NN1 )_) being_VBG measured_VVN among_II four_MC studies_NN2 ._. 
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Although_CS soccer_NN1 players_NN2 may_VM engage_VVI in_RP mentally_RR fatiguing_VVG tasks_NN2 before_II a_AT1 match_NN1 ,_, it_PPH1 is_VBZ unlikely_JJ that_CST any_DD players_NN2 would_VM perform_VVI a_AT1 task_NN1 similar_JJ to_II the_AT Stroop_NN1 task_NN1 before_II competition_NN1 ._. 
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Radiation_NN1 exposure_NN1 of_IO dynamic_JJ perfusion_NN1 imaging_NN1 is_VBZ higher_RRR compared_VVN with_IW "_" static_JJ "_" perfusion_NN1 imaging_NN1 ._. 
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We_PPIS2 restricted_VVD the_AT sample_NN1 to_II patients_NN2 who_PNQS were_VBDR discharged_VVN home_RL from_II the_AT ED_NP1 to_TO focus_VVI on_II a_AT1 group_NN1 of_IO patients_NN2 whose_DDQGE initial_JJ care_NN1 was_VBDZ provided_VVN primarily_RR ,_, and_CC often_RR exclusively_RR ,_, by_II emergency_NN1 physicians_NN2 ._. 
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<s>
Data_NN from_II animal_NN1 studies_NN2 have_VH0 shown_VVN that_CST increased_JJ serum_NN1 corticosterone_NN1 concentration_NN1 may_VM also_RR play_VVI a_AT1 role_NN1 in_II the_AT CR-induced_JJ protective_JJ effects_NN2 against_II cancer_NN1 ,_, as_CSA adrenalectomy_NN1 completely_RR reverses_VVZ the_AT tumor_NN1 inhibitory_JJ effect_NN1 of_IO CR_NP1 in_II some_DD studies_NN2 (_( Pashko_NP1 &;_NULL Schwartz_NP1 ,_, 1992_MC ,_, 1996_MC ;_; Stewart_NP1 et_RA21 al._RA22 ,_, 2005_MC )_) ._. 
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Nevertheless_RR the_AT first_MD author_NN1 obtained_VVD exceptionally_RR high_JJ intra-judge_JJ kappas_NN2 of_IO .81_MC and_CC .91_MC for_IF Origin_NN1 and_CC Pawn_NN1 scoring_NN1 while_CS acceptable_JJ inter-judge_JJ kappas_NN2 (_( .70_MC for_IF Origin_NN1 and_CC .75_MC for_IF Pawn_NN1 )_) were_VBDR obtained_VVN ._. 
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The_AT study_NN1 included_VVD six_MC visits_NN2 over_RG four_MC months_NNT2 with_IW an_AT1 extension_NN1 phase_NN1 to_II one_MC1 year_NNT1 for_IF participants_NN2 who_PNQS met_VVD the_AT primary_JJ outcome_NN1 ._. 
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<s>
There_EX is_VBZ some_DD evidence_NN1 that_CST it_PPH1 encourages_VVZ more_RGR '_NULL evidenced-based_JJ ,_, practice_NN1 particularly_RR with_IW use_NN1 of_IO decision_NN1 support_NN1 systems_NN2 ._. 
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<s>
Based_VVN on_II the_AT 294_MC infants_NN2 meeting_VVG the_AT inclusion_NN1 criteria_NN2 ,_, the_AT number_NN1 of_IO infants_NN2 with_IW moderate_JJ or_CC severe_JJ HIE_NP1 in_II 2008_MC was_VBDZ projected_VVN to_TO be_VBI 380_MC (_( 294/0.773_MF )_) ._. 
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<s>
Ten_MC patients_NN2 initially_RR did_VDD not_XX respond_VVI to_II the_AT applied_JJ sham_NN1 manoeuvre_NN1 ;_; three_MC remained_VVD positive_JJ at_II all_DB follow-up_JJ visits_NN2 ,_, two_MC remained_VVD positive_JJ and_CC also_RR developed_VVD BPPV_NP1 at_II the_AT contralateral_JJ side_NN1 ,_, and_CC three_MC were_VBDR initially_RR not_XX responsive_JJ but_CCB the_AT BPPV_NP1 spontaneously_RR resolved_VVN during_II follow-up_NN1 ._. 
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<s>
The_AT role_NN1 of_IO substrate_NN1 stiffness_NN1 and_CC the_AT extracellular_JJ matrix_NN1 The_AT physiological_JJ substrate_NN1 of_IO the_AT SC_FO cell_NN1 is_VBZ the_AT jCT_NNU '_NULL the_AT most_RGT external_JJ aspect_NN1 of_IO the_AT TM_NP1 ._. 
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METHODS_NN2 From_II August_NPM1 2011_MC to_II June_NPM1 2013_MC ,_, we_PPIS2 assessed_VVD consecutive_JJ HIV-infected_JJ Zambian_JJ adults_NN2 presenting_VVG with_IW new-onset_JJ seizure_NN1 for_IF enrollment_NN1 into_II the_AT Cohort_NN1 ofHIV-Associated_NN1 Seizure_NN1 and_CC Epilepsy_NP1 (_( CHASE_NN1 )_) study_NN1 ._. 
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<s>
Applying_VVG this_DD1 technique_NN1 to_II the_AT case_NN1 in_II Figures_NN2 8_MC ,_, a_AT1 3D_NNU graphic_JJ image_NN1 of_IO the_AT brain_NN1 can_VM be_VBI rendered_VVN that_CST simultaneously_RR demonstrates_VVZ not_XX just_RR where_CS the_AT focal_JJ lesion_NN1 is_VBZ located_VVN but_CCB where_RRQ other_JJ cortical_JJ volume_NN1 losses_NN2 have_VH0 occurred_VVN (_( warm_JJ colors_NN2 ,_, yellow_JJ to_II red_JJ )_) beyond_II those_DD2 visually_RR detected_VVN by_II just_RR viewing_VVG the_AT images_NN2 ._. 
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To_TO reduce_VVI subjectivity_NN1 and_CC the_AT potential_NN1 for_IF bias_NN1 ,_, screening_VVG ,_, abstraction_NN1 ,_, and_CC evaluation_NN1 of_IO all_DB records_NN2 were_VBDR conducted_VVN by_II at_RR21 least_RR22 two_MC independent_JJ reviewers_NN2 ,_, and_CC all_DB differences_NN2 were_VBDR resolved_VVN through_II consensus_NN1 ._. 
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<s>
The_AT maximum_JJ total_NN1 Hb_NP1 difference_NN1 was_VBDZ achieved_VVN when_CS average_JJ plasma_NN1 Hb_NP1 in_II the_AT HBOC-201_MC arm_NN1 decreased_VVN to_II 0.5_MC g/dL_FU ._. 
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<s>
Even_CS21 though_CS22 discharge_NN1 days_NNT2 varied_JJ and_CC data_NN collected_VVN around_II day_NNT1 10_MC and_CC at_II discharge_NN1 time_NNT1 were_VBDR sparse_JJ ,_, it_PPH1 appears_VVZ that_CST the_AT marker_NN1 values_NN2 between_II the_AT HBOC-201_MC and_CC the_AT RBC_NP1 groups_NN2 started_VVD to_TO converge_VVI from_II day_NNT1 4_MC to_II day_NNT1 10_MC ._. 
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<s>
The_AT primary_JJ objective_NN1 of_IO this_DD1 study_NN1 is_VBZ to_TO identify_VVI risk_NN1 factors_NN2 for_IF a_AT1 severe_JJ disease_NN1 course_NN1 among_II children_NN2 with_IW non-infectious_JJ uveitis_NN1 ,_, defined_VVN as_II a_AT1 history_NN1 of_IO ocular_JJ complications_NN2 or_CC a_AT1 VA_FW of_IO 20/200_MF or_CC worse_JJR ._. 
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<s>
The_AT authors_NN2 suggested_VVD that_DD1 compliance_NN1 was_VBDZ low_JJ due_II21 to_II22 the_AT necessity_NN1 of_IO having_VHG different_JJ disciplines_NN2 providing_VVG care_NN1 to_II the_AT same_DA patients_NN2 ,_, and_CC a_AT1 few_DA2 strategies_NN2 to_TO increase_VVI compliance_NN1 were_VBDR suggested_VVN :_: education_NN1 and_CC reeducation_NN1 of_IO the_AT multidisciplinary_JJ team_NN1 and_CC having_VHG patients_NN2 complete_VVI daily_JJ activity_NN1 logs_NN2 ._. 
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<s>
Data_NN Extraction_NN1 We_PPIS2 conducted_VVD meta-analysis_NN1 if_CS 2_MC or_CC more_DAR studies_NN2 were_VBDR available_JJ for_IF a_AT1 particular_JJ outcome_NN1 ._. 
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<s>
This_DD1 strategy_NN1 was_VBDZ used_VVN to_TO select_VVI consistent_JJ start_NN1 and_CC end_VVI points_NN2 for_IF the_AT extraction_NN1 of_IO oral_JJ movement_NN1 trajectories_NN2 on_II the_AT basis_NN1 of_IO lower_JJR lip_NN1 peak_NN1 opening_NN1 velocities_NN2 for_IF the_AT kinematic_JJ analysis_NN1 ._. 
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Logistic_JJ regression_NN1 validated_VVD the_AT association_NN1 with_IW 2q24.3_FO (_( appendix_NN1 )_) ._. 
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<s>
Mulders_NN2 and_CC Robertson_NP1 (_( 2001_MC ,_, 2005_MC )_) showed_VVD that_CST the_AT locus_NN1 coeruleus_NN sends_VVZ noradrenergic_JJ projections_NN2 to_II the_AT SOC_NN1 and_CC made_VVD the_AT claim_NN1 that_CST this_DD1 was_VBDZ the_AT only_JJ catecholaminergic_JJ innervation_NN1 of_IO the_AT SOC_NN1 ._. 
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<s>
When_CS making_VVG the_AT match_NN1 list_NN1 ,_, obstetrics_NN1 and_CC gynecology_NN1 faculty_NN1 served_VVN as_II the_AT primary_JJ advisor_NN1 for_IF 27%_NNU (_( n563_FO )_) ,_, the_AT clerkship_NN1 director_NN1 for_IF 24%_NNU (_( n556_FO )_) ,_, and_CC the_AT department_NN1 chair_NN1 for_IF 13%_NNU (_( n529_FO )_) of_IO the_AT respondents_NN2 ._. 
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<s>
Whereas_CS an_AT1 Xbp1_FO signature_NN1 derived_VVN from_II overexpression_NN1 of_IO Xbp1_FO in_II B_ZZ1 cells_NN2 (_( Shaffer_NP1 et_RA21 al._RA22 ,_, 2004_MC )_) was_VBDZ moderately_RR enriched_VVN in_II BTZ-sensitive_JJ primary_NN1 MM_NNU tumors_NN2 (_( q_ZZ1 =_FO 0.07_MC ;_; Figure_NN1 2C_FO )_) ,_, a_AT1 second_NNT1 Xbp1_FO signature_NN1 representing_VVG genes_NN2 with_IW Xbp1-binding_JJ promoters_NN2 ,_, was_VBDZ significantly_RR enriched_VVN (_( q_ZZ1 =_FO 0.026_MC ;_; Figure_NN1 2D_NNU )_) ._. 
</s>
<s>
Adult_NN1 male_NN1 ICR_NN1 mice_NN2 and_CC 24_MC h_ZZ1 neonatal_JJ Sprague-Dawley_NN1 (_( SD_NP1 )_) rats_NN2 were_VBDR purchased_VVN from_II Shanghai_NP1 SLAC_NP1 Laboratory_NN1 Animal_NN1 Corporation_NN1 (_( Shanghai_NP1 ,_, China_NP1 )_) ._. 
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The_AT two_MC extreme_JJ categories_NN2 had_VHD little_DA1 crossover_NN1 ._. 
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<s>
A_AT1 panoramic_JJ ultrasound_NN1 examination_NN1 was_VBDZ first_MD performed_VVN for_IF the_AT head_NN1 and_CC neck_NN1 with_IW a_AT1 12_MC MHz_NNU linear_JJ probe_NN1 (_( Toshiba_NP1 Aplio_NP1 SSA790_FO ,_, Toshiba_NP1 Medical_JJ Systems_NN2 ,_, Tochigi-ken_NN1 ,_, Japan_NP1 )_) ._. 
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<s>
However_RR ,_, in_II this_DD1 selected_JJ patient_JJ cohort_NN1 (_( which_DDQ excludes_VVZ patients_NN2 with_IW high-grade_JJ kidney_NN1 dysfunction_NN1 as_CSA such_DA patients_NN2 were_VBDR no_AT candidates_NN2 for_IF a_AT1 large_JJ surgical_JJ procedure_NN1 )_) ,_, we_PPIS2 observed_VVD no_AT association_NN1 of_IO kidney_NN1 function_NN1 (_( reflected_VVN by_II creatinine_NN1 levels_NN2 )_) and_CC CSS_NP1 (_( p=0.859_FO ,_, HR_NNU 1.1_MC ,_, 95%_NNU CI_NN1 0.37-3.2_MCMC )_) ._. 
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<s>
Consider_VV0 the_AT promotion_NN1 of_IO healthy_JJ lifestyle_NN1 and_CC physical_JJ activity_NN1 interventions_NN2 in_II all_DB people_NN with_IW mental_JJ illness_NN1 ._. 
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<s>
A_AT1 significant_JJ positive_JJ regression_NN1 coefficient_NN1 for_IF the_AT case/control_NN1 term_NN1 is_VBZ taken_VVN as_CSA evidence_NN1 that_CST case_NN1 CNVs_NP1 in_II 1_MC1 sample_NN1 are_VBR more_RGR likely_JJ than_CSN their_APPGE corresponding_JJ control_NN1 CNVs_NP1 to_TO overlap_VVI case_NN1 CNVs_NP1 in_II the_AT other_JJ sample_NN1 ,_, allowing_VVG for_IF CNV_NP1 size_NN1 (_( large_JJ CNVs_NP1 being_VBG more_RGR likely_JJ to_TO overlap_VVI than_CSN small_JJ ones_NN2 )_) ._. 
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Previous_JJ relative_JJ age_NN1 research_NN1 could_VM accurately_RR be_VBI described_VVN as_CSA variable-oriented_JJ analyses_NN2 ._. 
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The_AT limited_JJ evidence_NN1 available_JJ suggests_VVZ that_DD1 generalization_NN1 to_II nontreated_JJ languages_NN2 might_VM occur_VVI with_IW the_AT Lidcombe_NP1 Program_NN1 for_IF some_DD preschoolers_NN2 ._. 
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In_II Washington_NP1 State_NN1 ,_, over_II the_AT last_MD 26_MC years_NNT2 ,_, the_AT age-_NN1 and_CC sex-adjusted_JJ incidence_NN1 of_IO elective_JJ colectomy_NN1 for_IF diverticulitis_NN1 more_RRR than_CSN doubled_VVN ._. 
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<s>
Before_CS moderate_JJ hypofractionation_NN1 can_VM be_VBI recommended_VVN in_II daily_JJ practice_NN1 for_IF low-risk_NN1 and_CC intermediate-risk_JJ prostate_NN1 cancer_NN1 ,_, 10_MC mature_JJ data_NN from_II the_AT CHHiP_NN1 trial_NN1 are_VBR needed_VVN (_( showing_VVG the_AT non-inferiority_NN1 of_IO hypofractionated_JJ regimens_NN2 and_CC 5-year_JJ urinary_NN1 ,_, bowel_NN1 ,_, and_CC sexual_JJ adverse_JJ event_NN1 data_NN )_) ,_, as_CSA are_VBR results_NN2 from_II trials_NN2 such_II21 as_II22 the_AT Radiation_NN1 Therapy_NN1 Oncology_NN1 Group_NN1 0415_MC trial_NN1 and_CC the_AT PROFIT_NN1 trial_NN1 from_II the_AT Ontario_NP1 Clinical_JJ Oncology_NN1 Group_NN1 ._. 
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It_PPH1 is_VBZ estimated_VVN that_CST the_AT risk_NN1 of_IO serious_JJ emotional_JJ consequences_NN2 increases_VVZ by_II 50%_NNU among_II the_AT mothers_NN2 of_IO ill_JJ children_NN2 ._. 
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Initial_JJ analysis_NN1 of_IO the_AT quality_NN1 criterion_NN1 of_IO at_RR21 least_RR22 a_AT1 50%_NNU response_NN1 rate_NN1 to_TO indicate_VVI studies_NN2 of_IO quality_NN1 showed_VVD that_CST this_DD1 was_VBDZ a_AT1 valid_JJ cut-off_NN1 point_NN1 ._. 
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<s>
Additionally_RR ,_, a_AT1 number_NN1 of_IO patients_NN2 have_VH0 been_VBN reported_VVN with_IW psoriasis_NN1 and_CC glaucoma_NN1 ,_, the_AT latter_DA being_VBG a_AT1 common_JJ feature_NN1 in_II AGS_NN2 also_RR ._. 
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Moreover_RR ,_, the_AT linear_JJ regression_NN1 coefficient_NN1 was_VBDZ close_JJ to_II 1_MC1 &lsqb;_( p=1.013_FO ,_, 95%_NNU confidence_NN1 interval_NN1 (_( CI_FO )_) ,_, 0.991-1.034_MCMC &rsqb;_) ._. 
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<s>
General_JJ principles_NN2 also_RR hold_VV0 for_IF times_NNT2 when_RRQ palliative_JJ radiotherapy_NN1 may_VM not_XX be_VBI worthwhile_JJ ._. 
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The_AT total_JJ recording_NN1 time_NNT1 for_IF each_DD1 session_NNT1 was_VBDZ 30_MC seconds_NNT2 ._. 
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<s>
This_DD1 supports_VVZ the_AT appropriateness_NN1 of_IO estimating_VVG latent_JJ constructs_NN2 ._. 
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<s>
In_II contrast_NN1 to_II animal_NN1 and_CC clinical_JJ studies_NN2 ,_, studies_NN2 in_II volunteers_NN2 enable_VV0 a_AT1 more_RGR exact_JJ and_CC reliable_JJ determination_NN1 of_IO block_NN1 parameters_NN2 ._. 
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<s>
Methods_NN2 :_: Inpatientdata_NP1 sets_VVZ from_II the_AT California_NP1 Office_NN1 of_IO Statewide_JJ Health_NN1 Planningand_NP1 Development_NN1 wereanalyzed_VVD for_IF 2009_MC to_II 2011_MC ._. 
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<s>
These_DD2 discontinuations_NN2 were_VBDR disproportionately_RR higher_JJR in_II the_AT two_MC experimental_JJ arms_NN2 despite_II provision_NN1 of_IO clinical_JJ guidelines_NN2 for_IF the_AT management_NN1 of_IO cediranib_NN1 toxic_JJ effects_NN2 ._. 
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Although_CS being_VBG bone_NN1 markers_NN2 ,_, in_II this_DD1 study_NN1 ,_, BMP-4_MC and_CC MMP-13_MC did_VDD not_XX show_VVI the_AT expected_JJ changes_NN2 ._. 
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The_AT POSHA-S_JJ also_RR assesses_VVZ self-reactions_NN2 ,_, including_II affective_JJ and_CC intended_VVD behavioral_JJ responses_NN2 ,_, toward_II PWS_NP2 ._. 
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<s>
Published_VVN online_RR :_: 12_MC January_NPM1 2016_MC (_( C_ZZ1 )_) SIMI_NN1 2016_MC Abstract_JJ Acute_JJ lung_NN1 injury_NN1 (_( ALI_NP1 )_) is_VBZ a_AT1 common_JJ complication_NN1 in_II elderly_JJ pneumonia_NN1 patients_NN2 who_PNQS have_VH0 a_AT1 rapid_JJ progression_NN1 ,_, and_CC is_VBZ accompanied_VVN by_II a_AT1 high_JJ mortality_NN1 rate_NN1 ._. 
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<s>
In_RR21 addition_RR22 ,_, an_AT1 arrow_NN1 was_VBDZ placed_VVN pointing_VVG to_II the_AT approximate_JJ center_NN1 of_IO the_AT target_NN1 ,_, and_CC a_AT1 notation_NN1 was_VBDZ provided_VVN assigning_VVG the_AT lesion_NN1 to_II the_AT PZ_NP1 or_CC TZ_NP1 in_II31 view_II32 of_II33 distinct_JJ PI-RADS_NN2 V2_FO criteria_NN2 for_IF PZ_NP1 and_CC TZ_NP1 lesions_NN2 ._. 
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<s>
In_II a_AT1 Chinese_JJ study_NN1 of_IO patients_NN2 with_IW initial_NN1 N0_FO disease_NN1 ,_, elective_JJ nodal_JJ irradiation_NN1 was_VBDZ delivered_VVN to_II levels_NN2 Ib_VV0 ,_, II_MC ,_, and_CC III_MC cervical_JJ nodes_NN2 at_II the_AT discretion_NN1 of_IO the_AT treating_VVG oncologist_NN1 but_CCB not_XX specifically_RR to_II the_AT RPLNs_NP1 ._. 
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<s>
More_RGR generally_RR ,_, our_APPGE findings_NN2 demonstrate_VV0 the_AT power_NN1 of_IO physiologically_RR based_VVN screens_NN2 for_IF identifying_VVG bioactive_JJ agents_NN2 for_IF select_JJ neurotransmitter_NN1 systems_NN2 ._. 
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The_AT number_NN1 of_IO attempts_NN2 required_VVN for_IF insertion_NN1 of_IO the_AT Intlock_NP1 blade_NN1 ,_, and_CC the_AT number_NN1 of_IO attempts_NN2 required_VVN for_IF tracheal_JJ intubation_NN1 was_VBDZ counted_VVN ._. 
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<s>
Relative_NN1 and_CC absolute_JJ biases_NN2 were_VBDR calculated_VVN by_II comparing_VVG the_AT HbA1c_FO values_NN2 obtained_VVN with_IW D-100TM_JJ system_NN1 with_IW the_AT IFCC_NN1 target_NN1 values_NN2 ._. 
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<s>
Results_NN2 During_II the_AT study_NN1 period_NN1 ,_, 12_MC patients_NN2 were_VBDR diagnosed_VVN with_IW cesarean_JJ scar_NN1 pregnancy_NN1 and_CC cervical_JJ pregnancy_NN1 with_IW live_JJ embryos_NN2 at_II the_AT time_NNT1 of_IO the_AT treatment_NN1 ._. 
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<s>
Traditional_JJ treatment_NN1 of_IO chondral_JJ defects_NN2 involves_VVZ arthroscopic_JJ debridement_NN1 ._. 
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<s>
It_PPH1 was_VBDZ conducted_VVN in_II a_AT1 healthy_JJ aging_JJ sample_NN1 with_IW a_AT1 narrow_JJ range_NN1 of_IO ages_NN2 ,_, which_DDQ eliminated_VVD most_DAT of_IO the_AT potentially_RR confounding_VVG effect_NN1 of_IO variations_NN2 in_II age_NN1 ._. 
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<s>
This_DD1 demonstrates_VVZ that_CST perioperative_JJ iron_NN1 repletion_NN1 has_VHZ substantial_JJ benefit_NN1 in_II the_AT postoperative_JJ recovery_NN1 period_NN1 ,_, potentially_RR due_II21 to_II22 the_AT iron_NN1 repletion_NN1 allowing_VVG bone_NN1 marrow_NN1 to_TO increase_VVI erythropoiesis_NN1 ,_, compared_VVN with_IW transfused_JJ RBCs_NP1 which_DDQ are_VBR rapidly_RR cleared_VVN from_II the_AT circulation_NN1 and_CC have_VH0 a_AT1 shorter_JJR lifespan_NN1 than_CSN normal_JJ RBCs_NP1 ._. 
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<s>
In_RR21 addition_RR22 ,_, the_AT importance_NN1 of_IO conventional_JJ and_CC advanced_JJ magnetic_JJ resonance_NN1 imaging_NN1 techniques_NN2 in_II the_AT characterization_NN1 of_IO brain_NN1 iron_NN1 deposition_NN1 in_II MS_NN1 will_VM be_VBI reviewed_VVN ._. 
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<s>
Accessory_JJ parotid_JJ gland_NN1 tumor_NN1 malignancy_NN1 occurs_VVZ more_RGR often_RR than_CSN malignancy_NN1 of_IO tumors_NN2 of_IO the_AT main_JJ parotid_JJ gland_NN1 ;_; the_AT frequency_NN1 is_VBZ reported_VVN as_II 35%_NNU to_II 52%_NNU ._. 
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<s>
For_IF a_AT1 recent_JJ review_NN1 on_II the_AT role_NN1 of_IO ER_NP1 stress_NN1 and_CC the_AT UPR_NN1 in_II the_AT context_NN1 of_IO the_AT pathobiology_NN1 of_IO retinal_JJ degenerations_NN2 ,_, see_VV0 Zhang_NP1 et_RA21 al_RA22 ._. 
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<s>
(_( 2014_MC )_) .2_MC ._. 
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<s>
Endoplasmic_JJ reticulum_NN1 :_: structure_NN1 and_CC function_VV0 The_AT ER_NP1 is_VBZ a_AT1 major_JJ endomembrane_NN1 compartment_NN1 consisting_VVG of_IO an_AT1 extensively_RR folded_JJ tubulovesicular_JJ membrane_NN1 network_NN1 supported_VVN by_II the_AT gel-like_JJ cytoplasmic_JJ matrix_NN1 (_( reviewed_VVN in_II English_NN1 and_CC Voeltz_NP1 ,_, 2013_MC )_) ._. 
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A_AT1 flare-up_NN1 was_VBDZ defined_VVN by_II a_AT1 1-step_JJ increase_NN1 in_II scleral_JJ inflammation_NN1 ._. 
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<s>
To_TO reduce_VVI the_AT risk_NN1 of_IO this_DD1 complication_NN1 ,_, particular_JJ attention_NN1 should_VM be_VBI paid_VVN to_II drug_NN1 reservoir_NN1 volume_NN1 discrepancies_NN2 and_CC overdose_VV0 symptoms_NN2 reported_VVN by_II patients_NN2 ._. 
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<s>
Modulation_NN1 of_IO APP_NP1 Expression_NN1 Reduces_VVZ Ap_NP1 Deposition_NN1 in_II a_AT1 Mouse_NN1 Model_NN1 Ayodeji_NP1 A._NP1 Asuni1_FO ,_, Maitea_NP1 Guridi1_FO ,_, Joanna_NP1 E._NP1 Pankiewicz_NP1 ,_, Sandrine_NP1 Sanchez1_FO ,_, and_CC Martin_NP1 J._NP1 Sadowski_NP1 Department_NN1 of_IO Neurology_NP1 ,_, New_NP1 York_NP1 University_NN1 School_NN1 of_IO Medicine_NN1 ,_, New_NP1 York_NP1 ,_, NY_NP1 10016_MC Department_NN1 of_IO Psychiatry_NP1 ,_, New_NP1 York_NP1 University_NN1 School_NN1 of_IO Medicine_NN1 ,_, New_NP1 York_NP1 ,_, NY_NP1 10016_MC Department_NN1 of_IO Biochemistry_NP1 and_CC Molecular_JJ Pharmacology_NN1 ,_, New_NP1 York_NP1 University_NN1 School_NN1 of_IO Medicine_NN1 ,_, New_NP1 York_NP1 ,_, NY_NP1 10016_MC Abstract_JJ Objective-Proteolytic_JJ cleavage_NN1 of_IO the_AT amyloid_JJ precursor_NN1 protein_NN1 (_( APP_NP1 )_) generates_VVZ P-amyloid_NN1 (_( AP_NP1 )_) peptides_NN2 ._. 
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The_AT behavioural_JJ intervention_NN1 had_VHD little_DA1 focus_NN1 on_II sedentary_JJ time_NNT1 during_II the_AT day_NNT1 ._. 
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<s>
Pregnancy-associated_JJ hypertension_NN1 was_VBDZ also_RR shown_VVN to_TO have_VHI a_AT1 moderate_JJ effect_NN1 on_II SIDS_NP2 occurrence_NN1 ,_, possibly_RR a_AT1 consequence_NN1 of_IO the_AT increased_JJ susceptibility_NN1 to_II pregnancy-induced_JJ hypertension_NN1 complications_NN2 ,_, such_II21 as_II22 placenta_NN1 abruption_NN1 ,_, which_DDQ is_VBZ itself_PPX1 a_AT1 cause_NN1 of_IO intrauterine_JJ hypoxia_NN1 ._. 
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<s>
A_AT1 composite_JJ score_NN1 was_VBDZ created_VVN for_IF each_DD1 resident_NN1 ._. 
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<s>
Nevertheless_RR ,_, it_PPH1 is_VBZ important_JJ to_TO note_VVI that_CST despite_II being_VBG predominantly_RR euthymic_JJ ,_, over_RG 50%_NNU of_IO the_AT youths_NN2 in_II class_NN1 1_MC1 continued_JJ to_TO experience_VVI new_JJ syndromal_JJ manic_JJ or_CC depressive_NN1 episodes_NN2 ,_, indicating_VVG that_CST they_PPHS2 continued_VVD to_TO have_VHI active_JJ ,_, clinically_RR meaningful_JJ bipolar_JJ symptoms_NN2 and_CC the_AT need_NN1 for_IF maintenance_NN1 treatment_NN1 ._. 
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<s>
In_II studies_NN2 depending_VVG upon_II contrast_NN1 injection_NN1 ,_, this_DD1 would_VM also_RR require_VVI 2_MC separate_JJ patient_JJ examinations_NN2 ._. 
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<s>
She_PPHS1 had_VHD difficulty_NN1 rising_VVG from_II a_AT1 chair_NN1 and_CC her_APPGE gait_NN1 was_VBDZ of_IO reduced_JJ stride_NN1 length_NN1 ,_, with_IW episodes_NN2 of_IO freezing_JJ ._. 
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<s>
The_AT median_JJ field_NN1 of_IO view_NN1 was_VBDZ 37.0_MC cm_NNU (_( IQR_NP1 ,_, 35.0-41.0_MCMC cm_NNU )_) and_CC was_VBDZ used_VVN as_II an_AT1 estimate_NN1 of_IO patient_JJ body_NN1 habitus_NN1 ,_, because_CS body_NN1 mass_NN1 index_NN1 was_VBDZ inconsistently_RR available_JJ ._. 
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<s>
This_DD1 subgroup_NN1 was_VBDZ selected_VVN because_CS they_PPHS2 are_VBR leaders_NN2 in_II institutions_NN2 where_CS there_EX is_VBZ likely_JJ to_TO be_VBI a_AT1 residency_NN1 training_NN1 program_NN1 ,_, a_AT1 broad_JJ scope_NN1 of_IO surgical_JJ practitioners_NN2 ,_, a_AT1 connection_NN1 including_II some_DD oversight_NN1 of_IO those_DD2 practitioners_NN2 ,_, and_CC opportunities_NN2 for_IF innovation_NN1 ._. 
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<s>
Included_VVN among_II DNA_NN1 trans-posons_NN2 are_VBR the_AT SINEs_NN2 (_( SINE1_FO ,_, SINE2_FO ,_, and_CC SINE3_FO )_) ,_, which_DDQ are_VBR highly_RR repetitive_JJ DNA_NN1 sequences_NN2 that_CST are_VBR typically_RR less_DAR than_CSN 500bp_FO in_II size_NN1 and_CC scattered_VVN throughout_II the_AT genome_NN1 ._. 
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<s>
We_PPIS2 show_VV0 that_CST "_" magnitude-based_JJ inference_NN1 "_" is_VBZ not_XX a_AT1 progressive_JJ improvement_NN1 on_II modern_JJ statistics_NN ._. 
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<s>
The_AT inclusion_NN1 of_IO strategies_NN2 in_II routine_NN1 programme_NN1 delivery_NN1 provides_VVZ a_AT1 model_NN1 for_IF future_JJ research_NN1 ,_, and_CC there_EX might_VM be_VBI scope_NN1 to_TO test_VVI changes_NN2 to_II the_AT interventions_NN2 that_CST could_VM strengthen_VVI the_AT effects_NN2 ._. 
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<s>
At_RR21 least_RR22 5_MC consecutive_JJ enhanced_JJ MRI_JJ scans_NN2 performed_VVN with_IW the_AT exclusive_JJ use_NN1 of_IO lGBCA_NN1 ,_, followed_VVN by_II at_RR21 least_RR22 5_MC scans_NN2 with_IW the_AT exclusive_JJ use_NN1 of_IO mcGBCA-1_MC1 followed_VVN by_II another_DD1 MRI_NN1 with_IW an_AT1 unenhanced_JJ T1_FO MRI_NN2 for_IF reference_NN1 ._. 
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<s>
Ribeye_NN1 is_VBZ a_AT1 key_JJ organizer_NN1 of_IO hair-cell_JJ synapses_NN2 In_II both_DB2 fish_VV0 and_CC mammalian_JJ nascent_JJ hair_NN1 cells_NN2 ,_, Ribeye_NP1 can_VM be_VBI detected_VVN as_CSA small_JJ particles_NN2 throughout_II the_AT cytoplasm_NN1 (_( Sheets_NN2 et_RA21 al_RA22 ._. 
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<s>
,_, 2011_MC ;_; Sobkowicz_NP1 et_RA21 al_RA22 ._. 
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<s>
,_, 1986_MC ;_; Yu_NP1 and_CC Goodrich_NP1 ,_, 2014_MC )_) ._. 
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<s>
Flavanols_NN2 have_VH0 been_VBN proposed_VVN to_TO have_VHI multimodal_JJ activities_NN2 (_( Mandel_NP1 et_RA21 al._RA22 ,_, 2008_MC )_) ,_, concurrently_RR acting_VVG at_II multiple_JJ targets_NN2 and_CC could_VM potentially_RR impact_NN1 on_II Ab_FO aggregation_NN1 by_II favoring_VVG the_AT formation_NN1 of_IO off-target_JJ oligomers_NN2 (_( Ehrnhoefer_NP1 et_RA21 al._RA22 ,_, 2008_MC )_) but_CCB only_RR if_CS micromolar_JJ concentrations_NN2 could_VM be_VBI achieved_VVN in_RR21 vivo_RR22 ._. 
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<s>
In_II summary_NN1 ,_, real-time_JJ captioning_NN1 of_IO physicians_NN2 '_NULL speech_NN1 ,_, made_VVD possible_JJ by_II the_AT increasing_JJ availability_NN1 of_IO digital_JJ devices_NN2 with_IW speech-to-text_JJ capabilities_NN2 ,_, has_VHZ the_AT potential_JJ to_TO improve_VVI communication_NN1 during_II the_AT informed_JJ decision-making_JJ process_NN1 and_CC in_II physician-patient_NN1 encounters_VVZ in_RR21 general_RR22 ._. 
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<s>
Therapists_NN2 met_VVN with_IW researchers_NN2 weekly_RR during_II the_AT first_MD 3_MC months_NNT2 of_IO the_AT implementation_NN1 process_NN1 to_TO discuss_VVI potential_JJ barriers_NN2 and_CC facilitators_NN2 of_IO delivering_VVG these_DD2 interventions_NN2 in_II clinical_JJ care_NN1 ,_, including_II ensuring_VVG consistent_JJ outcome_NN1 measure_NN1 collection_NN1 ,_, with_IW intermittent_JJ ,_, informal_JJ meetings_NN2 over_II the_AT 16-month_JJ duration_NN1 ._. 
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The_AT portion_NN1 of_IO thejaw_NN1 displacement_NN1 signal_NN1 used_VVN for_IF the_AT STI_JJ calculation_NN1 included_VVD points_NN2 between_II the_AT peak_NN1 velocity_NN1 of_IO the_AT first_MD downward_JJ motion_NN1 of_IO the_AT jaw_NN1 in_II the_AT first_MD syllable_NN1 of_IO '_NULL buy_NN1 '_NULL and_CC the_AT last_MD upward_JJ jaw_NN1 motion_NN1 in_II the_AT second_NNT1 to_II the_AT last_MD syllable_NN1 '_NULL pup_NN1 '_NULL ._. 
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<s>
The_AT pain_NN1 measurements_NN2 in_II the_AT Biswas_NN2 et_RA21 al_RA22 study_NN1 18_MC may_VM be_VBI affected_VVN by_II this_DD1 bias_NN1 ._. 
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<s>
The_AT animal_NN1 was_VBDZ briefly_RR reanesthetized_VVN for_IF two_MC subsequent_JJ blood_NN1 draws_NN2 (_( ie_REX ,_, at_II 3-hour_NNT1 and_CC 24-hour_JJ time_NNT1 points_NN2 )_) ,_, followed_VVN by_II euthanasia_NN1 ._. 
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<s>
Another_DD1 limitation_NN1 is_VBZ the_AT reliance_NN1 on_II previous_JJ guidelines_NN2 for_IF surveillance_NN1 and_CC symptom_NN1 management_NN1 ._. 
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<s>
HHT_NP1 can_VM quantify_VVI this_DD1 phase_NN1 shift_VV0 so_CS21 that_CS22 it_PPH1 can_VM be_VBI included_VVN in_II the_AT regression_NN1 ,_, while_CS this_DD1 can_VM not_XX be_VBI done_VDN in_II the_AT time_NNT1 domain_NN1 ._. 
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<s>
Case_NN1 series_NN involving_VVG fewer_DAR than_CSN 10_MC patients_NN2 ,_, case_NN1 reports_NN2 ,_, letters_NN2 to_II editors_NN2 ,_, and_CC expert_NN1 reviews_NN2 were_VBDR excluded_VVN ._. 
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<s>
AWS_NN2 and_CC control_NN1 groups_NN2 were_VBDR compared_VVN in_II speech_NN1 accuracy_NN1 and_CC speech_NN1 kinematics_NN2 (_( lip_NN1 aperture_NN1 variability_NN1 and_CC speech_NN1 duration_NN1 )_) ._. 
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<s>
Studies_NN2 further_RRR identified_VVN DNA-PKcs_NN2 as_II a_AT1 modulator_NN1 of_IO cancer-associated_JJ pathways_NN2 distinct_JJ from_II DNA_NN1 repair_NN1 ,_, including_II hypoxia_NN1 ,_, metabolism_NN1 ,_, inflammatory_JJ response_NN1 ,_, and_CC transcriptional_JJ regulation_NN1 (_( Goodwin_NP1 and_CC Knudsen_NP1 ,_, 2014_MC )_) ._. 
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<s>
In_II the_AT Cohen_NP1 study_NN1 ,_, however_RR ,_, there_EX was_VBDZ no_AT advantage_NN1 to_II utilizing_VVG 50%_NNU or_CC 80%_NNU relief_NN1 in_II predicting_VVG RF_NP1 neurotomy_NN1 outcomes_NN2 ._. 
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<s>
In_II 46.6%_FO of_IO shortages_NN2 ,_, manufacturers_NN2 did_VDD not_XX give_VVI a_AT1 reason_NN1 ._. 
</s>
<s>
Discussion_NN1 Most_DAT guidelines_NN2 for_IF thyroid_JJ nodules_NN2 commonly_RR recommend_VV0 FNA_NN1 in_II nodules_NN2 that_CST are_VBR 1_MC1 cm_NNU or_CC larger_JJR with_IW the_AT exception_NN1 of_IO high-risk_JJ patients_NN2 because_CS there_EX is_VBZ a_AT1 lack_NN1 of_IO evidence_NN1 regarding_VVG whether_CSW diagnosis_NN1 of_IO microcarcinomas_NN2 provides_VVZ benefit_NN1 for_IF patient_JJ survival_NN1 ._. 
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<s>
We_PPIS2 believe_VV0 that_CST the_AT accessibility_NN1 of_IO this_DD1 non-invasive_JJ monitor_NN1 enables_VVZ measurement_NN1 of_IO CO_NP1 at_II an_AT1 early_JJ stage_NN1 in_II obstetric_JJ patients_NN2 ,_, before_CS significant_JJ clinical_JJ deterioration_NN1 has_VHZ occurred_VVN ._. 
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<s>
Through_II this_DD1 neuropsychiatric_JJ evaluation_NN1 a_AT1 descriptive_JJ diagnosis_NN1 and_CC if_CS appropriate_JJ a_AT1 categorical_JJ Diagnostic_JJ and_CC Statistical_JJ Manual_NN1 of_IO Mental_JJ Disorders_NN2 4th_MD Edition_NN1 (_( DSM4_FO )_) diagnosis_NN1 was_VBDZ made_VVN ._. 
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<s>
While_CS AANHPIs_NP1 have_VH0 30%_NNU to_II 40%_NNU lower_JJR incidence_NN1 and_CC mortality_NN1 rates_NN2 than_CSN non-Hispanic_JJ whites_NN2 for_IF all_DB cancers_NN2 combined_VVD ,_, risk_NN1 of_IO stomach_NN1 and_CC liver_NN1 cancers_NN2 is_VBZ double_JJ ._. 
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<s>
A_AT1 second_MD stimulation_NN1 sequence_NN1 was_VBDZ constructed_VVN based_VVN on_II the_AT ascending_JJ sequence_NN1 results_NN2 ._. 
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<s>
The_AT electrode_NN1 ,_, filled_VVN with_IW conductive_JJ gel_NN1 ,_, was_VBDZ connected_VVN via_II extension_NN1 cable_NN1 to_II a_AT1 constant_JJ current_JJ stimulator_NN1 (_( model_NN1 DS7A_FO ;_; Digitimer_NP1 )_) in_II the_AT experimenter_NN1 room_NN1 ._. 
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Median_JJ fall_NN1 rate_NN1 in_II the_AT rivastigmine_NN1 group_NN1 (_( n=64_FO ;_; one_PN1 outlier_JJR excluded_JJ )_) was_VBDZ 0.50_MC (_( IQR_NP1 0.140.89_MC )_) ,_, compared_VVN with_IW 1.14_MC (_( 0-27-2-6_MCMC )_) in_II the_AT placebo_NN1 group_NN1 (_( n=65_FO ;_; figure_NN1 2_MC )_) ._. 
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The_AT role_NN1 of_IO elective_JJ nodal_JJ irradiation_NN1 is_VBZ also_RR undefined_JJ in_II SNUC_NP1 ._. 
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<s>
This_DD1 has_VHZ been_VBN recognised_VVN by_II the_AT EWGSOP_NN1 who_PNQS have_VH0 recommended_VVN that_CST more_DAR research_NN1 is_VBZ urgently_RR needed_VVN in_BCL21 order_BCL22 to_TO obtain_VVI good_JJ reference_NN1 values_NN2 for_IF populations_NN2 around_II the_AT world_NN1 ._. 
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All_DB CT_NN1 examinations_NN2 were_VBDR adequate_JJ for_IF BMD_NP1 and_CC trabecular_JJ texture_NN1 analysis_NN1 ._. 
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<s>
Statistical_JJ Analyses_NN2 To_TO determine_VVI the_AT genotypic_JJ effects_NN2 on_II G72_FO expression_NN1 and_CC behavioral_JJ responses_NN2 ,_, a_AT1 two-way_JJ analysis_NN1 of_IO variance_NN1 (_( ANOVA_NP1 )_) was_VBDZ used_VVN ,_, followed_VVN by_II a_AT1 post_JJ21 hoc_JJ22 analysis_NN1 or_CC the_AT Student_NN1 '_NULL s_ZZ1 t-test_JJ where_CS appropriate_JJ ._. 
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<s>
Clearly_RR ,_, there_EX is_VBZ room_NN1 for_IF improvement_NN1 and_CC in_II melanoma_NN1 this_DD1 is_VBZ highlighted_VVN by_II the_AT observed_JJ increase_NN1 in_II progression-free_JJ survival_NN1 in_II BRAF/MEK_NP1 inhibitor_NN1 combination_NN1 therapies_NN2 compared_VVN with_IW BRAF_NP1 inhibitor_NN1 monotherapies_NN2 (_( Larkin_NP1 et_RA21 al._RA22 ,_, 2014_MC ;_; Long_RR et_RA21 al._RA22 ,_, 2015_MC )_) ._. 
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<s>
In_II BRAF_NP1 mutant_NN1 melanoma_NN1 cells_NN2 ,_, BRAF_NP1 is_VBZ the_AT driver_NN1 of_IO cellular_JJ signaling_VVG '_NULL the_AT prerequisite_NN1 to_II BRAF-targeted_JJ therapy_NN1 (_( Salama_NP1 and_CC Flaherty_NP1 ,_, 2013_MC )_) ._. 
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BCRL_NP1 is_VBZ a_AT1 chronic_JJ swelling_JJ of_IO the_AT arm_NN1 ,_, hand_NN1 and_CC associated_JJ trunk_NN1 quadrant_NN1 ._. 
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The_AT authors_NN2 also_RR commented_VVN on_II the_AT need_NN1 for_IF continuous_JJ education_NN1 to_TO ensure_VVI compliance_NN1 ._. 
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<s>
Because_II21 of_II22 progressive_JJ ear_NN1 deformity_NN1 and_CC obstruction_NN1 ,_, at_II age_NN1 7_MC months_NNT2 surgical_JJ excision_NN1 was_VBDZ performed_VVN with_IW the_AT use_NN1 of_IO general_JJ anesthesia_NN1 ._. 
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<s>
Recently_RR there_EX has_VHZ been_VBN increasing_JJ interest_NN1 in_II improving_VVG CRC_NP1 prognostication_NN1 using_VVG clinical_JJ ,_, inflammatory_JJ ,_, and_CC molecular_JJ biomarkers_NN2 ;_; however_RR ,_, there_EX remains_VVZ a_AT1 lack_NN1 of_IO reliable_JJ ,_, reproducible_JJ ,_, and_CC low-cost_JJ biomarkers_NN2 that_CST can_VM be_VBI readily_RR incorporated_VVN into_II routine_NN1 practice_NN1 to_TO optimally_RR predict_VVI prognosis_NN1 and_CC guide_VV0 treatment_NN1 ._. 
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The_AT TORS_NP2 step_VV0 distribution_NN1 between_II C.V_MC ._. 
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and_CC F.M_NP1 ._. 
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as_II the_AT main_JJ surgeons_NN2 was_VBDZ very_RG similar_JJ among_II the_AT 2_MC groups_NN2 ._. 
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<s>
The_AT area_NN1 of_IO vastus_JJ lateralis_NN1 MEP_NP1 was_VBDZ normalized_VVN to_II the_AT Mmax_NN1 measured_VVN during_II the_AT MVC_NP1 to_TO ensure_VVI the_AT magnetic_JJ stimulus_NN1 was_VBDZ activating_VVG a_AT1 high_JJ proportion_NN1 of_IO the_AT knee-extensor_JJ motor_NN1 units_NN2 ,_, and_CC to_TO quantify_VVI corticospinal_JJ excitability_NN1 during_II contraction_NN1 ._. 
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<s>
Women_NN2 in_II this_DD1 study_NN1 indicated_VVD more_RGR accommodating/helping_JJ attitudes_NN2 toward_II PWS_NP2 than_CSN men_NN2 (_( b_ZZ1 =_FO 4.45_MC ,_, t_ZZ1 =_FO 3.24_MC ,_, p_NNU less_DAR than_CSN .01_MC )_) ._. 
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The_AT significance_NN1 level_NN1 was_VBDZ set_VVN at_II 0.05_MC for_IF all_DB analyses_NN2 ._. 
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<s>
However_RR ,_, even_RR a_AT1 negative_JJ mpMRI_NN2 carries_VVZ some_DD risk_NN1 of_IO a_AT1 high-grade_JJ cancer_NN1 ;_; therefore_RR ,_, patients_NN2 need_VV0 to_TO be_VBI followed_VVN carefully_RR with_IW PSA_NP1 and_CC mpMRI_NN2 to_TO avoid_VVI missing_VVG such_DA tumors_NN2 ._. 
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<s>
However_RR ,_, a_AT1 significant_JJ reduction_NN1 in_II tumor_NN1 weight_NN1 was_VBDZ recorded_VVN in_II the_AT group_NN1 co-treated_VVN with_IW R406_FO and_CC paclitaxel_NN1 compared_VVN to_II the_AT control_NN1 group_NN1 (_( p_NNU less_DAR than_CSN 0.0004_MC )_) ._. 
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<s>
Other_JJ chemotherapeutics_NN2 have_VH0 little_DA1 activity_NN1 because_II21 of_II22 inherent_JJ resistance_NN1 of_IO glioblastoma_NN1 cells_NN2 against_II most_DAT cytotoxic_JJ drugs_NN2 ,_, or_CC the_AT inability_NN1 of_IO the_AT drugs_NN2 to_TO cross_VVI an_AT1 intact_JJ blood–brain_NN1 barrier_NN1 and_CC reach_VVI their_APPGE target_NN1 ._. 
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<s>
After_CS some_DD protocol_NN1 adjustment_NN1 halfway_RR through_II the_AT trial_NN1 including_II device_NN1 design_NN1 improvement_NN1 ,_, surgical_JJ modifications_NN2 ,_, and_CC the_AT addition_NN1 of_IO a_AT1 prophylactic_JJ intra-vitreal_JJ antibiotic_NN1 injection_NN1 at_II the_AT end_NN1 of_IO surgical_JJ implantation_NN1 ,_, the_AT rate_NN1 of_IO SAEs_NN2 reduced_VVD significantly_RR ,_, and_CC there_EX were_VBDR no_AT further_JJR cases_NN2 of_IO endophthalmitis_NN1 in_II the_AT second_MD half_NN1 of_IO the_AT study_NN1 (_( i.e._REX the_AT last_MD 15_MC cases_NN2 )_) (_( Humayun_NP1 et_RA21 al_RA22 ._. ?_AT1 2012_MC )_) ._. 
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<s>
More_RGR recently_RR ,_, Rizzo_NP1 et_RA21 al_RA22 ._. 
</s>
<s>
(_( 2014_MC )_) reported_VVD the_AT outcome_NN1 of_IO a_AT1 12-month_JJ follow-up_NN1 of_IO 6_MC patients_NN2 who_PNQS received_VVD the_AT implant_NN1 in_II a_AT1 single_JJ centre_NN1 performed_VVN by_II a_AT1 single_JJ surgeon_NN1 ._. 
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<s>
The_AT ion_NN1 generator_NN1 appeared_VVD to_TO be_VBI a_AT1 credible_JJ sham_NN1 treatment_NN1 in_II that_DD1 expectation_NN1 ratings_NN2 were_VBDR not_XX significantly_RR different_JJ between_II conditions_NN2 ._. 
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<s>
Next_MD ,_, the_AT probe_NN1 was_VBDZ rotated_VVN 90_MC in_II the_AT clockwise_JJ direction_NN1 ,_, and_CC the_AT transverse_JJ diameter_NN1 (_( D1_FO )_) and_CC anteroposterior_JJ diameter_NN1 (_( D2_FO )_) of_IO the_AT largest_JJT axial_JJ plane_NN1 of_IO the_AT cervix_NN1 were_VBDR measured_VVN (_( Fig._NN1 1A_FO )_) ._. 
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<s>
In_II rodent_NN1 models_NN2 of_IO hind_JJ limb_NN1 immobilization_NN1 ,_, for_REX21 example_REX22 ,_, muscle_NN1 loss_NN1 is_VBZ generally_RR greater_JJR in_II the_AT extensor_NN1 muscles_NN2 of_IO the_AT ankle_NN1 (_( soleus_NN and_CC gastrocnemius_NN1 )_) ._. 
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These_DD2 effects_NN2 were_VBDR attenuated_VVN by_II GDNF_NP1 ._. 
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<s>
Because_II21 of_II22 violations_NN2 of_IO multivariate_JJ normality_NN1 ,_, all_DB analyses_NN2 used_VVD the_AT MLR_NP1 estimator_NN1 ,_, which_DDQ computes_VVZ the_AT Yuan_NNU and_CC Bentler_NP1 T*W2_FO test_NN1 statistic_NN1 that_CST assesses_VVZ the_AT statistical_JJ significance_NN1 of_IO deviation_NN1 of_IO the_AT estimated_JJ covariance_NN1 matrix_NN1 from_II the_AT actual_JJ matrix.30_FO The_AT MLR_NP1 estimator_NN1 also_RR gives_VVZ robust_JJ SEs_NP2 that_CST are_VBR used_VVN in_II determination_NN1 of_IO the_AT statistical_JJ significance_NN1 of_IO parameter_NN1 estimates_NN2 ._. 
</s>
<s>
These_DD2 results_NN2 suggest_VV0 that_DD1 speech_NN1 production_NN1 system_NN1 in_II CWS_NP1 might_VM be_VBI affected_VVN by_II less_RGR accurate_JJ representations_NN2 of_IO speech_NN1 sounds_NN2 ._. 
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<s>
The_AT patient_NN1 was_VBDZ referred_VVN for_IF palliative_JJ chemotherapy_NN1 ._. 
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<s>
Open_JJ Access_NN1 article_NN1 distributed_VVN under_II the_AT terms_NN2 of_IO CC_NP1 BY_II ._. 
</s>
<s>
This_DD1 stable_JJ photoproduct_NN1 was_VBDZ suggested_VVN to_TO represent_VVI the_AT metamelanopsin_NN1 ,_, but_CCB it_PPH1 was_VBDZ remarkably_RR insensitive_JJ to_II subsequent_JJ treatment_NN1 with_IW hydroxyl-amine_NN1 ._. 
</s>
<s>
Hypofractionated_JJ radiotherapy_NN1 versus_II conventionally_RR fractionated_JJ radiotherapy_NN1 for_IF patients_NN2 with_IW intermediate-risk_JJ localised_JJ prostate_NN1 cancer_NN1 :_: 2-year_JJ patient-reported_JJ outcomes_NN2 of_IO the_AT randomised_JJ ,_, non-inferiority_NN1 ,_, phase_NN1 3_MC CHHiP_NP1 trial_NN1 Anna_NP1 Wilkins_NP1 ,_, Helen_NP1 Mossop_NP1 ,_, Isabel_NP1 Syndikus_NP1 ,_, Vincent_NP1 Khoo_NP1 ,_, David_NP1 Bloomfield_NP1 ,_, Chris_NP1 Parker/john_FU Logue_NN1 ,_, ChristopherScrase_NP1 ,_, Helen_NP1 Pattersonf_NP1 ,_, Alison_NP1 Birtle_NP1 ,_, john_NN1 Staffurth_NN1 ,_, Zafar_NP1 Malik_NP1 ,_, Miguel_NP1 Panades_NP2 ,_, Chinnamani_NP1 Eswar_NP1 ,_, john_NN1 Graham_NP1 ,_, Martin_NP1 Russell_NP1 ,_, Peter_NP1 Kirkbride_NP1 ,_, joe_VV0 M_ZZ1 O_ZZ1 '_NULL Sullivan_NP1 ,_, Annie_NP1 Gao_NP1 ,_, Clare_NP1 Cruickshank_NP1 ,_, Clare_NP1 Griffin_NP1 ,_, David_NP1 Dearnaley*_FO ,_, Emma_NP1 Hall*_FO Institute_NN1 of_IO Cancer_NN1 Research_NN1 ,_, London_NP1 ,_, UK_NP1 (_( A_ZZ1 Wilkins_NP1 FRCR_NP1 ,_, H_ZZ1 Mossop_NP1 MMathStat_NP1 ,_, V_ZZ1 Khoo_NP1 MD_NNA ,_, A_ZZ1 Gao_NP1 MSc_NNA ,_, C_NP1 Cruickshank_NP1 BSc_NNA (_( Hons_NN2 )_) ,_, C_NP1 Griffin_NP1 MSc_NNA ,_, Prof_NNB D_NP1 Dearnaley_NP1 FRCR_NP1 ,_, E_NP1 Hall_NP1 PhD_NNA )_) ;_; Clatterbridge_NP1 Cancer_NN1 Centre_NN1 ,_, Wirral_NP1 ,_, UK_NP1 (_( I_ZZ1 Syndikus_NP1 FRCR_NP1 )_) ;_; Royal_JJ Marsden_NP1 NHS_NP1 Foundation_NN1 Trust_NN1 ,_, London_NP1 ,_, UK_NP1 (_( V_ZZ1 Khoo_NP1 ,_, C_NP1 Parker_NP1 FRCR_NP1 ,_, Prof_NNB D_NP1 Dearnaley_NP1 )_) ;_; Brighton_NP1 and_CC Sussex_NP1 University_NN1 Hospitals_NN2 ,_, Brighton_NP1 ,_, UK_NP1 (_( D_ZZ1 Bloomfield_NP1 FRCR_NP1 )_) ;_; Christie_NP1 Hospital_NN1 ,_, Manchester_NP1 ,_, UK_NP1 (_( '_NULL Logue_NP1 FRCR_NP1 )_) ;_; Ipswich_NP1 Hospital_NN1 ,_, Ipswich_NP1 ,_, UK_NP1 (_( C_NP1 Scrase_NP1 FRCR_NP1 )_) ;_; Addenbrooke_NP1 '_NULL s_ZZ1 Hospital_NN1 ,_, Cambridge_NP1 ,_, UK_NP1 (_( H_ZZ1 Patterson_NP1 FRCR_NP1 )_) ;_; Rosemere_NP1 Cancer_NN1 Centre_NN1 ,_, Royal_JJ Preston_NP1 Hospital_NN1 ,_, UK_NP1 (_( A_ZZ1 Birtle_NP1 FRCR_NP1 )_) ;_; Cardiff_NP1 University_NN1 ,_, Cardiff_NP1 ,_, UK_NP1 (_( '_NULL Staffurth_NP1 MD_NNA )_) ;_; Velindre_NP1 Cancer_NN1 Centre_NN1 ,_, Cardiff_NP1 ,_, UK_NP1 (_( '_NULL Staffurth_NP1 )_) ;_; Whiston_NP1 Hospital_NN1 ,_, Prescot_NP1 ,_, UK_NP1 (_( Z_ZZ1 Malik_NP1 FRCR_NP1 )_) ;_; Lincoln_NP1 County_NN1 Hospital_NN1 ,_, Lincoln_NP1 ,_, UK_NP1 (_( M_ZZ1 Panades_VVZ MRCR_NP1 )_) ;_; Southport_NP1 General_JJ Infirmary_NN1 ,_, Southport_NP1 ,_, UK_NP1 (_( C_NP1 Eswar_NP1 FRCR_NP1 )_) ;_; Beacon_NP1 Centre_NN1 ,_, Musgrove_NP1 Park_NN1 Hospital_NN1 ,_, Taunton_NP1 ,_, UK_NP1 (_( Graham_NP1 FRCR_NP1 )_) ;_; Beatson_NP1 West_ND1 of_IO Scotland_NP1 Cancer_NN1 Centre_NN1 ,_, Glasgow_NP1 ,_, UK_NP1 (_( M_ZZ1 Russell_NP1 FRCR_NP1 )_) ;_; Sheffield_NP1 Teaching_VVG Hospitals_NN2 Foundation_NN1 Trust_NN1 ,_, Sheffield_NP1 ,_, UK_NP1 (_( P_ZZ1 Kirkbride_NP1 FRCR_NP1 )_) ;_; and_CC Queen_NN1 '_NULL s_ZZ1 University_NN1 Belfast_NP1 ,_, Belfast_NP1 ,_, UK_NP1 (_( Prof_NNB '_NULL M_NP1 O_NP1 '_NULL Sullivan_NP1 FRCR_NP1 )_) Correspondence_NN1 to_II :_: Dr_NNB Emma_NP1 Hall_NP1 ,_, Clinical_JJ Trials_NN2 and_CC Statistics_NN Unit_NN1 ,_, The_AT Institute_NN1 of_IO Cancer_NN1 Research_NN1 ,_, London_NP1 SM2_FO 5NG_FO ,_, UK_NP1 emma_NN1 ._. 
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<s>
Recently_RR there_EX is_VBZ a_AT1 rising_JJ interest_NN1 of_IO SB_NP1 consequences_NN2 and_CC the_AT idea_NN1 of_IO clearly_RR differentiating_VVG between_II the_AT distinct_JJ behaviours_NN2 of_IO SB_NP1 and_CC PA_NN1 ._. 
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<s>
Depending_II21 on_II22 whether_CSW they_PPHS2 favored_VVD the_AT hypothesis_NN1 of_IO recruitment_NN1 of_IO perilesional_JJ regions_NN2 or_CC the_AT effect_NN1 of_IO the_AT nondominant_JJ hemisphere_NN1 ,_, the_AT investigators_NN2 of_IO cortical_JJ stimulation_NN1 chose_VVD to_TO stimulate_VVI the_AT dominant_JJ hemisphere_NN1 or_CC to_TO inhibit_VVI the_AT nondominant_JJ hemisphere_NN1 ,_, respectively_RR ._. 
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<s>
Lower_JJR baseline_NN1 eGFR_NN1 ,_, preoperative_JJ hypertension_NN1 ,_, longer_JJR duration_NN1 of_IO the_AT procedure_NN1 ,_, longer_JJR ischaemia_NN1 time_NNT1 ,_, and_CC warm_JJ ischaemia_NN1 (_( as_CSA compared_VVN with_IW cold_JJ ischaemia_NN1 )_) were_VBDR associated_VVN with_IW worse_JJR postoperative_JJ renal_JJ function_NN1 (_( lower_JJR eGFR_NN1 )_) (_( Table2_FO ;_; P=0.001_FO for_IF hypertension_NN1 andP_VV0 less_DAR than_CSN 0.001_MC for_IF the_AT other_JJ factors_NN2 )_) ._. 
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<s>
The_AT raw_JJ means_NN and_CC SEs_NP2 of_IO postoperative_JJ pain_NN1 scores_NN2 and_CC postoperative_JJ opioid_JJ consumption_NN1 are_VBR illustrated_VVN in_II Figures_NN2 1_MC1 ,_, A_ZZ1 and_CC B_ZZ1 ,_, respectively_RR ._. 
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<s>
The_AT observed_JJ probabilities_NN2 for_IF these_DD2 three_MC pain_NN1 levels_NN2 were_VBDR 34_MC ,_, 49_MC ,_, and_CC 17%_NNU (_( fig._NN1 5A_FO )_) ._. 
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<s>
Risk_NN1 of_IO dementia_NN1 was_VBDZ examined_VVN for_IF haplogroups_NN2 L0_FO ,_, L1_FO ,_, and_CC L2_FO as_CSA compared_VVN to_II the_AT haplogroup_NN1 L3_FO reference_NN1 group_NN1 ._. 
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<s>
In_II this_DD1 study_NN1 ,_, we_PPIS2 tested_VVD the_AT concept_NN1 that_CST besides_II the_AT oncogene_NN1 itself_PPX1 ,_, factors_NN2 that_CST enable_VV0 permissiveness_NN1 of_IO normal_JJ pre-B_JJ cells_NN2 to_II oncogenic_JJ signaling_NN1 represent_VV0 a_AT1 class_NN1 oftherapeutic_JJ targets_NN2 forthe_VV0 treatment_NN1 of_IO acute_JJ lymphoblastic_JJ leukemia_NN1 (_( ALL_RR )_) ._. 
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<s>
For_IF both_RR RNFL_NP1 and_CC RT_NN1 measurements_NN2 ,_, best_JJT AUROC_NN1 values_NN2 were_VBDR found_VVN for_IF inferior_JJ RT_NN1 OCA1_FO and_CC OCA2_FO ,_, followed_VVN by_II inferior_JJ and_CC overall_JJ RNFL_NP1 thickness_NN1 ._. 
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<s>
TCDD_NP1 and_CC certain_JJ coplanar_JJ PCBs_NN2 activate_VV0 the_AT AhR_NN1 ,_, whereas_CS other_JJ non-coplanar_JJ PCBs_NN2 (_( ie_REX Aroclor_NP1 1254_MC ,_, PCB95_FO )_) fail_VV0 to_TO activate_VVI the_AT AhR_NN1 in_II TCDD_NP1 responsive_JJ mouse_NN1 lines_NN2 (_( Bemis_NP1 et_RA21 al_RA22 ._. 
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2005_MC )_) ._. 
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None_PN of_IO the_AT baseline_NN1 maternal_JJ and_CC fetal_JJ risk_NN1 factors_NN2 affected_VVN the_AT choice_NN1 of_IO treatment_NN1 ._. 
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<s>
The_AT first_MD 12_MC trial_NN1 subjects_NN2 ,_, representing_VVG Cohorts_NN2 A_ZZ1 to_II C_NP1 ,_, received_VVD HSSC_NP1 transplants_NN2 into_II the_AT L2-L4_JJ lumbar_NN1 segments_NN2 of_IO the_AT spinal_JJ cord_NN1 ._. 
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<s>
Notably_RR ,_, as_CSA mentioned_VVN above_RL ,_, 1_MC1 patient_NN1 who_PNQS was_VBDZ initially_RR deemed_VVN as_CSA having_VHG a_AT1 benign_JJ cyst_NN1 by_II cytology_NN1 (_( and_CC not_XX HPV_NP1 tested_VVD on_II this_DD1 cytology_NN1 )_) ,_, was_VBDZ later_RRR diagnosed_VVN with_IW an_AT1 BOT_NP1 SCC_NP1 (_( Table_NN1 1_MC1 )_) ._. 
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<s>
The_AT main_JJ effect_NN1 of_IO group_NN1 was_VBDZ again_RT significant_JJ for_IF the_AT maximum_JJ urge_NN1 rating_VVG across_II all_DB phases_NN2 (_( P_ZZ1 =_FO .021_MC ;_; UUI_NP1 participants_NN2 &lsqb;_( 6.4_MC plus_II and_CC minus_II 2.2_MC &rsqb;_) >_FO controls_NN2 &lsqb;_( 4.8_MC plus_II and_CC minus_II 3.0_MC &rsqb;_) )_) ,_, while_CS the_AT main_JJ effect_NN1 of_IO phase_NN1 remained_VVD significant_JJ for_IF all_DB measures_NN2 (_( all_RR P_NNU less_DAR than_CSN .001_MC )_) ._. 
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The_AT chest_NN1 X-ray_NN1 and_CC echocardiogram_NN1 were_VBDR normal_JJ ._. 
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Almost_RR half_DB of_IO the_AT patients_NN2 with_IW SWEDD_NP1 (_( 40/90_MF )_) in_II the_AT PRECEPT_NP1 Parkinson_NP1 '_NULL s_ZZ1 disease_NN1 clinical_JJ trial_NN1 (_( N_ZZ1 =_FO 799_MC )_) had_VHD their_APPGE diagnosis_NN1 changed_VVN to_II a_AT1 condition_NN1 not_XX associated_VVN with_IW dopamine_NN1 denervation_NN1 at_II 22-month_JJ follow-up_NN1 by_II study_NN1 investigators_NN2 blinded_VVN to_II the_AT dopaminergic_JJ scan_NN1 status_NN1 with_IW the_AT most_RGT common_JJ revised_JJ diagnosis_NN1 being_VBG tremor_NN1 ,_, followed_VVN by_II '_NULL no_AT neurological_JJ diagnosis_NN1 '_NULL and_CC vascular_JJ parkinsonism_NN1 ,_, highlighting_VVG the_AT diagnostic_JJ difficulties_NN2 in_II the_AT early_JJ disease_NN1 stage_NN1 ,_, and_CC even_RR in_II Parkinson_NP1 '_NULL s_ZZ1 disease_NN1 patients_NN2 with_IW SPECT-confirmed_JJ dopaminergic_JJ deficits_NN2 (_( N=707_FO )_) ,_, 5_MC cases_NN2 had_VHD been_VBN re-evaluated_VVN as_CSA having_VHG a_AT1 tremor_NN1 syndrome_NN1 not_XX associated_VVN with_IW dopamine_NN1 denervation_NN1 and_CC 13_MC had_VHD their_APPGE diagnosis_NN1 revised_VVN to_II vascular_JJ parkinsonism_NN1 ._. 
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<s>
Although_CS the_AT telemetric_JJ programmer_NN1 had_VHD indicated_VVN that_CST the_AT pump_NN1 was_VBDZ expected_VVN to_TO have_VHI 21.8_MC mL_NNU of_IO fentanyl_NN1 left_VVN in_II the_AT reservoir_NN1 ,_, only_RR 12.5_MC mL_NNU of_IO fentanyl_NN1 was_VBDZ aspirated_VVN ._. 
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<s>
A_AT1 brain_NN1 and_CC abdominal_JJ examination_NN1 was_VBDZ carried_VVN out_RP for_IF the_AT 12_MC volunteers_NN2 (_( 8_MC males_NN2 ;_; age_NN1 ,_, 31_MC plus_II and_CC minus_II 8_MC years_NNT2 )_) ._. 
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They_PPHS2 were_VBDR tested_VVN twice_RR with_IW 1_MC1 h_ZZ1 gap_NN1 between_II sessions_NNT2 ._. 
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<s>
The_AT hypothesis_NN1 that_CST cognition_NN1 is_VBZ an_AT1 intermediate_JJ phenotype_NN1 for_IF schizophrenia_NN1 implies_VVZ that_CST rs10174400_FO should_VM discriminate_VVI cases_NN2 from_II controls_NN2 ,_, at_RR21 least_RR22 to_II some_DD degree.17_FO No_AT case/_NN1 control_NN1 signal_NN1 was_VBDZ observed_VVN in_II the_AT discovery_NN1 sample_NN1 ._. 
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These_DD2 differences_NN2 disappeared_VVD when_RRQ Pemt_NP1 mice_NN2 were_VBDR supplemented_VVN with_IW choline_NN1 ._. 
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Further_JJR details_NN2 about_II IY_NP1 groups_NN2 are_VBR available_JJ (_( http_NNU :_: )_) ._. 
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<s>
Acknowledgements_NN2 We_PPIS2 would_VM like_VVI to_TO thank_VVI Mr_NNB Michail_NP1 Tsakalidis_NP1 who_PNQS participated_VVD in_II writing_NN1 and_CC technical_JJ editing_NN1 of_IO the_AT manuscript_NN1 ._. 
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<s>
Trauma_NN1 centers_NN2 treated_VVN higher_JJR proportions_NN2 of_IO moderate_JJ injuries_NN2 (_( New_JJ Injury_NN1 Severity_NN1 Score_NN1 5_MC to_II 15_MC )_) compared_VVN with_IW nontrauma_NN1 centers_NN2 and_CC treated_VVN different_JJ types_NN2 of_IO injuries_NN2 ._. 
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OCA1_FO had_VHD higher_JJR AUROC_NN1 curve_NN1 values_NN2 than_CSN OCA3_FO in_II all_DB quadrants_NN2 ._. 
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<s>
This_DD1 article_NN1 is_VBZ published_VVN with_IW open_JJ access_NN1 at_II Springerlink.com_NP1 Abstract_VV0 We_PPIS2 present_VV0 prospective_JJ blood_NN1 pressure_NN1 (_( BP_NP1 )_) and_CC hear_VV0 rate_NN1 (_( HR_NNU )_) changes_NN2 in_II smokers_NN2 invited_VVN to_TO switch_VVI to_II e-cigarettes_NN2 in_II the_AT ECLAT_NN1 study_NN1 ._. 
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<s>
In_II 2006_MC ,_, patients_NN2 with_IW one_MC1 or_CC more_DAR complex_JJ chronic_JJ conditions_NN2 accounted_VVN for_IF 10.1%_FO of_IO pediatric_JJ hospital_NN1 admissions_NN2 ,_, 40.6%_FO of_IO pediatric_JJ hospital_NN1 charges_NN2 ,_, and_CC 43.2%_FO of_IO pediatric_JJ deaths_NN2 ._. 
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<s>
In_II the_AT cochleae_NN2 of_IO wild_JJ type_NN1 mice_NN2 ,_, Cx30_FO puncta_NN1 were_VBDR localized_VVN in_II the_AT spiral_JJ limbus_NN1 area_NN1 and_CC medial_JJ to_II the_AT inner_JJ hair_NN1 cell_NN1 area_NN1 (_( Fig._NN1 3A_FO )_) and_CC in_II pillar_NN1 and_CC Deiters_NP1 cells_NN2 (_( not_XX shown_VVN )_) ._. 
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Survival_NN1 was_VBDZ the_AT only_JJ identifiable_JJ risk_NN1 factor_NN1 for_IF seizure_NN1 recurrence_NN1 ._. 
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<s>
Despite_II this_DD1 ,_, a_AT1 gold_NN1 standard_NN1 or_CC universally_RR preferred_JJ scale_NN1 that_CST differentiates_VVZ between_II distress_NN1 and_CC pain_NN1 is_VBZ yet_RR to_TO emerge_VVI from_II published_JJ research_NN1 ._. 
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<s>
Conversely_RR ,_, laparoscopic_JJ surgeries_NN2 are_VBR associated_VVN with_IW a_AT1 faster_JJR recovery_NN1 of_IO grip_NN1 strength_NN1 and_CC inspiratory_JJ force_NN1 as_RG early_RR as_CSA 2_MC to_II 3_MC h_ZZ1 after_II emergence_NN1 from_II anesthesia_NN1 ._. 
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<s>
RR_NP1 has_VHZ received_VVN a_AT1 grant_NN1 from_II the_AT Health_NN1 Foundation_NN1 and_CC Legal_JJ and_CC General_JJ and_CC the_AT Dunhill_NP1 Medical_JJ ._. 
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<s>
U._NP1 Meier-Kriesche_NP1 is_VBZ a_AT1 salaried_JJ employee_NN1 of_IO Bristol-Myers_NP1 Squibb_NP1 ._. 
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<s>
The_AT epochs_NN2 contaminated_VVN by_II artifacts_NN2 exceeding_VVG ±125V_FO at_II any_DD electrode_NN1 were_VBDR omitted_VVN from_II the_AT averaging_NN1 procedure_NN1 ._. 
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<s>
Guinea_NP1 pigs_NN2 were_VBDR exposed_VVN to_II 24_MC hours_NNT2 of_IO noise_NN1 (_( 12-24_MCMC kHz_NNU at_II 116_MC dB_NNU )_) to_TO induce_VVI a_AT1 high-frequency_JJ hearing_NN1 loss_NN1 ._. 
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<s>
A_AT1 recent_JJ report_NN1 13_MC showed_VVD high-resolution_JJ OCT_NPM1 traces_NN2 suggesting_VVG EZ_NN1 improvement_NN1 as_RG early_RR as_CSA 2_MC months_NNT2 after_II cessation_NN1 of_IO the_AT drug_NN1 ._. 
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<s>
The_AT Association_NN1 of_IO American_JJ Medical_JJ Colleges_NN2 definition_NN1 of_IO those_DD2 underrepresented_JJ in_II medicine_NN1 (_( URM_NP1 )_) is_VBZ evolving_VVG depending_II21 on_II22 changing_JJ demographics_NN2 in_II the_AT general_JJ population_NN1 ._. 
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<s>
Children_NN2 with_IW ADHD_NP1 and/or_CC CD_NN1 behaviors_NN2 can_VM be_VBI monitored_VVN for_CS overweight/obesity_FU at_II an_AT1 early_JJ stage_NN1 ,_, thus_RR potentially_RR averting_VVG a_AT1 developmental_JJ trajectory_NN1 of_IO obesity_NN1 ._. 
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<s>
Peak_NN1 tumor_NN1 uptake_NN1 for_IF I-SGMIB-Nanobody_NP1 was_VBDZ 24.50%_FO ±_FO 9.89%_FO injected_VVD dose/g_FU at_II 2_MC h_ZZ1 ,_, 2-_NN1 to_II 4-fold_JJ higher_JJR than_CSN observed_VVN with_IW other_JJ labeling_JJ methods_NN2 ,_, and_CC was_VBDZ reduced_VVN by_II 90%_NNU with_IW trastuzumab_NN1 blocking_NN1 ,_, confirming_VVG the_AT HER2_FO specificity_NN1 of_IO localization_NN1 ._. 
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<s>
The_AT difference_NN1 between_II groups_NN2 in_II time_NNT1 to_II treatment_NN1 failure_NN1 (_( days_NNT2 )_) was_VBDZ assessed_VVN using_VVG the_AT Wilcoxon_NP1 test_NN1 ,_, stratified_VVN by_II country_NN1 ._. 
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<s>
We_PPIS2 can_VM speculate_VVI that_CST biomarkers_NN2 used_VVD singularly_RR could_VM be_VBI more_RGR useful_JJ in_II predicting_VVG outcomes_NN2 ._. 
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<s>
Of_IO note_NN1 ,_, PF-06463922_MC significantly_RR inhibited_JJ tumor_NN1 growth_NN1 in_II crizotinib-resistant_JJ models_NN2 harboring_VVG mutant_NN1 ALK_NN1 ,_, including_II the_AT most_RGT resistant_JJ G1202R_FO mutant_NN1 ._. 
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<s>
At_II the_AT end_NN1 of_IO the_AT experiment_NN1 (_( 14_MC months_NNT2 postinjection_NN1 )_) ,_, all_DB monkeys_NN2 were_VBDR euthanized_VVN by_II sodium_NN1 pentobarbital_JJ overdose_NN1 (_( 150mg/kg_NNU iv_MC )_) ,_, followed_VVN by_II perfusion_NN1 with_IW saline_JJ solution_NN1 (_( containing_VVG 1%_NNU heparin_NN1 )_) and_CC 4%_NNU paraformaldehyde_NN1 ,_, and_CC brains_NN2 were_VBDR quickly_RR removed_VVN and_CC processed_VVN for_IF histological_JJ studies_NN2 ._. 
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<s>
Psychometric_JJ analyses_NN2 of_IO concurrent_JJ validity_NN1 ,_, specificity_NN1 ,_, sensitivity_NN1 ,_, positive/_JJ negative_JJ predictive_JJ value_NN1 ,_, and_CC interrater_JJR reliability_NN1 were_VBDR also_RR done_VDN ._. 
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However_RR ,_, unpublished_JJ Natsal_NN1 data_NN show_VV0 a_AT1 two-fold_JJ increase_NN1 in_II use_NN1 of_IO long-acting_JJ reversible_JJ contraception_NN1 methods_NN2 by_II sexually_RR active_JJ 16-17_MCMC year_NNT1 olds_NN2 between_II Natsal-2_MC and_CC Natsal-3_MC ._. 
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After_II screening_VVG by_II title_NN1 and_CC abstract_JJ ,_, full_JJ articles_NN2 were_VBDR then_RT obtained_VVN for_IF 10_MC trials_NN2 and_CC their_APPGE eligibility_NN1 assessed_VVN against_II the_AT inclusion_NN1 criteria_NN2 ._. 
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<s>
The_AT HR_NNU for_IF cediranib_NN1 versus_II placebo_NN1 ,_, adjusted_VVN for_IF stratification_NN1 factors_NN2 ,_, was_VBDZ 0_MC ._. 
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I_PPIS1 score_VV0 ,_, analysed_VVN in_II all_DB participants_NN2 with_IW at_RR21 least_RR22 one_MC1 postbaseline_NN1 measurement_NN1 ._. 
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<s>
We_PPIS2 observed_VVD a_AT1 favorable_JJ short-term_JJ complication_NN1 profile_NN1 ,_, supporting_VVG the_AT early_JJ postoperative_JJ safety_NN1 of_IO WLS_NP1 in_II select_JJ adolescents_NN2 ._. 
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<s>
This_DD1 single-blind_NN1 randomized_VVD controlled_JJ trial_NN1 compared_VVD language_NN1 outcomes_NN2 from_II 4_MC investigational_JJ participants_NN2 who_PNQS received_VVD CS_NP2 plus_II language_NN1 therapy_NN1 (_( CS/LT_FU )_) and_CC 4_MC controls_NN2 who_PNQS received_VVD the_AT identical_JJ LT_NNB but_CCB no_AT CS_NP2 ._. 
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<s>
Both_DB2 cultures_NN2 still_RR responded_VVN to_TO MEK_VVI inhibitor_NN1 with_IW reduced_JJ ERK_NN1 phosphorylation_NN1 (_( Figure_NN1 7C_FO )_) ,_, suggesting_VVG that_CST the_AT resistance_NN1 had_VHD developed_VVN by_II acquiring_VVG additional_JJ survival_NN1 advantages_NN2 ._. 
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Second_MD ,_, intra-and_CC inter-assay_JJ variations_NN2 of_IO our_APPGE method_NN1 were_VBDR confirmed_VVN to_TO be_VBI low_JJ ._. 
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<s>
An_AT1 example_NN1 of_IO the_AT magnitude_NN1 of_IO heterogeneity_NN1 between_II our_APPGE metabolomics_NN1 data_NN and_CC existing_JJ expression_NN1 data_NN was_VBDZ in_II the_AT genes_NN2 and_CC metabolites_NN2 constituting_VVG the_AT KEGG_NP1 TCA_NP1 cycle_NN1 pathway_NN1 ._. 
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<s>
Intervention_NN1 studies_NN2 to_TO clarify_VVI an_AT1 optimal_JJ loading_NN1 program_NN1 ,_, as_II31 well_II32 as_II33 the_AT eventual_JJ development_NN1 of_IO a_AT1 prevention_NN1 program_NN1 would_VM also_RR be_VBI beneficial_JJ ._. 
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<s>
Women_NN2 undergoing_VVG LEEP_NN1 for_IF CIN_NP1 or_CC microinvasive_JJ cancer_NN1 on_II the_AT basis_NN1 of_IO abnormal_JJ Pap_NN1 test_NN1 or_CC colposcopic_JJ findings_NN2 and_CC willingness_NN1 to_TO complete_VVI a_AT1 1-year_JJ follow-up_JJ protocol_NN1 were_VBDR invited_VVN for_IF this_DD1 study_NN1 ._. 
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<s>
Surgery_NN1 is_VBZ common_JJ worldwide_RL ,_, with_IW greater_JJR than_CSN 200_MC million_NNO surgical_JJ procedures_NN2 occurring_VVG annually_RR ._. 
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<s>
The_AT experiment_NN1 was_VBDZ run_VVN in_II an_AT1 AVTEC_NP1 Amplisilence_NP1 double-walled_JJ acoustic_JJ chamber_NN1 ._. 
</s>
<s>
For_IF this_DD1 study_NN1 we_PPIS2 selected_VVD patients_NN2 with_IW mild_JJ dementia_NN1 at_II baseline_NN1 (_( Functional_JJ Assessment_NN1 Staging_NN1 score_NN1 ,_, 3-4_MCMC ;_; and_CC Clinical_JJ Dementia_NN1 Rating_NN1 score_NN1 ,_, 0.5-1_MCMC )_) ._. 
</s>
<s>
An_AT1 interesting_JJ finding_NN1 was_VBDZ that_DD1 pain_NN1 areas_NN2 were_VBDR drawn_VVN slightly_RR larger_JJR on_II the_AT 2D_NNU line_NN1 drawings_NN2 in_II31 comparison_II32 with_II33 the_AT 3D_NNU body_NN1 schema_NN1 ,_, in_II a_AT1 fixed_JJ and_CC systematic_JJ fashion_NN1 ._. 
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<s>
How_RRQ to_TO irradiate_VVI Experiences_NN2 with_IW re-treatment_NN1 of_IO patients_NN2 with_IW head_NN1 and_CC neck_NN1 cancer_NN1 gained_VVN during_II the_AT last_MD decades_NNT2 provide_VV0 a_AT1 solid_JJ ground_NN1 for_IF refinement_NN1 of_IO the_AT existing_JJ reirradiation_NN1 strategies_NN2 ._. 
</s>
<s>
However_RR ,_, it_PPH1 is_VBZ not_XX known_VVN whether_CSW the_AT direct_JJ protective_JJ effects_NN2 of_IO amantadine_NN1 on_II neurons_NN2 play_VV0 a_AT1 role_NN1 in_II its_APPGE improvement_NN1 of_IO cognitive_JJ impairment_NN1 after_II surgery_NN1 ._. 
</s>
<s>
Like_II PRPH2/RDS_FU ,_, ROM-1_MC1 is_VBZ localized_VVN to_II the_AT rim_NN1 region_NN1 of_IO both_RR rod_NN1 and_CC cone_NN1 OSs_NN1 (_( despite_II the_AT name_NN1 )_) (_( Bascom_NP1 et_RA21 al._RA22 ,_, 1992_MC ;_; Moritz_NP1 and_CC Molday_NP1 ,_, 1996_MC )_) ._. 
</s>
<s>
Adequate_JJ levels_NN2 of_IO basal_JJ cortisol_NN1 are_VBR necessary_JJ for_IF normal_JJ brain_NN1 function_NN1 as_CSA they_PPHS2 play_VV0 a_AT1 role_NN1 in_II plasticity_NN1 and_CC survival_NN1 of_IO neurons_NN2 ._. 
</s>
<s>
Patient_JJ participants_NN2 were_VBDR asked_VVN to_TO provide_VVI reactions_NN2 individually_RR to_II descriptions_NN2 of_IO the_AT emerging_JJ themes_NN2 of_IO the_AT study_NN1 ,_, and_CC then_RT engage_VV0 in_II dialogue_NN1 with_IW the_AT other_JJ participants_NN2 ._. 
</s>
<s>
Data_NN were_VBDR analyzed_VVN using_VVG the_AT 1-way_JJ analysis_NN1 of_IO variance_NN1 (_( ANOVA_NP1 )_) ,_, post_RR21 hoc_RR22 least_RGT significant_JJ difference_NN1 ,_, repeated-measure_JJ ANOVA_NN1 ,_, and_CC &lsqb;_( chi_NN1 &rsqb;_) 2_MC test_NN1 ._. 
</s>
<s>
A_AT1 major_JJ obstacle_NN1 limiting_JJ gene_NN1 therapy_NN1 for_IF muscle_NN1 diseases_NN2 comes_VVZ from_II the_AT fact_NN1 that_CST systemic_JJ gene_NN1 transfer_NN1 to_II striated_JJ muscles_NN2 is_VBZ hampered_VVN by_II the_AT vascular_JJ endothelium_NN1 ,_, which_DDQ represents_VVZ a_AT1 barrier_NN1 to_II distribution_NN1 of_IO vectors_NN2 through_II the_AT bloodstream_NN1 ._. 
</s>
<s>
Several_DA2 laboratories_NN2 have_VH0 shown_VVN that_DD1 exercise_NN1 enhances_VVZ insulin_NN1 sensitivity_NN1 in_II individuals_NN2 across_II the_AT glucose_NN1 tolerance_NN1 continuum_NN1 ,_, and_CC the_AT increase_NN1 in_II skeletal_JJ muscle_NN1 glucose_NN1 disposal_NN1 often_RR is_VBZ used_VVN as_II a_AT1 primary_JJ mechanism_NN1 to_TO explain_VVI reductions_NN2 in_II postprandial_JJ blood_NN1 glucose_NN1 after_II exercise_NN1 training_NN1 (_( 14_MC )_) ._. 
</s>
<s>
Rates_NN2 of_IO patient_JJ participation_NN1 in_II A-CHESS_NN1 were_VBDR high_RR compared_VVN to_II usual_JJ rates_NN2 of_IO participation_NN1 in_II aftercare_NN1 for_IF AUDs_NN2 ._. 
</s>
<s>
Fourth_MD ,_, we_PPIS2 can_VM not_XX observe_VVI any_DD services_NN2 used_VVN by_II health_NN1 care_NN1 professionals_NN2 who_PNQS were_VBDR not_XX paid_VVN by_II Medicaid_NP1 ,_, for_REX21 example_REX22 ,_, psychosocial_JJ services_NN2 in_II school_NN1 ,_, and_CC we_PPIS2 do_VD0 not_XX have_VHI information_NN1 on_II the_AT quality_NN1 or_CC type_NN1 of_IO psychosocial_JJ services_NN2 delivered_VVD ._. 
</s>
<s>
Intrathecal_JJ but_CCB not_XX s.c_NNU ._. 
</s>
<s>
morphine_NN1 induces_VVZ scratching_VVG behavior_NN1 in_II mice_NN2 ._. 
</s>
<s>
For_REX21 example_REX22 ,_, improvements_NN2 in_II visual_JJ memory_NN1 after_II 6_MC min_NNU of_IO moderate-intensity_JJ cycling_NN1 have_VH0 been_VBN associated_VVN with_IW increases_NN2 in_II norepinephrine_NN1 assessed_VVN from_II saliva_NN1 immediately_RR after_II exercise_NN1 both_RR in_II healthy_JJ elderly_JJ subjects_NN2 and_CC subjects_NN2 with_IW mild_JJ cognitive_JJ impairment_NN1 (_( 24_MC )_) ._. 
</s>
<s>
Baseline_NN1 characteristics_NN2 (_( age_NN1 ,_, sex_NN1 ,_, ethnicity_NN1 ,_, diagnosis_NN1 method_NN1 ,_, tumor_NN1 cell_NN1 type_NN1 and_CC grade_NN1 ,_, performance_NN1 status_NN1 ,_, extrahepatic_JJ disease_NN1 ,_, portal_NN1 vein_NN1 thrombosis_NN1 ,_, hypovascular_JJ lesions_NN2 ,_, previous_JJ nonliver-directed_JJ treatment_NN1 ,_, concurrent_JJ somatostatin_NN1 therapy_NN1 ,_, type_NN1 and_CC number_NN1 of_IO TACE_NP1 procedures_NN2 ,_, duration_NN1 between_II imaging_NN1 and_CC TACE_NP1 ,_, and_CC number_NN1 of_IO deaths_NN2 )_) were_VBDR recorded_VVN ._. 
</s>
<s>
However_RR ,_, it_PPH1 was_VBDZ later_RRR realized_VVN that_CST some_DD pathological_JJ definitions_NN2 were_VBDR necessary_JJ to_TO obtain_VVI a_AT1 reproducible_JJ patient_JJ stratification_NN1 ,_, and_CC a_AT1 second_MD consensus_NN1 for_IF obtaining_VVG uniform_JJ processing_NN1 of_IO enucleated_JJ eyes_NN2 and_CC for_IF using_VVG similar_JJ definitions_NN2 for_IF pathological_JJ examination_NN1 was_VBDZ obtained_VVN ._. 
</s>
<s>
Exposure_NN1 of_IO retinal_JJ microglia_NN1 to_II other_JJ retinoids_NN2 (_( 13-cis_JJ retinal_JJ and_CC all-trans_NN2 retinal_JJ )_) did_VDD not_XX alter_VVI the_AT mRNA_NN1 expression_NN1 of_IO CFB_NP1 and_CC CFH_NP1 significantly_RR (_( Supplementary_JJ Fig._NN1 2C_FO )_) ._. 
</s>
<s>
Huijnen_NP1 et_RA21 al_RA22 and_CC McCracken_NP1 and_CC Samuel_NP1 18found_FO that_DD1 subgroups_VVZ of_IO individuals_NN2 who_PNQS reported_VVD high_JJ levels_NN2 of_IO both_RR avoidance_NN1 and_CC overactivity_NN1 ,_, or_CC high_JJ levels_NN2 of_IO avoidance_NN1 but_CCB low_JJ levels_NN2 of_IO overactivity_NN1 ,_, had_VHD higher_JJR levels_NN2 of_IO self-reported_JJ disability_NN1 compared_VVN with_IW a_AT1 '_NULL low_JJ avoidance_NN1 ,_, high_JJ overactivity_NN1 '_NULL subgroup_NN1 ._. 
</s>
<s>
Only_RR 1_MC1 study_NN1 in_II our_APPGE meta-analysis_NN1 investigated_VVD the_AT neuropsychological_JJ correlates_NN2 of_IO psychotic_JJ experiences_NN2 across_II adulthood5_FO and_CC reported_VVN on_II a_AT1 single_JJ cognitive_JJ domain_NN1 ._. 
</s>
<s>
The_AT exposure_NN1 duration_NN1 at_II a_AT1 single_JJ focal_JJ spot_NN1 was_VBDZ chosen_VVN to_TO be_VBI 30_MC seconds_NNT2 ,_, which_DDQ corresponded_VVD to_II the_AT delivery_NN1 of_IO 30_MC pulses_NN2 ,_, after_II which_DDQ the_AT size_NN1 of_IO the_AT lysed_JJ lesion_NN1 reaches_VVZ saturation_NN1 ._. 
</s>
<s>
For_IF network_NN1 inference_NN1 ,_, a_AT1 trade-off_NN1 exists_VVZ between_II the_AT sparsity_NN1 and_CC the_AT quality_NN1 of_IO the_AT employed_JJ gene-gene_JJ interactions_NN2 ._. 
</s>
<s>
Therefore_RR ,_, identifying_VVG compounds_NN2 that_CST induce_VV0 and_CC increase_VV0 PGC-1&lsqb;alpha&rsqb;_JJ expression_NN1 may_VM be_VBI a_AT1 novel_NN1 and_CC useful_JJ therapeutic_JJ strategy_NN1 in_II the_AT prevention_NN1 of_IO ICUAW_NN1 in_II critically_RR ill_JJ immobile_JJ patients_NN2 ._. 
</s>
<s>
The_AT proportion_NN1 of_IO patients_NN2 in_II the_AT HBOC-201_MC group_NN1 that_CST avoided_VVD RBC_NP1 transfusion_NN1 was_VBDZ 0.427_MC (_( 95%_NNU confidence_NN1 interval_NN1 ,_, 0.321_MC -_- 0.533_MC )_) ._. 
</s>
<s>
In_II humans_NN2 ,_, endothelial_JJ enriched_JJ miR-126_MC levels_NN2 in_II plasma_NN1 negatively_RR correlated_VVN with_IW age_NN1 in_II asymptomatic_JJ control_NN1 patients_NN2 ,_, stating_VVG a_AT1 reflection_NN1 of_IO age_NN1 associated_VVN intrinsic_JJ decline_NN1 in_II endothelial_JJ function_NN1 ._. 
</s>
<s>
Wilcoxon_NP1 Signed_VVD Rank_NP1 test_NN1 )_) ,_, indicating_VVG that_CST the_AT patients_NN2 were_VBDR able_JK to_TO use_VVI retinotopically_RR represented_VVN visual_JJ form_NN1 as_II31 well_II32 as_II33 other_JJ non-geometric_JJ cues_NN2 to_TO identify_VVI the_AT objects_NN2 (_( see_VV0 Fig._NN1 17_MC )_) ._. 
</s>
<s>
Unsurprisingly_RR ,_, the_AT same_DA two_MC patients_NN2 who_PNQS performed_VVD well_RR in_II shape_NN1 recognition_NN1 and_CC letter_NN1 reading_NN1 tasks_NN2 ,_, also_RR performed_VVN substantially_RR better_RRR than_CSN the_AT rest_NN1 of_IO the_AT group_NN1 in_II this_DD1 object_NN1 recognition_NN1 task_NN1 ,_, achieving_VVG 68.8%_FO and_CC 37.5%_FO correct_JJ identification_NN1 of_IO the_AT solid_JJ objects_NN2 ,_, and_CC 75%_NNU and_CC 50%_NNU correct_JJ identification_NN1 of_IO the_AT outlined_JJ objects_NN2 respectively_RR ._. 
</s>
<s>
In_II regions_NN2 where_RRQ filtration_NN1 demand_NN1 and_CC the_AT transendothelial_JJ pressure_NN1 drop_NN1 is_VBZ larger_JJR '_NULL SC_FO cells_NN2 experience_VV0 larger_JJR deformations_NN2 on_II31 account_II32 of_II33 giant_JJ vacuole_NN1 formation_NN1 or_CC '_NULL ballooning_NN1 '_NULL of_IO the_AT inner_JJ wall_NN1 ._. 
</s>
<s>
Women_NN2 discontinued_VVD the_AT intervention_NN1 if_CS an_AT1 ongoing_JJ pregnancy_NN1 was_VBDZ achieved_VVN ,_, and_CC if_CS a_AT1 pregnancy_NN1 ended_VVN in_II a_AT1 miscarriage_NN1 ,_, they_PPHS2 were_VBDR allowed_VVN to_TO resume_VVI the_AT intervention_NN1 ._. 
</s>
<s>
A_ZZ1 2011_MC study_NN1 comparing_VVG the_AT rate_NN1 of_IO burnout_NN1 in_II U.S._NP1 physicians_NN2 to_II that_DD1 of_IO the_AT general_JJ population_NN1 found_VVD that_CST almost_RR half_DB of_IO physicians_NN2 experienced_VVD at_RR21 least_RR22 one_MC1 symptom_NN1 ,_, which_DDQ was_VBDZ significantly_RR higher_JJR than_CSN population_NN1 controls_NN2 (_( 27.8%_FO )_) .22_MC It_PPH1 also_RR compared_VVN rates_NN2 of_IO burnout_NN1 among_II physician_NN1 specialties_NN2 and_CC found_VVD that_DD1 pediatrics_NN1 subspecialties_NN2 had_VHD one_MC1 of_IO the_AT lowest_JJT rates_NN2 (_( 42%_NNU )_) ,_, but_CCB EM_FU had_VHN the_AT highest_JJT (_( 67%_NNU )_) ._. 
</s>
<s>
Discussion_NN1 This_DD1 study_NN1 investigated_VVD 4_MC commonly_RR used_VVD 3D_NNU sequences_NN2 including_VVG pre_II contrast_NN1 3D_NNU FLAIR_NN1 ,_, 3D_NNU FIESTA-C_NP1 ,_, post_NN1 contrast_NN1 3D_NNU FLAIR_NN1 and_CC 3D_NNU FSPGR_NP1 to_II image_NN1 patients_NN2 with_IW unilateral_JJ ISSNHL_NP1 and_CC tested_VVD whether_CSW FLAIR_NN1 high_JJ signal_NN1 is_VBZ a_AT1 relevant_JJ clinical_JJ prognostic_JJ predictor_NN1 of_IO hearing_VVG outcomes_NN2 ._. 
</s>
<s>
Among_II adult_JJ chronic_JJ pain_NN1 patients_NN2 ,_, there_EX is_VBZ an_AT1 association_NN1 between_II psychiatric_JJ comorbidities_NN2 and_CC likelihood_NN1 of_IO progressing_VVG to_TO abuse_VVI of_IO opioids.28-31_MC Future_JJ studies_NN2 to_TO better_RRR characterize_VVI risk_NN1 factors_NN2 and_CC reasons_NN2 for_IF analgesic_NN1 nonadherence_NN1 in_II the_AT pediatric_JJ pain_NN1 population_NN1 may_VM be_VBI helpful_JJ in_II identifying_VVG those_DD2 for_IF whom_PNQO increased_JJ monitoring_NN1 may_VM be_VBI useful_JJ ._. 
</s>
<s>
Patients_NN2 with_IW periductal_JJ infiltrating_JJ pattern_NN1 may_VM benefit_VVI more_RRR from_II HAI_JJ than_CSN those_DD2 with_IW mass-forming_JJ pattern_NN1 ._. 
</s>
<s>
This_DD1 contribution_NN1 appears_VVZ to_TO be_VBI generally_RR consistent_JJ across_II different_JJ domains_NN2 of_IO function_NN1 ._. 
</s>
<s>
Other_JJ relationships_NN2 :_: author_NN1 has_VHZ a_AT1 patent_JJ pending_JJ for_IF high-intensity_JJ focused_JJ ultrasound_NN1 ._. 
</s>
<s>
Target_NN1 lymphoblasts_NN2 were_VBDR phytohemagglutinin_NN1 stimulated_VVN and_CC labeled_VVN with_IW 51Cr_FO ._. 
</s>
<s>
Widespread_JJ PPT_NP1 was_VBDZ chosen_VVN to_TO prevent_VVI a_AT1 very_RG low_JJ PPT_NP1 in_II 1_MC1 painful_JJ region_NN1 from_II largely_RR affecting_VVG whether_CSW a_AT1 patient_NN1 was_VBDZ classified_VVN as_CSA having_VHG low_JJ or_CC high_JJ pain_NN1 sensitivity_NN1 (_( see_VV0 the_AT Subgrouping_NN1 of_IO patients_NN2 section_NN1 )_) ._. 
</s>
<s>
There_EX was_VBDZ a_AT1 broad_JJ range_NN1 of_IO 12-month_JJ prevalence_NN1 among_II the_AT disorders_NN2 examined_VVD ._. 
</s>
<s>
Mild_JJ and_CC strong_JJ stimuli_NN2 were_VBDR delivered_VVN in_II an_AT1 alternating_JJ pattern_NN1 ,_, with_IW a_AT1 2-h_ZZ1 interval_NN1 between_II successive_JJ strong_JJ stimuli_NN2 ._. 
</s>
<s>
Repeating_VVG the_AT analysis_NN1 calculating_VVG relative_JJ risks_NN2 rather_II21 than_II22 ORs_NN2 did_VDD not_XX alter_VVI the_AT conclusions_NN2 ._. 
</s>
<s>
Two_MC further_RRR randomised_JJ trials_NN2 in_II recurrent_JJ ovarian_JJ cancer_NN1 have_VH0 shown_VVN significant_JJ improvement_NN1 in_II progression-free_JJ survival_NN1 through_II the_AT addition_NN1 of_IO bevacizumab_NN1 to_II conventionally_RR administered_VVN carboplatin_NN1 and_CC gemcitabine_VV0 chemotherapy_NN1 both_RR in_II the_AT platinum-sensitive_JJ and_CC platinum-resistant_JJ relapsed_JJ setting.7,8_FO These_DD2 data_NN were_VBDR used_VVN to_TO support_VVI bevacizumab_NN1 licensing_VVG through_II the_AT European_JJ Medicines_NN2 Agency_NN1 for_IF use_NN1 in_II the_AT first-line_JJ setting_NN1 for_IF patients_NN2 with_IW at_RR21 least_RR22 International_JJ Federation_NN1 of_IO Gynecology_NP1 and_CC Obstetrics_NN1 (_( FIGO_NP1 )_) stage_NN1 IIIB_NN1 disease_NN1 (_( according_II21 to_II22 1988_MC staging_NN1 criteria_NN2 )_) ,_, at_RR21 first_RR22 recurrence_NN1 for_IF patients_NN2 with_IW platinum-sensitive_JJ disease_NN1 not_XX previously_RR treated_VVN with_IW bevacizumab_NN1 or_CC other_JJ VEGF-targeted_JJ drugs_NN2 ,_, and_CC in_II the_AT setting_NN1 of_IO platinum-resistant_JJ recurrence_NN1 combined_VVN with_IW paclitaxel_NN1 ,_, topotecan_NN1 ,_, or_CC pegylated_VVD liposomal_JJ doxorubicin.9_FO Bevacizumab_NP1 has_VHZ also_RR been_VBN approved_VVN in_II the_AT platinum-refractory_JJ setting_NN1 by_II the_AT US_NP1 Food_NN1 and_CC Drug_NN1 Administration_NN1 ._. 
</s>
<s>
It_PPH1 is_VBZ more_RGR durable_JJ than_CSN foams_NN2 and_CC gels_NN2 with_IW higher_JJR shock_NN1 attenuation_NN1 ._. 
</s>
<s>
We_PPIS2 found_VVD that_CST fetal_JJ side_NN1 placental_JJ inflammation-not_XX HCA-was_VBDZ associated_VVN with_IW adverse_JJ neurological_JJ outcome_NN1 at_II 6_MC months_NNT2 ,_, similar_JJ to_II findings_NN2 described_VVN by_II Redline_NP1 et_RA21 al_RA22 in_II an_AT1 extremely_RR low-birthweight_JJ population_NN1 ._. 
</s>
<s>
Percutaneous_JJ histologic_JJ adenocarcinoma_NN1 (_( well_RR differentiated_VVN ,_, G1_FO ;_; moderately_RR differentiated_VVN ,_, G2_FO ;_; poorly_RR differentiated_VVN adenocarcinoma_NN1 ,_, G3_FO )_) or_CC biliary_JJ cytologic_JJ adenocarcinoma_NN1 was_VBDZ evaluated_VVN ._. 
</s>
<s>
This_DD1 implies_VVZ a_AT1 potential_JJ role_NN1 for_IF T_ZZ1 cells_NN2 directed_VVN to_II melanoma-associated_JJ antigens_NN2 ._. 
</s>
<s>
In_RR21 addition_RR22 ,_, few_DA2 studies_NN2 reported_VVD user_NN1 satisfaction_NN1 ._. 
</s>
<s>
Therefore_RR ,_, the_AT signal_NN1 intensity_NN1 of_IO liver_NN1 is_VBZ increased_VVN ._. 
</s>
<s>
Specimens_NN2 were_VBDR centrifuged_VVN at_II 3000_MC xg_NNU during_II 15_MC min_NNU to_TO obtain_VVI platelet_NN1 poor_JJ plasma_NN1 ,_, which_DDQ was_VBDZ aliquoted_VVN and_CC stored_VVN at_II '_NULL 70_MC C._NP1 Additional_JJ validation_NN1 might_VM eliminate_VVI some_DD candidate_NN1 transcripts_NN2 and_CC it_PPH1 should_VM allow_VVI future_JJ diagnostic_JJ distinctions_NN2 on_II the_AT basis_NN1 of_IO a_AT1 much_RR smaller_JJR set_NN1 of_IO transcripts_NN2 ._. 
</s>
<s>
However_RR ,_, for_IF the_AT maximum_JJ range_NN1 of_IO motion_NN1 of_IO the_AT knee_NN1 ,_, the_AT TENS_MC2 group_NN1 had_VHD a_AT1 significant_JJ improvement_NN1 on_II day_NNT1 10_MC and_CC during_II the_AT follow-up.32_JJ The_AT study_NN1 by_II Ng_NP1 et_RA21 al_RA22 34_MC indicated_VVD that_CST there_EX was_VBDZ no_AT significant_JJ difference_NN1 between_II the_AT TENS_MC2 group_NN1 and_CC the_AT control_NN1 group_NN1 in_II the_AT total_JJ passive_JJ knee_NN1 ROM_NN1 ._. 
</s>
<s>
Scoring_VVG Before_II scoring_VVG a_AT1 patient-participant_JJ '_NULL s_ZZ1 responses_NN2 for_IF a_AT1 particular_JJ encounter_NN1 ,_, the_AT recording_NN1 of_IO that_DD1 encounter_NN1 was_VBDZ examined_VVN in_BCL21 order_BCL22 to_TO determine_VVI which_DDQ of_IO the_AT key_JJ items_NN2 the_AT physician_NN1 had_VHD covered_VVN ._. 
</s>
<s>
For_IF participants_NN2 with_IW outstanding_JJ assessment_NN1 sessions_NNT2 at_II study_NN1 completion_NN1 (_( n=8_FO )_) ,_, all_DB available_JJ data_NN was_VBDZ included_VVN ._. 
</s>
<s>
Patients_NN2 who_PNQS did_VDD not_XX complete_VVI the_AT 2-year_JJ follow-up_NN1 were_VBDR censored_VVN at_II drop_NN1 out_RP ._. 
</s>
<s>
Table_NN1 4_MC (_( available_JJ at_II www.aaojournal.org_NNU )_) shows_VVZ intraocular_JJ pressure_NN1 and_CC visual_JJ field_NN1 mean_JJ deviation_NN1 according_II21 to_II22 diagnosis_NN1 ._. 
</s>
<s>
Once_CS the_AT tumors_NN2 reached_VVD a_AT1 median_JJ tumor_NN1 volume_NN1 of_IO 230240_MC mm3_FO ,_, PDX-bearing_JJ mice_NN2 were_VBDR randomized_VVN into_II statistically_RR identical_JJ cohorts_NN2 (_( 10_MC mice/group_FU )_) and_CC treated_VVN continuously_RR with_IW 100_MC mg/kg_NNU once_RR daily_JJ of_IO ABT-199_MC ;_; 30_MC mg/kg_NNU once_RR daily_JJ of_IO MLN8237_FO for_IF 1_MC1 week_NNT1 ,_, followed_VVN by_II 2_MC weeks_NNT2 without_IW treatment_NN1 and_CC the_AT cycle_NN1 resumed_VVN on_II week_NNT1 4_MC ;_; the_AT combination_NN1 of_IO ABT-199_MC 100_MC mg/kg_NNU once_RR daily_RR being_VBG given_VVN continuously_RR with_IW the_AT MLN8237_FO 30_MC mg/kg_NNU once_RR daily_RR dosed_VVN for_IF 1_MC1 week_NNT1 with_IW 2_MC weeks_NNT2 break_NN1 ;_; appropriate_JJ vehicle_NN1 control_NN1 of_IO 60%_NNU Phosal50_FO ,_, 30%_NNU PEG400_FO ,_, 10%_NNU EtOH_NN1 as_CSA ABT-199_MC vehicle_NN1 and_CC 10%_NNU ,_, 1%_NNU Na_FO butyrate_NN1 as_CSA vehicle_NN1 for_IF MLN8237_FO by_II oral_JJ gavage_NN1 in_II 100_MC ml/10_FU g_NNU of_IO body_NN1 weight_NN1 ._. 
</s>
<s>
As_II a_AT1 result_NN1 ,_, re-expression_NN1 of_IO KDM4C_FO was_VBDZ able_JK to_TO rescue_VVI the_AT transformation_NN1 defects_NN2 associated_VVN Kdm4c_FO shRNAs_NN2 (_( Figure_NN1 S5D_FO )_) ._. 
</s>
<s>
Bonus_NN1 programs_NN2 in_II which_DDQ patients_NN2 receive_VV0 incentives_NN2 if_CS they_PPHS2 receive_VV0 care_NN1 from_II less_RGR expensive_JJ clinicians_NN2 or_CC facilities_NN2 may_VM also_RR increase_VVI patient_JJ interest_NN1 in_II price_NN1 data_NN ._. 
</s>
<s>
A_AT1 measurement_NN1 as_CSA obtained_VVN with_IW this_DD1 approach_NN1 is_VBZ presented_VVN in_II Fig._NN1 15_MC ._. 
</s>
<s>
We_PPIS2 used_VVD R_NP1 version_NN1 3.0.2_MC for_IF Gray_NP1 '_NULL s_ZZ1 test_NN1 and_CC Intercooled_JJ Stata_NN1 version_NN1 12.1_MC for_IF all_DB other_JJ analyses_NN2 ._. 
</s>
<s>
Among_II the_AT many_DA2 molecules_NN2 probed_VVN for_IF retinal_JJ repair_NN1 ,_, we_PPIS2 selected_VVD treatments_NN2 (_( deemed_VVN as_CSA having_VHG a_AT1 strong_JJ rationale_NN1 )_) designed_VVD for_IF increasing_JJ neuroprotection_NN1 ,_, or_CC decreasing_JJ cellular_JJ oxidative_JJ stress_NN1 ,_, or_CC inhibiting_VVG photoreceptor_NN1 apoptosis_NN1 ,_, or_CC attenuating_VVG retinal_JJ inflammation_NN1 ._. 
</s>
<s>
Concussions_NN2 will_VM never_RR be_VBI eliminated_VVN from_II sports_NN2 ._. 
</s>
<s>
Moreover_RR ,_, comprehensive_JJ liver_NN1 function_NN1 can_VM be_VBI assessed_VVN by_II a_AT1 blood_NN1 test_NN1 ,_, but_CCB this_DD1 can_VM not_XX assess_VVI the_AT function_NN1 ofliver_NN1 segments_NN2 or_CC sub-segments_NN2 ._. 
</s>
<s>
Of_IO the_AT 570_MC fetuses_NN2 ,_, 369_MC (_( 65%_NNU )_) were_VBDR in_II the_AT 18_MC weeks_NNT2 to_II less_DAR than_CSN 24_MC weeks_NNT2 group_NN1 (_( 110%_NNU of_IO required_JJ )_) and_CC 201_MC (_( 35%_NNU )_) in_II the_AT 24_MC weeks_NNT2 and_CC older_JJR group_NN1 (_( 120%_NNU of_IO required_JJ )_) ._. 
</s>
<s>
All_DB patients_NN2 have_VH0 had_VHN a_AT1 history_NN1 of_IO epithelial_JJ herpetic_JJ keratitis_NN1 with_IW no_AT stromal_JJ involvement_NN1 ._. 
</s>
<s>
None_PN of_IO the_AT studies_NN2 dealing_VVG with_IW measurement_NN1 error_NN1 defined_VVD a_AT1 minimal_JJ important_JJ change_NN1 ._. 
</s>
<s>
The_AT TGFBR1_FO inhibitor_NN1 ,_, SD208_FO ,_, prevented_VVD promoter_NN1 activation_NN1 by_II TGF-p_NNU (_( Figure_NN1 4C_FO )_) ._. 
</s>
<s>
Furthermore_RR ,_, distinguished_JJ authors_NN2 from_II this_DD1 research_NN1 area_NN1 were_VBDR contacted_VVN through_II email_NN1 for_IF any_DD missed_JJ and_CC relevant_JJ studies_NN2 ._. 
</s>
<s>
This_DD1 study_NN1 was_VBDZ supported_VVN by_II the_AT Institute_NN1 for_IF Clinical_JJ Evaluative_JJ Sciences_NN2 (_( ICES_NN2 )_) ,_, which_DDQ is_VBZ funded_VVN by_II an_AT1 annual_JJ grant_NN1 from_II the_AT Ontario_NP1 Ministry_NN1 of_IO Health_NN1 and_CC Long-Term_JJ Care_NN1 (_( MOHLTC_NP1 )_) ._. 
</s>
<s>
However_RR ,_, despite_II these_DD2 limitations_NN2 ,_, significant_JJ between-group_JJ differences_NN2 were_VBDR found_VVN in_II the_AT primary_JJ outcome_NN1 measure_NN1 ._. 
</s>
<s>
For_IF the_AT condition_NN1 to_TO be_VBI considered_VVN '_NULL acute_JJ ,_, '_NULL there_EX had_VHD to_TO be_VBI a_AT1 sudden_JJ inward_JJ deviation_NN1 of_IO the_AT eyes_NN2 as_CSA noted_VVN by_II the_AT patient_NN1 (_( by_II the_AT onset_NN1 of_IO diplopia_NN1 )_) or_CC by_II a_AT1 caregiver_NN1 observing_VVG a_AT1 sudden_JJ and_CC dramatic_JJ change_NN1 in_II eye_NN1 alignment_NN1 ._. 
</s>
<s>
The_AT UPSIT_NN1 was_VBDZ administered_VVN every_AT1 8_MC weeks_NNT2 ;_; scores_NN2 range_VV0 from_II 0_MC to_II 40_MC (_( higher_JJR scores_NN2 of_IO 35-40_MCMC indicate_VV0 normal_JJ sense_NN1 of_IO smell_NN1 and_CC lower_JJR scores_NN2 of_IO 0-18_MCMC indicate_VV0 anosmia_NN1 )_) ._. 
</s>
<s>
Finally_RR ,_, our_APPGE results_NN2 ,_, obtained_VVD mainly_RR in_II patients_NN2 with_IW Child-Pugh_NP1 class_NN1 A_ZZ1 cirrhosis_NN1 ,_, may_VM not_XX be_VBI generalized_VVN to_II those_DD2 with_IW advanced_JJ cirrhosis_NN1 ._. 
</s>
<s>
Other_JJ variables_NN2 included_VVD whether_CSW respondents_NN2 had_VHD reported_VVN any_DD type_NN1 of_IO employment_NN1 outside_II the_AT home_NN1 in_II the_AT week_NNT1 prior_II21 to_II22 completing_VVG the_AT survey_NN1 ,_, the_AT number_NN1 of_IO live_JJ deliveries_NN2 they_PPHS2 had_VHD experienced_VVN ,_, and_CC whether_CSW they_PPHS2 reported_VVD having_VHG health_NN1 insurance_NN1 ._. 
</s>
<s>
The_AT mean_JJ total_JJ VoiSS_NN1 (_( maximum_JJ score_NN1 120_MC )_) for_IF all_DB patients_NN2 was_VBDZ 39.7_MC (_( SD_NP1 22.2_MC )_) ._. 
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<s>
Similarly_RR ,_, in_II acne_NN1 a_AT1 recent_JJ eye-tracking_JJ study_NN1 demonstrated_VVD that_CST participants_NN2 exhibited_VVD an_AT1 attentional_JJ bias_NN1 towards_II acne_NN1 lesions_NN2 in_II31 comparison_II32 with_II33 controls_NN2 ._. 
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<s>
In_II31 view_II32 of_II33 the_AT extent_NN1 of_IO linkage_NN1 disequilibrium_NN1 between_II the_AT variants_NN2 associated_VVN with_IW all_DB epilepsy_NN1 in_II the_AT 2q24.3_FO region_NN1 (_( figure_NN1 2_MC )_) ,_, we_PPIS2 did_VDD logistic_JJ regression_NN1 conditioned_VVN on_II the_AT most_RGT significant_JJ variant_NN1 identified_VVN from_II the_AT univariate_NN1 analysis_NN1 (_( rs6732655_FO )_) ._. 
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<s>
ASB_NP1 activity_NN1 remained_VVD stable_JJ in_II all_DB analyses_NN2 ,_, i.e._REX ,_, for_IF 60_MC days_NNT2 ,_, as_CSA shown_VVN by_II Castilhos_NP1 et_RA21 al_RA22 .._... 
</s>
<s>
Spectral_JJ Imaging_NN1 Confocal_JJ Microscope_NN1 System_NN1 at_II the_AT Nikon_NN1 Imaging_NN1 Center_NN1 and_CC Cell_NN1 Imaging_NN1 Facility_NN1 at_II Northwestern_JJ University_NN1 ._. 
</s>
<s>
Statistical_JJ Analysis_NN1 Preoperative_JJ patient_JJ characteristics_NN2 were_VBDR summarized_VVN using_VVG counts_NN2 and_CC proportions_NN2 for_IF categorical_JJ variables_NN2 and_CC median_JJ and_CC interquartile_JJ range_NN1 for_IF continuous_JJ variables_NN2 ._. 
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<s>
The_AT use_NN1 of_IO healthy_JJ controls_NN2 for_IF genetic_JJ association_NN1 at_II the_AT level_NN1 of_IO brain_NN1 function_NN1 avoids_VVZ potential_JJ confounders_NN2 related_VVN to_II chronic_JJ illness_NN1 and_CC medical_JJ treatment_NN1 ._. 
</s>
<s>
The_AT main_JJ hypothesis_NN1 was_VBDZ that_CST the_AT VNS_NP1 would_VM be_VBI a_AT1 better_JJR and_CC more_RGR consistent_JJ indicator_NN1 of_IO treatment_NN1 success_NN1 than_CSN percentage_NN1 repigmentation_NN1 ._. 
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<s>
Several_DA2 approaches_NN2 to_II vaccine_NN1 development_NN1 are_VBR being_VBG investigated.68_FO A_ZZ1 live_JJ attenuated_JJ vaccine_NN1 for_IF intranasal_JJ administration_NN1 would_VM stimulate_VVI both_RR topical_JJ and_CC systemic_JJ immunity_NN1 ;_; such_DA a_AT1 vaccine_NN1 is_VBZ being_VBG developed_VVN with_IW the_AT use_NN1 of_IO reverse_JJ genetics_NN1 to_TO modify_VVI specific_JJ genes_NN2 ._. 
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<s>
Thus_RR ,_, for_REX21 example_REX22 ,_, the_AT minor_JJ allele_NN1 of_IO the_AT SNP_NP1 rs13702_FO in_II the_AT lipoprotein_NN1 lipase_NN1 (_( LPL_NP1 )_) 3UTR_FO gene_NN1 disrupts_VVZ an_AT1 miRNA_NN1 recognition_NN1 element_NN1 seed_NN1 site_NN1 for_IF the_AT human_NN1 miRNA-410_MC ,_, resulting_VVG in_II a_AT1 gain-of-function_NN1 and_CC lower_JJR plasma_NN1 triglycerides_NN2 and_CC interactions_NN2 with_IW PUFA_NP1 intake_NN1 in_II determining_JJ plasma_NN1 triglycerides_NN2 (_( Richardson_NP1 et_RA21 al._RA22 ,_, 2013_MC )_) ._. 
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<s>
Sociodemographic_JJ and_CC Psychiatric_JJ Covariates_NN2 We_PPIS2 used_VVD mean_JJ lifetime_NNT1 disposable_JJ income_NN1 (_( divided_VVN into_II thirds_MF )_) ,_, dichotomized_VVD into_II lowest_JJT tertile_JJ vs_II top_NN1 2_MC tertiles_NN2 ._. 
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<s>
Also_RR ,_, the_AT authors_NN2 described_VVD that_CST a_AT1 panel_NN1 including_II miR-141_MC ,_, 151-3p_NNU ,_, 152_MC and_CC 423-3p_NNU was_VBDZ associated_VVN with_IW a_AT1 poorer_JJR outcome_NN1 and/or_CC a_AT1 higher_JJR Gleason_NN1 score_NN1 ._. 
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<s>
There_EX is_VBZ an_AT1 emerging_JJ consensus_NN1 that_CST depression_NN1 is_VBZ characterized_VVN by_II a_AT1 fundamental_JJ mood-congruent_JJ processing_NN1 bias_NN1 ;_; that_REX21 is_REX22 ,_, a_AT1 greater_JJR sensitivity_NN1 to_II punishment_NN1 and_CC an_AT1 impaired_JJ hedonic_JJ capacity_NN1 ._. 
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<s>
Although_CS early_RR neurodevelopmental_JJ assessment_NN1 is_VBZ important_JJ for_IF the_AT timely_JJ identification_NN1 of_IO children_NN2 at_II risk_NN1 for_IF long-term_JJ neurologic_JJ impairment_NN1 or_CC developmental_JJ delay_NN1 ,_, its_APPGE capacity_NN1 to_TO predict_VVI later_JJR functioning_NN1 is_VBZ limited.35-37_MC Many_DA2 children_NN2 will_VM catch_VVI up_II21 to_II22 their_APPGE peers_NN2 by_II school_NN1 age_NN1 ,_, whereas_CS other_JJ children_NN2 will_VM have_VHI persistent_JJ impairment_NN1 ._. 
</s>
<s>
Nievergelt_VV0 ,_, and_CC Baker_NP1 had_VHD full_JJ access_NN1 to_II all_DB the_AT data_NN in_II the_AT study_NN1 and_CC take_VV0 responsibility_NN1 for_IF the_AT integrity_NN1 of_IO the_AT data_NN and_CC the_AT accuracy_NN1 of_IO the_AT data_NN analysis_NN1 ._. 
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<s>
The_AT reason_NN1 for_IF this_DD1 improvement_NN1 is_VBZ not_XX clear_JJ and_CC is_VBZ likely_JJ to_TO be_VBI predominantly_RR due_II21 to_II22 improved_JJ odorant_JJ delivery_NN1 to_II the_AT olfactory_JJ epithelium_NN1 ;_; however_RR ,_, this_DD1 improvement_NN1 remains_VVZ clinically_RR insignificant_JJ ._. 
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<s>
In_II tumors_NN2 with_IW a_AT1 2+_FO score_NN1 ,_, gene_NN1 amplification_NN1 by_II using_VVG fluorescence_NN1 in_RR21 situ_RR22 hybridization_NN1 was_VBDZ used_VVN to_TO determine_VVI HER2_FO status_NN1 ._. 
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<s>
This_DD1 could_VM refine_VVI our_APPGE understanding_NN1 of_IO the_AT relationship_NN1 between_II variability_NN1 and_CC risk_NN1 by_II determining_VVG the_AT importance_NN1 of_IO the_AT rate_NN1 and_CC frequency_NN1 of_IO ST_NP1 segment_NP1 changes_NN2 ._. 
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<s>
Only_RR one_MC1 of_IO the_AT three_MC patients_NN2 who_PNQS died_VVD of_IO progressive_JJ disease_NN1 carried_VVD a_AT1 BRAF_NN1 mutation_NN1 ._. 
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<s>
ICG_NP1 had_VHD been_VBN used_VVN extensively_RR for_IF medical_JJ purposes_NN2 since_II 1957_MC ,_, and_CC ,_, currently_RR ,_, its_APPGE application_NN1 is_VBZ mainly_RR involved_JJ in_II the_AT measurement_NN1 of_IO blood_NN1 flow_NN1 and_CC in_II ophthalmology_NN1 for_IF the_AT diagnosis_NN1 of_IO age-related_JJ macular_JJ degeneration_NN1 ._. 
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<s>
The_AT cells_NN2 are_VBR obtained_VVN from_II a_AT1 non-weight-bearing_JJ region_NN1 of_IO the_AT knee_NN1 and_CC then_RT grown_VVN in_RR21 vitro_RR22 for_IF 4_MC to_II 6_MC weeks_NNT2 ._. 
</s>
<s>
In_II31 terms_II32 of_II33 a_AT1 ?why_JJ not?_NN1 mentality_NN1 ,_, in_II some_DD instances_NN2 ,_, participants_NN2 were_VBDR not_XX aware_JJ of_IO specific_JJ benefits_NN2 of_IO counseling_NN1 ,_, and_CC did_VDD not_XX always_RR have_VHI concrete_JJ reasons_NN2 for_IF participating_VVG ._. 
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<s>
The_AT EEG_NN1 was_VBDZ recorded_VVN by_II BrainVision_NP1 Recorder(C)_NP1 v.1.10_FO software_NN1 (_( Brain_NN1 Products_NN2 ,_, Germany_NP1 )_) ._. 
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<s>
Another_DD1 advantage_NN1 of_IO DOCT_NP1 relates_VVZ to_II its_APPGE easy_JJ operation_NN1 and_CC short_JJ mea-surement_NN1 time_NNT1 ,_, a_AT1 feature_NN1 that_CST was_VBDZ already_RR important_JJ when_CS classical_JJ OCT_NPM1 found_VVD its_APPGE way_NN1 into_II clinical_JJ routine_NN1 ._. 
</s>
<s>
We_PPIS2 used_VVD the_AT data_NN published_VVN by_II Esmaoglu_NP1 and_CC colleagues_NN2 ,_, who_PNQS showed_VVD prolongation_NN1 of_IO sensory_JJ block_NN1 from_II 670_MC (_( 70_MC )_) to_II 880_MC (_( 70_MC )_) min_NNU in_II humans_NN2 receiving_VVG axillary_JJ plexus_NN1 block_NN1 ._. 
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<s>
The_AT novelty_NN1 of_IO the_AT present_JJ investigation_NN1 is_VBZ that_CST we_PPIS2 tested_VVD the_AT effects_NN2 of_IO caffeinated_JJ energy_NN1 drinks_NN2 on_II traditional_JJ (_( e.g._REX ,_, squat_JJ and_CC countermovement_NN1 jumps_VVZ )_) and_CC volleyball-specific_JJ jumps_NN2 such_II21 as_II22 the_AT block_NN1 jump_NN1 and_CC spike_VV0 jump_NN1 ._. 
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<s>
The_AT LoB_NP1 is_VBZ 0.0492_MC miumol/L_FU and_CC the_AT delta_NN1 percentile_NN1 LoD_NP1 is_VBZ 0.349_MC miumol/L_FU ._. 
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<s>
Although_CS previous_JJ studies_NN2 including_II the_AT Cochrane_NP1 Review_NP1 have_VH0 demonstrated_VVN no_AT benefit_NN1 and_CC higher_JJR cost_NN1 to_II robotic_JJ surgery_NN1 compared_VVN with_IW traditional_JJ laparoscopy_NN1 ,_, many_DA2 studies_NN2 were_VBDR limited_VVN by_II smaller_JJR samples_NN2 and_CC single_JJ high-volume_JJ institutions_NN2 and_CC prior_JJ cost_NN1 data_NN do_VD0 not_XX account_VVI for_IF the_AT potential_JJ increased_JJ morbidity_NN1 and_CC cost_NN1 associated_VVN with_IW conversion_NN1 ._. 
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<s>
The_AT primary_JJ outcome_NN1 of_IO the_AT study_NN1 was_VBDZ change_NN1 in_II burnout_NN1 rates_NN2 ._. 
</s>
<s>
Small_NP1 to_II medium_JJ treatment_NN1 effects_NN2 favoring_VVG response_NN1 to_II psychotherapy_NN1 were_VBDR observed_VVN for_IF patients_NN2 with_IW only_RR one_MC1 current_JJ anxiety_NN1 disorder_NN1 (_( number_NN1 needed_VVN to_II treat=4.76_FO )_) ,_, whereas_CS there_EX was_VBDZ less_DAR of_IO a_AT1 difference_NN1 in_II recovery_NN1 rates_NN2 for_IF psychotherapy_NN1 compared_VVN with_IW collaborative_JJ care_NN1 for_IF individuals_NN2 with_IW two_MC or_CC more_RGR current_JJ anxiety_NN1 disorders_NN2 (_( number_NN1 needed_VVN to_II treat=7.69_FO ,_, small_JJ to_II medium_JJ effect_NN1 )_) ._. 
</s>
<s>
The_AT FreeSurfer_NN1 processing_NN1 protocol_NN1 applied_VVN to_II the_AT present_JJ data_NN included_VVD thorough_JJ human_JJ quality_NN1 control_NN1 (_( QC_NN1 )_) supervision_NN1 ,_, by_II which_DDQ the_AT parcellation_NN1 results_NN2 were_VBDR designated_VVN as_CSA pass_NN1 or_CC fail_VV0 for_IF the_AT hippocampus_NN1 (_( http_NNU :_: )_) ._. 
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<s>
The_AT authors_NN2 interpreted_VVD their_APPGE findings_NN2 as_CSA evidence_NN1 that_CST the_AT negative_JJ effects_NN2 of_IO diabetes_NN1 on_II arterial_JJ wall_NN1 properties_NN2 in_II their_APPGE cohort_NN1 was_VBDZ more_RGR evident_JJ in_II the_AT large_JJ central_JJ arteries_NN2 than_CSN in_II the_AT smaller_JJR peripheral_JJ arteries_NN2 ._. 
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<s>
It_PPH1 is_VBZ thus_RR envisaged_VVN that_CST focal_JJ electrical_JJ stimulating_JJ patterns_NN2 with_IW a_AT1 multi-electrode_JJ array_NN1 in_II the_AT macular_JJ region_NN1 would_VM more_RGR likely_RR manifest_VVI retinotopic_JJ correlations_NN2 along_II the_AT visual_JJ pathway_NN1 ._. 
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<s>
The_AT setting_NN1 was_VBDZ among_II individuals_NN2 with_IW familial_JJ PD_NP1 enrolled_VVD from_II academic_JJ movement_NN1 disorder_NN1 specialty_NN1 clinics_NN2 across_II the_AT United_NP1 States_NP1 ._. 
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<s>
The_AT primary_JJ auditory_JJ cortex_NN1 hemodynamic_JJ responses_NN2 due_II21 to_II22 different_JJ temporal_JJ patterns_NN2 of_IO imaging_VVG related_JJ acoustic_JJ noise_NN1 were_VBDR compared_VVN across_II conditions_NN2 and_CC hemispheres_NN2 ._. 
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<s>
The_AT Health_NN1 Services_NN2 Research_NN1 Unit_NN1 is_VBZ core_NN1 funded_VVN by_II the_AT Chief_JJ Scientist_NN1 Office_NN1 of_IO the_AT Scottish_JJ Government_NN1 Health_NN1 and_CC Social_JJ Care_NN1 Directorates_NN2 ._. 
</s>
<s>
By_II using_VVG these_DD2 research_NN1 values_NN2 ,_, we_PPIS2 compared_VVD the_AT UF-1000i_FO and_CC the_AT XN-1000_MC in_II the_AT lower_JJR concentration_NN1 range_NN1 (_( less_DAR than_CSN 1000_MC x_ZZ1 10_MC 6/L_MC )_) ._. 
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<s>
Methods_NN2 '_NULL In_II this_DD1 randomised_JJ ,_, double-blind_JJ ,_, placebo-controlled_JJ trial_NN1 we_PPIS2 recruited_VVD participants_NN2 aged_VVN 30-80_MCMC years_NNT2 with_IW possible_JJ or_CC probable_JJ multiple_JJ system_NN1 atrophy_NN1 from_II ten_MC US_NP1 medical_JJ centres_NN2 ._. 
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<s>
The_AT relationship_NN1 between_II cognition_NN1 ,_, stress_NN1 ,_, glucocorticoids_NN2 ,_, and_CC other_JJ stress-response_JJ hormones_NN2 and_CC neuro-chemicals_NN2 is_VBZ complicated_JJ but_CCB worth_II exploring_VVG in_II this_DD1 context_NN1 ._. 
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<s>
To_TO determine_VVI if_CSW the_AT low_JJ concentration_NN1 of_IO chelated_JJ manganese_NN1 in_II Teslascan_NN1 would_VM be_VBI useful_JJ in_II functional_JJ studies_NN2 ,_, it_PPH1 was_VBDZ observed_VVN that_CST the_AT Mn2+_FO in_II Teslascan_NN1 is_VBZ taken_VVN up_RP by_II the_AT rat_NN1 retina_NN1 in_II a_AT1 stimulus-dependent_JJ manner_NN1 (_( Berkowitz_NP1 et_RA21 al._RA22 ,_, 2013_MC ;_; Tofts_NP1 et_RA21 al._RA22 ,_, 2010_MC )_) ._. 
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<s>
Depletion_NN1 of_IO IL-10_MC with_IW IL-10_MC mAb_VV0 significantly_RR upregulated_VVD IFNg_NP1 and_CC TNFa_NP1 expression_NN1 in_II CD4+_FO T_ZZ1 cells_NN2 (_( Fig._NN1 4b_FO ,_, c_ZZ1 )_) ._. 
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<s>
The_AT great_JJ majority_NN1 of_IO lifespan-augmenting_JJ mutations_NN2 were_VBDR discovered_VVN in_II the_AT nematode_NN1 C._NP1 elegans_NP1 (_( Klass_NP1 ,_, 1983_MC )_) and_CC further_RRR replicated_VVN in_II other_JJ model_NN1 organisms_NN2 from_II yeast_NN1 to_II mice_NN2 (_( Gems_NN2 and_CC Partridge_NN ,_, 2013_MC )_) ._. 
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<s>
These_DD2 proteins_NN2 can_VM bind_VVI to_II small_JJ molecules_NN2 like_II DNA_NN1 or_CC to_II other_JJ proteins_NN2 '_NULL which_DDQ results_VVZ in_II an_AT1 electrostatic_JJ complex_NN1 ._. 
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<s>
All_DB data_NN were_VBDR made_VVN anonymous_JJ and_CC transferred_VVN through_II the_AT internet_NN1 (_( http_NNU :_: //www.quips-projekt.de/_JJ )_) to_II the_AT external_JJ database_NN1 for_IF the_AT benchmark_NN1 project_NN1 of_IO QUIPS_NP2 allowing_VVG an_AT1 anonymous_JJ comparison_NN1 with_IW the_AT results_NN2 of_IO other_JJ participating_JJ hospitals_NN2 (_( procedure_NN1 codes_NN2 in_II Supplemental_JJ Table_NN1 1_MC1 ,_, Supplemental_JJ Digital_JJ Content_NN1 1_MC1 ,_, http_NNU :_: //links.lww.com/CJP/_VV0 A78_FO )_) ._. 
</s>
<s>
They_PPHS2 also_RR included_VVD many_DA2 important_JJ covariates_NN2 such_II21 as_II22 baseline_NN1 cognitive_JJ status_NN1 ,_, thus_RR strengthening_VVG causality_NN1 following_VVG multivariable_JJ adjustment_NN1 ._. 
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<s>
Declaration_NN1 of_IO interests_NN2 EDA_NP1 received_VVD research_NN1 funding_NN1 from_II UK_NP1 Medical_JJ Research_NN1 Council_NN1 ,_, British_JJ Heart_NN1 Foundation_NN1 ,_, National_JJ Institute_NN1 of_IO Health_NN1 Research_NN1 ,_, NHS_NP1 Blood_NN1 and_CC Transplant_NN1 ,_, European_JJ Commission_NN1 Framework_NN1 Programme_NN1 during_II the_AT conduct_NN1 of_IO the_AT study_NN1 ;_; and_CC personal_JJ fees_NN2 from_II Elsevier_NP1 (_( France_NP1 )_) ._. 
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<s>
Moreover_RR ,_, the_AT Vp_NP1 repertoire_NN1 revealed_VVD that_DD1 tumor_NN1 cells_NN2 are_VBR specifically_RR enriched_VVN in_II the_AT CD7N_FO fraction_NN1 ,_, usually_RR to_II almost_RR 100%_NNU after_II assessing_VVG clonality_NN1 in_II the_AT context_NN1 of_IO the_AT T-cell_NN1 receptor_NN1 ._. 
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<s>
All_DB these_DD2 data_NN support_VV0 the_AT significant_JJ role_NN1 of_IO the_AT non-enzymatic_JJ post-translational_JJ reactions_NN2 and_CC their_APPGE by-products_NN2 in_II the_AT occurrence_NN1 of_IO cardiovascular_JJ events_NN2 and_CC especially_RR in_II the_AT development_NN1 of_IO CAD_NN1 ._. 
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<s>
In_II pooled_JJ analysis_NN1 we_PPIS2 subsequently_RR dichotomized_VVD patients_NN2 into_II low_JJ LMR_NP1 (_( less_RRR than_CSN and_CC equal_JJ to_II 2.38_MC )_) and_CC high_JJ LMR_NP1 (_( >2.38_FO )_) groups_NN2 ._. 
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<s>
During_II extended_JJ follow-up_NN1 of_IO overall_JJ survival_NN1 ,_, one_MC1 further_JJR treatment-related_JJ grade_NN1 3_MC event_NN1 (_( gastrointestinal_JJ fistula_NN1 in_II a_AT1 bevacizumab-treated_JJ patient_NN1 )_) ,_, three_MC grade_NN1 2_MC treatment-related_JJ events_NN2 (_( cardiac_JJ failure_NN1 ,_, sarcoidosis_NN1 ,_, and_CC foot_NN1 fracture_NN1 ,_, all_DB in_II bevacizumab-treated_JJ patients_NN2 )_) ,_, and_CC one_MC1 grade_NN1 1_MC1 treatment-related_JJ event_NN1 (_( vaginal_JJ haemorrhage_NN1 ,_, in_II a_AT1 patient_NN1 treated_VVN with_IW standard_JJ chemotherapy_NN1 )_) were_VBDR also_RR reported_VVN ._. 
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<s>
Mundy_NP1 et_RA21 al_RA22 evaluated_VVD the_AT effects_NN2 of_IO early_JJ mobilisation_NN1 performed_VVN by_II nurses_NN2 on_II 456_MC patients_NN2 who_PNQS were_VBDR hospitalised_VVN for_IF community-acquired_JJ pneumonia_NN1 and_CC found_VVN that_DD1 hospitalisation_NN1 length_NN1 and_CC costs_NN2 were_VBDR reduced_VVN ,_, with_IW no_AT adverse_JJ events_NN2 ._. 
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<s>
This_DD1 also_RR is_VBZ true_JJ for_IF falls_NN2 that_CST have_VH0 a_AT1 large_JJ laterally_RR directed_VVN component_NN1 to_II which_DDQ older_JJR adults_NN2 generally_RR seem_VV0 to_TO be_VBI vulnerable_JJ ._. 
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<s>
No_AT significant_JJ association_NN1 between_II Ktrans_NN2 values_NN2 and_CC the_AT presence_NN1 of_IO HARM_NN1 sign_NN1 ,_, which_DDQ was_VBDZ seen_VVN in_II only_RR 7_MC patients_NN2 ,_, was_VBDZ observed_VVN ._. 
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<s>
However_RR ,_, the_AT vehicle-fed_JJ group_NN1 that_CST was_VBDZ subjected_VVN to_II SD_NP1 before_II the_AT starvation_NN1 period_NN1 showed_VVD a_AT1 significant_JJ increase_NN1 in_II sleep_NN1 that_CST lasted_VVD through_II the_AT second_MD daytime_NNT1 period_NN1 of_IO recovery_NN1 (_( fig._NN1 7C_FO )_) ._. 
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<s>
We_PPIS2 assume_VV0 our_APPGE result_NN1 to_TO be_VBI more_RGR precise_JJ ,_, since_CS Lee_NP1 et_RA21 al_RA22 used_VVD a_AT1 per-lesion-based_JJ analysis_NN1 ,_, allowing_VVG to_TO count_VVI either_RR true-positive_JJ or_CC false-negative_JJ lesions_NN2 ,_, ignoring_VVG AEF_NN1 measurements_NN2 in_II true-negative_JJ liver_NN1 segments_NN2 ._. 
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<s>
Patients_NN2 with_IW an_AT1 ocular_JJ complication_NN1 during_II baseline_NN1 were_VBDR excluded_VVN ._. 
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<s>
Endoplasmic_JJ reticulum_NN1 (_( ER_FU )_) stress_NN1 ,_, as_CSA measured_VVN by_II BiP_NP1 ,_, PDI_NP1 ,_, and_CC CHOP_VV0 expression_NN1 ,_, was_VBDZ also_RR examined_VVN as_II a_AT1 function_NN1 of_IO age_NN1 in_II the_AT WT_NN1 and_CC KO_NN1 mice_NN2 (_( Fig._NN1 5_MC )_) ._. 
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<s>
Although_CS skeletal_JJ muscle_NN1 titin_NN1 isoform_NN1 presented_VVD more_DAR sites_NN2 for_IF arginylation_NN1 than_CSN cardiac_JJ titin_NN1 ,_, one_MC1 site_NN1 found_VVN in_II the_AT heart_NN1 is_VBZ located_VVN in_II the_AT titin_NN1 serine-threonine_NN1 kinase_NN1 domain_NN1 (_( C24818_FO )_) ._. 
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<s>
Longer-term_JJ observational_JJ studies_NN2 that_CST examine_VV0 risk_NN1 status_NN1 could_VM support_VVI registries_NN2 through_II which_DDQ subjects_NN2 indicate_VV0 their_APPGE willingness_NN1 to_TO participate_VVI in_II future_JJ clinical_JJ trials_NN2 and_CC biomarker_NN1 initiatives_NN2 ._. 
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<s>
Propensity_NN1 score_NN1 matching_NN1 resulted_VVN in_II 260_MC pairs_NN2 of_IO matched_JJ patients_NN2 ._. 
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<s>
However_RR ,_, neither_RR SBP-1_MC1 ,_, NHR-49_MC ,_, nor_CC the_AT detoxification_NN1 regulator_NN1 NHR-8_MC (_( Lindblom_NP1 &;_NULL Dodd_NP1 ,_, 2006_MC )_) affect_VV0 MDT-15-dependent_NP1 detoxification_NN1 genes_NN2 (_( Taubert_NP1 et_RA21 al._RA22 ,_, 2008_MC )_) ,_, suggesting_VVG that_CST MDT-15_MC must_VM interact_VVI with_IW yet_RR unidentified_JJ transcription_NN1 factors_NN2 to_TO regulate_VVI stress_NN1 response_NN1 genes_NN2 ._. 
</s>
<s>
Cricoid_JJ pressure_NN1 was_VBDZ applied_VVN at_II a_AT1 standardized_JJ force_NN1 of_IO 30_MC N_NNU ,_, which_DDQ sufficiently_RR prevents_VVZ regurgitation_NN1 into_II the_AT pharynx_NN1 ,_, even_RR in_II patients_NN2 with_IW a_AT1 full_JJ stomach_NN1 undergoing_VVG Caesarean_NN1 section_NN1 ._. 
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<s>
Despite_II this_DD1 ,_, it_PPH1 is_VBZ generally_RR agreed_VVN that_CST the_AT characteristics_NN2 of_IO a_AT1 healthy_JJ microbiota_NN1 include_VV0 community_NN1 stability_NN1 and_CC increased_JJ species_NN diversity_NN1 ._. 
</s>
<s>
The_AT median_JJ values_NN2 of_IO N-terminal_JJ pro-brain_JJ natriuretic_JJ peptide_NN1 (_( NT_NP1 pro-BNP_JJ )_) or_CC BNP_NP1 were_VBDR 3,610_MC &lsqb;_( 22_MC &rsqb;_) ,_, with_IW 440_MC cases_NN2 (_( 35.7_MC %_NNU )_) with_IW values_NN2 over_II greater_JJR than_CSN 5000_MC pg/mL_FU ._. 
</s>
<s>
Troponin-T_NP1 or_CC I_PPIS1 ,_, registered_VVN in_II 1025_MC cases_NN2 (_( 83.1_MC %_NNU of_IO cases_NN2 )_) ,_, were_VBDR over_II cut-off_NN1 levels_NN2 in_II 278_MC cases_NN2 (_( 22.5_MC %_NNU )_) ._. 
</s>
<s>
Forthe_VV0 latter_DA ,_, we_PPIS2 demonstrated_VVD that_CST R406_FO suppressed_JJ phosphorylation_NN1 of_IO other_JJ SYK_NN1 substrates_NN2 including_II pSTAT3_FO and_CC pAKT_NN1 of_IO which_DDQ phosphorylation_NN1 was_VBDZ reported_VVN to_TO protect_VVI tumor_NN1 cells_NN2 from_II chemotherapy-induced_JJ cytotoxicity_NN1 ._. 
</s>
<s>
This_DD1 remains_VVZ a_AT1 ripe_JJ area_NN1 for_IF future_JJ inquiry_NN1 ._. 
</s>
<s>
Patients_NN2 reporting_VVG chronic_JJ pain_NN1 had_VHD more_DAR postoperative_JJ pain_NN1 but_CCB patients_NN2 with_IW higher_JJR ASA_NN1 status_NN1 reported_VVD less_DAR pain_NN1 ._. 
</s>
<s>
Additional_JJ supportive_JJ analyses_NN2 were_VBDR conducted_VVN for_IF the_AT change_NN1 from_II baseline_NN1 in_II CSFT_NP1 and_CC BCVA_NN1 at_II all_DB time_NNT1 points_NN2 in_II the_AT study_NN1 ._. 
</s>
<s>
The_AT hemoglobin_NN1 concentration_NN1 is_VBZ separately_RR measured_VVN and_CC G6PD_FO activity_NN1 is_VBZ derived_VVN by_II manual_JJ calculation_NN1 and_CC expressed_VVN as_CSA units_NN2 per_II gram_NNU1 of_IO hemoglobin_NN1 ._. 
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<s>
We_PPIS2 are_VBR grateful_JJ to_II the_AT University_NN1 of_IO Pernambuco_NP1 ,_, the_AT Federal_JJ University_NN1 of_IO Pernambuco_NP1 ,_, the_AT London_NP1 School_NN1 of_IO Hygiene_NN1 &;_NULL Tropical_JJ Medicine_NN1 ,_, and_CC Fiocruz_NP1 Pernambuco_NP1 for_IF giving_VVG the_AT investigators_NN2 time_VV0 to_TO work_VVI in_II the_AT study_NN1 (_( RAAX_NP1 ,_, TVBA_NP1 ,_, DBM-F_NP1 ,_, LCR_NP1 ,_, WVS_NP1 ,_, MFPMA_NP1 ,_, CB_NP1 ,_, CMTM_NP1 ,_, SV_NP1 ,_, APLM_NP1 ,_, ETAM-J_NP1 ,_, RD_NN1 ,_, MTC_NP1 ,_, and_CC URM_NP1 )_) ._. 
</s>
<s>
There_EX is_VBZ some_DD research_NN1 showing_VVG that_CST steroids_NN2 prescribed_VVN for_IF medical_JJ purposes_NN2 can_VM lead_VVI to_II cognitive_JJ impairment_NN1 ,_, though_CS it_PPH1 is_VBZ unclear_JJ whether_CSW these_DD2 impairments_NN2 are_VBR persistent_JJ ._. 
</s>
<s>
Whole-mount_JJ dissections_NN2 (_( Fig._NN1 1B_FO )_) allowed_VVD for_IF a_AT1 consistent_JJ view_NN1 of_IO the_AT HCs_NP2 for_IF the_AT entire_JJ length_NN1 of_IO the_AT Organ_NN1 of_IO Corti_NP1 ,_, and_CC this_DD1 tissue_NN1 preparation_NN1 allowed_VVD us_PPIO2 to_TO label_VVI various_JJ features_NN2 using_VVG immunohistochemical_JJ markers_NN2 ._. 
</s>
<s>
Obstetrics_NN1 and_CC gynecology_NN1 faculty_NN1 (_( 25%_NNU )_) and_CC the_AT obstetrics_NN1 and_CC gynecology_NN1 program_NN1 director_NN1 (_( 18%_NNU )_) at_II a_AT1 student_NN1 '_NULL s_ZZ1 home_NN1 institution_NN1 were_VBDR also_RR commonly_RR cited_VVN as_II the_AT primary_JJ advisor_NN1 (_( Table_NN1 2_MC )_) ._. 
</s>
<s>
Last_MD but_CCB not_XX least_RRT ,_, there_EX is_VBZ the_AT possibility_NN1 that_CST such_DA studies_NN2 do_VD0 not_XX take_VVI into_II account_NN1 other_JJ population_NN1 characteristics_NN2 (_( e.g._REX ,_, age_NN1 ,_, gender_NN1 ,_, weight_NN1 increase_NN1 ,_, caffeine_NN1 and_CC alcohol_NN1 intake_NN1 )_) ,_, which_DDQ may_VM play_VVI a_AT1 crucial_JJ role_NN1 when_CS determining_VVG potential_JJ causation_NN1 ._. 
</s>
<s>
In_II the_AT 1960s_MC2 ,_, fewer_DAR than_CSN half_DB the_AT children_NN2 in_II whom_PNQO cancer_NN1 was_VBDZ diagnosed_VVN were_VBDR still_RR alive_JJ 5_MC years_NNT2 later_RRR ._. 
</s>
<s>
Among_II females_NN2 ,_, no_AT diagnostic_JJ profile_NN1 predominated_VVD at_II follow-up_NN1 ._. 
</s>
<s>
The_AT difference_NN1 suggested_VVD that_CST the_AT change_NN1 in_II the_AT CD7N_FO proportion_NN1 could_VM be_VBI more_RGR important_JJ to_TO predict_VVI the_AT prognosis_NN1 ._. 
</s>
<s>
To_II our_APPGE knowledge_NN1 ,_, this_DD1 is_VBZ the_AT first_MD study_NN1 to_TO report_VVI the_AT prevalence_NN1 of_IO FRAs_NP2 in_II a_AT1 sample_NN1 of_IO children_NN2 with_IW ASD_NP1 who_PNQS did_VDD not_XX possess_VVI significant_JJ neurological_JJ abnormalities_NN2 ._. 
</s>
<s>
In_II this_DD1 sense_NN1 '_NULL cancer_NN1 and_CC regenerative_JJ failure_NN1 could_VM be_VBI viewed_VVN as_CSA different_JJ sides_NN2 of_IO the_AT same_DA coin_NN1 ._. 
</s>
<s>
RESULTS_NN2 '_NULL The_AT overall_JJ tissue_NN1 preparation_NN1 failure_NN1 rate_NN1 was_VBDZ 5.2%_FO ._. 
</s>
<s>
A_AT1 loss_NN1 of_IO being_VBG that_RG -1_MC argue_VV0 -_- is_VBZ at_II the_AT origin_NN1 of_IO the_AT ordinariness_NN1 of_IO terrorists_NN2 and_CC the_AT experience_NN1 of_IO void_NN1 in_II psychotics_NN1 ._. 
</s>
<s>
These_DD2 studies_NN2 reveal_VV0 numerous_JJ disparities_NN2 for_IF patients_NN2 with_IW SMI_NN2 and_CC cancer_NN1 in_II diagnosis_NN1 and_CC time_NNT1 to_II treatment_NN1 ;_; receipt_NN1 of_IO chemotherapy_NN1 ,_, radiation_NN1 ,_, and_CC surgery_NN1 ;_; and_CC clinical_JJ trial_NN1 participation_NN1 ._. 
</s>
<s>
The_AT finding_NN1 that_CST YMSM_NP1 who_PNQS disclosed_VVD their_APPGE HIV_NP1 status_NN1 to_II sex_NN1 partners_NN2 were_VBDR more_RGR likely_JJ to_TO report_VVI any_DD CAI_JJ than_CSN those_DD2 not_XX disclosing_VVG their_APPGE status_NN1 is_VBZ consistent_JJ with_IW other_JJ research_NN1 and_CC may_VM suggest_VVI that_CST many_DA2 YMSM_NN1 in_II the_AT sample_NN1 engaged_VVN in_II serosorting_VVG as_II a_AT1 harm_NN1 reduction_NN1 strategy_NN1 ,_, given_VVN the_AT significant_JJ association_NN1 of_IO disclosure_NN1 to_II any_DD CAI_NN2 but_CCB not_XX to_II serodiscordant_JJ CAI_NN2 ._. 
</s>
<s>
As_RR21 yet_RR22 no_AT studies_NN2 have_VH0 assessed_VVN the_AT role_NN1 of_IO pain_NN1 intensity_NN1 or_CC psychosocial_JJ variables_NN2 in_II predicting_VVG the_AT work_NN1 status_NN1 of_IO CRPS_NP1 patients_NN2 ._. 
</s>
<s>
In_II the_AT absence_NN1 of_IO political_JJ action_NN1 ,_, only_RR traditional_JJ Medicare_NP1 beneficiaries_NN2 will_VM be_VBI excluded_VVN from_II the_AT benefits_NN2 of_IO telehealth_NN1 that_CST now_RT increasingly_RR extend_VV0 to_II the_AT commercially_RR insured_VVN ,_, Medicaid_NP1 beneficiaries_NN2 ,_, military_JJ personnel_NN2 ,_, prisoners_NN2 ,_, and_CC veterans_NN2 ._. 
</s>
<s>
The_AT difference_NN1 in_II change_NN1 from_II baseline_NN1 to_II 12_MC months_NNT2 between_II the_AT two_MC study_NN1 groups_NN2 was_VBDZ analysed_VVN using_VVG the_AT Mann-Whitney_NP1 U_JJ test_NN1 due_II21 to_II22 the_AT non-normality_NN1 of_IO the_AT data_NN ._. 
</s>
<s>
Functional_JJ outcomes_NN2 are_VBR presented_VVN in_II Figure_NN1 2_MC ._. 
</s>
<s>
To_TO address_VVI this_DD1 ,_, a_AT1 cell_NN1 free_JJ recombinant_NN1 BACE1_FO assay_NN1 was_VBDZ used_VVN ._. 
</s>
<s>
Consistent_JJ with_IW previous_JJ results_NN2 ,_, we_PPIS2 found_VVD no_AT adverse_JJ effect_NN1 of_IO nonglycosylated_JJ PRPH2/RDS_FU in_II rods_NN2 ;_; rdsN229SN229S_FO animals_NN2 exhibited_VVD normal_JJ PRPH2/RDS_FU and_CC ROM-1_MC1 levels_NN2 and_CC no_AT defects_NN2 in_II retinal_JJ structure_NN1 or_CC function_NN1 ._. 
</s>
<s>
Critical_JJ revision_NN1 of_IO the_AT manuscript_NN1 for_IF important_JJ intellectual_JJ content_NN1 :_: Van_NP1 Driest_NP1 ,_, Wells_NP1 ,_, Stallings_NN2 ,_, Bush_NP1 ,_, Gordon_NP1 ,_, Nickerson_NP1 ,_, Kim_NP1 ,_, Crosslin_NP1 ,_, Jarvik_NP1 ,_, Carrell_NP1 ,_, Ralston_NP1 ,_, Larson_NP1 ,_, Bielinski_NP1 ,_, Olson_NP1 ,_, Ye_PPY ,_, Kullo_NP1 ,_, Abul-Husn_NP1 ,_, Scott_NP1 ,_, Bottinger_NP1 ,_, Almoguera_NP1 ,_, Connolly_NP1 ,_, Chiavacci_NP1 ,_, Hakonarson_NP1 ,_, Rasmussen-Torvik_NP1 ,_, Pan_NP1 ,_, Persell_NP1 ,_, Smith_NP1 ,_, Chisholm_NP1 ,_, Kitchner_NP1 ,_, Wallace_NP1 ,_, Doheny_NP1 ,_, Shoemaker_NN1 ,_, Li_NP1 ,_, Manolio_NP1 ,_, Callis_NP1 ,_, Macaya_NP1 ,_, Williams_NP1 ,_, Carey_NP1 ,_, Kapplinger_NP1 ,_, Ackerman_NP1 ,_, Ritchie_NP1 ,_, Denny_NP1 ,_, Roden_NP1 ._. 
</s>
<s>
The_AT Obuchowski_JJ measures_NN2 are_VBR a_AT1 generalization_NN1 of_IO the_AT area_NN1 under_II the_AT receiver_NN1 operating_VVG characteristic_JJ curve_NN1 to_TO allow_VVI for_IF a_AT1 reference_NN1 standard_NN1 that_CST has_VHZ more_DAR than_CSN two_MC categories_NN2 ._. 
</s>
<s>
However_RR ,_, this_DD1 study_NN1 was_VBDZ performed_VVN only_RR on_II septic_JJ patients_NN2 ._. 
</s>
<s>
However_RR ,_, the_AT number_NN1 of_IO days_NNT2 free_JJ from_II renal-replacement_JJ therapy_NN1 was_VBDZ significantly_RR higher_JJR ,_, and_CC the_AT rate_NN1 of_IO catheter-related_JJR bloodstream_NN1 infections_NN2 was_VBDZ significantly_RR lower_JJR ,_, in_II the_AT delayed-strategy_JJ group_NN1 than_CSN in_II the_AT early-strategy_JJ group_NN1 (_( Table_NN1 2_MC )_) ._. 
</s>
<s>
The_AT rate_NN1 of_IO complications_NN2 that_CST were_VBDR potentially_RR related_VVN to_II acute_JJ kidney_NN1 injury_NN1 or_CC renal-replacement_JJ therapy_NN1 did_VDD not_XX differ_VVI significantly_RR between_II the_AT two_MC study_NN1 groups_NN2 ,_, with_IW the_AT exception_NN1 of_IO hypophosphatemia_NN1 ,_, which_DDQ was_VBDZ more_RGR common_JJ in_II the_AT early-strategy_JJ group_NN1 (_( Table_NN1 2_MC )_) ._. 
</s>
<s>
Linear_JJ corrections_NN2 for_IF these_DD2 interferences_NN2 are_VBR feasible_JJ and_CC would_VM facilitate_VVI the_AT interchangeable_JJ use_NN1 of_IO DNa_NN1 and_CC INa_NP1 data_NN ,_, thereby_RR improving_VVG the_AT diagnosis_NN1 and_CC treatment_NN1 of_IO the_AT dysnatremias_NN2 ,_, as_II31 well_II32 as_II33 laboratory_NN1 testing_NN1 of_IO concordance_NN1 between_II the_AT two_MC methods_NN2 ._. 
</s>
<s>
Parents_NN2 often_RR lack_VV0 knowledge_NN1 ,_, which_DDQ can_VM make_VVI them_PPHO2 feel_VVI insecure_JJ ,_, and_CC take_VV0 actions_NN2 that_CST are_VBR not_XX beneficial_JJ for_IF the_AT child_NN1 and_CC only_RR increase_VV0 the_AT problem_NN1 ._. 
</s>
<s>
Sentence_NN1 identification_NN1 scores_NN2 ,_, shown_VVN in_II Figure_NN1 4_MC ,_, were_VBDR also_RR consistent_JJ with_IW the_AT speechtracking_NN1 and_CC consonant_JJ identification_NN1 scores_NN2 :_: there_EX was_VBDZ a_AT1 significant_JJ group_NN1 by_II interval_NN1 interaction_NN1 (_( p_NNU less_DAR than_CSN 0.01_MC )_) and_CC an_AT1 advantage_NN1 for_IF the_AT gradual_JJ group_NN1 at_II test_NN1 interval_NN1 1_MC1 (_( p_NNU less_DAR than_CSN 0.05_MC )_) that_CST disappeared_VVD at_II later_JJR test_NN1 intervals_NN2 ._. 
</s>
<s>
All_DB approaches_NN2 have_VH0 strengths_NN2 and_CC limitations_NN2 and_CC provide_VV0 different_JJ insights_NN2 about_II vascular_JJ function_NN1 ,_, as_CSA reviewed_VVN elsewhere_RL ;_; this_DD1 variation_NN1 may_VM complicate_VVI comparisons_NN2 among_II studies_NN2 that_CST use_VV0 different_JJ methods_NN2 ._. 
</s>
<s>
As_CSA Spielman_NP1 and_CC Yoo_NP1 (_( 32_MC )_) advise_VV0 :_: "_" If_CS you_PPY '_NULL re_II going_VVGK to_TO spend_VVI time_NNT1 and_CC money_NN1 painting_VVG a_AT1 picture_NN1 of_IO the_AT relationship_NN1 between_II the_AT environment_NN1 and_CC health_NN1 ,_, invest_VV0 in_II the_AT frame_NN1 -_- unless_CS the_AT frame_NN1 is_VBZ well_RR designed_VVN ,_, the_AT painting_NN1 isn_NN1 '_NULL t_ZZ1 going_VVG to_TO be_VBI very_RG good_JJ ._. "_" 
</s>
<s>
We_PPIS2 found_VVD that_DD1 MR-proANP_NN1 measured_VVN during_II the_AT index_NN1 visit_NN1 and_CC 7_MC days_NNT2 later_RRR was_VBDZ a_AT1 strong_JJ predictor_NN1 for_IF 10-year_JJ all-cause_JJ mortality_NN1 with_IW robust_JJ results_NN2 across_II several_DA2 subgroups_NN2 ._. 
</s>
<s>
In_RR21 particular_RR22 ,_, studies_NN2 that_CST compare_VV0 the_AT effectiveness_NN1 of_IO providing_VVG participants_NN2 with_IW a_AT1 socioculturally_RR relevant_JJ physical_JJ activity_NN1 program_NN1 compared_VVN with_IW a_AT1 standardized_JJ program_NN1 (_( or_CC a_AT1 program_NN1 that_CST had_VHD been_VBN socioculturally_RR targeted_VVN for_IF a_AT1 different_JJ subgroup_NN1 )_) would_VM provide_VVI valuable_JJ data_NN to_TO test_VVI the_AT model_NN1 ._. 
</s>
<s>
We_PPIS2 also_RR hand-searched_JJ the_AT reference_NN1 lists_NN2 of_IO retrieved_JJ articles_NN2 to_TO identify_VVI additional_JJ studies_NN2 of_IO interest_NN1 ._. 
</s>
<s>
It_PPH1 has_VHZ been_VBN estimated_VVN that_CST up_RG21 to_RG22 299,000_MC new_JJ patients_NN2 each_DD1 year_NNT1 may_VM experience_VVI persistent_JJ pain_NN1 following_II TKR_NP1 ;_; this_DD1 number_NN1 may_VM increase_VVI to_II between_II 700,000_MC and_CC 1.5_MC million_NNO as_II the_AT frequency_NN1 of_IO TKR_NP1 increases_VVZ ._. 
</s>
<s>
MALAT1_FO is_VBZ a_AT1 long_JJ intergenic_JJ noncoding_NN1 (_( linc_NN1 )_) RNA_NN1 ,_, already_RR described_VVN in_II the_AT literature_NN1 as_II a_AT1 regulator_NN1 of_IO cell_NN1 cycle_NN1 progression_NN1 (_( Tripathi_NP1 et_RA21 al._RA22 ,_, 2013_MC )_) ._. 
</s>
<s>
No_AT binding_NN1 of_IO the_AT nontargetedUSPIO_NN1 to_II HUVEC_NP1 or_CC MDA-MB-231_NP1 cells_NN2 was_VBDZ observed_VVN (_( Fig._NN1 11C_FO )_) ._. 
</s>
<s>
These_DD2 vascular_JJ effects_NN2 may_VM explain_VVI how_RRQ histamine_VV0 also_RR is_VBZ involved_JJ in_II glucose_NN1 delivery_NN1 and_CC uptake_NN1 ;_; however_RR ,_, nonvascular_JJ effects_NN2 also_RR may_VM be_VBI important_JJ ._. 
</s>
<s>
Intervention_NN1 effects_NN2 Figure_NN1 3_MC presents_VVZ the_AT observed_JJ data_NN of_IO objectively_RR measured_VVN ,_, wheeled_VVD physical_JJ activity_NN1 ._. 
</s>
<s>
At_II nodule-level_JJ analysis_NN1 ,_, the_AT generalized_JJ estimating_VVG equation_NN1 method_NN1 was_VBDZ used_VVN for_IF comparison_NN1 ._. 
</s>
<s>
The_AT preoperative_JJ clinical_JJ characteristics_NN2 of_IO the_AT patients_NN2 were_VBDR comparable_JJ between_II the_AT 2_MC groups_NN2 as_CSA shown_VVN in_II Table_NN1 2_MC ._. 
</s>
<s>
The_AT most_RGT frequent_JJ pain_NN1 therapy_NN1 side_NN1 effect_NN1 was_VBDZ drowsiness_NN1 (_( 53%_NNU )_) ._. 
</s>
<s>
All_DB of_IO the_AT concerts_NN2 had_VHD alcohol_NN1 presence_NN1 ,_, as_II31 well_II32 as_II33 90.91_MC %_NNU of_IO the_AT football_NN1 games_NN2 (_( mostly_RR through_II )_) ._. 
</s>
<s>
Further_JJR research_NN1 in_II the_AT form_NN1 of_IO a_AT1 factorial_JJ study_NN1 (_( whereby_RRQ participants_NN2 are_VBR randomised_VVN to_TO receive_VVI a_AT1 personalised_JJ invitation_NN1 to_II a_AT1 local_JJ SSS_NP1 ,_, or_CC an_AT1 invitation_NN1 to_II a_AT1 taster_NN1 session_NNT1 ,_, or_CC both_RR ,_, or_CC neither_RR )_) is_VBZ necessary_JJ to_TO estimate_VVI the_AT separate_JJ effects_NN2 of_IO the_AT two_MC components_NN2 ._. 
</s>
<s>
Le_NP1 et_RA21 al_RA22 reported_VVD that_CST the_AT overall_JJ risk_NN1 of_IO nodal_JJ involvement_NN1 at_II diagnosis_NN1 and_CC on_II follow-up_NN1 was_VBDZ 28%_NNU for_IF squamous_JJ cell_NN1 carcinoma_NN1 of_IO the_AT maxillary_JJ sinus_NN1 ._. 
</s>
<s>
To_TO further_RRR assess_VVI clinically_RR relevant_JJ trends_NN2 identified_VVN in_II the_AT univariable_JJ analysis_NN1 ,_, we_PPIS2 compared_VVD the_AT characteristics_NN2 of_IO patients_NN2 who_PNQS required_VVD no_AT injections_NN2 (_( n_ZZ1 =_FO 121_MC ;_; 24_MC ._. 
</s>
<s>
Although_CS these_DD2 findings_NN2 are_VBR consistent_JJ with_IW the_AT decreased_JJ DPOAEs_NP2 in_II the_AT current_JJ study_NN1 ,_, longitudinal_JJ studies_NN2 will_VM be_VBI necessary_JJ to_TO determine_VVI if_CSW the_AT trends_NN2 noted_VVN in_II this_DD1 study_NN1 are_VBR consistent_JJ with_IW progressive_JJ hearing_NN1 loss_NN1 in_II diabetes_NN1 ._. 
</s>
<s>
Despite_II normolipidemia_NN1 ,_, the_AT subjects_NN2 with_IW the_AT unfavorable_JJ apoB/apoA-I_NN1 ratio_NN1 had_VHD higher_JJR values_NN2 of_IO TG_NP1 and_CC AIP_NP1 and_CC lower_JJR values_NN2 of_IO LDL-C/apoB_NN1 ratio_NN1 ,_, which_DDQ indicates_VVZ an_AT1 increase_NN1 of_IO the_AT number_NN1 of_IO TG-rich_JJ lipoproteins_NN2 and_CC small_JJ ,_, dense_JJ low-density_JJ lipoproteins_NN2 ._. 
</s>
<s>
The_AT number_NN1 of_IO tumors_NN2 in_II Pik3caRBD/-_FU mice_NN2 was_VBDZ strikingly_RR reduced_VVN when_CS compared_VVN to_II their_APPGE control_NN1 counterparts_NN2 ,_, indicating_VVG that_DD1 suppression_NN1 of_IO RAS_NP2 interaction_NN1 with_IW p110a_FO greatly_RR impairs_VVZ tumor_NN1 growth_NN1 and_CC maintenance_NN1 at_II this_DD1 stage(Figure1B).We_FO also_RR observed_VVN a_AT1 decrease_NN1 in_II tumor_NN1 number_NN1 in_II Pik3caRBD/-_FU mice_NN2 at_II the_AT end_NN1 of_IO the_AT experiment_NN1 when_CS compared_VVN to_II Pik3caRBD/flox_NN1 miceat4weeks_FO of_IO age_NN1 prior_II21 to_II22 the_AT beginning_NN1 of_IO tamoxifen_JJ treatment_NN1 ,_, thus_RR suggesting_VVG tumor_NN1 regression_NN1 in_II Pik3caRBD/-_FU mice_NN2 and_CC not_XX just_RR slower_JJR tumor_NN1 development_NN1 ._. 
</s>
<s>
All_DB research_NN1 has_VHZ been_VBN approved_VVN continuously_RR by_II relevant_JJ institutional_JJ review_NN1 boards_NN2 ._. 
</s>
<s>
Thus_RR ,_, the_AT authors_NN2 concluded_VVD that_CST both_DB2 methods_NN2 were_VBDR needed_VVN to_TO achieve_VVI the_AT highest_JJT predictive_JJ accuracy_NN1 ._. 
</s>
<s>
Dr_NNB Delage_NP1 reports_VVZ receipt_NN1 of_IO speaker_NN1 honoraria_NN1 from_II Novartis_NP1 and_CC Boehringer_NP1 Ingelheim_NP1 ._. 
</s>
<s>
These_DD2 cells_NN2 express_VV0 low_JJ levels_NN2 of_IO HLA_NP1 class_NN1 I_ZZ1 antigens_NN2 and_CC do_VD0 not_XX express_VVI HLA_NP1 class_NN1 II_MC antigens_NN2 (_( Ryan_NP1 et_RA21 al_RA22 ._. 
</s>
<s>
'_NULL 2005_MC )_) ._. 
</s>
<s>
Inhibition_NN1 of_IO CTGF_NP1 by_II intravitreal_JJ injection_NN1 of_IO CTGF_NP1 antibody_NN1 blocked_VVD the_AT growth_NN1 of_IO superior_JJ vascular_JJ plexus_NN1 and_CC filopodial_JJ burst_NN1 during_II vessel_NN1 development_NN1 ._. 
</s>
<s>
In_II this_DD1 pilot_NN1 trial_NN1 ,_, mortality_NN1 rates_NN2 were_VBDR not_XX different_JJ between_II groups_NN2 ._. 
</s>
<s>
During_II the_AT session_NNT1 ,_, patients_NN2 partially_RR completed_VVD their_APPGE therapeutic_JJ tasks_NN2 (_( 50%_NNU )_) for_IF the_AT day_NNT1 under_II the_AT study_NN1 coordinator_NN1 '_NULL s_ZZ1 supervision_NN1 and_CC clarified_VVD any_DD questions_NN2 regarding_II their_APPGE swallowing_VVG ._. 
</s>
<s>
While_CS these_DD2 findings_NN2 indicate_VV0 the_AT importance_NN1 of_IO the_AT UPR_NN1 and_CC ER_NP1 function_NN1 in_II both_DB2 normal_JJ as_II31 well_II32 as_II33 disease-related_JJ cellular_JJ activities_NN2 ,_, they_PPHS2 also_RR reflect_VV0 the_AT complexity_NN1 and_CC challenges_NN2 in_II fully_RR understanding_VVG the_AT mechanisms_NN2 and_CC physiological_JJ significance_NN1 of_IO these_DD2 pathways_NN2 ._. 
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<s>
Previous_JJ literature_NN1 examining_VVG maternal_JJ mortality_NN1 among_II women_NN2 of_IO advanced_JJ maternal_JJ age_NN1 is_VBZ therefore_RR limited_VVN ._. 
</s>
<s>
In_II patients_NN2 with_IW glaucoma_NN1 '_NULL high_JJ preoperative_JJ IOP_NN1 '_NULL or_CC both_RR '_NULL it_PPH1 can_VM be_VBI difficult_JJ to_TO distinguish_VVI whether_CSW the_AT increase_NN1 in_II IOP_NP1 is_VBZ primarily_RR a_AT1 postoperative_JJ complication_NN1 '_NULL or_CC rather_RR part_NN1 of_IO a_AT1 glaucoma_NN1 condition_NN1 itself_PPX1 ._. 
</s>
<s>
We_PPIS2 constructed_VVD first-level_JJ maps_NN2 to_TO isolate_VVI (_( 1_MC1 )_) interference-related_JJ activity_NN1 during_II correct_JJ trials_NN2 (_( incongruent_JJ correct_JJ vs_II congruent_JJ correct_JJ trials_NN2 )_) and_CC (_( 2_MC )_) error-related_JJ activity_NN1 (_( in-congruent_JJ incorrect_JJ vs_II incongruent_JJ correct_JJ trials_NN2 )_) ._. 
</s>
<s>
Without_IW this_DD1 understanding_NN1 ,_, it_PPH1 is_VBZ impossible_JJ to_TO know_VVI whether_CSW efforts_NN2 should_VM target_VVI decreasing_JJ use_NN1 of_IO laboratories_NN2 and_CC imaging_NN1 or_CC increasing_VVG the_AT use_NN1 of_IO these_DD2 tools_NN2 to_TO decrease_VVI missed_JJ pulmonary_JJ embolism_NN1 diagnoses_NN2 ._. 
</s>
<s>
If_CS the_AT use_NN1 of_IO psychotropic_JJ medication_NN1 increases_VVZ the_AT risk_NN1 of_IO preterm_NN1 birth_NN1 ,_, then_RT women_NN2 who_PNQS are_VBR able_JK to_TO at_II least_RGT temporarily_RR discontinue_VV0 treatment_NN1 may_VM elect_VVI to_TO do_VDI so_RR ._. 
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<s>
According_II21 to_II22 long-term_JJ oncologic_JJ outcomes_NN2 ,_, which_DDQ were_VBDR obtained_VVN in_II our_APPGE study_NN1 ,_, the_AT answer_NN1 is_VBZ no_UH ._. 
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<s>
Study_NN1 supervision_NN1 :_: Uusitalo_NP1 ,_, Lernmark_NP1 ,_, Hagopian_JJ ,_, She_PPHS1 ,_, Toppari_NP1 ,_, Ziegler_NP1 ,_, Krischer_NP1 ,_, Norris_NP1 ,_, Virtanen_NP1 ._. 
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<s>
The_AT difference_NN1 was_VBDZ not_XX significant_JJ ,_, perhaps_RR due_II21 to_II22 small_JJ sample_NN1 size_NN1 ._. 
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<s>
Transient_JJ postoperative_JJ ptosis_NN1 (_( 50%_NNU )_) and_CC exotropia_NN1 (_( 56%_NNU )_) were_VBDR common_JJ in_II the_AT chemodenervation_NN1 group_NN1 ._. 
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<s>
There_EX were_VBDR 23_MC patients_NN2 in_II the_AT placebo_NN1 group_NN1 who_PNQS completed_VVD the_AT 16-week_JJ treatment_NN1 period_NN1 and_CC 28_MC in_II the_AT dupilumab_NN1 group_NN1 ._. 
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<s>
To_II our_APPGE knowledge_NN1 ,_, the_AT PQ_NP1 is_VBZ the_AT first_MD tool_NN1 that_CST combines_VVZ the_AT benefits_NN2 of_IO electronic_JJ administration_NN1 ,_, real-time_JJ data_NN collection_NN1 ,_, and_CC illustration_NN1 of_IO pain_NN1 through_II a_AT1 mixture_NN1 of_IO icons_NN2 and_CC word_NN1 descriptors_NN2 on_II a_AT1 detailed_JJ virtual_JJ body-map_NN1 ._. 
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<s>
With_IW the_AT current_JJ implementation_NN1 ,_, in_II conventional_JJ 2-dimensional_JJ brain_NN1 imaging_NN1 ,_, slice_VV0 acceleration_NN1 factors_NN2 of_IO 2_MC or_CC 3_MC can_VM be_VBI used_VVN ,_, preserving_VVG SNR_NP1 when_CS compared_VVN with_IW the_AT identical_JJ nonaccelerated_JJ scan_NN1 ,_, with_IW little_DA1 to_II no_AT image_NN1 artifacts_NN2 (_( Fig._NN1 6_MC )_) ._. 
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<s>
Romero-Sanchez_NP1 et_RA21 al_RA22 ._. 
</s>
<s>
measured_VVD the_AT serum_NN1 concentration_NN1 of_IO MCP-1_MC1 in_II 50_MC patients_NN2 with_IW ankylosing_VVG spondylitis_NN1 ,_, 27_MC patients_NN2 with_IW mechanical_JJ LBP_NP1 and_CC 53_MC healthy_JJ individuals_NN2 ._. 
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<s>
We_PPIS2 proposed_VVD to_TO study_VVI a_AT1 convenient_JJ sample_NN1 size_NN1 ,_, with_IW 40_MC participants_NN2 in_II each_DD1 group_NN1 ._. 
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<s>
The_AT subjects_NN2 had_VHD no_AT acute_JJ or_CC chronic_JJ pain_NN1 conditions_NN2 ,_, and_CC none_PN took_VVD medication_NN1 one_MC1 day_NNT1 prior_II21 to_II22 the_AT study_NN1 ._. 
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<s>
Indeed_RR ,_, drug-tolerant_JJ A375-GFP_JJ cells_NN2 display_VV0 increased_JJ expression_NN1 of_IO genes_NN2 characteristic_NN1 for_IF rewired_JJ cells_NN2 (_( Figure_NN1 S1F_FO )_) ._. 
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<s>
Novel_JJ selective_JJ chemical_JJ inhibitors_NN2 for_IF endoplasmic_JJ aminopeptidases_NN2 are_VBR currently_RR been_VBN developed_VVN (_( Papakyriakou_NP1 et_RA21 al_RA22 ._. '_NULL 
</s>
<s>
2013_MC ;_; Zervoudi_NP1 et_RA21 al_RA22 ._. '_NULL 
</s>
<s>
2013_MC )_) ._. 
</s>
<s>
When_CS analyzing_VVG the_AT incidence_NN1 of_IO adverse_JJ events_NN2 in_II PSA_NP1 in_II RCTs_NP1 ,_, we_PPIS2 found_VVD that_CST the_AT incidence_NN1 of_IO agitation_NN1 ,_, apnea_NN1 ,_, bradycardia_NN1 ,_, hypotension_NN1 ,_, hypoxia_NN1 ,_, and_CC vomiting_NN1 were_VBDR higher_JJR ._. 
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<s>
Measuring_VVG sites_NN2 for_IF airway_NN1 pressure_NN1 (_( Paw_NP1 )_) and_CC flow_NN1 are_VBR at_II the_AT proximal_JJ end_NN1 of_IO the_AT DLT_NP1 ._. 
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<s>
Participants_NN2 in_II the_AT control_NN1 group_NN1 reported_VVD significant_JJ pretreatment_NN1 to_II posttreatment_NN1 improvements_NN2 in_II life_NN1 satisfaction_NN1 ,_, and_CC pretreatment_NN1 to_II follow-up_JJ improvements_NN2 in_II pain_NN1 intensity_NN1 and_CC pain_NN1 control_NN1 ._. 
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<s>
Pain_NN1 catastrophizing_VVG :_: The_AT 13-item_JJ Pain_NN1 Catastrophizing_VVG Scale_NN1 (_( PCS_NN2 )_) 80_MC assesses_VVZ 3_MC domains_NN2 of_IO pain-related_JJ catastrophizing_NN1 (_( rumination_NN1 ,_, helplessness_NN1 ,_, and_CC magnification_NN1 )_) using_VVG a_AT1 0to_FO 4_MC rating_NN1 scale_NN1 (_( '_NULL Not_XX at_II all_DB '_NULL to_II '_NULL All_DB the_AT time_NNT1 '_NULL )_) ._. 
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<s>
However_RR ,_, its_APPGE origin_NN1 was_VBDZ at_II the_AT lower_JJR area_NN1 of_IO the_AT wall_NN1 ,_, at_II an_AT1 area_NN1 that_CST ,_, although_CS close_JJ ,_, did_VDD not_XX adjoin_VVI the_AT margins_NN2 of_IO the_AT middle_JJ meatal_JJ antrostomy_NN1 ._. 
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<s>
The_AT images_NN2 are_VBR transferred_VVN to_II the_AT cloud_NN1 for_IF analysis_NN1 ._. 
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<s>
This_DD1 points_VVZ to_II the_AT importance_NN1 of_IO maintaining_VVG meshes_NN2 in_II a_AT1 flat_NN1 (_( as_II31 opposed_II32 to_II33 folded_JJ )_) configuration_NN1 to_TO minimize_VVI the_AT amount_NN1 of_IO material_NN1 per_II area_NN1 and_CC of_IO choosing_VVG meshes_NN2 in_II which_DDQ the_AT spaces_NN2 between_II fibers_NN2 (_( pores_NN2 )_) are_VBR wide_JJ enough_RR that_CST the_AT host_NN1 response_NN1 to_II 2_MC adjacent_JJ fibers_NN2 does_VDZ not_XX overlap_VVI ._. 
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<s>
By_II analyzing_VVG the_AT findings_NN2 from_II 18_MC published_JJ studies_NN2 including_II 4,607_MC participants_NN2 ,_, the_AT authors_NN2 found_VVD that_CST the_AT effect_NN1 of_IO OPRM1_FO A118G_FO on_II postoperative_JJ pain_NN1 is_VBZ greatly_RR driven_VVN by_II ethnicity_NN1 and_CC is_VBZ most_RGT obvious_JJ in_II Asian_JJ but_CCB not_XX Caucasian_JJ patient_JJ populations_NN2 ._. 
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<s>
The_AT most_RGT common_JJ TEAEs_NP2 leading_VVG to_II discontinuation_NN1 were_VBDR insomnia_NN1 (_( 8_MC patients_NN2 ,_, 2.9%_FO )_) ,_, aggression_NN1 (_( 5_MC patients_NN2 ,_, 1.8%_FO )_) ,_, and_CC decreased_JJ appetite_NN1 ,_, headache_NN1 ,_, and_CC depressed_JJ mood_NN1 (_( each_DD1 in_II 4_MC participants_NN2 ,_, 1.4%_FO )_) ._. 
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<s>
On_II the_AT contrary_NN1 ,_, lesion_NN1 size_NN1 was_VBDZ larger_JJR in_II AM+/_JJ CNV_NP1 model_NN1 mice_NN2 ,_, presumably_RR due_II21 to_II22 the_AT antiinflammatory_JJ function_NN1 of_IO AM.Despite_NP1 the_AT success_NN1 of_IO anti-vascular_JJ endothelial_JJ growth_NN1 factor_NN1 agents_NN2 for_IF the_AT treatment_NN1 of_IO retinochoroidal_JJ disease_NN1 ,_, therapeutic_JJ shortcomings_NN2 remain_VV0 ._. 
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<s>
The_AT percent_NNU improvement_NN1 in_II the_AT global_JJ wall-motion_JJ index_NN1 was_VBDZ larger_JJR for_IF patients_NN2 who_PNQS were_VBDR free_JJ of_IO moderate_JJ or_CC severe_JJ mitral_JJ regurgitation_NN1 at_II 2_MC years_NNT2 than_CSN for_IF those_DD2 with_IW such_DA mitral_JJ regurgitation_NN1 (_( 16.5_MC plus_II and_CC minus_II 20.1%_FO vs._II 7.4_MC plus_II and_CC minus_II 16.7%_FO ,_, P=0.008_FO )_) (_( Fig._NN1 1_MC1 )_) ._. 
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<s>
Functional_JJ aspects_NN2 of_IO ribbon_NN1 synapses_VVZ The_AT study_NN1 of_IO ribbon_NN1 synapses_VVZ in_II zebrafish_NN1 hair_NN1 cells_NN2 has_VHZ profited_VVN from_II recently_RR developed_JJ methods_NN2 that_CST enable_VV0 quantification_NN1 of_IO deficits_NN2 in_II synaptic_JJ transmission_NN1 ._. 
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<s>
This_DD1 is_VBZ probably_RR due_II21 to_II22 its_APPGE broader_JJR approach_NN1 to_II the_AT diagnosis_NN1 of_IO frailty_NN1 and_CC the_AT inclusion_NN1 of_IO cognitive_JJ and_CC psychosocial_JJ markers_NN2 rather_II21 than_II22 solely_RR relying_VVG on_II physical_JJ markers_NN2 ._. 
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<s>
For_IF those_DD2 of_IO us_PPIO2 who_PNQS have_VH0 already_RR introduced_VVN mindfulness_NN1 into_II our_APPGE integrated_JJ therapy_NN1 programs_NN2 for_IF many_DA2 years_NNT2 now_RT ,_, we_PPIS2 have_VH0 a_AT1 new_JJ practical_JJ tool_NN1 to_TO use_VVI with_IW our_APPGE clients_NN2 ._. 
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<s>
Other_JJ factors_NN2 associated_VVN with_IW persistent_JJ muscle_NN1 weakness_NN1 include_VV0 older_JJR age_NN1 ,_, dementia_NN1 ,_, cancer_NN1 diagnoses_NN2 ,_, malnutrition_NN1 ,_, social_JJ isolation_NN1 ,_, and_CC preexisting_VVG functional_JJ immobility_NN1 ._. 
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<s>
Include_VV0 healthy_JJ lifestyle_NN1 goals_NN2 in_II treatment_NN1 planning_VVG for_IF people_NN with_IW mental_JJ illness_NN1 ._. 
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<s>
Declaration_NN1 of_IO interests_NN2 All_DB authors_NN2 report_NN1 grants_VVZ from_II the_AT National_JJ Institute_NN1 for_IF Health_NN1 Research_NN1 (_( NIHR_NP1 )_) during_II the_AT course_NN1 of_IO the_AT study_NN1 ._. 
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<s>
Gabapentin_NN1 Group_NN1 :_: Group_NN1 G_NP1 This_DD1 group_NN1 received_VVD Gabapentin_NP1 capsules_NN2 (_( Neurontin_NP1 Capsule_NN1 ;_; Pfizer_NP1 )_) :_: 1200_MC mg_NNU (_( 3_MC capsules_NN2 of_IO 400_MC mg_NNU dosage_NN1 )_) 2_MC hours_NNT2 before_II surgery_NN1 and_CC 12_MC hours_NNT2 after_II surgery_NN1 and_CC 400_MC mg_NNU 3_MC times_NNT2 daily_RR for_IF 2_MC days_NNT2 ._. 
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<s>
Regardless_RR ,_, the_AT detection_NN1 of_IO SS18-SSX_JJ gene_NN1 fusion_NN1 remains_VVZ the_AT gold_NN1 standard_NN1 ._. 
</s>
<s>
Avoidance_NN1 strategies_NN2 included_VVD anybehavioral_JJ response_NN1 to_II anticipation_NN1 that_CST participants_NN2 reported_VVD employing_VVG in_II an_AT1 attempt_NN1 to_TO hide_VVI orescape_NN1 from_II an_AT1 impending_JJ moment_NN1 of_IO stuttering_VVG ._. 
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<s>
A_AT1 second_NNT1 larger_JJR retrospective_JJ study_NN1 of_IO 3533_MC nulliparous_JJ women_NN2 with_IW prolonged_JJ second_MD stage_NN1 plus_II epidural_NN1 who_PNQS were_VBDR allowed_VVN to_TO labor_VVI longer_RRR also_RR confirmed_VVD a_AT1 similar_JJ CD_NN1 rate_NN1 of_IO 20.0%_FO ._. 
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<s>
Studies_NN2 focused_VVN on_II direct_JJ head_NN1 impacts_NN2 to_II animals_NN2 and_CC cadavers_NN2 ,_, which_DDQ related_VVD the_AT resulting_JJ linear_JJ accelerations_NN2 to_II injury_NN1 tolerance_NN1 ._. 
</s>
<s>
The_AT prevailing_JJ hypothesis_NN1 in_II the_AT AD_NN1 field_NN1 previously_RR was_VBDZ that_DD1 atopy_NN1 is_VBZ due_II21 to_II22 an_AT1 '_NULL overactive_JJ '_NULL Th-2_MC immune_JJ system_NN1 ._. 
</s>
<s>
Mean_JJ BMI_NN1 was_VBDZ also_RR high_JJ in_II men_NN2 and_CC women_NN2 in_II high-income_JJ English-speaking_JJ countries_NN2 ,_, and_CC in_II women_NN2 in_II southern_JJ Africa_NP1 and_CC in_II the_AT Middle_JJ East_ND1 and_CC north_ND1 Africa_NP1 ._. 
</s>
<s>
The_AT direct_JJ effect_NN1 ofradiation_NN1 on_II muscle_NN1 ultimately_RR results_VVZ in_II fibrosis_NN1 and_CC contracture_VV0 with_IW a_AT1 gradual_JJ onset_NN1 noted_VVN at_II about_RG 9_MC weeks_NNT2 after_II treatment_NN1 is_VBZ completed_VVN ._. 
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<s>
The_AT OASES-S_NP1 assesses_VVZ all_DB of_IO the_AT aspects_NN2 of_IO a_AT1 child_NN1 '_NULL s_ZZ1 experience_NN1 of_IO the_AT stuttering_JJ disorder_NN1 as_CSA reflected_VVN in_II the_AT ICF_NN1 ._. 
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<s>
This_DD1 educational_JJ initiative_NN1 to_TO promote_VVI scholarly_JJ dialogue_NN1 in_II the_AT digital_JJ community_NN1 attracted_VVD a_AT1 global_JJ audience_NN1 by_II using_VVG various_JJ social_JJ media_NN platforms_NN2 ,_, including_II a_AT1 blog_NN1 ,_, Twitter_VV0 ,_, and_CC Google_NP1 Hangout_NP1 ._. 
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<s>
Located_VVN at_II 2p16.1_FO ,_, the_AT interval_NN1 contained_VVD genes_NN2 encoding_VVG vaccinia-related_JJ kinase_NN1 2_MC (_( VRK2_FO )_) and_CC Fanconi_JJ anaemia_NN1 ,_, complementation_NN1 group_NN1 L_ZZ1 (_( FANCL_NP1 ;_; figure_NN1 4_MC )_) ._. 
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<s>
The_AT combination_NN1 of_IO a_AT1 changing_JJ legislative_JJ environment_NN1 and_CC several_DA2 recent_JJ medical_JJ device_NN1 controversies_NN2 in_II the_AT field_NN1 underscores_VVZ the_AT need_NN1 for_IF to_TO understand_VVI critical_JJ issues_NN2 surrounding_VVG medical_JJ device_NN1 regulation_NN1 ._. 
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<s>
Later_JJR patients_NN2 undergo_VV0 a_AT1 progressive_JJ decline_NN1 of_IO visual_JJ acuity_NN1 in_II the_AT central_JJ field_NN1 as_II31 well_II32 as_II33 an_AT1 impairment_NN1 ofchromatic_JJ discrimination_NN1 ,_, due_II21 to_II22 the_AT gradual_JJ demise_NN1 of_IO cones_NN2 ._. 
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<s>
If_CS cerebral_JJ motor_NN1 structures_NN2 controlling_VVG leg_NN1 movements_NN2 are_VBR necessary_JJ for_IF locomotor_NN1 adaptation_NN1 of_IO spatial_JJ gait_NN1 parameters_NN2 ,_, we_PPIS2 would_VM expect_VVI persons_NN2 with_IW poststroke_NN1 hemiparesis_NN1 to_TO demonstrate_VVI reduced_JJ adaptation_NN1 of_IO the_AT step_NN1 length_NN1 spatial_JJ component_NN1 ._. 
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<s>
Technology_NN1 and_CC Vendors_NN2 Although_CS technological_JJ capability_NN1 is_VBZ not_XX a_AT1 true_JJ barrier_NN1 ,_, the_AT implementation_NN1 of_IO technology_NN1 and_CC execution_NN1 of_IO use_NN1 cases_NN2 by_II health_NN1 information_NN1 exchanges_NN2 and_CC their_APPGE vendors_NN2 remain_VV0 a_AT1 major_JJ barrier_NN1 ._. 
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<s>
Finally_RR ,_, the_AT fact_NN1 that_CST the_AT sample_NN1 was_VBDZ drawn_VVN from_II a_AT1 specialist_NN1 dermatology_NN1 clinic_NN1 also_RR places_VVZ boundaries_NN2 on_II the_AT generalizability_NN1 of_IO the_AT results_NN2 ._. 
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<s>
Identical_JJ titration_NN1 was_VBDZ performed_VVN for_IF those_DD2 taking_VVG placebo_NN1 to_TO maintain_VVI masking_NN1 ._. 
</s>
<s>
Importantly_RR ,_, although_CS we_PPIS2 were_VBDR able_JK to_TO define_VVI at_II baseline_NN1 subgroups_NN2 of_IO women_NN2 with_IW higher_JJR rates_NN2 of_IO preterm_NN1 birth_NN1 (_( including_II those_DD2 with_IW a_AT1 short_JJ cervix_NN1 and_CC those_DD2 with_IW a_AT1 positive_JJ fibronectin_NN1 test_NN1 )_) ,_, our_APPGE data_NN suggest_VV0 that_CST the_AT efficacy_NN1 of_IO progesterone_NN1 (_( for_IF all_DB outcomes_NN2 )_) is_VBZ similar_JJ across_II groups_NN2 ._. 
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<s>
There_EX was_VBDZ a_AT1 subtle_JJ ,_, yet_RR important_JJ difference_NN1 in_II the_AT association_NN1 between_II familiarity_NN1 with_IW PWS_NP2 and_CC the_AT two_MC reactions_NN2 components_NN2 ._. 
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<s>
Anatomically_RR ,_, these_DD2 nuclei_NN2 can_VM be_VBI readily_RR appreciated_VVN macroscopically_RR because_II21 of_II22 a_AT1 pigment_NN1 accumulated_VVN within_II the_AT cells_NN2 called_VVN neuromelanin_NN1 ._. 
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<s>
Traditional_JJ surgical_JJ approaches_NN2 have_VH0 been_VBN performed_VVN through_II external-access_JJ incisions_NN2 (_( lateral_JJ rhinotomy_NN1 ,_, bicoronal_JJ flap_NN1 ,_, or_CC a_AT1 combination_NN1 of_IO the_AT two_MC )_) ,_, and_CC such_DA approaches_NN2 can_VM lead_VVI to_II local_JJ complications_NN2 ._. 
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<s>
The_AT results_NN2 obtained_VVN for_IF the_AT safety-analysis_JJ set_NN1 were_VBDR consistent_JJ with_IW those_DD2 obtained_VVN for_IF the_AT ITT_NP1 set_VVD ._. 
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<s>
Therefore_RR ,_, this_DD1 finding_NN1 was_VBDZ concluded_VVN not_XX to_TO contribute_VVI to_II the_AT molecular_JJ diagnosis_NN1 of_IO IRD_NN1 for_IF this_DD1 individual_NN1 ._. 
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<s>
Abstract_JJ Genome-wide_JJ association_NN1 studies_NN2 have_VH0 identified_VVN SNPs_NP2 that_CST are_VBR sensitive_JJ for_IF tau_NN1 or_CC TDP-43_MC pathology_NN1 in_II frontotemporal_JJ lobar_NN1 degeneration_NN1 (_( FTLD_NP1 )_) ._. 
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<s>
We_PPIS2 generated_VVD a_AT1 knockin_NN1 mouse_NN1 model_NN1 carrying_VVG the_AT N229S_FO mutation_NN1 in_II the_AT endogenous_JJ Rds_NN2 locus_NN1 (_( Stuck_JJ et_RA21 al._RA22 ,_, 2015_MC )_) ._. 
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<s>
These_DD2 results_NN2 suggest_VV0 that_CST on_II occasion_NN1 the_AT intracellular_JJ calcium_NN1 level_NN1 may_VM be_VBI high_JJ enough_RR to_TO allow_VVI for_IF spontaneous_JJ release_NN1 ,_, but_CCB otherwise_RR evoked_VVN activity_NN1 is_VBZ absent_JJ in_II cav1_FO ._. 
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<s>
Importantly_RR ,_, fatigue_NN1 can_VM occur_VVI at_II different_JJ levels_NN2 from_II the_AT brain_NN1 to_II the_AT skeletal_JJ muscles_NN2 ._. 
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<s>
A_AT1 study_NN1 of_IO MS_NN1 plaques_NN2 revealed_VVD decreased_JJ levels_NN2 of_IO antioxidants_NN2 and_CC increased_JJ free-radical_JJ activity_NN1 (_( Langemann_NP1 et_RA21 al._RA22 ,_, 1992_MC )_) ._. 
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<s>
The_AT manuscript_NN1 will_VM undergo_VVI copyediting_VVG ,_, typesetting_NN1 ,_, and_CC review_NN1 of_IO the_AT resulting_JJ proof_NN1 before_CS it_PPH1 is_VBZ published_VVN in_II its_APPGE final_JJ citable_JJ form_NN1 ._. 
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<s>
To_II date_NN1 ,_, over_RG 100_MC devices_NN2 have_VH0 been_VBN implanted_VVN worldwide_RL ,_, representing_VVG the_AT largest_JJT group_NN1 of_IO patients_NN2 currently_RR treated_VVN with_IW visual_JJ prostheses_NN2 ._. 
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<s>
Those_DD2 training_VVG in_II VE_NP1 improved_VVD MAL-AS_NP2 scores_NN2 at_II POST_NN1 by_II 0.5_MC points_NN2 (_( t_ZZ1 =_FO 1.97_MC ;_; p_NNU less_DAR than_CSN .05_MC ;_; ES_NP1 =_FO 0.63_MC ;_; Figure_NN1 4G_NNU )_) and_CC RPSS_NP1 53_MC close_JJ total_JJ scores_NN2 at_II RET_NP1 by_II 2.2_MC points_NN2 (_( t_ZZ1 =_FO 2.38_MC ;_; p_NNU less_DAR than_CSN .05_MC ;_; ES_NP1 =510.47_FO ;_; Figure_NN1 4E_FO )_) ._. 
</s>
<s>
Introduction_NN1 Migraine_NP1 affects_VVZ 12%_NNU of_IO adults_NN2 in_II the_AT USA_NP1 ,_, making_VVG this_DD1 condition_NN1 a_AT1 common_JJ concern_NN1 for_IF many_DA2 patients_NN2 and_CC their_APPGE doctors.1_FO Often_RR overlooked_VVN is_VBZ the_AT high_JJ prevalence_NN1 of_IO psychiatric_JJ comorbidities_NN2 associated_VVN with_IW migraine_NN1 ,_, such_II21 as_II22 depression_NN1 ,_, anxiety_NN1 and_CC post-traumatic_JJ stress_NN1 disorder.2_FO '_NULL 4_MC Migraineurs_NN2 with_IW psychiatric_JJ comorbidity_NN1 have_VH0 higher_JJR healthcare_NN1 utilisation_NN1 tendencies_NN2 than_CSN migraineurs_NN2 without_IW psychiatric_JJ comorbidity.5_FO If_CS left_JJ untreated_JJ ,_, these_DD2 comorbid_JJ psychiatric_JJ conditions_NN2 can_VM increase_VVI the_AT risk_NN1 of_IO migraine_NN1 chronification_NN1 ,_, the_AT evolution_NN1 of_IO episodic_JJ migraine_NN1 (_( EM_FU )_) into_II chronic_JJ migraine_NN1 (_( CM_NNU )_) (_( ie_REX ,_, at_RR21 least_RR22 15_MC headache_NN1 days_NNT2 a_AT1 month_NNT1 ,_, including_VVG at_RR21 least_RR22 8_MC days/month_FU with_IW full-blown_JJ migraines_NN2 )_) ._. 
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<s>
The_AT superior_JJ and_CC nasal_JJ quadrants_NN2 of_IO OCA1_FO and_CC OCA3_FO had_VHD the_AT similar_JJ ROC_NN1 curves_NN2 (_( psuperior=0._FO 4784_MC and_CC pnasai=_FO 0_MC ._. 
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<s>
In_II a_AT1 separate_JJ study_NN1 by_II the_AT same_DA group_NN1 using_VVG mono-polar_JJ cathode_NN1 stimulation_NN1 ,_, the_AT authors_NN2 found_VVD that_CST with_IW smaller_JJR electrode_NN1 sizes_NN2 (_( 5_MC mm_NNU in_II diameter_NN1 )_) ,_, and_CC shorter_JJR stimulating_JJ durations_NN2 (_( 0.1_MC ms_NN1 pulses_NN2 )_) ,_, the_AT threshold_NN1 for_IF directly_RR activating_VVG RGC_NP1 was_VBDZ much_RR lower_JJR (_( 37_MC times_NNT2 lower_RRR )_) than_CSN that_DD1 required_VVN to_TO activate_VVI the_AT RGC_NP1 indirectly_RR via_II synaptic_JJ transmission_NN1 ._. 
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<s>
Thus_RR return_VV0 on_II effort_NN1 and_CC investment_NN1 in_II this_DD1 area_NN1 should_VM be_VBI substantial_JJ ._. 
</s>
<s>
The_AT Radiation_NN1 Therapy_NN1 Oncology_NN1 Group_NN1 (_( RTOG_NP1 )_) and_CC the_AT European_JJ Organization_NN1 for_IF Research_NN1 and_CC Treatment_NN1 of_IO Cancer_NN1 collaborated_VVD to_TO develop_VVI '_NULL late_JJ effects_NN2 in_II normal_JJ tissue_NN1 '_NULL morbidity_NN1 scales_NN2 ,_, and_CC the_AT National_JJ Cancer_NN1 Institute_NN1 consensus_NN1 conferences_NN2 have_VH0 introduced_VVN the_AT subjective_JJ ,_, objective_NN1 ,_, management_NN1 ,_, analysis_NN1 (_( SOMA_NP1 )_) classification_NN1 for_IF late_JJ cancer_NN1 therapy_NN1 toxicities_NN2 ._. 
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<s>
We_PPIS2 used_VVD the_AT Adult_NN1 Service_NN1 Use_NN1 Schedule_NN1 to_TO measure_VVI other_JJ health_NN1 and_CC social_JJ care_NN1 services_NN2 used_VVD ,_, including_II psychotropic_JJ medications_NN2 ._. 
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<s>
Its_APPGE axis_NN1 of_IO rotation_NN1 ,_, thickness_NN1 ,_, well_RR hidden_VVN donor_NN1 site_NN1 scar_NN1 ,_, thin_JJ pliable_JJ skin_NN1 ,_, and_CC superior_JJ skin_NN1 color_NN1 match_NN1 with_IW the_AT face_NN1 make_VV0 it_PPH1 an_AT1 appealing_JJ flap_NN1 in_II cervicofacial_JJ reconstruction_NN1 ._. 
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<s>
In_II our_APPGE experience_NN1 ,_, this_DD1 conclusion_NN1 is_VBZ very_RG common_JJ when_CS examining_VVG the_AT usefulness_NN1 of_IO new_JJ biomarkers_NN2 ._. 
</s>
<s>
Impairment_NN1 of_IO Protein_NN1 Synthesis_NN1 Although_CS there_EX is_VBZ evidence_NN1 from_II human_JJ studies_NN2 demonstrating_VVG that_CST the_AT basal_JJ rate_NN1 of_IO protein_NN1 synthesis_NN1 begins_VVZ to_TO decrease_VVI in_II the_AT immediate_JJ period_NN1 after_II disuse_NN1 ,_, the_AT cellular_JJ mechanisms_NN2 responsible_JJ for_IF this_DD1 reduction_NN1 in_II protein_NN1 synthesis_NN1 are_VBR poorly_RR understood_VVN ._. 
</s>
<s>
Axial_JJ slices_NN2 1_MC1 and_CC 5_MC mm_NNU thick_JJ were_VBDR reconstructed_VVN ._. 
</s>
<s>
Exposure_NN1 therapy_NN1 has_VHZ been_VBN shown_VVN to_TO lead_VVI to_II reductions_NN2 in_II tics_NN2 and_CC premonitory_JJ urges_NN2 ,_, and_CC a_AT1 similar_JJ mechanism_NN1 is_VBZ thought_VVN to_TO underlie_VVI behavior_NN1 therapy_NN1 for_IF tics_NN2 ._. 
</s>
<s>
Given_CS21 that_CS22 a_AT1 better_JJR understanding_NN1 of_IO these_DD2 mechanisms_NN2 may_VM allow_VVI the_AT development_NN1 of_IO new_JJ therapeutic_JJ approaches_NN2 ,_, transcriptomic_JJ and_CC proteomic_JJ studies_NN2 have_VH0 recently_RR been_VBN performed_VVN to_TO unravel_VVI this_DD1 issue_NN1 (_( Tababat-Khani_NN1 et_RA21 al._RA22 ,_, 2015_MC ;_; Quin_NP1 et_RA21 al._RA22 ,_, 2015_MC )_) ._. 
</s>
<s>
Intravitreal_JJ anti-vascular_JJ endothelial_JJ growth_NN1 factor_NN1 (_( VEGF_NP1 )_) agents_NN2 have_VH0 emerged_VVN as_CSA new_JJ treatments_NN2 for_IF the_AT more_RGR advanced_JJ stages_NN2 of_IO DR_NNB ._. 
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<s>
As_RR21 well_RR22 ,_, most_DAT participants_NN2 felt_VVD that_CST educational_JJ interventions_NN2 for_IF the_AT perioperative_JJ multidisciplinary_JJ team_NN1 members_NN2 ,_, patients_NN2 ,_, and_CC families_NN2 were_VBDR essential_JJ to_II successful_JJ implementation_NN1 and_CC uptake_NN1 ._. 
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<s>
Patients_NN2 should_VM not_XX discontinue_VVI the_AT use_NN1 of_IO prescription_NN1 fluoride_NN1 until_CS instructed_VVN to_TO do_VDI so_RR by_II the_AT dental_JJ professional_JJ ._. 
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<s>
In_BCL21 order_BCL22 to_TO identify_VVI melanopsin-expressing_JJ cells_NN2 usually_RR a_AT1 fluorescent_JJ reporter_NN1 is_VBZ co-expressed_VVN ._. 
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<s>
From_II the_AT difference_NN1 in_II TTPs_NP1 ,_, the_AT peak-to-peak_JJ transit_NN1 time_NNT1 could_VM be_VBI calculated_VVN ._. 
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<s>
Puncture_NN1 and_CC Postdural_JJ Puncture_NN1 Headache_NN1 What_DDQ Are_VBR Our_APPGE Options_NN2 ?_? 
</s>
<s>
Hence_RR ,_, it_PPH1 is_VBZ expected_VVN that_CST in_II a_AT1 few_DA2 years_NNT2 it_PPH1 will_VM be_VBI possible_JJ to_TO identify_VVI the_AT disease-causing_JJ genes_NN2 and_CC mutations_NN2 in_II approximately_RR 95%_NNU of_IO all_DB the_AT RP_NP1 patients_NN2 ,_, albeit_CS the_AT number_NN1 of_IO still_RR unknown_JJ RP_NP1 genes_NN2 can_VM not_XX be_VBI reliably_RR predicted_VVN ._. 
</s>
<s>
In_RR21 addition_RR22 ,_, an_AT1 ANCOVA_NN1 of_IO CFB_NP1 in_II mean_JJ diurnal_JJ IOP_NN1 was_VBDZ performed_VVN with_IW fixed-effect_JJ terms_NN2 for_IF treatment_NN1 and_CC diurnal_JJ baseline_NN1 IOP_NN1 at_II each_DD1 postbaseline_NN1 visit_NN1 ._. 
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<s>
We_PPIS2 appreciate_VV0 that_CST not_XX all_DB would_VM agree_VVI with_IW including_VVG deep_RR gray_JJ and_CC white_JJ matter_NN1 hyperintensities_NN2 in_II the_AT term_NN1 WMH_NP1 ,_, but_CCB we_PPIS2 are_VBR simply_RR using_VVG it_PPH1 as_II an_AT1 operational_JJ term_NN1 in_II this_DD1 instance_NN1 ._. 
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<s>
Subsequent_JJ comparisons_NN2 of_IO the_AT Likert_NP1 and_CC PIRADS_NN2 reporting_VVG schemes_NN2 have_VH0 yielded_VVN similar_JJ results.14_FO ,_, 15_MC To_TO assess_VVI inter-observer_JJ agreement_NN1 ,_, 132_MC scans_NN2 from_II the_AT lead_NN1 site_NN1 were_VBDR re-reported_VVN by_II a_AT1 blinded_JJ second_MD radiologist_NN1 based_VVN at_II that_DD1 site_NN1 ._. 
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<s>
The_AT mean_JJ surgical_JJ time_NNT1 was_VBDZ longer_JJR for_IF IOL_NN1 repositioning_NN1 than_CSN for_IF IOL_NN1 exchange_NN1 ._. 
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<s>
The_AT average_JJ beyond-clinic_NN1 %SS_FO from_II the_AT two_MC parent_NN1 recordings_NN2 is_VBZ presented_VVN in_II Table_NN1 1_MC1 ._. 
</s>
<s>
Search_NN1 Strategy_NN1 Medline_NP1 ,_, EMBASE_NP1 ,_, CINAHL_NP1 ,_, and_CC the_AT Cochrane_NP1 Library_NN1 databases_NN2 were_VBDR searched_VVN through_II July_NPM1 2013_MC ._. 
</s>
<s>
Fewer_DAR Asian_JJ Americans_NN2 (_( 49%_NNU )_) consume_VV0 alcohol_NN1 than_CSN NHWs_NP1 (_( 72%_NNU )_) ,_, although_CS the_AT prevalence_NN1 in_II Asian_JJ American_JJ men_NN2 (_( 60%_NNU )_) is_VBZ much_RR higher_JJR than_CSN in_II Asian_JJ American_JJ women_NN2 (_( 39%_NNU )_) .20_MC US-born_JJ Asian_JJ Americans_NN2 (_( 61%_NNU )_) are_VBR also_RR more_RGR likely_JJ to_TO consume_VVI alcohol_NN1 than_CSN those_DD2 who_PNQS are_VBR foreign-born_JJ (_( 46%_NNU )_) .20_MC Screening_NN1 ,_, brief_JJ intervention_NN1 ,_, and_CC referral_NN1 to_II treatment_NN1 by_II a_AT1 clinician_NN1 for_IF alcohol_NN1 use_NN1 ,_, including_II use_NN1 that_CST does_VDZ not_XX constitute_VVI an_AT1 alcohol_NN1 use_NN1 disorder_NN1 but_CCB does_VDZ put_VVI the_AT patient_NN1 at_II risk_NN1 for_IF alcohol-related_JJ diseases_NN2 ,_, can_VM be_VBI effective_JJ in_II reducing_VVG alcohol_NN1 use.121_FO Culturally_RR specific_JJ approaches_NN2 for_IF addressing_VVG alcohol_NN1 use_NN1 in_II Asian_JJ Americans_NN2 include_VV0 using_VVG translated_JJ materials_NN2 ,_, increasing_JJ awareness_NN1 of_IO the_AT health_NN1 hazards_NN2 of_IO excessive_JJ alcohol_NN1 use_NN1 ,_, and_CC recognizing_VVG familial_JJ consequences.121_FO Infectious_JJ agents_NN2 H._NP1 pylori_NN2 ._. 
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<s>
In_RR21 addition_RR22 ,_, from_II the_AT data_NN ,_, it_PPH1 can_VM not_XX be_VBI extrapolated_VVN whether_CSW there_EX had_VHD indeed_RR been_VBN any_DD MALT_NN1 lymphomas_NN2 among_II these_DD2 patients_NN2 ;_; nevertheless_RR ,_, the_AT mode_NN1 of_IO action_NN1 makes_VVZ idelalisib_VVI an_AT1 interesting_JJ agent_NN1 for_IF MALT_NN1 lymphoma_NN1 ._. 
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<s>
In_II contrast_NN1 to_II the_AT quivering_JJ mutants_NN2 ,_, in_II Kv1.1_FO mutants_NN2 all_DB ABR_VV0 wave_NN1 components_NN2 were_VBDR present_JJ and_CC ABR_VV0 thresholds_NN2 were_VBDR not_XX significantly_RR different_JJ between_II mutant_NN1 and_CC wild-type_JJ mice_NN2 (_( Allen_NP1 et_RA21 al._RA22 ,_, 2012_MC )_) ._. 
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<s>
Design_NN1 Smokers_NN2 participated_VVD in_II the_AT following_JJ 2_MC imaging_JJ sessions_NNT2 :_: after_II 24_MC hours_NNT2 of_IO biochemically_RR confirmed_VVN abstinence_NN1 (_( carbon_NN1 monoxide_NN1 level_NN1 ,_, less_DAR than_CSN 10_MC ppm_NNU )_) and_CC after_II smoking_VVG as_RR21 usual_RR22 (_( last_MD cigarette_NN1 about_RG 20_MC minutes_NNT2 before_II the_AT scan_NN1 )_) ._. 
</s>
<s>
When_CS pre-MRI_JJ and_CC post-MRI_JJ battery_NN1 voltage_NN1 measurements_NN2 were_VBDR compared_VVN ,_, a_AT1 small_JJ decrease_NN1 was_VBDZ noted_VVN for_IF both_RR pacemakers_NN2 and_CC ICDs_NP2 ._. 
</s>
<s>
As_CSA expected_VVN ,_, radiation-induced_JJ complications_NN2 occur_VV0 with_IW greater_JJR frequency_NN1 and_CC severity_NN1 for_IF repeat_NN1 EPBT_NN1 than_CSN for_IF primary_JJ EPBT_NN1 alone_RR ._. 
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<s>
ERG_NP1 measures_VVZ an_AT1 important_JJ but_CCB limited_JJ aspect_NN1 of_IO global_JJ rod_NN1 function_NN1 :_: movement_NN1 of_IO monovalent_JJ ions_NN2 on_II a_AT1 millisecond_NNT1 time_NNT1 scale_NN1 after_II a_AT1 flash_NN1 of_IO light_NN1 in_RR21 vivo_RR22 ._. 
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<s>
PCR_NP1 reactions_NN2 were_VBDR performed_VVN in_II a_AT1 total_JJ volume_NN1 of_IO 25_MC L_NNU in_II LightCycler_NP1 plaques_NN2 with_IW a_AT1 reaction_NN1 mixture_NN1 containing_VVG 5_MC L_NNU of_IO DNA_NN1 sample_NN1 ,_, 0.5_MC M_NNU of_IO each_DD1 generic_JJ primer_NN1 ,_, 2.5_MC (_( iM_NN1 of_IO the_AT blocking_JJ primer_NN1 ,_, 2.8_MC (_( iM_VV0 MgC_NP1 ,_, 0.95_MC (_( iL_FW of_IO distilled_JJ water_NN1 and_CC 12.5_MC (_( iL_FW of_IO LightCycler(R)_NP1 480_MC HRM_NP1 Master_NN1 (_( Roche_NP1 Diagnostics_NN1 ,_, Basel_NP1 ,_, Switzerland_NP1 )_) ._. 
</s>
<s>
The_AT proportion_NN1 of_IO patients_NN2 in_II whom_PNQO postoperative_JJ atrial_JJ fibrillation_NN1 developed_VVD was_VBDZ 28.1%_FO among_II those_DD2 who_PNQS had_VHD undergone_VVN isolated_JJ CABG_NN1 ,_, 33.7%_FO among_II those_DD2 who_PNQS had_VHD undergone_VVN isolated_JJ valve_NN1 surgery_NN1 ,_, and_CC 47.3%_FO among_II those_DD2 who_PNQS had_VHD undergone_VVN combined_JJ procedures_NN2 ._. 
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<s>
McArdle_NP1 disease_NN1 patients_NN2 with_IW appropriate_JJ exercise_NN1 habits_NN2 can_VM be_VBI almost_RR as_CSA aerobically_RR fit_VV0 as_RG unaffected_JJ people_NN ._. 
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<s>
These_DD2 results_NN2 ,_, which_DDQ likely_RR provide_VV0 a_AT1 proxy_NN1 measure_NN1 of_IO gadolinium_NN1 deposition_NN1 ,_, confirm_VV0 previous_JJ research_NN1 findings_NN2 that_CST there_EX is_VBZ gadolinium_NN1 deposition_NN1 in_II wide_JJ regions_NN2 of_IO the_AT brain_NN1 ,_, including_II hemispheric_JJ gray_JJ matter_NN1 ._. 
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<s>
When_CS an_AT1 error_NN1 was_VBDZ made_VVN ,_, participants_NN2 were_VBDR required_VVN to_TO return_VVI to_II the_AT start_NN1 of_IO the_AT current_JJ row_NN1 of_IO words_NN2 and_CC continue_VV0 as_RG normal_JJ ._. 
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<s>
The_AT activation_NN1 of_IO all_DB these_DD2 pathways_NN2 leads_VVZ to_II abnormalities_NN2 in_II both_DB2 the_AT neural_JJ retina_NN1 (_( retinal_JJ neurodegeneration_NN1 )_) and_CC the_AT capillary_JJ bed_NN1 located_VVN in_II the_AT inner_JJ retina_NN1 (_( microangiopathic_JJ injury_NN1 )_) .3.1.1_MC ._. 
</s>
<s>
Advanced_JJ glycated_JJ end_NN1 products_NN2 Advanced_VVD glycated_JJ end_NN1 products_NN2 (_( AGEs_NN2 )_) and_CC its_APPGE receptors_NN2 (_( RAGEs_VVZ )_) have_VH0 been_VBN detected_VVN in_II vascular_JJ cells_NN2 ,_, neurons_NN2 and_CC glia_NN1 of_IO diabetic_JJ retina_NN1 (_( Chen_NP1 et_RA21 al._RA22 ,_, 2013_MC )_) ._. 
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<s>
Although_CS this_DD1 article_NN1 focuses_VVZ on_II health_NN1 information_NN1 exchange_NN1 as_CSA it_PPH1 relates_VVZ to_II the_AT practice_NN1 of_IO emergency_NN1 medicine_NN1 ,_, there_EX are_VBR some_DD common_JJ requirements_NN2 that_CST cross_VV0 specialties_NN2 that_CST are_VBR also_RR discussed_VVN ._. 
</s>
<s>
We_PPIS2 further_RRR demonstrated_VVD that_CST the_AT selective_JJ Cx36_FO blocker_NN1 Meflo_NP1 could_VM reverse_VVI the_AT activation_NN1 of_IO gamma-frequency_JJ oscillatory_JJ activity_NN1 and_CC relieve_VV0 the_AT behavioral_JJ sensitization_NN1 induced_VVN by_II CCI_MC ._. 
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<s>
With_II31 regard_II32 to_II33 age_NN1 ,_, the_AT greatest_JJT fall_NN1 in_II probability_NN1 of_IO survival_NN1 was_VBDZ seen_VVN in_II the_AT age_NN1 range_NN1 45_MC to_II 70_MC years_NNT2 &lsqb;_( 45_MC years_NNT2 30-day_JJ survival_NN1 probability_NN1 =_FO 0.86_MC ;_; 95%_NNU confidence_NN1 interval_NN1 (_( 95%_NNU CI_FO )_) 0.78_MC '_NULL 0.91_MC ,_, 70_MC years_NNT2 30-day_JJ survival_NN1 probability_NN1 =_FO 0.71_MC ;_; 95%_NNU CI_FO 0.59_MC '_NULL 0.80_MC &rsqb;_) ,_, in_II contrast_NN1 to_II a_AT1 steady_JJ decline_NN1 elsewhere_RL (_( Fig._NN1 3_MC )_) ._. 
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<s>
Role_NN1 of_IO the_AT Funder/Sponsor_NN1 :_: The_AT funding_NN1 source_NN1 had_VHD no_AT role_NN1 in_II the_AT design_NN1 and_CC conduct_NN1 of_IO the_AT study_NN1 ;_; collection_NN1 ,_, management_NN1 ,_, analysis_NN1 ,_, and_CC interpretation_NN1 of_IO the_AT data_NN ;_; preparation_NN1 ,_, review_NN1 ,_, or_CC approval_NN1 of_IO the_AT manuscript_NN1 ;_; and_CC decision_NN1 to_TO submit_VVI the_AT manuscript_NN1 for_IF publication_NN1 ._. 
</s>
<s>
Given_CS21 that_CS22 US_NP1 plays_VVZ such_DA an_AT1 essential_JJ role_NN1 in_II today_RT '_NULL s_ZZ1 practice_NN1 of_IO EM_FU ,_, it_PPH1 is_VBZ important_JJ that_CST its_APPGE application_NN1 is_VBZ standardized_VVN across_II residency_NN1 programs_NN2 ._. 
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<s>
Conclusion_NN1 :_: The_AT results_NN2 indicate_VV0 that_CST negative_JJ communication_NN1 attitudes_NN2 can_VM be_VBI an_AT1 effect_NN1 of_IO stuttering_VVG ._. 
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<s>
In_II 2VO-model_NN1 there_EX is_VBZ neurodegeneration_NN1 of_IO various_JJ cerebral_JJ structures_NN2 ,_, particularly_RR in_II the_AT CA1_FO pyramidal_JJ cell_NN1 layer_NN1 of_IO the_AT hippocampus_NN1 ,_, a_AT1 brain_NN1 region_NN1 known_VVN to_TO be_VBI highly_RR implicated_VVN in_II spatial_JJ learning_NN1 and_CC memory_NN1 (_( Rolls_NP1 and_CC Kesner_NP1 ,_, 2006_MC )_) ,_, and_CC also_RR susceptible_JJ to_II post-ischemic_JJ inflammatory_JJ phenomena_NN2 and_CC p-amyloid_JJ accumulation_NN1 (_( Sekeljic_NN1 et_RA21 al._RA22 ,_, 2012_MC )_) ._. 
</s>
<s>
Using_VVG a_AT1 dual-head_NN1 power_NN1 injector_NN1 (_( Nemoto_NP1 Kyorindo_NP1 ,_, Tokyo_NP1 ,_, Japan_NP1 )_) ,_, a_AT1 60%_NNU iopamidol_NN1 300_MC mg_NNU I/mL_FU (_( Iopamiron_NP1 300_MC ;_; Bayer_NP1 Yakuhin_NP1 Ltd_JJ ,_, Osaka_NP1 ,_, Japan_NP1 )_) /40%_FU saline_JJ (_( 180_MC mg_NNU I/mL_FU )_) vol/vol_NN1 bolus_NN1 was_VBDZ injected_VVN ,_, followed_VVN by_II 20_MC mL_NNU of_IO saline_JJ flush_NN1 ,_, via_II a_AT1 20-_NN1 to_II 22-gauge_JJ catheter_NN1 in_II the_AT right_JJ antecubital_JJ vein_NN1 ._. 
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<s>
Afterwards_RT ,_, independent_JJ back_NN1 translations_NN2 were_VBDR performed_VVN by_II two_MC English_JJ native_JJ speakers_NN2 who_PNQS were_VBDR also_RR fluent_JJ in_II Portuguese_NN1 ._. 
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<s>
After_CS written_VVN informed_JJ consent_NN1 was_VBDZ obtained_VVN ,_, 60_MC patients_NN2 aged_II 20_MC '_NULL 85_MC yr_NNU who_PNQS were_VBDR to_TO undergo_VVI general_JJ anaesthesia_NN1 in_II the_AT supine_JJ position_NN1 were_VBDR randomly_RR assigned_VVN ,_, using_VVG the_AT envelope_NN1 method_NN1 ,_, to_II one_MC1 of_IO two_MC groups_NN2 :_: the_AT cricoid_JJ pressure_NN1 (_( CP_NP1 )_) group_NN1 (_( n=30_FO )_) or_CC the_AT sham_NN1 group_NN1 (_( n=30_FO )_) ._. 
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<s>
Calculations_NN2 estimated_VVD the_AT heritability_NN1 to_TO be_VBI 0.35_MC ,_, meaning_VVG that_DD1 genetic_JJ factors_NN2 explained_VVD 35%_NNU of_IO variance_NN1 (_( 95%_NNU confidence_NN1 interval_NN1 &lsqb;_( CI_FO &rsqb;_) ,_, 13?_FO "_" 54_MC )_) in_II progression_NN1 of_IO nuclear_JJ cataract_NN1 ,_, with_IW individual_JJ environmental_JJ factors_NN2 accounting_VVG for_IF the_AT remaining_JJ 65%_NNU (_( 95%_NNU CI_FO ,_, 46?_FO "_" 87_MC )_) ._. 
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<s>
To_TO test_VVI associations_NN2 between_II micronutrient_JJ intake_NN1 and_CC cataract_VVI progression_NN1 ,_, we_PPIS2 used_VVD univariable_JJ regression_NN1 (_( Table_NN1 2_MC )_) followed_VVD by_II stepwise_JJ regression_NN1 in_II 2054_MC female_JJ twins_NN2 who_PNQS had_VHD baseline_NN1 data_NN on_II nutrient_NN1 intake_NN1 ._. 
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<s>
This_DD1 work_NN1 was_VBDZ supported_VVN by_II the_AT Medical_JJ Research_NN1 Council_NN1 (_( G0700355to_FO WN_NP1 )_) ,_, the_AT NIHR_NP1 BRC_NP1 for_IF Mental_JJ Health_NN1 at_II the_AT South_ND1 London_NP1 and_CC Maudsley_NP1 NHS_NP1 Foundation_NN1 Trust_NN1 ,_, the_AT National_JJ Council_NN1 for_IF Replacement_NN1 ,_, Refinement_NN1 and_CC Reduction_NN1 of_IO Animals_NN2 in_II Research_NN1 ,_, and_CC the_AT Progressive_JJ Supranuclear_JJ Palsy_NN1 (_( PSP_NP1 )_) Association_NN1 ._. 
</s>
<s>
Aggregating_VVG GPS_NN2 points_VVZ into_II specific_JJ and_CC meaningful_JJ spatial_JJ elements_NN2 is_VBZ essential_JJ for_IF transforming_VVG the_AT overwhelming_JJ amount_NN1 of_IO GPS_NN2 points_VVZ into_II more_RGR manageable_JJ data_NN sets_NN2 ,_, as_RG well_RR as_CSA for_IF the_AT development_NN1 of_IO more_RGR targeted_JJ research_NN1 questions_NN2 ._. 
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<s>
SRC_NP1 or_CC mild_JJ traumatic_JJ brain_NN1 injury_NN1 (_( mTBI_NN2 )_) accounts_VVZ for_IF 80%_NNU of_IO all_DB reported_VVD TBIs_NP1 ._. 
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<s>
Real-Time_NN1 Captioning_VVG for_IF Improving_VVG Informed_JJ Consent_NN1 :_: Patient_JJ and_CC Physician_NN1 Benefits_NN2 Author_NN1 :_: Spehar_NP1 ,_, Brent_NP1 PhD*_FO ;_; Tye-Murray_NP1 ,_, Nancy_NP1 PhD*_FO ;_; Myerson_NP1 ,_, Joel_NP1 PhD_NNA ;_; Murray_NP1 ,_, David_NP1 J._NP1 MD_NNA Abstract_JJ Background_NN1 and_CC Objectives_NN2 :_: New_JJ methods_NN2 are_VBR needed_VVN to_TO improve_VVI physicians_NN2 '_NULL skill_NN1 in_II communicating_JJ information_NN1 and_CC to_TO enhance_VVI patients_NN2 '_NULL ability_NN1 to_TO recall_VVI that_DD1 information_NN1 ._. 
</s>
<s>
The_AT exposure_NN1 variables_NN2 explored_VVN in_II the_AT analysis_NN1 were_VBDR age_NN1 ,_, ethnicity_NN1 ,_, BMI_NP1 ,_, marital_JJ status_NN1 ,_, substance_NN1 misuse_NN1 ,_, smoking_JJ status_NN1 during_II pregnancy_NN1 ,_, previous_JJ pregnancy_NN1 problems_NN2 ,_, preexisting_VVG medical_JJ problems_NN2 (_( further_RRR information_NN1 in_II Supporting_JJ Information_NN1 Appendix_NN1 S1_FO )_) ,_, gestational_JJ diabetes_NN1 ,_, previous_JJ fetal_JJ loss_NN1 or_CC termination_NN1 ,_, parity_NN1 ,_, multiple_JJ pregnancy_NN1 and_CC inadequate_JJ use_NN1 of_IO antenatal_JJ care_NN1 ._. 
</s>
<s>
CONCLUSIONS_NN2 Calcium_NN1 levels_NN2 seem_VV0 to_TO play_VVI an_AT1 important_JJ role_NN1 in_II cell_NN1 survival_NN1 of_IO bupivacaine-induced_JJ cell_NN1 death_NN1 within_II the_AT investigated_JJ concentration_NN1 range_NN1 (_( 1.6_MC '_NULL 7.9_MC mM_NNU )_) ._. 
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<s>
Retinal_JJ concentrations_NN2 of_IO 5-cholestenoic_JJ acid_NN1 were_VBDR discovered_VVN to_TO vary_VVI greater_JJR than_CSN 5-fold_JJ in_II different_JJ individuals_NN2 and_CC did_VDD not_XX correlate_VVI with_IW the_AT CYP27A1_FO protein_NN1 levels_NN2 (_( Liao_NP1 et_RA21 al._RA22 ,_, 2011_MC )_) ._. 
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<s>
Real-time_JJ ultrasonographic_JJ visualization_NN1 of_IO peripheral_JJ nerves_NN2 ,_, needle_NN1 placement_NN1 ,_, and_CC local_JJ anesthetic_JJ spread_NN1 has_VHZ allowed_VVN a_AT1 greater_JJR number_NN1 of_IO anesthesiologists_NN2 to_TO have_VHI confidence_NN1 to_TO provide_VVI the_AT opioid_NN1 sparing_VVG and_CC analgesic_NN1 benefits_NN2 of_IO regional_JJ anesthesia_NN1 (_( RA_NP1 )_) ._. 
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<s>
Milhorn_VV0 and_CC Korpi-Steiner_NP1 based_VVD their_APPGE simulated_JJ solutions_NN2 on_II the_AT geometric_JJ means_NN from_II the_AT McChesney_NP1 paper_NN1 ._. 
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<s>
CDEs_NN2 can_VM be_VBI applied_VVN to_II clinical_JJ practice_NN1 ,_, research_NN1 ,_, and_CC performance_NN1 improvement_NN1 initiatives_NN2 in_II radiology_NN1 ._. 
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<s>
Of_IO the_AT 8_MC participants_NN2 in_II the_AT MTD_NP1 group_NN1 ,_, 6_MC responded_VVD to_II follow-up_JJ questioning_NN1 with_IW 5_MC reporting_VVG good_JJ benefit_NN1 from_II behavioral_JJ voice_NN1 therapy_NN1 and_CC 1_MC1 reporting_NN1 fair_JJ benefit_NN1 from_II behavioral_JJ voice_NN1 therapy_NN1 ._. 
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<s>
Because_II21 of_II22 its_APPGE low_JJ instantaneous_JJ pressure_NN1 ,_, right_JJ atrium_NN1 wall_NN1 collapse_NN1 during_II ventricular_JJ systole_NN1 is_VBZ the_AT earliest_JJT echocar-diographic_JJ finding_NN1 of_IO compression_NN1 ,_, followed_VVN by_II early_JJ diastolic_JJ collapse_NN1 of_IO the_AT right_JJ ventricle_NN1 ._. 
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<s>
Each_DD1 object_NN1 was_VBDZ presented_VVN twice_RR in_II random_JJ order_NN1 per_II trial_NN1 ,_, and_CC the_AT patient_NN1 was_VBDZ allowed_VVN 30_MC s_ZZ1 to_TO give_VVI a_AT1 forced-choice_NN1 answer_NN1 ._. 
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<s>
Funding_VVG National_JJ Institute_NN1 for_IF Health_NN1 Research_NN1 Health_NN1 Technology_NN1 Assessment_NN1 programme_NN1 ._. 
</s>
<s>
The_AT second_MD hypothesis_NN1 is_VBZ that_DD1 problem-solving_NN1 skills_NN2 development_NN1 mediates_VVZ improvement_NN1 of_IO depression_NN1 ._. 
</s>
<s>
Recently_RR ,_, high_JJ opening_NN1 injection_NN1 pressure_NN1 (_( OIP_NP1 )_) was_VBDZ reported_VVN to_TO detect_VVI contact_NN1 of_IO the_AT needle-tip_NN1 with_IW the_AT nerve_NN1 roots_NN2 during_II brachial_JJ plexus_NN1 blockade_NN1 ._. 
</s>
<s>
Interitem_VV0 correlation_NN1 coefficients_NN2 ranged_VVN from_II 0.48_MC to_II 0.97_MC ,_, indicating_VVG a_AT1 moderate_JJ to_II strong_JJ relationship_NN1 between_II the_AT speeds_NN2 tested_VVD ._. 
</s>
<s>
With_IW conventional_JJ infusions_NN2 ,_, the_AT ratio_NN1 between_II infusion_NN1 rate_NN1 and_CC plasma_NN1 drug_NN1 concentration_NN1 dramatically_RR changes_VVZ over_II time_NNT1 and_CC with_IW infusion_NN1 history_NN1 ._. 
</s>
<s>
In_II the_AT current_JJ study_NN1 ,_, all_DB participants_NN2 were_VBDR evaluated_VVN by_II MRA_NP1 ,_, which_DDQ detected_VVD cerebral_JJ vasoconstriction_NN1 in_II 5_MC of_IO 17_MC patients_NN2 with_IW PRES_NNB (_( 29.4%_FO )_) ._. 
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<s>
Second_MD ,_, the_AT number_NN1 of_IO patients_NN2 with_IW recurrence_NN1 or_CC metastasis_NN1 was_VBDZ too_RG small_RR compared_VVN with_IW the_AT study_NN1 population_NN1 for_IF our_APPGE results_NN2 to_TO have_VHI statistical_JJ power_NN1 when_CS analyzing_VVG the_AT association_NN1 between_II positive_JJ features_NN2 of_IO the_AT guidelines_NN2 for_IF thyroid_JJ nodules_NN2 and_CC recurrence_NN1 or_CC persistence_NN1 of_IO disease_NN1 ,_, or_CC distant_JJ metastasis_NN1 ._. 
</s>
<s>
Furthermore_RR ,_, EG3287_FO prevents_VVZ the_AT formation_NN1 of_IO the_AT VEGFR/VEGF/NRP1_NN1 complex_NN1 and_CC VEGFR2_FO phosphorylation_NN1 (_( Jia_NP1 et_RA21 al._RA22 ,_, 2006_MC )_) .6.1.3_MC ._. 
</s>
<s>
Conclusions:Patients_FO with_IW high_JJ rCBVNER_NN1 and_CC NER_FU crossing_NN1 the_AT midline_NN1 and_CC those_DD2 with_IW high_JJ rCBVNER_NN1 and_CC wild-type_JJ EGFR_NN1 mutation_NN1 showed_VVD poor_JJ survival_NN1 ._. 
</s>
<s>
Over_II the_AT past_JJ 25_MC years_NNT2 ,_, mortality_NN1 from_II liver_NN1 cancer_NN1 has_VHZ increased_VVN by_RP about_II 60%_NNU ,_, which_DDQ is_VBZ a_AT1 greater_JJR increase_NN1 than_CSN for_IF any_DD other_JJ type_NN1 of_IO cancer_NN1 ._. 
</s>
<s>
The_AT selective_JJ ,_, potent_JJ nature_NN1 of_IO GSK2879552_FO and_CC GSK-LSD1_NN1 make_VV0 these_DD2 compounds_NN2 ideal_JJ chemical_NN1 probes_VVZ to_TO investigate_VVI the_AT biological_JJ activity_NN1 of_IO LSD1_FO ._. 
</s>
<s>
Eluants_NN2 were_VBDR monitored_VVN at_II 430_MC and_CC 320_MC nm_FU ;_; the_AT fractions_NN2 containing_VVG A2E_FO were_VBDR collected_VVN ,_, pooled_VVD ,_, and_CC dried_VVN under_II nitrogen_NN1 ._. 
</s>
<s>
Similarly_RR ,_, intra-class_JJ correlation_NN1 analyses_NN2 were_VBDR performed_VVN on_II blinded_JJ recounts_NN2 of_IO tissue_NN1 from_II both_DB2 tissue_NN1 preparation_NN1 methods_NN2 to_TO provide_VVI a_AT1 measure_NN1 of_IO intra-rater_JJ reliability_NN1 ._. 
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<s>
We_PPIS2 also_RR had_VHD detailed_VVN information_NN1 on_II a_AT1 variety_NN1 of_IO lifestyle_NN1 risk_NN1 factors_NN2 which_DDQ improved_VVD our_APPGE ability_NN1 to_TO adjust_VVI for_IF confounding_VVG ._. 
</s>
<s>
The_AT copy_NN1 number_NN1 changes_NN2 in_II the_AT PIK3CA_FO gene_NN1 were_VBDR evaluated_VVN with_IW real-time_JJ quantitative_JJ PCR_NP1 ,_, as_CSA previously_RR reported_VVN using_VVG the_AT 7500_MC Real_JJ Time_NNT1 PCR_NP1 System_NN1 (_( Applied_JJ Biosystems_NN2 )_) ._. 
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<s>
Taken_VVN all_DB together_RL ,_, one_PN1 concludes_VVZ :_: improved_JJ memory_NN1 abilities_NN2 seen_VVN in_II KTP-derivatives-treated_NP1 2VO_FO female_JJ rats_NN2 is_VBZ due_II21 to_II22 the_AT neuroprotective_JJ effects_NN2 ofpeptides_VVZ on_II CA1_FO neurons_NN2 ._. 
</s>
<s>
The_AT PWT_NP1 values_NN2 of_IO the_AT RL_NP1 group_NN1 at_II 0.5_MC hour_NNT1 (_( 40.9_MC plus_II and_CC minus_II 3.0_MC g_NNU )_) and_CC 2_MC hours_NNT2 (_( 44.6_MC plus_II and_CC minus_II 1.6_MC g_NNU )_) after_II discontinuing_VVG infusion_NN1 were_VBDR also_RR lower_JJR than_CSN the_AT baseline_NN1 level_NN1 (_( P_NNU less_DAR than_CSN 0.05_MC )_) but_CCB higher_JJR than_CSN the_AT corresponding_JJ values_NN2 in_II the_AT group_NN1 receiving_VVG R_ZZ1 (_( P_NNU less_DAR than_CSN 0.05_MC )_) ._. 
</s>
<s>
This_DD1 is_VBZ an_AT1 index_NN1 of_IO phonological_JJ complexitybased_JJ on_II speech_NN1 samples_NN2 from_II seven_MC children_NN2 (_( 17-48_MC months_NNT2 )_) nearthe_VV0 age_NN1 of_IO stuttering_VVG onset_NN1 ._. 
</s>
<s>
These_DD2 data_NN support_VV0 our_APPGE ._. nding_VVG that_DD1 IkB/cactus_NN1 cooperates_VVZ with_IW Polycomb-mediated_JJ repression_NN1 ,_, independently_RR of_IO NF-kB/dorsal_JJ ,_, which_DDQ is_VBZ relevant_JJ for_IF the_AT regulation_NN1 of_IO epidermal_JJ development_NN1 in_II the_AT ._. y_ZZ1 ._. 
</s>
<s>
Taken_VVN together_RL ,_, these_DD2 results_NN2 suggest_VV0 that_CST the_AT gradual_JJ group_NN1 was_VBDZ able_JK to_TO achieve_VVI asymptotic_JJ speech_NN1 perception_NN1 scores_NN2 much_RR earlier_RRR than_CSN the_AT standard_JJ group_NN1 for_IF the_AT consonant_NN1 ,_, sentence_NN1 ,_, and_CC speechtracking_VVG tasks_NN2 but_CCB not_XX for_IF the_AT vowel_NN1 task_NN1 ,_, where_CS there_EX was_VBDZ no_AT difference_NN1 between_II the_AT two_MC groups_NN2 ._. 
</s>
<s>
If_CS these_DD2 were_VBDR not_XX available_JJ ,_, published_VVD data_NN on_II vascular_JJ events_NN2 were_VBDR extracted_VVN from_II trial_NN1 reports_NN2 ._. 
</s>
<s>
The_AT German_JJ S3-Guideline/National_JJ Disease_NN1 Management_NN1 Guideline_NN1 Unipolar_NP1 Depression12_FO recommends_VVZ psychoeducation_NN1 or_CC more_RGR intensive_JJ psychological_JJ interventions_NN2 ,_, and_CC the_AT prescription_NN1 of_IO antidepressant_JJ medication_NN1 ,_, if_CS depressive_NN1 symptoms_NN2 intensify_VV0 (_( eg_REX ,_, if_CS MDD_NP1 is_VBZ diagnosed_VVN )_) ._. 
</s>
<s>
Discussion_NN1 In_II this_DD1 study_NN1 ,_, we_PPIS2 uncovered_VVD a_AT1 novel_JJ variant_NN1 at_II 16p11.2_FO ,_, rs4583255&lsqb;T&rsqb;_FO ,_, showing_VVG genome-wide_JJ significant_JJ association_NN1 with_IW psychosis_NN1 (_( OR_CC =_FO 1.08_MC ,_, P_ZZ1 =_FO 6.6_MC x_ZZ1 10-11_MCMC )_) ._. 
</s>
<s>
Three_MC simple_JJ representative_JJ examples_NN2 will_VM illustrate_VVI the_AT point_NN1 ._. 
</s>
<s>
Therefore_RR ,_, our_APPGE non-inferiority_JJ margin_NN1 was_VBDZ 1.9_MC PHQ-9_MC points_NN2 (_( ie_REX ,_, 0.5x3.8_FO )_) ._. 
</s>
<s>
At_II the_AT end_NN1 of_IO the_AT study_NN1 ,_, tumors_NN2 were_VBDR harvested_VVN and_CC analyzed_VVN for_IF proliferation_NN1 and_CC apoptosis_NN1 ._. 
</s>
<s>
These_DD2 efforts_NN2 are_VBR largely_RR specifications_NN2 of_IO best_JJT practices_NN2 for_IF creating_VVG reports_NN2 in_II specific_JJ clinical_JJ contexts_NN2 ,_, detailing_VVG the_AT types_NN2 of_IO information_NN1 that_CST should_VM be_VBI included_VVN in_II a_AT1 report_NN1 ,_, and_CC determining_VVG which_DDQ terms_VVZ to_TO use_VVI as_CSA descriptors_NN2 ._. 
</s>
<s>
In_II 1994_MC ,_, WHO_PNQS recommended_VVD magnesium_NN1 sulfate_NN1 as_II the_AT standard_JJ treatment_NN1 for_IF pre-eclampsia_NN1 and_CC eclampsia_NN1 ,_, and_CC within_II 2_MC years_NNT2 ,_, it_PPH1 was_VBDZ placed_VVN on_II WHO_NP1 '_NULL s_ZZ1 Essential_JJ Medicines_NN2 List_NN1 ._. 
</s>
<s>
Acknowledgements_NN2 The_AT authors_NN2 thank_VV0 Prof._NNB Nicholas_NP1 Brennan_NP1 for_IF his_APPGE helpful_JJ suggestions_NN2 in_II the_AT manuscript_NN1 '_NULL s_ZZ1 revision_NN1 ._. 
</s>
<s>
All_DB scans_NN2 were_VBDR performed_VVN by_II one_MC1 operator_NN1 (_( J.W._NP1 )_) with_IW the_AT subject_NN1 wearing_VVG light_JJ indoor_JJ clothing_NN1 ._. 
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<s>
Despite_II the_AT scope_NN1 of_IO IH_NP1 and_CC modest_JJ results_NN2 of_IO reactive_JJ treatment_NN1 strategies_NN2 ,_, approaches_VVZ to_II this_DD1 complex_NN1 ,_, multifactorial_JJ process_NN1 have_VH0 not_XX evolved_VVN with_IW the_AT general_JJ zeitgeist_NN1 of_IO preventative_JJ medical_JJ care_NN1 ._. 
</s>
<s>
Individual_JJ stimuli_NN2 were_VBDR given_VVN 10_MC s_ZZ1 apart_RL ._. 
</s>
<s>
The_AT average_JJ age_NN1 was_VBDZ 63.3_MC and_CC it_PPH1 decreased_VVD from_II 67.4_MC to_II 62.5_MC (_( P_NNU less_DAR than_CSN 0.001_MC )_) (_( Table_NN1 1_MC1 )_) over_II the_AT study_NN1 period_NN1 ._. 
</s>
<s>
The_AT following_JJ antibodies_NN2 and_CC titers_NN2 were_VBDR used_VVN :_: Mouse_NN1 anti-human_NN1 SIRT1_FO monoclonal_JJ IgG_NN1 (_( 1:300_MC )_) ,_, Goat_NN1 anti-human_NN1 SIRT2_FO monoclonal_JJ IgG_NN1 (_( 1:200_MC )_) ,_, and_CC Rabbit_NN1 anti-human_NN1 SIRT3_FO polyclonal_JJ IgG_NN1 (_( 1:500_MC )_) ._. 
</s>
<s>
Previous_JJ reports_NN2 on_II auditory_JJ function_NN1 in_II these_DD2 monkeys_NN2 have_VH0 been_VBN published_VVN (_( Fowler_NP1 et_RA21 al._RA22 ,_, 2002_MC ;_; Fowler_NP1 et_RA21 al._RA22 ,_, 2008_MC ;_; Fowler_NP1 et_RA21 al._RA22 ,_, 2010_MC )_) ._. 
</s>
<s>
Using_VVG the_AT biopsychosocial_JJ framework_NN1 ,_, future_JJ studies_NN2 should_VM collect_VVI detailed_JJ information_NN1 about_II pain_NN1 and_CC the_AT social_JJ factors_NN2 that_CST affect_VV0 pain_NN1 perceptions_NN2 ._. 
</s>
<s>
We_PPIS2 used_VVD ICD-9_MC and_CC ICD-10_MC coding_NN1 to_II group_NN1 the_AT deaths_NN2 into_II three_MC mutually_RR exclusive_JJ categories_NN2 :_: recurrence_NN1 or_CC progression_NN1 of_IO the_AT primary_JJ cancer_NN1 ;_; external_JJ causes_NN2 ,_, including_II accidents_NN2 ,_, suicides_NN2 ,_, and_CC poisonings_NN2 (_( ICD-9_MC codes_NN2 800-999_MCMC and_CC ICD-10_MC codes_NN2 V00-V99_NN1 ,_, W00-W99_NN1 ,_, X00-X99_NN1 ,_, and_CC Y00-Y89_NN1 )_) ;_; and_CC health-related_JJ causes_NN2 ,_, including_II subsequent_JJ neoplasms_NN2 (_( ICD-9_MC codes_NN2 140-239_MCMC and_CC ICD-10_MC codes_NN2 C00-C97_NN1 and_CC D10-D36_NN1 )_) ,_, cardiac_JJ causes_NN2 (_( ICD-9_MC codes_NN2 390-398_MCMC ,_, 402_MC ,_, 404_MC ,_, and_CC 410-429_MCMC and_CC ICD-10_MC codes_NN2 I00-I02_NN1 ,_, I05-I09_NN1 ,_, I11_FO ,_, I13_FO ,_, I14_FO ,_, I20-I28_NN1 ,_, and_CC I30-I52_NN1 )_) ,_, pulmonary_JJ causes_NN2 (_( ICD-9_MC codes_NN2 460-519_MCMC and_CC ICD-10_MC codes_NN2 J00-J99_NN1 )_) ,_, and_CC all_DB other_JJ causes_NN2 ._. 
</s>
<s>
Patient_JJ medical_JJ records_NN2 were_VBDR reviewed_VVN ,_, and_CC patient_JJ age_NN1 and_CC sex_NN1 were_VBDR recorded_VVN ._. 
</s>
<s>
In_II this_DD1 study_NN1 ,_, remoteness_NN1 was_VBDZ not_XX found_VVN to_TO be_VBI a_AT1 significant_JJ predictor_NN1 of_IO outcome_NN1 ._. 
</s>
<s>
The_AT protocol_NN1 was_VBDZ approved_VVN by_II Institutional_JJ Animal_NN1 Care_NN1 and_CC Use_VV0 Committee_NN1 of_IO the_AT Saint_NP1 Louis_NP1 University_NN1 School_NN1 of_IO Medicine_NN1 ._. 
</s>
<s>
However_RR ,_, none_PN of_IO the_AT other_JJ ROIs_NN2 were_VBDR correlated_VVN with_IW parent-reported_NN1 CU_FO traits_NN2 ._. 
</s>
<s>
The_AT conventional_JJ threshold_NN1 for_IF a_AT1 positive_JJ test_NN1 result_NN1 is_VBZ 500_MC ng/dL_NN1 ,_, with_IW recommendations_NN2 to_TO order_VVI imaging_VVG for_IF results_NN2 above_II that_DD1 level_NN1 ._. 
</s>
<s>
Methods_NN2 :_: A_ZZ1 monoclonal_JJ antibody_NN1 raised_VVN against_II human_JJ Hp_NN1 was_VBDZ shown_VVN to_TO distinguish_VVI between_II the_AT three_MC Hp_NNU phenotypes_NN2 in_II an_AT1 enzyme_NN1 linked_VVN immunosorbent_JJ assay_NN1 (_( ELISA_NP1 )_) ._. 
</s>
<s>
It_PPH1 is_VBZ unknown_JJ whether_CSW this_DD1 age-related_JJ reduction_NN1 in_II endothelial_JJ progenitor_NN1 cells_NN2 results_NN2 in_II senescence_NN1 '_NULL apoptosis_NN1 and_CC depletion_NN1 of_IO the_AT progenitor_NN1 pool_NN1 in_II the_AT bone_NN1 marrow_NN1 or_CC from_II reduced_JJ levels_NN2 of_IO angiogenic_JJ and_CC mobilizing_VVG cytokines_NN2 '_NULL such_II21 as_II22 vascular_JJ endothelial_JJ growth_NN1 factor_NN1 and_CC nitric_JJ oxide_NN1 ._. 
</s>
<s>
These_DD2 pedigrees_NN2 illustrate_VV0 possible_JJ intrafamily_RR oligogenic_JJ inheritance_NN1 or_CC phenocopies_NN2 that_CST would_VM likely_RR be_VBI missed_VVN by_II family-based_JJ sequencing_NN1 study_NN1 designs_NN2 based_VVN on_II monogenic_JJ and_CC completely_RR penetrant_JJ inheritance_NN1 models_NN2 ._. 
</s>
<s>
It_PPH1 must_VM also_RR be_VBI noted_VVN that_DD1 treatment_NN1 of_IO locally_RR advanced_VVD SCCHN_NP1 in_II Asia_NP1 is_VBZ generally_RR based_VVN on_II surgical_JJ approaches_NN2 and_CC radiotherapy_NN1 rather_II21 than_II22 chemotherapy_NN1 ._. 
</s>
<s>
Correspondence_NN1 to_II :_: Tatsuya_NP1 Nishii_NP1 ,_, MD_NNA ,_, PhD_NN1 ,_, Department_NN1 of_IO Radiology_NP1 ,_, Kobe_NP1 University_NN1 Graduate_NN1 School_NN1 of_IO Medicine_NN1 ,_, 7-5-1_MCMC Kusunoki-cho_NN1 ,_, Chuo-ku_NN1 ,_, Kobe_NP1 ,_, Hyogo_NP1 650-0017_MCMC ,_, Japan_NP1 ._. 
</s>
<s>
These_DD2 findings_NN2 are_VBR not_XX consistent_JJ with_IW a_AT1 pathologic_JJ inflammatory_JJ response.25_FO Rather_RR ,_, the_AT presence_NN1 of_IO abundant_JJ viral_JJ antigen_NN1 suggests_VVZ active_JJ RSV_NP1 replication_NN1 and_CC direct_JJ virally_RR induced_VVN cytotoxicity.25_FO At_RR21 least_RR22 in_II infants_NN2 who_PNQS have_VH0 not_XX had_VHN a_AT1 previous_JJ infection_NN1 ,_, overwhelming_JJ RSV_NP1 disease_NN1 appears_VVZ to_TO be_VBI related_VVN to_II the_AT lack_NN1 of_IO an_AT1 adaptive_JJ cytotoxic_JJ T-cell_NN1 response_NN1 in_II the_AT host_NN1 ;_; the_AT result_NN1 is_VBZ dependence_NN1 on_II the_AT less_RGR effective_JJ innate_JJ immune_JJ response_NN1 for_IF the_AT termination_NN1 of_IO viral_JJ replication_NN1 ._. 
</s>
<s>
In_II an_AT1 equine_JJ population_NN1 ,_, Fortier_NP1 and_CC colleagues_NN2 created_VVD full-thickness_JJ defects_NN2 in_II the_AT femoral_JJ lateral_JJ trochlear_NN1 ridge_NN1 and_CC performed_VVD marrow_NN1 stimulation_NN1 with_IW or_CC without_IW the_AT injection_NN1 of_IO autologous_JJ BMAC_NN1 ._. 
</s>
<s>
The_AT involvement_NN1 of_IO the_AT Dp140_FO isoform_VV0 in_II cognitive_JJ impairment_NN1 was_VBDZ previously_RR identified_VVN ._. 
</s>
<s>
The_AT search_NN1 terms_NN2 "_" amyloid_JJ angiopathy_NN1 ,_, "_" "_" congophilic_JJ angiopathy_NN1 ,_, "_" "_" CAA_NP1 ,_, "_" "_" intracranial_JJ h(a)emorrhage_NN1 ,_, "_" "_" intracerebral_JJ h(a)emorrhage_NN1 ,_, "_" "_" cerebral/brain_FU ,_, "_" "_" cerebral/_JJ cortical/brain_FU microinfarct_NN1 ,_, "_" as_II31 well_II32 as_II33 a_AT1 broader_JJR search_NN1 strategy_NN1 for_IF ICH_FW studies4_FO were_VBDR used_VVN ._. 
</s>
<s>
Moreover_RR ,_, none_PN of_IO these_DD2 reviews_NN2 differentiated_VVN between_II assessments_NN2 concentrating_VVG on_II the_AT evaluation_NN1 of_IO true_JJ recovery_NN1 and_CC those_DD2 allowing_VVG compensatory_JJ strategies_NN2 ._. 
</s>
<s>
Cervicomedullary_JJ motor_NN1 evoked_VVD potentials_NN2 were_VBDR generally_RR unchanged_JJ immediately_RR after_II training_NN1 ._. 
</s>
<s>
The_AT 5-year_JJ disease-free_JJ survival_NN1 rate_NN1 was_VBDZ 81.9%_FO and_CC 78.7%_FO ,_, respectively_RR (_( P_ZZ1 =_FO 0.547_MC )_) ._. 
</s>
<s>
All_DB authors_NN2 read_VV0 and_CC approved_VVD the_AT final_JJ manuscript_NN1 ._. 
</s>
<s>
EE_UH contributed_VVN to_II the_AT content_NN1 and_CC reviewed_VVN the_AT manuscript_NN1 ._. 
</s>
<s>
Nevertheless_RR ,_, temporal_JJ changes_NN2 in_II the_AT gaps_NN2 between_II groups_NN2 are_VBR secondary_JJ to_II the_AT increase_NN1 that_CST all_DB groups_NN2 experience_VV0 over_II time_NNT1 ._. 
</s>
<s>
After_II excluding_VVG contaminated_JJ or_CC dirty_JJ cases_NN2 (_( i.e._REX ,_, exclusion_NN1 based_VVN on_II wound_NN1 classification_NN1 )_) ,_, 860_MC patients_NN2 remained_VVD ,_, and_CC attending_VVG handoffs_NN2 remained_VVD significantly_RR associated_VVN with_IW complications_NN2 even_RR after_II adjustment_NN1 (_( OR_CC =_FO 1.40_MC ,_, P_ZZ1 =_FO 0.0329_MC )_) ._. 
</s>
<s>
In_II other_JJ words_NN2 ,_, analgesics_NN2 are_VBR prescribed_VVN without_IW regard_NN1 for_IF the_AT patient_NN1 '_NULL s_ZZ1 innate_JJ suitability_NN1 to_TO metabolize_VVI these_DD2 medications_NN2 ._. 
</s>
<s>
Neurons_NN2 in_II the_AT SPN_NP1 possess_VV0 both_RR intrinsic_JJ (_( Felix_NP1 et_RA21 al_RA22 ._. 
</s>
<s>
,_, 2011_MC )_) and_CC synaptic_JJ (_( Kulesza_NP1 et_RA21 al_RA22 ._. 
</s>
<s>
,_, 2007_MC )_) properties_NN2 that_CST make_VV0 them_PPHO2 well_RR suited_VVN for_IF encoding_VVG coarse_JJ temporal_JJ information_NN1 important_JJ for_IF vocalization_NN1 processing_NN1 (_( Eggermont_NP1 ,_, 2010_MC )_) ._. 
</s>
<s>
C-reactive_JJ protein_NN1 ,_, a_AT1 '_NULL acid_NN1 glycoprotein_NN1 ,_, albumin_NN1 and_CC creatinine_NN1 were_VBDR measured_VVN ._. 
</s>
<s>
Her_APPGE leadership_NN1 was_VBDZ insightful_JJ ,_, important_JJ ,_, energizing_VVG ,_, and_CC critical_JJ to_II the_AT success_NN1 of_IO the_AT collaboration_NN1 ._. 
</s>
<s>
Nogo-A_NP1 is_VBZ expressed_VVN by_II both_RR oligodendrocytes_NN2 and_CC neurons_NN2 in_II the_AT aged_JJ hippocampal_JJ formation_NN1 and_CC over-expressed_VVN by_II hippocampal_JJ neurons_NN2 in_II AD_RA (_( Gil_NP1 et_RA21 al._RA22 ,_, 2006_MC )_) ._. 
</s>
<s>
Although_CS all_DB pregnant_JJ women_NN2 at_II 20_MC weeks_NNT2 of_IO gestation_NN1 were_VBDR included_VVN in_II the_AT analyses_NN2 of_IO early-onset_JJ preeclampsia_NN1 ,_, only_RR those_DD2 with_IW ongoing_JJ pregnancies_NN2 at_II 34_MC weeks_NNT2 were_VBDR included_VVN in_II the_AT analyses_NN2 of_IO late-onset_JJ preeclampsia_NN1 ._. 
</s>
<s>
Differences_NN2 in_II severe_JJ cardiotoxicity_NN1 across_II subgroups_NN2 of_IO EBC_NN1 patients_NN2 Severe_JJ cardiotoxicity_NN1 Across_II 58_MC studies_NN2 ,_, 844_MC total_JJ incident_NN1 cases_NN2 of_IO severe_JJ cardiac_JJ events_NN2 were_VBDR reported_VVN during_II follow-up_NN1 ;_; of_IO these_DD2 ,_, 557_MC occurred_VVD in_II EBC_NP1 ,_, 203_MC in_II MBC_NP1 ,_, and_CC 84_MC in_II mixed_JJ populations_NN2 ._. 
</s>
<s>
Distant_JJ metastasis_NN1 was_VBDZ detected_VVN in_II 12_MC patients_NN2 (_( 1.4%_FO ;_; 12_MC of_IO 873_MC )_) ,_, in_II three_MC patients_NN2 at_II initial_JJ diagnosis_NN1 of_IO thyroid_JJ cancer_NN1 and_CC in_II nine_MC patients_NN2 during_II follow-up_JJ surveillance_NN1 (_( mean_JJ interval_NN1 from_II surgery_NN1 ,_, 56.0_MC months_NNT2 ;_; range_NN1 ,_, 9-98_MCMC months_NNT2 )_) ._. 
</s>
<s>
In_II contrast_NN1 ,_, after_CS MDT_NP1 discussion_NN1 ,_, patients_NN2 with_IW more_RGR complex_JJ disease_NN1 had_VHD their_APPGE management_NN1 changed_VVN in_II more_DAR than_CSN 50%_NNU of_IO patients_NN2 ._. 
</s>
<s>
Alternate_JJ measures_NN2 of_IO physical_JJ activity_NN1 were_VBDR also_RR calculated_VVN including_II total_JJ metabolic_JJ equivalents_NN2 (_( METs_NN2 )_) and_CC moderate-to-vigorous_JJ METs_NN2 ._. 
</s>
<s>
Deletion_NN1 sites_NN2 are_VBR not_XX fully_RR saturated_VVN ._. 
</s>
<s>
Other_JJ similar_JJ instruments_NN2 have_VH0 a_AT1 less_RGR well-defined_JJ factor_NN1 structure_NN1 ._. 
</s>
<s>
The_AT authors_NN2 would_VM like_VVI to_TO thank_VVI the_AT Exome_NN1 Aggregation_NN1 Consortium_NN1 (_( ExAC_NP1 )_) ,_, Cambridge_NP1 ,_, MA_NNA ,_, U.S.A._NP1 (_( http_NNU :_: //_VV0 exac.broadinstitute.org_NNU )_) ._. 
</s>
<s>
The_AT researcher_NN1 and_CC the_AT mothers_NN2 (_( when_CS present_JJ )_) completed_VVD an_AT1 11-point_JJ Box_NN1 Scale_NN1 30_MC during_II the_AT heel_NN1 lance_NN1 ._. 
</s>
<s>
All_DB patients_NN2 not_XX withdrawn_VVN from_II the_AT trial_NN1 (_( SD-rATG_NN1 42_MC of_IO 44_MC patients_NN2 and_CC DD-rATG_NN1 49_MC of_IO 51_MC patients_NN2 )_) were_VBDR followed_VVN for_IF 12_MC months_NNT2 (_( Figure_NN1 1_MC1 )_) ._. 
</s>
<s>
Tables_NN2 3_MC and_CC 4_MC show_VV0 a_AT1 summary_NN1 of_IO the_AT variables_NN2 included_VVN in_II the_AT models_NN2 with_IW their_APPGE coefficients_NN2 ,_, standard_JJ error_NN1 ,_, odds_NN2 ratios_NN2 and_CC 95%_NNU confidence_NN1 intervals_NN2 ._. 
</s>
<s>
The_AT concentrations_NN2 were_VBDR measured_VVN during_II and_CC after_CS the_AT treatment_NN1 period_NN1 ._. 
</s>
<s>
Keypoints:The_FO Epley_NP1 manoeuvre_NN1 is_VBZ a_AT1 highly_RR effective_JJ treatment_NN1 for_IF posterior_JJ canal_NN1 BPPV_NP1 in_II both_DB2 the_AT short_JJ and_CC long_JJ term_NN1 ._. 
</s>
<s>
Corresponding_JJ author_NN1 :_: D._NP1 S._NP1 Fink_NP1 ,_, Department_NN1 of_IO Otolaryngology-Head_NN1 and_CC Neck_NN1 Surgery_NN1 ,_, Louisiana_NP1 State_NN1 University_NN1 Health_NN1 Sciences_NN2 Center_NN1 ,_, 4995_MC Essen_NP1 Lane_NNL1 ,_, Suite_NN1 B_ZZ1 ,_, Baton_NP1 Rouge_NP1 ,_, LA_NP1 70810_MC ._. 
</s>
<s>
The_AT cochleostomy_NN1 was_VBDZ sealed_VVN with_IW muscle_NN1 plugs_NN2 ._. 
</s>
<s>
Cells_NN2 are_VBR also_RR evenly_RR distributed_VVN throughout_II the_AT membrane_NN1 ,_, and_CC MACI_NN2 rarely_RR requires_VVZ a_AT1 large_JJ arthrotomy_NN1 ._. 
</s>
<s>
The_AT first_MD two_MC factors_NN2 are_VBR particularly_RR influenced_VVN by_II the_AT individual_NN1 '_NULL s_ZZ1 actual_JJ circulating_JJ volume_NN1 ._. 
</s>
<s>
This_DD1 prolonged_JJ residence_NN1 time_NNT1 in_II the_AT subretinal_JJ space_NN1 can_VM further_RRR potentiate_VVI lipofuscin_NN1 accumulation_NN1 ,_, leading_VVG to_II further_JJR retention_NN1 in_II a_AT1 positive_JJ feedback_NN1 cycle_NN1 ._. 
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<s>
In_II our_APPGE study_NN1 ,_, we_PPIS2 attempted_VVD quantitative_JJ assessment_NN1 by_II using_VVG changes_NN2 in_II T1_FO and_CC T2_FO regionally_RR and_CC globally_RR ._. 
</s>
<s>
We_PPIS2 sequentially_RR evaluated_VVD the_AT performances_NN2 of_IO two_MC nucleic_JJ acid_NN1 amplification_NN1 tests_NN2 (_( NAATs_NP2 )_) and_CC one_MC1 serology_NN1 assay_NN1 for_IF HCV_NP1 genotype_NN1 :_: Abbott_NP1 RealTime_NNT1 genotype_NN1 II_MC (_( RealTime_NNT1 II_MC )_) ,_, GeneMatrix_NP1 restriction_NN1 fragment_NN1 mass_NN1 polymorphism_NN1 (_( RFMP_NP1 )_) ,_, and_CC Sysmex_NP1 HISCL_NP1 HCV_NP1 Gr_NP1 (_( HISCL_NP1 Gr_NP1 )_) ._. 
</s>
<s>
All_DB administrations_NN2 of_IO gadodiamide_NN1 or_CC gadopentetate_VV0 dimeglumine_NN1 occurred_VVD before_II the_AT FDA_NN1 contraindication_NN1 on_II using_VVG these_DD2 agents_NN2 in_II patients_NN2 with_IW GFR_NP1 less_DAR than_CSN 30_MC mL/min_NNU per_II 1.73_MC m2_FO ._. 
</s>
<s>
Four_MC participants_NN2 (_( 2_MC controls_NN2 ,_, 1_MC1 unilateral_JJ case_NN1 ,_, and_CC 1_MC1 bilateral_JJ case_NN1 )_) did_VDD not_XX answer_VVI questions_NN2 on_II home_NN1 pesticide_NN1 use_NN1 and_CC were_VBDR therefore_RR excluded_VVN from_II the_AT present_JJ analyses_NN2 ._. 
</s>
<s>
Those_DD2 patients_NN2 ,_, plus_II an_AT1 additional_JJ patient_NN1 from_II an_AT1 as_RR21 yet_RR22 unpublished_JJ report_NN1 ,_, have_VH0 been_VBN plotted_VVN on_II Milhorn_NP1 and_CC Korpi-Steiner_NP1 '_NULL s_ZZ1 Figure_NN1 2_MC (_( which_DDQ was_VBDZ modified_VVN from_II McChesney_NP1 )_) (_( Fig._NN1 1_MC1 )_) ._. 
</s>
<s>
Therefore_RR ,_, automated_JJ CSF_NP1 TF_NN1 assay_NN1 in_II clinical_JJ biochemistry_NN1 laboratories_NN2 is_VBZ a_AT1 good_JJ screening_NN1 tool_NN1 for_IF CFD_NP1 ._. 
</s>
<s>
As_CSA increases_VVZ ,_, the_AT points_NN2 are_VBR distributed_VVN along_RP and_CC around_II a_AT1 curve_NN1 ;_; Figure_NN1 3_MC shows_VVZ the_AT distribution_NN1 for_IF ._. 
</s>
<s>
Forced_JJ mouth_NN1 opening_VVG under_II general_JJ anaesthesia_NN1 can_VM improve_VVI trismus_NN1 ,_, but_CCB the_AT effect_NN1 is_VBZ often_RR short-lived_JJ and_CC potentially_RR complicated_VVN by_II alveolus_NN1 fracture_NN1 and_CC adjacent_JJ soft_JJ tissue_NN1 injury_NN1 ._. 
</s>
<s>
By_II delivering_VVG nociceptive_JJ selective_JJ stimuli_NN2 to_II the_AT same_DA sites_NN2 ,_, we_PPIS2 also_RR detected_VVN ,_, for_IF the_AT first_MD time_NNT1 ,_, a_AT1 clear_JJ gradient_NN1 of_IO spatial_JJ acuity_NN1 for_IF pain_NN1 ._. 
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<s>
Surgery_NN1 early_RR after_II PCI_NP1 is_VBZ often_RR urgent_JJ because_CS the_AT ACC/AHA_FU guidelines_NN2 recommend_VV0 postponing_VVG early_RR elective_JJ surgery_NN1 ,_, and_CC this_DD1 fact_NN1 probably_RR contributed_VVN to_II the_AT high_JJ incidence_NN1 of_IO MACE_NN1 in_II the_AT study_NN1 by_II Vicenzi_NP1 and_CC colleagues_NN2 ._. 
</s>
<s>
In_RR21 addition_RR22 ,_, features_NN2 of_IO social_JJ anxiety_NN1 disorder_NN1 ,_, such_II21 as_II22 fear_NN1 of_IO negative_JJ evaluation_NN1 and_CC safety_NN1 behaviours_NN2 ,_, have_VH0 been_VBN found_VVN to_TO feature_VVI prominently_RR in_II stuttering_VVG ,_, and_CC may_VM also_RR serve_VVI to_TO maintain_VVI social_JJ anxiety_NN1 and_CC exacerbate_VVI stuttering_VVG ._. 
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<s>
However_RR ,_, despite_II the_AT increased_JJ healing_JJ potential_NN1 with_IW bony_JJ involvement_NN1 ,_, the_AT predominant_JJ repair_NN1 tissue_NN1 is_VBZ fibrocartilage_NN1 ._. 
</s>
<s>
Squamous_JJ cell_NN1 carcinoma_NN1 of_IO the_AT oropharynx_NN1 (_( T1-T2_NN1 ,_, N0_FO )_) Offer_VV0 people_NN the_AT choice_NN1 of_IO transoral_JJ surgical_JJ resection_NN1 or_CC primary_JJ radiotherapy_NN1 for_IF T1-T2_NN1 N0_FO tumours_NN2 of_IO the_AT oropharynx_NN1 &lsqb;_( Based_VVN on_II very_RG low-_JJ to_II moderate-quality_JJ evidence_NN1 from_II retrospective_JJ studies_NN2 and_CC the_AT experience_NN1 and_CC opinion_NN1 of_IO the_AT GDG_NP1 &rsqb;_) ._. 
</s>
<s>
Testicular_JJ germ_NN1 cell_NN1 tumors_NN2 (_( TGCTs_NP1 )_) account_VV0 for_IF approximately_RR 97%_NNU of_IO all_DB testicular_JJ cancers.62_FO The_AT 2_MC main_JJ types_NN2 of_IO TGCTs_NP1 are_VBR seminomas_NN2 and_CC nonseminomas_NN2 ._. 
</s>
<s>
Diabetes_NN1 was_VBDZ defined_VVN as_II a_AT1 discharge_NN1 diagnosis_NN1 of_IO diabetes_NN1 (_( ICD-10_MC codes_NN2 E11_FO )_) within_II the_AT last_MD 10_MC years_NNT2 or_CC redeemed_JJ prescription_NN1 of_IO antidiabetic_JJ drugs_NN2 (_( ATC_NP1 codes_NN2 A10_FO )_) within_II 90_MC days_NNT2 ._. 
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<s>
The_AT lysates_NN2 were_VBDR cleared_VVN of_IO cell_NN1 membrane_NN1 debris_NN1 by_II centrifugation_NN1 at_II 10,000_MC x_ZZ1 g_ZZ1 for_IF 20min_NNU at_II 4C_FO ,_, and_CC the_AT total_JJ protein_NN1 concentration_NN1 in_II the_AT supernatant_NN1 was_VBDZ determined_VVN using_VVG BCA_NN1 assay_NN1 and_CC diluted_VVN to_II 1_MC1 ng/L_FU ._. 
</s>
<s>
APP_NP1 was_VBDZ immunoprecipitated_VVN with_IW C-terminal_JJ mAb_NN1 (_( clone_VV0 C1/6.1_FU ;_; Covance_NP1 Inc._JJ ,_, Princeton_NP1 ,_, NJ_NP1 )_) 18_MC (_( 10_MC mAb/200l_FU sample_NN1 )_) ._. 
</s>
<s>
There_EX were_VBDR two_MC screening_NN1 questions_NN2 about_II burnout_NN1 (_( Table_NN1 2_MC )_) ._. 
</s>
<s>
In_II all_DB ,_, 335_MC patients_NN2 (_( 78%_NNU )_) were_VBDR treated_VVN with_IW G-CSF_NN1 after_II FN_NP1 developed_VVD ,_, whereas_CS 95_MC patients_NN2 (_( 22%_NNU )_) did_VDD not_XX receive_VVI therapeutic_JJ G-CSF_NN1 ._. 
</s>
<s>
Furthermore_RR ,_, as_II a_AT1 result_NN1 of_IO repeated_JJ muscle_NN1 contractions_NN2 ,_, increases_VVZ in_II blood_NN1 temperature_NN1 can_VM occur_VVI and_CC this_DD1 also_RR may_VM contribute_VVI to_II ATP_NN1 release_NN1 during_II exercise_NN1 (_( 21_MC )_) ._. 
</s>
<s>
The_AT cut-off_NN1 points_NN2 were_VBDR as_CSA follows_VVZ :_: less_DAR than_CSN and_CC equal_JJ to_II -2.60_MC (_( ALBI_NP1 grade_VV0 1_MC1 )_) ,_, more_RRR than_CSN -2.60to_NNU -1.39_MC orless_JJ (_( ALBI_NP1 grade_NN1 2_MC )_) ,_, and_CC more_DAR than_CSN -1.39_MC (_( ALBI_NP1 grade_NN1 3_MC )_) ._. 
</s>
<s>
Research_NN1 shows_VVZ a_AT1 higher_JJR incidence_NN1 of_IO burnout_NN1 ,_, depression_NN1 ,_, and_CC hostility_NN1 among_II residents_NN2 when_CS compared_VVN to_II the_AT general_JJ population_NN1 ._. 
</s>
<s>
At_RR21 least_RR22 four_MC studies_NN2 have_VH0 demonstrated_VVN that_CST among_II individuals_NN2 with_IW GTS_NP1 ,_, males_NN2 are_VBR more_RGR likely_JJ to_TO have_VHI tics_NN2 ,_, while_CS females_NN2 are_VBR more_RGR likely_JJ to_TO have_VHI obsessive_JJ -_- compulsive_JJ behaviours_NN2 (_( OCB_NP1 )_) /disorders_FU (_( OCD_NP1 )_) ._. 
</s>
<s>
Alternative_JJ risk-reduction_JJ strategies_NN2 in_II young_JJ drivers_NN2 with_IW a_AT1 neurobiological_JJ basis_NN1 for_IF their_APPGE driving_JJ risk_NN1 may_VM be_VBI needed_VVN such_II21 as_II22 the_AT use_NN1 of_IO in-vehicle_JJ technologies_NN2 (_( eg_REX ,_, high_JJ g-force_JJ detection_NN1 systems_NN2 technology47,48_FO )_) ._. 
</s>
<s>
Recurrent_JJ medulloblastoma_NN1 is_VBZ a_AT1 considerable_JJ therapeutic_JJ challenge_NN1 in_II paediatric_JJ neuro-oncology_NN1 :_: rescue_VV0 therapy_NN1 is_VBZ effective_JJ only_RR in_II children_NN2 who_PNQS did_VDD not_XX receive_VVI radiotherapy_NN1 as_II part_NN1 of_IO their_APPGE first-line_JJ treatment_NN1 ._. 
</s>
<s>
All_DB analyses_NN2 were_VBDR conducted_VVN using_VVG SAS_NP1 ,_, version_NN1 9.3_MC ,_, with_IW an_AT1 &lsqb;_( alpha_NN1 &rsqb;_) level_NN1 of_IO 0.05_MC throughout_RL ._. 
</s>
<s>
For_REX21 example_REX22 ,_, there_EX are_VBR few_DA2 epidemiologic_JJ data_NN on_II Hispanics_NP1 ,_, now_RT the_AT largest_JJT minority_NN1 group_NN1 in_II the_AT United_NP1 States_NP1 ._. 
</s>
<s>
The_AT term_NN1 '_NULL debridement_NN1 '_NULL in_II the_AT literature_NN1 is_VBZ quite_RG vague_JJ ,_, and_CC it_PPH1 may_VM represent_VVI a_AT1 variety_NN1 of_IO procedures_NN2 including_II chondroplasty_NN1 ,_, synovectomy_NN1 ,_, and_CC meniscectomy_NN1 ._. 
</s>
<s>
However_RR ,_, slope_NN1 estimates_VVZ in_II probable_JJ multiple_JJ system_NN1 atrophy_NN1 ,_, which_DDQ comprises_VVZ late-stage_JJ disease_NN1 ,_, reach_VV0 a_AT1 plateau_NN1 phase_NN1 with_IW a_AT1 flat_JJ slope_NN1 of_IO 0.375_MC for_IF UMSARS_NN2 I._NP1 The_AT difference_NN1 in_II ECD_NP1 loss_NN1 between_II the_AT 2_MC groups_NN2 was_VBDZ statistically_RR significant_JJ (_( 95%_NNU confidence_NN1 interval_NN1 '_NULL -0.5%_FO to_II -10.9%_FO loss_NN1 ;_; P_ZZ1 =_FO 0.04_MC )_) ._. 
</s>
<s>
Patients_NN2 who_PNQS experienced_VVD STEMI_NN2 with_IW TIMI_JJ risk_NN1 score_VV0 greater_JJR than_CSN and_CC equal_JJ to_II 4_MC had_VHD over_RG 7.3_MC %_NNU 30-day_JJ mortality_NN1 and_CC over_RG 4.2_MC %_NNU 1-year_JJ mortality_NN1 &lsqb;_( 13_MC &rsqb;_) ._. 
</s>
<s>
In_RR21 addition_RR22 ,_, compared_VVN with_IW the_AT control_NN1 group_NN1 ,_, 6_MC weeks_NNT2 FC_NP1 diet_NN1 treatment_NN1 increased_VVD the_AT levels_NN2 in_II the_AT hippocampus_NN1 of_IO ChAT_NN1 with_IW 21%_NNU ._. 
</s>
<s>
Behavioral_JJ testing_NN1 conducted_VVN towards_II the_AT end_NN1 of_IO the_AT treatment_NN1 included_VVD the_AT object_NN1 recognition_NN1 and_CC the_AT radial_JJ arm_NN1 maze_NN1 tests_NN2 ,_, which_DDQ both_DB2 assess_VV0 animals_NN2 '_NULL memory_NN1 ._. 
</s>
<s>
It_PPH1 is_VBZ unclear_JJ whether_CSW and_CC how_RGQ closely_RR neuromelanin-related_JJ SNpc_NP1 signal_NN1 intensity_NN1 changes_NN2 correlate_VV0 to_II the_AT Unified_JJ Parkinson?s_NP2 Disease_NN1 Rating_NN1 Scale_NN1 (_( UPDRS_NP2 )_) scores_NN2 as_II a_AT1 more_RGR accurate_JJ estimator_NN1 of_IO disease_NN1 severity_NN1 ._. 
</s>
<s>
The_AT HI-D_VVD monkeys_NN2 had_VHD the_AT lowest_JJT SNR_NP1 ,_, which_DDQ is_VBZ associated_VVN with_IW the_AT poorest_JJT cochlear_JJ function_NN1 ._. 
</s>
<s>
Consensus_NN1 Statement_NN1 Training_NN1 in_II new_JJ technology_NN1 should_VM be_VBI included_VVN in_II the_AT fellowship_NN1 experience_NN1 ._. 
</s>
<s>
Acknowledgments_NN2 These_DD2 studies_NN2 and_CC this_DD1 analysis_NN1 were_VBDR conducted_VVN by_II XenoPort_NP1 ,_, Inc._JJ ,_, Santa_NP1 Clara_NP1 ,_, CA_NP1 ._. 
</s>
<s>
Because_CS primary_JJ care_NN1 clinicians_NN2 were_VBDR not_XX known_VVN to_II us_PPIO2 ,_, we_PPIS2 could_VM not_XX adjust_VVI for_IF clinician_NN1 in_II the_AT analyses_NN2 ._. 
</s>
<s>
Studies_NN2 involving_VVG extremely_RR premature_JJ infants_NN2 have_VH0 shown_VVN that_CST Bayley-III_MC Cognitive_JJ Composite_JJ scores_NN2 are_VBR ,_, on_II average_NN1 ,_, 10_MC to_II 11_MC points_VVZ higher_JJR than_CSN the_AT Bayley-II_MC Mental_JJ Developmental_JJ Index_NN1 scores.17,18_FO To_TO address_VVI this_DD1 limitation_NN1 ,_, we_PPIS2 defined_VVD cognitive_JJ impairment_NN1 using_VVG a_AT1 conservative_NN1 Bayley-III_MC Cognitive_JJ Composite_JJ score_NN1 lower_JJR than_CSN 85_MC ,_, which_DDQ is_VBZ one_MC1 standard_JJ deviation_NN1 below_II the_AT mean_JJ score_NN1 of_IO 100_MC ._. 
</s>
<s>
Sufficient_JJ spatial_JJ resolution_NN1 can_VM be_VBI achieved_VVN in_II this_DD1 fashion_NN1 to_TO clearly_RR separate_VVI subendocardial_JJ from_II transmural_JJ perfusion_NN1 defects_NN2 ,_, and_CC to_TO delineate_VVI small_JJ perfusion_NN1 defects_NN2 ._. 
</s>
<s>
Another_DD1 approach_NN1 would_VM look_VVI at_II the_AT plot_NN1 of_IO predicted_JJ vs._II observed_JJ risk_NN1 -_- an_AT1 illustration_NN1 of_IO this_DD1 approach_NN1 has_VHZ been_VBN presented_VVN in_II a_AT1 recent_JJ paper_NN1 on_II reporting_VVG guidelines_NN2 for_IF biomarker_NN1 studies_NN2 in_II CVD_NP1 risk_NN1 prediction_NN1 by_II Hlatky_NP1 et_RA21 al_RA22 .._... 
</s>
<s>
Table_NN1 3_MC presents_VVZ detailed_JJ ,_, descriptive_JJ terms_NN2 for_IF documenting_VVG physical_JJ examination_NN1 findings_NN2 pertinent_JJ to_II female_JJ sexual_JJ function_NN1 by_II anatomic_JJ location_NN1 ._. 
</s>
<s>
We_PPIS2 show_VV0 here_RL that_CST genetically_RR blocking_VVG the_AT interaction_NN1 of_IO RAS_NP2 with_IW p110a_FO causes_VVZ partial_JJ regression_NN1 of_IO tumors_NN2 ,_, followed_VVN by_II long-term_JJ tumor_NN1 stasis_NN1 ,_, although_CS by_II itself_PPX1 it_PPH1 is_VBZ not_XX sufficient_JJ to_TO cause_VVI complete_JJ regression_NN1 of_IO established_JJ tumors_NN2 in_II the_AT autochthonous_JJ setting_NN1 ._. 
</s>
<s>
Finally_RR ,_, with_IW the_AT exception_NN1 of_IO Van_NP1 Voorhees_NP1 et_RA21 al._RA22 ,_, ethnicity_NN1 was_VBDZ seldom_RR reported_VVN across_II studies_NN2 ._. 
</s>
<s>
We_PPIS2 defined_VVD the_AT postcontrol_NN1 group_NN1 as_II all_DB patients_NN2 admitted_VVN to_II the_AT private_JJ group_NN1 of_IO surgeons_NN2 in_II Orthopedic_NP1 or_CC Neurosurgery_NN1 between_II September_NPM1 2012_MC and_CC September_NPM1 2013_MC ._. 
</s>
<s>
However_RR ,_, there_EX are_VBR a_AT1 number_NN1 of_IO difficulties_NN2 that_CST arise_VV0 when_CS trying_VVG to_TO model_VVI human_JJ disease_NN1 in_II mice_NN2 and_CC this_DD1 is_VBZ especially_RR true_JJ for_IF the_AT SN_NN1 ,_, when_CS you_PPY consider_VV0 the_AT life_NN1 span_NN1 of_IO mice_NN2 and_CC the_AT fact_NN1 that_CST their_APPGE SN_NN1 neurons_NN2 do_VD0 not_XX contain_VVI neuromelanin_NN1 ._. 
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<s>
We_PPIS2 focused_VVD on_II the_AT most_RGT populated_JJ counties_NN2 to_TO minimize_VVI fluctuation_NN1 that_CST would_VM be_VBI seen_VVN with_IW low-population_JJ counties_NN2 ._. 
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<s>
Frailty_NN1 is_VBZ a_AT1 geriatric_JJ syndrome_NN1 used_VMK to_TO define_VVI older_JJR adults_NN2 with_IW impaired_JJ resistance_NN1 to_II stressors_NN2 due_II21 to_II22 a_AT1 decline_NN1 in_II physiologic_JJ reserve_NN1 (_( Bergman_NP1 et_RA21 al._RA22 ,_, 2007_MC )_) ._. 
</s>
<s>
MEC_NP1 05-240_MCMC ,_, approval_NN1 date_NN1 8_MC March_NPM1 2006_MC )_) ._. 
</s>
<s>
Results_NN2 :_: None_PN of_IO the_AT three_MC warm-up_JJ protocols_NN2 had_VHD significant_JJ effects_NN2 on_II muscle_NN1 activity_NN1 levels_NN2 (_( P_ZZ1 >_FO 0.10_MC )_) ._. 
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<s>
Suh_NP1 et_RA21 al_RA22 retrospectively_RR evaluated_VVD 12_MC patients_NN2 who_PNQS received_VVD micro-vascular_JJ free_JJ flap_NN1 reconstruction_NN1 for_IF recurrent_NN1 or_CC second_MD primary_JJ head_NN1 and_CC neck_NN1 cancer_NN1 in_II a_AT1 previously_RR irradiated_JJ field_NN1 ._. 
</s>
<s>
If_CS these_DD2 events_NN2 were_VBDR more_RGR common_JJ ,_, the_AT increased_JJ risk_NN1 of_IO 30-day_JJ stroke_NN1 found_VVN in_II this_DD1 study_NN1 would_VM result_VVI in_II much_RR larger_JJR numbers_NN2 of_IO missed_JJ posterior_JJ fossa_NN1 strokes_NN2 ._. 
</s>
<s>
An_AT1 explanation_NN1 for_IF this_DD1 finding_NN1 is_VBZ the_AT fact_NN1 that_CST in_II unbounded_JJ events_NN2 ,_, the_AT audience_NN1 tends_VVZ to_TO be_VBI widely_RR scattered_VVN ,_, and_CC is_VBZ thus_RR more_RGR vulnerable_JJ to_II the_AT hazards_NN2 of_IO the_AT terrain_NN1 ._. 
</s>
<s>
Moreover_RR ,_, the_AT first_MD ,_, more_RGR simplified_JJ model_NN1 also_RR presented_VVN a_AT1 better_JJR fit_NN1 compared_VVN to_II the_AT model_NN1 including_II the_AT 3-way_JJ interaction_NN1 (_( AIC_NP1 =_FO 2924.95_MC versus_II 2938.69_MC ;_; BIC_NP1 =_FO 3064.30_MC versus_II 3128.21_MC ,_, respectively_RR )_) ._. 
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<s>
Potential_JJ Conflicts_NN2 of_IO Interest_NN1 P.H._NN1 :_: consultancy_NN1 ,_, Colgate_NP1 Palmolive_NP1 Europe_NP1 ._. 
</s>
<s>
Although_CS several_DA2 promising_JJ BACE1_FO inhibitors_NN2 are_VBR being_VBG tested_VVN in_II human_JJ clinical_JJ trials_NN2 ,_, many_DA2 questions_NN2 remain_VV0 about_II the_AT safety_NN1 of_IO these_DD2 drugs_NN2 ,_, the_AT optimum_JJ level_NN1 of_IO BACE1_FO inhibition_NN1 to_TO achieve_VVI efficacy_NN1 without_IW unacceptable_JJ side-effects_NN2 ,_, and_CC the_AT stage_NN1 of_IO disease_NN1 at_II which_DDQ to_TO treat_VVI for_IF greatest_JJT therapeutic_JJ gain_NN1 ._. 
</s>
<s>
High-dose_JJ hook_NN1 effect_NN1 Recombinant_JJ human_JJ AMH_NN1 (_( Beckman_NP1 Coulter_NP1 ,_, Brea_NP1 ,_, CA_NP1 ,_, USA_NP1 )_) was_VBDZ added_VVN into_II the_AT PM_NP1 serum_NN1 pool_NN1 (_( see_VV0 above_RL )_) in_II concentrations_NN2 up_RG21 to_RG22 13,000_MC ng/mL_FU and_CC measured_VVN on_II cobas_NN2 e_ZZ1 411_MC and_CC e_ZZ1 601_MC ,_, respectively_RR ._. 
</s>
<s>
In_II this_DD1 study_NN1 ,_, as_CSA in_II other_JJ studies_NN2 (_( Sack_VV0 et_RA21 al._RA22 ,_, 10_MC Ralston_NP1 et_RA21 al._RA22 ,_, 13_MC and_CC Mateer_NP1 et_NP1 al.16_FO )_) ,_, we_PPIS2 found_VVD no_AT abdominal_JJ trauma_NN1 following_VVG the_AT use_NN1 of_IO IAC-CPR_NN1 ._. 
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<s>
We_PPIS2 identified_VVD four_MC novel_JJ mutations_NN2 in_II PSEN1_FO and_CC one_MC1 novel_JJ mutation_NN1 in_II APP_NP1 ._. 
</s>
<s>
Jia_NP1 Yi_NP1 achieved_VVD and_CC maintained_VVD low_JJ rates_NN2 of_IO 0-1.9%_FO SS_NP1 across_II languages_NN2 for_IF 12_MC months_NNT2 post-Stage_NN1 1_MC1 ._. 
</s>
<s>
Because_II21 of_II22 the_AT many_DA2 comparisons_NN2 made_VVN with_IW these_DD2 data_NN ,_, P_ZZ1 values_NN2 for_IF differences_NN2 in_II mortality_NN1 among_II patients_NN2 with_IW specific_JJ cancer_NN1 types_NN2 or_CC from_II specific_JJ causes_NN2 should_VM be_VBI regarded_VVN as_CSA exploratory_JJ ._. 
</s>
<s>
The_AT tissue_NN1 was_VBDZ collected_VVN only_RR after_II acquiring_VVG consent_NN1 from_II the_AT next_MD of_IO kin_NN along_II21 with_II22 permission_NN1 to_TO review_VVI medical_JJ records_NN2 and_CC to_TO conduct_VVI a_AT1 telephone_NN1 interview_NN1 with_IW a_AT1 primary_JJ caregiver_NN1 ._. 
</s>
<s>
More_DAR than_CSN 70%_NNU of_IO patients_NN2 who_PNQS have_VH0 bladder_NN1 cancer_NN1 are_VBR diagnosed_VVN with_IW nonmuscle-invasive_JJ disease.11_FO Treatment_NN1 and_CC survival_NN1 For_IF nonmuscle-invasive_JJ cancers_NN2 ,_, most_DAT patients_NN2 are_VBR diagnosed_VVN and_CC treated_VVN with_IW transurethral_JJ resection_NN1 of_IO the_AT bladder_NN1 tumor_NN1 (_( TURBT_NP1 )_) ,_, which_DDQ may_VM be_VBI followed_VVN by_II intravesical_JJ chemotherapy_NN1 (_( 22%_NNU )_) or_CC biologic_JJ therapy_NN1 with_IW bacillus_NN1 Calmette-Guerin_NP1 (_( 29%_NNU )_) .14_MC (_( The_AT NCDB_NP1 does_VDZ not_XX distinguish_VVI between_II systemic_JJ and_CC intravesical_JJ chemotherapy_NN1 but_CCB ,_, based_VVN on_II treatment_NN1 guidelines_NN2 ,_, it_PPH1 is_VBZ likely_JJ that_CST virtually_RR all_DB chemotherapy_NN1 is_VBZ intravesical_JJ administration_NN1 ._. )_) 
</s>
<s>
Among_II patients_NN2 with_IW muscle-invasive_JJ disease_NN1 ,_, about_II one-half_MF undergo_VV0 TURBT_NP1 ,_, and_CC 39%_NNU undergo_VV0 cystectomy_NN1 ,_, with_IW or_CC without_IW chemotherapy_NN1 and/or_CC radiation_NN1 (_( Fig._NN1 12_MC )_) ._. 
</s>
<s>
Conway_NP1 et_RA21 al_RA22 ._. 
</s>
<s>
determined_VVN that_CST dividing_VVG a_AT1 caffeine_NN1 dose_NN1 (_( e.g._REX ,_, 3_MC mg/kg_NNU before_II exercise_NN1 and_CC 3_MC mg/kg_NNU during_II exercise_NN1 )_) produces_VVZ no_AT ergogenic_JJ effect_NN1 over_II the_AT ingestion_NN1 of_IO a_AT1 bolus_NN1 dose_NN1 (_( 6_MC mg/kg_NNU before_II exercise_NN1 )_) in_II a_AT1 group_NN1 of_IO cyclist_NN1 and_CC triathletes_NN2 performing_VVG a_AT1 30-min_JJ cycling_NN1 time_NNT1 trial_NN1 ._. 
</s>
<s>
However_RR ,_, higher_JJR physical_JJ capacity_NN1 may_VM not_XX automatically_RR lead_VVI to_II a_AT1 more_RGR active_JJ lifestyle_NN1 ;_; a_AT1 behavioural_JJ change_NN1 may_VM also_RR be_VBI needed_VVN ._. 
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<s>
Methods_NN2 This_DD1 longitudinal_JJ ,_, naturalistic_JJ study_NN1 was_VBDZ conducted_VVN during_II the_AT first_MD 18_MC months_NNT2 of_IO licensure_NN1 of_IO teenaged_JJ drivers_NN2 ._. 
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<s>
All_DB mice_NN2 in_II the_AT control_NN1 group_NN1 were_VBDR killed_VVN on_II day_NNT1 13_MC ,_, 24_MC hr_NNU after_II the_AT last_MD dose_NN1 of_IO vehicle_NN1 ._. 
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The_AT home-delivered_JJ meals_NN2 social_JJ worker_NN1 recognized_VVD her_APPGE depression_NN1 and_CC referred_VVD her_PPHO1 to_II the_AT study_NN1 ._. 
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The_AT fact_NN1 that_RG early_RR mutations_NN2 are_VBR allowed_VVN to_TO accumulate_VVI to_II significant_JJ levels_NN2 may_VM be_VBI interpreted_VVN as_CSA evidence_NN1 for_IF some_DD sort_NN1 of_IO selective_JJ pressure_NN1 ._. 
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<s>
Accordingly_RR ,_, recent_JJ research_NN1 has_VHZ sought_VVN to_TO elucidate_VVI the_AT potential_NN1 for_IF preferential_JJ effects_NN2 of_IO NO3-_NN1 on_II human_JJ Type_NN1 II_MC skeletal_JJ muscle_NN1 in_RR21 vivo_RR22 ._. 
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<s>
RNA_NN1 was_VBDZ extracted_VVN from_II serum_NN1 of_IO mothers_NN2 and_CC neonates_NN2 (_( cases_NN2 and_CC controls_NN2 )_) and_CC cerebrospinal_JJ fluid_NN1 samples_NN2 (_( of_IO cases_NN2 )_) and_CC analysed_VVN by_II RT-PCR_NN1 for_IF detection_NN1 of_IO worldwide_JJ African_JJ and_CC Asian_JJ Zika_NN1 virus_NN1 genomes_NN2 using_VVG primers_NN2 designed_VVN by_II Lanciotti_NP1 and_CC colleagues_NN2 ._. 
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We_PPIS2 found_VVD that_DD1 of_IO the_AT 2378_MC deaths_NN2 that_CST occurred_VVD 6_MC months_NNT2 or_CC more_RRR after_II diagnosis_NN1 ,_, approximately_RR half_DB were_VBDR due_II21 to_II22 external_JJ causes_NN2 ,_, almost_RR entirely_RR injuries_NN2 and_CC suicides_NN2 ._. 
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<s>
This_DD1 consideration_NN1 has_VHZ led_VVN to_II the_AT development_NN1 of_IO prosthetic_JJ groups_NN2 that_CST can_VM be_VBI conjugated_VVN to_II internalizing_VVG mAbs_NN2 so_RR that_DD1 labeled_JJ catabolites_NN2 generated_VVN from_II the_AT conjugate_NN1 are_VBR trapped_VVN within_II the_AT cell_NN1 ._. 
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<s>
Unfortunately_RR ,_, due_II21 to_II22 the_AT small_JJ number_NN1 of_IO samples_NN2 available_JJ ,_, it_PPH1 was_VBDZ not_XX possible_JJ to_TO correlate_VVI calpain-1_MC1 activity_NN1 and_CC NCX3_FO cleavage_NN1 in_II brain_NN1 from_II other_JJ tauopathies_NN2 ._. 
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<s>
It_PPH1 is_VBZ one_MC1 of_IO the_AT most_RGT frequent_JJ genetic_JJ myopathies_NN2 ,_, e.g._REX a_AT1 prevalence_NN1 of_IO 1/167,000_MF in_II Spain_NP1 as_II21 of_II22 January_NPM1 2011_MC ,_, with_IW both_DB2 sexes_NN2 equally_RR affected_VVN ._. 
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<s>
These_DD2 data_NN suggested_VVD that_CST in_II cones_NN2 ,_, OS/lamellae_FU morphogenesis_NN1 is_VBZ initiated_VVN by_II the_AT addition_NN1 of_IO opsin-containing_JJ membrane_NN1 ,_, with_IW rim_NN1 formation_NN1 (_( mediated_VVN by_II PRPH2/RDS_FU )_) occurring_VVG second_NNT1 ._. 
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<s>
In_II study_NN1 1_MC1 ,_, we_PPIS2 investigated_VVD whether_CSW CS+RT_FO initiated_VVD 14_MC days_NNT2 after_II MC_NN1 infarcts_NN2 ,_, with_IW or_CC without_IW forced_JJ use_NN1 ,_, yields_VVZ enduring_JJ improvements_NN2 in_II skilled_JJ motor_NN1 function_NN1 as_CSA assessed_VVN for_IF 9_MC to_II 10_MC months_NNT2 posttreatment_NN1 ._. 
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<s>
In_RR21 addition_RR22 ,_, in_JJ21 vitro_JJ22 tests_NN2 were_VBDR performed_VVN on_II 17_MC commonly_RR used_JJ pharmaceuticals_NN2 (_( acetyl-cystein_NN1 ,_, ampicillin_NN1 ,_, ascorbic_JJ acid_NN1 ,_, cyclosporine_NN1 ,_, cefoxitin_NN1 ,_, heparin_NN1 ,_, intralipid(R)_VV0 ,_, levodopa_NN1 ,_, methyldopa_NN1 ,_, metronidazole_NN1 ,_, phenylbutazone_VV0 ,_, doxycycline_VV0 ,_, acetylsalicylic_JJ acid_NN1 ,_, rifampicin_NN1 ,_, acetaminophen_NN1 ,_, ibu-profen_JJ and_CC theophylline_NN1 )_) at_II approximately_RR five_MC times_NNT2 the_AT amount_NN1 of_IO the_AT common_JJ therapeutic_JJ concentration_NN1 ._. 
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Indeed_RR ,_, the_AT depletion_NN1 of_IO MITF_NN1 from_II MITF-expressing_JJ NRAS_NP2 mutant_NN1 melanoma_NN1 cells_NN2 significantly_RR sensitized_VVD these_DD2 cells_NN2 to_TO MEK_VVI inhibition_NN1 (_( Figure_NN1 7A_FO )_) ._. 
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<s>
Its_APPGE roots_NN2 take_VV0 hold_VV0 as_RG early_RR as_CSA medical_JJ school_NN1 ,_, and_CC the_AT problem_NN1 continues_VVZ to_TO grow_VVI as_II training_NN1 progresses_VVZ ._. 
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The_AT therapy_NN1 was_VBDZ continued_VVN with_IW oral_JJ antibiotics_NN2 for_IF 1_MC1 week_NNT1 after_II surgery_NN1 ._. 
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<s>
We_PPIS2 performed_VVD this_DD1 systematic_JJ review_NN1 and_CC meta-analysis_NN1 to_TO conclusively_RR determine_VVI whether_CSW TENS_MC2 is_VBZ an_AT1 effective_JJ therapy_NN1 for_IF knee_NN1 OA_NP1 ._. 
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As_CSA shown_VVN in_II Table_NN1 4_MC ,_, these_DD2 expectations_NN2 were_VBDR supported_VVN with_IW minor_JJ exceptions_NN2 ._. 
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Samples_NN2 were_VBDR also_RR immunoprecipitated_VVN with_IW mAbs_NN2 against_II P-actin_NN1 or_CC connexin_NN1 43_MC (_( clone_VV0 CXN-6_MC )_) ._. 
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<s>
However_RR ,_, it_PPH1 is_VBZ unclear_JJ as_II21 to_II22 how_RRQ this_DD1 might_VM affect_VVI concussion_NN1 risk_NN1 in_II football_NN1 players_NN2 ._. 
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Studies_NN2 included_VVD were_VBDR from_II the_AT developed_JJ world_NN1 ,_, therefore_RR limiting_VVG more_RGR global_JJ recommendations_NN2 ._. 
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<s>
Results_NN2 :_: Women_NN2 with_IW anorexia_NN1 nervosa_NN1 had_VHD higher_JJR skewness_NN1 and_CC kurtosis_NN1 ,_, lower_JJR MPP_NP1 (_( P_NNU less_DAR than_CSN .001_MC )_) ,_, and_CC a_AT1 trend_NN1 toward_II lower_JJR entropy_NN1 (_( P_ZZ1 =_FO .07_MC )_) compared_VVN with_IW control_NN1 subjects_NN2 ._. 
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<s>
Although_CS comparisons_NN2 to_II results_NN2 obtained_VVN in_II other_JJ xenograft_NN1 models_NN2 must_VM be_VBI done_VDN with_IW caution_NN1 ,_, it_PPH1 is_VBZ encouraging_JJ to_TO note_VVI that_CST the_AT magnitude_NN1 of_IO tumor_NN1 accumulation_NN1 observed_VVN with_IW I-SGMIB-Nanobody_NP1 also_RR was_VBDZ 2_MC -_- 4_MC times_NNT2 higher_RRR than_CSN reported_VVN for_IF other_JJ anti-HER2_NN1 -_- targeted_VVD Nanobodies_NP1 labeled_VVD with_IW 99mTc_FO ,_, 177Lu_FO ,_, and_CC 68Ga_FO ,_, as_II31 well_II32 as_II33 99mTc-labeled_JJ and_CC 68Ga-labeled_JJ Nanobodies_NN2 targeting_VVG EGFR_NN1 ._. 
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<s>
Estimates_NN2 were_VBDR based_VVN on_II previously_RR identified_VVN factors_NN2 ,_, described_VVN in_II a_AT1 systematic_JJ review_NN1 and_CC meta-analysis.16_JJ Cross-sectional_JJ analyses_NN2 have_VH0 compared_VVN higher_JJR risk_NN1 subjects_NN2 (_( defined_VVN as_CSA those_DD2 above_II the_AT 15th_MD centile_JJ of_IO risk_NN1 estimates_VVZ )_) ,_, with_IW lower_JJR risk_NN1 subjects_NN2 (_( participants_NN2 with_IW risk_NN1 estimates_VVZ below_II the_AT 85th_MD centile_JJ )_) in_II31 terms_II32 of_II33 objective_JJ smell_NN1 and_CC finger_NN1 tapping_VVG ,_, as_II31 well_II32 as_II33 subjective_JJ REM-sleep_JJ behaviour_NN1 disorder_NN1 (_( RBD_NP1 )_) .13_MC Detailed_JJ methods_NN2 are_VBR described_VVN in_II the_AT online_JJ supplementary_JJ material_NN1 ._. 
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<s>
Additional_JJ research_NN1 and_CC program_NN1 development_NN1 is_VBZ needed_VVN to_TO address_VVI the_AT gaps_NN2 in_II the_AT literature_NN1 such_II21 as_II22 small_JJ sample_NN1 sizes_NN2 ,_, use_NN1 of_IO questionable_JJ control_NN1 groups_NN2 ,_, lack_NN1 of_IO information_NN1 on_II reasons_NN2 for_IF poor_JJ adherence_NN1 ,_, need_VV0 for_IF comparative_JJ trials_NN2 including_II different_JJ types_NN2 of_IO Web_NN1 interventions_NN2 for_IF the_AT same_DA disorder_NN1 ,_, and_CC lack_NN1 of_IO satisfaction_NN1 ratings_NN2 by_II participants_NN2 ._. 
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<s>
Clinical_JJ ,_, demographic_JJ and_CC socioeconomic_JJ variables_NN2 Visual_JJ acuity_NN1 was_VBDZ measured_VVN using_VVG the_AT Early_JJ Treatment_NN1 Diabetic_NN1 Retinopathy_NN1 Study_NN1 chart21_FO and_CC change_VV0 in_II visual_JJ acuity_NN1 during_II follow-up_NN1 was_VBDZ calculated_VVN as_II the_AT difference_NN1 between_II the_AT logMAR_NN1 visual_JJ acuity_NN1 at_II the_AT last_MD followup_NN1 visit_NN1 and_CC the_AT baseline_NN1 visit_NN1 ._. 
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Outside_RL vs._II inside_RL There_EX were_VBDR 45_MC events_NN2 (_( 56.96_MC %_NNU )_) held_VVD outside_RL ._. 
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<s>
Body_NN1 length_NN1 showed_VVD concordant_JJ differences_NN2 between_II 129S2_FO and_CC B6_FO mice_NN2 (_( Fig._NN1 2B_FO )_) ,_, with_IW B6_FO being_VBG significantly_RR shorter_JJR ._. 
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Compared_VVN to_II conventional_JJ techniques_NN2 ,_, no_AT obvious_JJ survival_NN1 advantage_NN1 can_VM be_VBI observed_VVN with_IW IMRT_NP1 or_CC SBRT_NP1 ._. 
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<s>
DISCUSSION_NN1 ENB_NP1 is_VBZ a_AT1 rare_JJ malignancy_NN1 of_IO neural_JJ crest_NN1 origin_NN1 with_IW only_RR about_RG 1400_MC cases_NN2 reported_VVN since_CS it_PPH1 was_VBDZ first_MD described_VVN by_II Berger_NP1 et_RA21 al_RA22 in_II 1924_MC ._. 
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<s>
Of_IO those_DD2 with_IW any_DD lifetime_NNT1 psychiatric_JJ and_CC substance_NN1 abuse_NN1 comorbidity_NN1 ,_, 1461_MC (_( 3.8%_FO )_) died_VVD during_II the_AT follow-up_JJ period_NN1 (_( 6_MC months_NNT2 after_II TBI_NP1 )_) compared_VVN with_IW 917_MC (_( 0.5%_FO )_) of_IO those_DD2 without_IW any_DD psychiatric_JJ diagnoses_NN2 (_( eFigure_VV0 1_MC1 in_II the_AT Supplement_NN1 )_) ._. 
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The_AT 40_MC min-recording_NN1 allowed_VVN for_IF speech_NN1 samples_NN2 of_IO 1000+_FO syllables_NN2 ._. 
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Groups_NN2 of_IO 10_MC tumor-bearing_JJ mice_NN2 were_VBDR treated_VVN with_IW a_AT1 saline_JJ placebo_NN1 ,_, 7.4_MC MBq_NP1 ,_, 22.2_MC MBq_NP1 or_CC 2_MC x_ZZ1 14.8_MC MBq_NP1 of_IO 188Re-(Arg11)CCMSH_NN1 on_II day_NNT1 4_MC and_CC 7_MC (_( 2nd_MD dose_NN1 of_IO 2_MC x_ZZ1 14.8_MC MBq_NP1 )_) ._. 
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<s>
Only_RR the_AT first_MD phase_NN1 of_IO crossover_NN1 trials_NN2 was_VBDZ included_VVN to_TO avoid_VVI carry-over_JJ effects_NN2 of_IO interventions_NN2 with_IW a_AT1 long_JJ duration_NN1 of_IO action_NN1 ._. 
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<s>
PATH_NN1 integrates_VVZ a_AT1 problem_NN1 solving_NN1 approach_NN1 with_IW compensatory_JJ strategies_NN2 ,_, environmental_JJ adaptations_NN2 ,_, and_CC caregiver_VV0 participation_NN1 to_TO improve_VVI patients_NN2 '_NULL emotion_NN1 regulation_NN1 ._. 
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All_DB participants_NN2 gave_VVD written_JJ informed_JJ consent_NN1 ._. 
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There_EX seems_VVZ to_TO be_VBI no_AT standard_NN1 for_IF experimental_JJ protocols_NN2 ._. 
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<s>
Based_VVN on_II these_DD2 results_NN2 ,_, the_AT three-_NN1 and_CC four-factor_JJ EFA_NN1 models_NN2 were_VBDR further_RRR evaluated_VVN using_VVG CFA_NP1 in_BCL21 order_BCL22 to_TO build_VVI the_AT hierarchical_JJ models_NN2 ._. 
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<s>
NHANES_NP2 participants_NN2 were_VBDR obtained_VVN through_II stratified_JJ ,_, multistage_VV0 probability_NN1 sample_NN1 design_NN1 with_IW unequal_JJ probabilities_NN2 of_IO selection_NN1 ._. 
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<s>
Procedures_NN2 During_II analysis_NN1 ,_, the_AT dependent_JJ variable_NN1 was_VBDZ the_AT stuttering_JJ classification_NN1 of_IO each_DD1 initial_JJ word_NN1 ,_, or_CC rather_RR whether_CSW the_AT word_NN1 was_VBDZ produced_VVN with_IW or_CC without_IW a_AT1 stuttering-like_JJ disfluency(SLD)_NN1 ._. 
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<s>
We_PPIS2 focused_VVD on_II language_NN1 comprehension_NN1 because_CS it_PPH1 is_VBZ typically_RR preserved_VVN across_II the_AT adult_NN1 life_NN1 span_NN1 ,_, and_CC on_II syntax_NN1 in_RR21 particular_RR22 ,_, because_CS it_PPH1 is_VBZ known_VVN to_TO involve_VVI a_AT1 strongly_RR left-lateralized_JJ neural_JJ system_NN1 ._. 
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<s>
Genic_JJ intolerance_NN1 RVIS_NN1 percentiles29_FO and_CC CADD_NP1 C-scores28_NN1 were_VBDR computed_VVN to_TO characterize_VVI the_AT potential_JJ effect_NN1 of_IO functional_JJ mutations_NN2 at_II the_AT gene_NN1 level_NN1 and_CC variant_NN1 level_NN1 ,_, respectively_RR ._. 
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<s>
Respectively_RR ,_, one_MC1 ,_, two_MC ,_, three_MC ,_, and_CC four_MC stents_NN2 were_VBDR used_VVN to_TO complete_VVI the_AT TIPS_NN2 procedure_NN1 in_II 19_MC (_( 36%_NNU )_) ,_, 26_MC (_( 49%_NNU )_) ,_, seven_MC (_( 13%_NNU )_) ,_, and_CC one_MC1 (_( 2%_NNU )_) patients_NN2 ._. 
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<s>
In_BCL21 order_BCL22 to_TO explore_VVI the_AT rate_NN1 of_IO complications_NN2 such_II21 as_II22 aqueous_JJ misdirection_NN1 or_CC corneal_JJ decompensation_NN1 after_II LPI_NP1 ,_, we_PPIS2 also_RR assessed_VVN the_AT proportion_NN1 of_IO patients_NN2 who_PNQS underwent_VVD vitrectomy_NN1 or_CC keratoplasty_NN1 after_II the_AT bilateral_JJ LPIs_NN1 ._. 
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<s>
Individuals_NN2 of_IO mixed_JJ ethnicity_NN1 were_VBDR excluded_VVN ;_; HapMap_VV0 data_NN has_VHZ 1_MC1 403896_MC SNPs_NP2 available_JJ from_II 11_MC ethnicities_NN2 ._. 
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Only_JJ data_NN with_IW at_RR21 least_RR22 600_MC min_NNU d_ZZ1 1_MC1 of_IO wear_NN1 time_NNT1 were_VBDR included_VVN in_II analyses_NN2 ._. 
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Patients_NN2 eventually_RR acquire_VV0 resistance_NN1 and_CC progress_NN1 to_II castration_NN1 resistant_JJ PCa_NP1 (_( CRPC_NP1 )_) ._. 
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Our_APPGE study_NN1 shows_VVZ that_CST the_AT expression_NN1 of_IO Pitx3_FO ,_, Otx2_FO ,_, or_CC DCC_MC is_VBZ not_XX restricted_VVN to_II particular_JJ subpopulations_NN2 of_IO brainstem_NN1 dopamine_NN1 neurons_NN2 in_II aged_JJ humans_NN2 ._. 
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DISCUSSION_NN1 Methylnaltrexone_NN1 is_VBZ a_AT1 peripherally_RR acting_VVG miu-opioid_JJ receptor_NN1 antagonist_NN1 that_CST targets_NN2 the_AT underlying_JJ pathophysiology_NN1 of_IO OIC_NP1 :_: opioid_JJ agonism_NN1 of_IO miu-opioid_JJ receptors_NN2 in_II the_AT GI_NN1 tract_NN1 ._. 
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In_II the_AT first-stage_JJ analysis_NN1 of_IO 118_MC subjects_NN2 ,_, the_AT SNPs_NP2 that_CST showed_VVD statistical_JJ P-values_NN2 of_IO less_DAR than_CSN 0.05_MC were_VBDR selected_VVN as_II the_AT candidate_NN1 SNPs_NP2 for_IF the_AT second-stage_JJ analysis_NN1 among_II the_AT 295_MC 036_MC SNPs_NP2 ._. 
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The_AT Metabolic_JJ Reserve_NN1 (_( MR_NNB )_) index_NN1 was_VBDZ developed_VVN as_II a_AT1 combinatorial_JJ index_NN1 to_TO facilitate_VVI the_AT translation_NN1 of_IO pharmacogenomics_NN2 to_II personalized_JJ medicine_NN1 for_IF drugs_NN2 that_CST are_VBR metabolized_VVN or_CC activated_VVN by_II multiple_NN1 CYP450_FO isoenzymes.6_FO Each_DD1 of_IO the_AT 2_MC alleles_NN2 for_IF CYP2D6_FO ,_, CYP2C9_FO ,_, and_CC CYP2C19_FO are_VBR scored_VVN and_CC summed_VVN (_( see_VV0 Table_NN1 2_MC for_IF allele_NN1 scoring_NN1 )_) ._. 
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This_DD1 reduced_JJ ventilation_NN1 of_IO the_AT middle_JJ ear_NN1 in_II bottle-fed_JJ infants_NN2 may_VM be_VBI another_DD1 mechanism_NN1 for_IF increased_JJ risk_NN1 of_IO OM_NN1 in_II this_DD1 group_NN1 ._. 
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TURBT_NP1 followed_VVD by_II combined_JJ chemotherapy_NN1 and_CC radiation_NN1 therapy_NN1 is_VBZ as_RG effective_JJ as_CSA cystectomy_NN1 at_II preventing_VVG recurrence_NN1 in_II appropriately_RR selected_VVN cases.121-123_MC Chemotherapy_NN1 is_VBZ usually_RR the_AT first_MD treatment_NN1 for_IF cancers_NN2 that_CST have_VH0 metastasized_VVN ,_, but_CCB other_JJ treatments_NN2 might_VM be_VBI used_VVN as_RR21 well_RR22 ._. 
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OBJECTIVE_JJ To_TO clarify_VVI the_AT association_NN1 between_II LOC_NP1 at_II onset_NN1 of_IO SAH_NP1 ,_, complications_NN2 while_CS in_II the_AT hospital_NN1 ,_, and_CC long-term_JJ outcome_NN1 after_II SAH.DESIGN_NP1 ,_, SETTING_VVG ,_, AND_CC PARTICIPANTS_NN2 A_ZZ1 retrospective_JJ analysis_NN1 was_VBDZ conducted_VVN of_IO 1460_MC consecutively_RR treated_VVN patients_NN2 with_IW spontaneous_JJ SAH_NN1 who_PNQS were_VBDR part_NN1 of_IO a_AT1 prospective_JJ observational_JJ cohort_NN1 study_NN1 at_II a_AT1 large_JJ urban_JJ academic_JJ medical_JJ center_NN1 (_( the_AT Columbia_NP1 University_NN1 SAH_NN1 Outcomes_NN2 Project_NN1 or_CC SHOP_NN1 )_) ._. 
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However_RR ,_, the_AT impact_NN1 of_IO integrating_VVG hs-cTn_JJ measures_NN2 into_II the_AT HEART_NN1 Pathway_NN1 has_VHZ yet_RR to_TO be_VBI determined_VVN ._. 
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<s>
To_TO assess_VVI the_AT relative_JJ cell_NN1 surface_NN1 expression_NN1 of_IO L-type_NN1 Ca2+_FO channels_NN2 in_II hippocampal_JJ pyramidal_JJ neurons_NN2 ,_, cell_NN1 surface_NN1 biotinylation_NN1 experiments_NN2 were_VBDR conducted_VVN on_II acute_JJ hippocampal_JJ slices_NN2 (_( n_ZZ1 =_FO 8,250_MC lm_NNU slices_NN2 per_II rat_NN1 )_) from_II nine_MC young_JJ and_CC nine_MC aged_JJ rats_NN2 ._. 
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Significantly_RR higher_JJR improvement_NN1 ratings_NN2 were_VBDR found_VVN for_IF treated_JJ compared_VVN with_IW untreated_JJ children_NN2 on_II ratings_NN2 of_IO verbal_JJ communication_NN1 (_( primary_JJ outcome_NN1 )_) ,_, receptive_JJ and_CC expressive_JJ language_NN1 ,_, attention_NN1 and_CC stereotypical_JJ behavior_NN1 ._. 
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<s>
The_AT OIR_NN1 model_NN1 has_VHZ been_VBN used_VVN recently_RR to_TO define_VVI the_AT function_NN1 of_IO NRP1_FO and_CC its_APPGE ligands_NN2 in_II retinal_JJ neovascularisation_NN1 ,_, whilst_CS a_AT1 mouse_NN1 model_NN1 of_IO diabetes_NN1 has_VHZ also_RR been_VBN used_VVN to_TO study_VVI the_AT role_NN1 of_IO NRP1_FO and_CC its_APPGE ligands_NN2 in_II diabetic_JJ retinopathy_NN1 and_CC ocular_JJ oedema_NN1 (_( Section_NN1 6_MC )_) ._. 
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Retinal_JJ vein_NN1 occlusions_NN2 (_( RVO_NP1 )_) are_VBR the_AT second_MD most_RGT common_JJ type_NN1 of_IO retinal_JJ vascular_JJ disorder_NN1 after_II diabetic_JJ retinal_JJ disease_NN1 ,_, can_VM occur_VVI at_II almost_RR any_DD age_NN1 ,_, but_CCB mostly_RR in_II patients_NN2 aged_VVN over_RG 50_MC ,_, and_CC they_PPHS2 cause_VV0 sudden_JJ unilateral_JJ loss_NN1 of_IO vision_NN1 (_( Rogers_NP1 et_RA21 al._RA22 ,_, 2010_MC )_) ._. 
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<s>
First_MD ,_, after_II performing_VVG contrast-enhanced_JJ CT_NN1 of_IO the_AT neck_NN1 in_II the_AT post-RT_NN1 setting_NN1 ,_, the_AT negative_JJ predictive_JJ value_NN1 for_IF regional_JJ metastases_NN2 is_VBZ greater_JJR than_CSN 94%_NNU ._. 
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<s>
SKN-1_MC1 is_VBZ largely_RR dispensable_JJ for_IF tBOOH-induced_JJ transcription_NN1 ,_, whereas_CS MDT-15_MC is_VBZ necessary_JJ (_( Fig._NN1 5A_FO )_) ._. 
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<s>
Trainers_NN2 kept_VVD a_AT1 log_NN1 of_IO participants_NN2 '_NULL completion_NN1 ,_, modification_NN1 ,_, and_CC level_NN1 of_IO difficulty_NN1 of_IO exercises_NN2 completed_VVN by_II each_DD1 patient_NN1 and_CC any_DD adverse_JJ events_NN2 at_II each_DD1 session_NNT1 ._. 
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With_IW the_AT strongest_JJT relative_JJ drop_NN1 in_II early_JJ adulthood_NN1 ,_, this_DD1 decrement_NN1 leveled_VVD off_RP by_II 9_MC months_NNT2 ,_, reaching_VVG a_AT1 final_JJ 65%_NNU reduction_NN1 by_II 12_MC months_NNT2 ._. 
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The_AT pro-apoptotic_JJ functions_NN2 of_IO p53_FO have_VH0 also_RR been_VBN actively_RR investigated_VVN in_II both_DB2 cancerous_JJ and_CC non-cancerous_JJ tissue_NN1 types_NN2 '_NULL with_IW many_DA2 studies_NN2 supporting_VVG the_AT role_NN1 of_IO p53_FO in_II cell_NN1 death_NN1 mechanisms_NN2 in_II the_AT nervous_JJ system_NN1 ._. 
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<s>
A_AT1 preliminary_JJ analysis_NN1 revealed_VVD that_CST the_AT results_NN2 of_IO this_DD1 investigation_NN1 were_VBDR not_XX affected_VVN by_II the_AT menstrual_JJ cycle_NN1 and_CC thus_RR ,_, all_DB participants_NN2 were_VBDR treated_VVN as_II a_AT1 single_JJ group_NN1 ._. 
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The_AT combined_JJ PASI_NN1 50_MC was_VBDZ 64%_NNU with_IW FAEs_NN2 ,_, compared_VVN with_IW 14%_NNU for_IF placebo_NN1 ,_, representing_VVG a_AT1 number_NN1 needed_VVD to_TO treat_VVI to_TO benefit_VVI (_( NNTB_NP1 )_) of_IO 2_MC ._. 
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<s>
This_DD1 suggests_VVZ that_CST during_II biogenesis_NN1 of_IO discs_NN2 ,_, PRPH2/RDS_FU is_VBZ initially_RR concentrated_VVN at_II the_AT axoneme_NN1 and_CC subsequently_RR spreads_VVZ throughout_II the_AT rim_NN1 (_( Ding_NP1 et_RA21 al._RA22 ,_, 2015_MC )_) ._. 
</s>
<s>
In_II cones_NN2 ,_, even_RR mature_JJ discs_NN2 remain_VV0 at_RR21 least_RR22 partially_RR '_NULL open_JJ '_NULL and_CC contiguous_JJ with_IW the_AT plasma_NN1 membrane_NN1 (_( Fig._NN1 3B_FO )_) ,_, thus_RR to_II a_AT1 certain_JJ extent_NN1 they_PPHS2 resemble_VV0 newly_RR forming_VVG rod_NN1 discs_NN2 ._. 
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<s>
Herein_RR ,_, we_PPIS2 describe_VV0 briefly_RR 2_MC examples_NN2 of_IO measuring_VVG these_DD2 forms_NN2 of_IO coordination_NN1 in_II the_AT midbrain_NN1 and_CC prefrontal_JJ cortex_NN1 of_IO rodents_NN2 ._. 
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<s>
Incidence_NN1 rates_NN2 are_VBR lowest_JJT among_II Chinese_NP1 (_( 4.5_MC )_) and_CC Asian_JJ Indian/Pakistani_NN1 (_( 4.2_MC )_) women_NN2 ._. 
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<s>
Third_MD ,_, theories_NN2 do_VD0 not_XX incorporate_VVI concepts_NN2 such_II21 as_II22 fluctuation_NN1 or_CC stability_NN1 or_CC consider_VV0 how_RRQ these_DD2 properties_NN2 may_VM be_VBI predictive_JJ of_IO behavior_NN1 above_RL and_CC beyond_II the_AT average_JJ levels_NN2 of_IO measured_JJ constructs_NN2 ._. 
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<s>
After_CS introduction_NN1 of_IO the_AT catheters_NN2 into_II the_AT pulmonary_JJ artery_NN1 and_CC ascending_JJ aorta_NN1 ,_, we_PPIS2 observed_VVD the_AT dogs_NN2 for_IF 30_MC min_NNU to_TO ensure_VVI stable_JJ haemodynamic_JJ conditions_NN2 before_CS we_PPIS2 started_VVD data_NN collection_NN1 ._. 
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<s>
At_II 31_MC of_IO the_AT 33_MC loci_NN2 ,_, ORs_NN2 in_II the_AT psychosis_NN1 follow-up_NN1 group_NN1 were_VBDR in_II the_AT same_DA direction_NN1 as_CSA in_II the_AT discovery_NN1 data_NN set_VV0 (_( SGENE-plus+ISC+MGS_FO )_) (_( Supplementary_JJ Table_NN1 3_MC )_) ._. 
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<s>
This_DD1 is_VBZ problematic_JJ because_CS current_JJ regulations_NN2 allow_VV0 for_IF considerable_JJ state-level_JJ discretion_NN1 in_II the_AT definition_NN1 of_IO specific_JJ pediatric_JJ essential_JJ health_NN1 benefits_NN2 ,_, including_II habilitative_JJ services_NN2 ,_, which_DDQ are_VBR those_DD2 services_NN2 and_CC devices_NN2 that_CST help_VV0 children_NN2 with_IW special_JJ health_NN1 care_NN1 needs_NN2 attain_VV0 and_CC maintain_VV0 skills_NN2 and_CC functioning_VVG for_IF daily_JJ living_NN1 ._. 
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<s>
The_AT provision_NN1 of_IO care_NN1 at_II a_AT1 distance_NN1 could_VM help_VVI address_NN1 long-standing_JJ concerns_NN2 about_II the_AT distribution_NN1 and_CC number_NN1 of_IO physicians35_FO and_CC provide_VV0 greater_JJR flexibility_NN1 to_II both_RR patients_NN2 and_CC clinicians_NN2 with_II31 respect_II32 to_II33 their_APPGE location_NN1 and_CC availability_NN1 ._. 
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<s>
Table_NN1 S4_FO Overlap_NN1 of_IO DMRs_NP1 and_CC VMRs_NP1 with_IW DNase_NN1 I_MC1 hypersensitivity_NN1 hot_JJ spots_NN2 of_IO three_MC other_JJ blood_NN1 cell_NN1 types_NN2 ._. 
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<s>
Results_NN2 :_: All_DB patients_NN2 with_IW normal_JJ appearing_VVG streamlines_VVZ (_( n_ZZ1 =_FO 6_MC )_) showed_VVD an_AT1 acute_JJ inflammatory_JJ demyelinating_JJ pathology_NN1 in_II the_AT further_JJR clinical_JJ work-up_NN1 ._. 
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<s>
In_II31 addition_II32 to_II33 the_AT highest_JJT AUC_NN1 ,_, nT2_FO was_VBDZ also_RR associated_VVN with_IW the_AT lowest_JJT AIC_NP1 value_NN1 ,_, indicating_VVG its_APPGE highest_JJT predictive_JJ value_NN1 ._. 
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<s>
The_AT DHI_NN1 was_VBDZ significantly_RR lower_JJR in_II the_AT Epleygroup_NN1 at_II all_DB follow-up_JJ assessments_NN2 (_( median_JJ scores_NN2 12_MC months_NNT2 0_MC (_( 0_MC -_- 51_MC )_) versus_II 20_MC (_( 0_MC -_- 76_MC )_) ,_, P_ZZ1 =_FO 0.003_MC )_) ._. 
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<s>
OBJECTIVE_NN1 :_: To_TO describe_VVI the_AT advising_VVG practices_NN2 at_II medical_JJ schools_NN2 and_CC interview_NN1 patterns_NN2 among_II medical_JJ students_NN2 pursuing_VVG obstetrics_NN1 and_CC gynecology_NN1 residency_NN1 training_NN1 ._. 
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<s>
The_AT presence_NN1 of_IO CP_NP1 antigens_NN2 and_CC nucleic_JJ acids_NN2 has_VHZ been_VBN demonstrated_VVN by_II immunohistochemistry_NN1 ,_, double_JJ immunofluorescence_NN1 ,_, and_CC polymerase_NN1 chain_NN1 reaction_NN1 (_( PCR_NP1 )_) techniques_NN2 on_II laser-captured_JJ cells_NN2 ._. 
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<s>
The_AT authors_NN2 declare_VV0 no_AT conflicts_NN2 of_IO interest_NN1 ._. 
</s>
<s>
Subsequently_RR ,_, 0.6_MC mg/kg_NNU of_IO rocuronium_NN1 was_VBDZ administered_VVN ,_, and_CC a_AT1 laryngeal_JJ mask_NN1 airway_NN1 (_( LMA_NP1 ,_, LMA_NP1 Supreme_JJ ;_; Teleflex_NP1 Med._NP1 ,_, NC_NP1 )_) inserted_VVD followed_VVN by_II mechanical_JJ ventilation_NN1 ._. 
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<s>
The_AT '_NULL Erk-rebound_JJ '_NULL setting_NN1 after_II initial_JJ lowering_NN1 of_IO Erk_NN1 signaling_VVG thresholds_NN2 (_( PD0325901_FO '_NULL pretreatment_NN1 )_) sensitized_VVD pre-B_JJ ALL_DB cells_NN2 to_II subsequent_JJ DUSP6_FO inhibition_NN1 and_CC reduced_VVD the_AT lC50_FO for_IF BCI_NP1 from_II 2_MC ._. 
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<s>
In_II the_AT UNOS_NP2 ECD_VV0 cohort_NN1 ,_, Kaplan_NP1 '_NULL Meier_NP1 estimated_VVD rates_NN2 of_IO death_NN1 or_CC graft_VV0 loss_NN1 at_II month_NNT1 84_MC for_IF MI_NP1 belatacept_NN1 ,_, LI_NP1 belatacept_NN1 and_CC CsA_NP1 were_VBDR 35.8%_FO ,_, 40.1%_FO and_CC 41.2%_FO ,_, respectively_RR ._. 
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<s>
The_AT distinction_NN1 between_II different_JJ tissues_NN2 is_VBZ based_VVN on_II Hounsfield_NP1 units_NN2 (_( HU_NP1 )_) ._. 
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<s>
This_DD1 statement_NN1 is_VBZ not_XX in_II31 keeping_II32 with_II33 established_JJ literature_NN1 and_CC practice_NN1 ;_; however_RR ,_, on_II closer_JJR inspection_NN1 of_IO the_AT results_NN2 ,_, it_PPH1 is_VBZ clear_JJ that_CST the_AT teaching_NN1 hospitals_NN2 included_VVN in_II the_AT study_NN1 were_VBDR seeing_VVG a_AT1 more_RGR complex_JJ caseload_NN1 ._. 
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<s>
Our_APPGE findings_NN2 introduce_VV0 new_JJ knowledge_NN1 and_CC propose_VV0 new_JJ hypotheses_NN2 regarding_II the_AT neuropsychology_NN1 of_IO psychotic_JJ experiences_NN2 in_II adults_NN2 ._. 
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<s>
A_ZZ1 VA_FW loss_NN1 of_IO 15_MC letters_NN2 or_CC more_RRR was_VBDZ reported_VVN in_II a_AT1 similar_JJ percentage_NN1 (_( 5.3%_FO )_) of_IO patients_NN2 receiving_VVG aflibercept_NN1 at_II week_NNT1 52_MC in_II the_AT COPERNICUS_NN1 study_NN1 ,_, which_DDQ included_VVD patients_NN2 with_IW retinal_JJ nonperfusion_NN1 at_II baseline.25_FO Moreover_RR ,_, in_II the_AT CRYSTAL_NN1 study_NN1 ,_, at_RR21 least_RR22 in_II some_DD patients_NN2 ,_, withdrawal_NN1 of_IO initial_JJ monthly_JJ treatments_NN2 and_CC switch_VV0 to_II an_AT1 individualized_JJ dosing_NN1 regimen_NN1 driven_VVN by_II VA_FW stabilization_NN1 criteria_NN2 may_VM have_VHI occurred_VVN too_RG early_RR ,_, because_CS the_AT stability_NN1 and_CC retreatment_NN1 criteria_NN2 were_VBDR based_VVN on_II VA_FW loss_NN1 as_II a_AT1 consequence_NN1 of_IO disease_NN1 activity_NN1 ._. 
</s>
<s>
A_AT1 segmented_JJ regression_NN1 analysis_NN1 of_IO drug_NN1 shortages_NN2 before_II and_CC after_II January_NPM1 2008_MC was_VBDZ performed_VVN to_TO assess_VVI these_DD2 trends_NN2 ._. 
</s>
<s>
While_CS there_EX were_VBDR changes_NN2 in_II gene_NN1 expression_NN1 of_IO several_DA2 neuroendocrine_JJ markers_NN2 in_II31 response_II32 to_II33 GSK2879552_FO ,_, gastrin_NN1 releasing_VVG peptide_NN1 (_( GRP_NP1 )_) expression_NN1 was_VBDZ most_RGT consistently_RR altered_VVN across_II multiple_JJ cell_NN1 lines_NN2 (_( Table_NN1 S6_FO )_) ._. 
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<s>
A_AT1 comparison_NN1 of_IO the_AT fitted_JJ curves_NN2 (_( fig._NN1 2C_FO )_) showed_VVD that_CST the_AT current_NN1 evoked_VVN by_II GABA_NP1 and_CC etomidate_NN1 (_( 1_MC1 miuM_NN1 )_) in_II IL-1miu-treated_JJ neurons_NN2 was_VBDZ equivalent_JJ to_II the_AT current_NN1 evoked_VVN by_II a_AT1 much_RR higher_JJR concentration_NN1 of_IO etomidate_NN1 (_( 4.3_MC miuM_NN1 )_) in_II control_NN1 neurons_NN2 ._. 
</s>
<s>
Psychosocial_JJ stress_NN1 is_VBZ a_AT1 behavioral_JJ factor_NN1 implicated_VVD in_II risk_NN1 of_IO preterm_NN1 birth_NN1 ,_, although_CS negative_JJ associations_NN2 are_VBR also_RR found_VVN in_II the_AT literature_NN1 ._. 
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<s>
Replication_NN1 in_II an_AT1 independent_JJ cohort_NN1 confirmed_VVD these_DD2 findings_NN2 for_IF four_MC of_IO five_MC modules_NN2 &lsqb;_( Fig._NN1 2B_FO ,_, C_ZZ1 ,_, E_ZZ1 and_CC F_ZZ1 &rsqb;_) ,_, underpinning_VVG the_AT robustness_NN1 of_IO the_AT proposed_JJ approach_NN1 ._. 
</s>
<s>
However_RR ,_, very_RG few_DA2 targets_NN2 of_IO the_AT Wnt_NP1 signaling_VVG pathway_NN1 in_II C._NP1 elegans_NP1 development_NN1 have_VH0 been_VBN identified_VVN ._. 
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<s>
The_AT authors_NN2 declare_VV0 no_AT conflict_NN1 of_IO interest_NN1 ._. 
</s>
<s>
We_PPIS2 also_RR assessed_VVD the_AT amount_NN1 of_IO NCX1_FO in_II these_DD2 brain_NN1 samples_NN2 to_TO determine_VVI whether_CSW there_EX are_VBR alterationsin_NN1 the_AT amounts_NN2 or_CC activity_NN1 of_IO this_DD1 related_JJ ion_NN1 exchanger_NN1 in_II neurodegenerative_JJ disease_NN1 brain_NN1 ,_, which_DDQ may_VM indicate_VVI compensation_NN1 for_IF loss_NN1 of_IO NCX3_FO function_NN1 ._. 
</s>
<s>
All_DB data_NN were_VBDR initially_RR assessed_VVN for_IF missing_JJ data_NN ,_, linearity_NN1 ,_, constant_JJ variance_NN1 ,_, and_CC outliers_NN2 ._. 
</s>
<s>
Every_AT1 cell_NN1 '_NULL s_ZZ1 complete_JJ synaptic_JJ flow_NN1 must_VM be_VBI mapped_VVN ,_, not_XX inferred_VVN ._. 
</s>
<s>
The_AT finding_NN1 that_CST ROCK2_FO and_CC DNA-PKcs_NN2 inhibitors_NN2 functioned_VVD cooperatively_RR to_TO suppress_VVI migration_NN1 and_CC invasion_NN1 suggests_VVZ that_CST pathways_NN2 in_II31 addition_II32 to_II33 Rho/Rac_FU signaling_NN1 may_VM contribute_VVI to_II DNA-PKcs-induced_JJ metastasis_NN1 (_( eg_REX Wnt-p-catenin_NP1 ,_, TGFp_NP1 )_) ,_, and_CC it_PPH1 is_VBZ intriguing_JJ to_TO speculate_VVI that_CST DNA-PKcs_NN2 forms_VVZ a_AT1 central_JJ signaling_JJ point_NN1 modulating_VVG metastatic_JJ networks_NN2 ._. 
</s>
<s>
As_II no_AT definite_JJ secondary_JJ cause_NN1 of_IO hypokalemia_NN1 could_VM be_VBI found_VVN the_AT patient_NN1 was_VBDZ not_XX put_VVN on_II any_DD prophylactic_JJ therapy_NN1 ._. 
</s>
<s>
Linear_JJ acceleration_NN1 and_CC angular_JJ velocity_NN1 were_VBDR continuously_RR sampled_VVN (_( 1_MC1 kHz_NNU rate_NN1 )_) and_CC the_AT samples_NN2 collected_VVN during_II the_AT 5-min_JJ interval_NN1 were_VBDR stored_VVN for_IF off-line_JJ analysis_NN1 ._. 
</s>
<s>
Given_VVN low_JJ literacy_NN1 levels_NN2 in_II Sierra_NP1 Leone_NP1 ,_, all_DB participants_NN2 aged_II 18_MC years_NNT2 and_CC older_JJR provided_CS verbal_JJ consent_NN1 ;_; those_DD2 younger_JJR than_CSN 18_MC years_NNT2 provided_CS verbal_JJ assent_NN1 ,_, and_CC a_AT1 primary_JJ caregiver_NN1 provided_CS verbal_JJ consent_NN1 ._. 
</s>
<s>
Discussion_NN1 Over_II the_AT past_JJ four_MC decades_NNT2 ,_, we_PPIS2 have_VH0 transitioned_VVN from_II a_AT1 world_NN1 in_II which_DDQ underweight_JJ prevalence_NN1 was_VBDZ more_RRR than_CSN double_RR that_DD1 of_IO obesity_NN1 ,_, to_II one_PN1 in_II which_DDQ more_DAR people_NN are_VBR obese_JJ than_CSN underweight_JJ ,_, both_RR globally_RR and_CC in_II all_DB regions_NN2 except_II parts_NN2 of_IO sub-Saharan_JJ Africa_NP1 and_CC Asia_NP1 ._. 
</s>
<s>
A_AT1 final_JJ limitation_NN1 is_VBZ that_CST our_APPGE symptom_NN1 outcomes_NN2 were_VBDR derived_VVN mainly_RR from_II self-report_JJ measures_NN2 ._. 
</s>
<s>
However_RR ,_, in_II a_AT1 preplanned_JJ analysis_NN1 ,_, women_NN2 at_II high_JJ risk_NN1 of_IO disease_NN1 progression_NN1 had_VHD a_AT1 significant_JJ improvement_NN1 in_II overall_JJ survival_NN1 with_IW the_AT addition_NN1 of_IO bevacizumab_NN1 to_II standard_JJ chemotherapy_NN1 ._. 
</s>
<s>
Serum_NN1 (_( 200_MC miuL_NN1 )_) was_VBDZ charged_VVN on_II the_AT column_NN1 and_CC eluted_VVN at_II a_AT1 flow_NN1 rate_NN1 of_IO 200_MC pL/min_FU ._. 
</s>
<s>
We_PPIS2 included_VVD residents_NN2 in_II the_AT specialty_NN1 denominators_NN2 because_CS our_APPGE examination_NN1 of_IO the_AT data_NN showed_VVD that_DD1 industry_NN1 reported_VVD many_DA2 payments_NN2 beyond_II the_AT requirements_NN2 ._. 
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<s>
Response_NN1 options_NN2 range_VV0 from_II 1_MC1 (_( strongly_RR disagree_VV0 )_) to_II 4_MC (_( strongly_RR agree_VV0 )_) ._. 
</s>
<s>
A_AT1 key_JJ criticism_NN1 explicitly_RR mentioned_VVN as_CSA motivating_VVG "_" magnitude-based_JJ inference_NN1 "_" is_VBZ that_CST "_" the_AT null_JJ hypothesis_NN1 of_IO no_AT relationship_NN1 or_CC no_AT difference_NN1 is_VBZ always_RR false_JJ -_- there_EX are_VBR no_AT truly_RR zero_MC effects_NN2 in_II nature_NN1 "_" ._. 
</s>
<s>
Reactive_JJ oxygen_NN1 species_NN (_( ROS_NP1 )_) play_VV0 important_JJ signaling_JJ roles_NN2 in_II metazoans_NN2 ,_, but_CCB also_RR cause_VV0 significant_JJ molecular_JJ damage_NN1 ._. 
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<s>
Injections_NN2 of_IO corticosteroids_NN2 or_CC hyaluronic_JJ acid_NN1 could_VM be_VBI considered_VVN in_II the_AT setting_NN1 of_IO osteoarthritis_NN1 ._. 
</s>
<s>
Pediatrics_NN1 is_VBZ a_AT1 branch_NN1 of_IO medicine_NN1 that_CST specializes_VVZ in_II health_NN1 care_NN1 of_IO children_NN2 and_CC adolescents_NN2 ._. 
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<s>
This_DD1 finding_NN1 suggests_VVZ that_CST the_AT improvement_NN1 in_II child_NN1 communication_NN1 and_CC autism_NN1 symptoms_NN2 during_II treatment_NN1 could_VM have_VHI become_VVN self-sustaining_NN1 during_II the_AT years_NNT2 following_RA the_AT end_NN1 of_IO treatment_NN1 ,_, independent_JJ of_IO the_AT initial_JJ parental_JJ behavioural_JJ change_NN1 that_CST mediated_VVD them_PPHO2 ._. 
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<s>
The_AT present_JJ study_NN1 also_RR found_VVN a_AT1 high_JJ female:male_FO ratio_NN1 of_IO 7.8:1_MC ._. 
</s>
<s>
Although_CS the_AT first_MD episode_NN1 of_IO NMO_NN1 can_VM occur_VVI at_II any_DD age_NN1 from_II childhood_NN1 to_II old_JJ age_NN1 ,_, in_II most_DAT reported_JJ series_NN the_AT average_JJ age_NN1 at_II onset_NN1 is_VBZ in_II the_AT 4th_MD decade_NNT1 ._. 
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<s>
Correlations_NN2 between_II teacher_NN1 and_CC parent_NN1 ratings_NN2 were_VBDR modest_JJ at_II age_NN1 9_MC (_( r_ZZ1 =_FO .32_MC ,_, p_NNU less_DAR than_CSN .001_MC )_) and_CC 12_MC (_( r_ZZ1 =_FO .25_MC ,_, p_NNU less_DAR than_CSN .001_MC )_) ._. 
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<s>
Anesthesiology_NN1 '_NULL s_ZZ1 articles_NN2 are_VBR made_VVN freely_RR accessible_JJ to_II all_DB readers_NN2 ,_, for_IF personal_JJ use_NN1 only_RR ,_, 6_MC months_NNT2 from_II the_AT cover_NN1 date_NN1 of_IO the_AT issue_NN1 ._. 
</s>
<s>
In_II the_AT last_MD decade_NNT1 ,_, the_AT United_JJ States?_NN1 use_NN1 of_IO advanced_JJ imaging_NN1 (_( computed_JJ tomography_NN1 &lsqb;_( CT_NP1 &rsqb;_) or_CC magnetic_JJ resonance_NN1 imaging_NN1 )_) in_II the_AT evaluation_NN1 of_IO injured_JJ patients_NN2 has_VHZ increased_VVN almost_RR 3-fold_JJ without_IW an_AT1 equivalent_JJ increase_NN1 in_II life-threatening_NN1 conditions.1_FO Not_XX surprisingly_RR ,_, the_AT appropriate_JJ clinical_JJ utility_NN1 of_IO pan-CT_NN1 (_( CT_NN1 of_IO the_AT brain_NN1 ,_, cervical_JJ spine_NN1 ,_, chest_NN1 ,_, abdomen_NN1 ,_, and_CC pelvis_NN1 )_) in_II the_AT evaluation_NN1 of_IO the_AT subset_NN1 of_IO injured_JJ patients_NN2 who_PNQS sustain_VV0 blunt_JJ trauma_NN1 remains_VVZ controversial_JJ ._. 
</s>
<s>
Address_NN1 reprint_NN1 requests_NN2 to_II Dr._NNB Meissner_NP1 at_II Tufts_NN2 Medical_JJ Center_NN1 ,_, 800_MC Washington_NP1 St._NNL1 ,_, Boston_NP1 ,_, MA_NNA 02111_MC ,_, or_CC at_II ._. 
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<s>
STA(R)-Thrombin_NP1 2_MC (_( Diagnostica_NP1 Stago_NP1 )_) and_CC Biophen_NP1 Heparin_NP1 LRT_NP1 (_( Hyphen_NN1 BioMed_VVD ,_, Andresy_NP1 ,_, France_NP1 )_) were_VBDR used_JJ to_II measure_NN1 ,_, respectively_RR ,_, thrombin_NN1 time_NNT1 (_( TT_UH )_) and_CC anti_JJ Xa_NP1 activity_NN1 ._. 
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<s>
Tel._NN1 :_: +31715269735_MC ;_; fax_VV0 :_: +31715268280_MC ;_; e-mail_NN1 :_: M.Beekman@lumc.nl_FO and_CC Marcel_NP1 Reinders_NP1 ,_, The_AT Delft_NP1 Bioinformatics_NP1 Lab_NN1 ,_, Delft_NP1 University_NN1 of_IO Technology_NN1 ,_, Mekelweg_NP1 4_MC ,_, 2628_MC CD_NN1 Delft_NN1 ,_, The_AT Netherlands_NP1 ._. 
</s>
<s>
The_AT results_NN2 of_IO multivariate_JJ logistic_JJ regression_NN1 analysis_NN1 may_VM be_VBI dependent_JJ on_II the_AT regression_NN1 method_NN1 used_VVN (_( ie_REX ,_, the_AT backward_JJ stepwise_JJ elimination_NN1 method_NN1 in_II our_APPGE study_NN1 )_) ._. 
</s>
<s>
Favorable_JJ outcome_NN1 was_VBDZ defined_VVN as_CSA Cerebral_JJ Performance_NN1 Category_NN1 (_( CPC_NP1 )_) score_VV0 1_MC1 or_CC 2_MC ,_, that_REX21 is_REX22 ,_, '_NULL alive_JJ with_IW good_JJ cerebral_JJ performance_NN1 or_CC sufficient_JJ cerebral_JJ function_NN1 for_IF independent_JJ activities_NN2 of_IO daily_JJ life_NN1 ,_, with_IW or_CC without_IW mild_JJ neurological_JJ or_CC psychologic_JJ deficits_NN2 ._. 
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<s>
To_TO decide_VVI this_DD1 hypothesis_NN1 ,_, a_AT1 trial_NN1 using_VVG randomized_VVD on_RP and_CC off_II double-blind_JJ periods_NN2 should_VM be_VBI designed_VVN ,_, the_AT off_JJ periods_NN2 corresponding_VVG in_II this_DD1 technique_NN1 to_II a_AT1 sham_NN1 stimulation_NN1 as_II ECS_NP2 does_VDZ not_XX induce_VVI immediate_JJ perception_NN1 by_II the_AT patient_NN1 ._. 
</s>
<s>
These_DD2 subject-specific_JJ aHDRs_NN2 were_VBDR then_RT averaged_VVN across_II all_DB subjects_NN2 to_TO obtain_VVI group_NN1 aHDRs_NN2 corresponding_VVG to_II each_DD1 experimental_JJ condition_NN1 for_IF the_AT left_JJ and_CC right_RR primary_JJ auditory_JJ cortices_NN2 ._. 
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<s>
This_DD1 work_NN1 was_VBDZ also_RR supported_VVN in_RR21 part_RR22 by_II a_AT1 grant_NN1 from_II the_AT Shanghai_NP1 Municipal_JJ Government_NN1 ,_, Shanghai_NP1 ,_, China_NP1 (_( grant_VV0 no._NN1 20114217_MC )_) ._. 
</s>
<s>
In_RR21 addition_RR22 ,_, several_DA2 next-generation_JJ anti-inflammatory_JJ medications_NN2 ,_, such_II21 as_II22 tocilizumab_NN1 and_CC anakinra_NN1 ,_, have_VH0 been_VBN approved_VVN for_IF use_NN1 in_II humans_NN2 ._. 
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<s>
The_AT major_JJ challenges_NN2 to_II successful_JJ clinical_JJ translation_NN1 of_IO radiolabeled_JJ MC1-R_NP1 avid_JJ peptides_NN2 for_IF melanoma_NN1 imaging_NN1 and_CC therapy_NN1 are_VBR high_JJ non-specific_JJ kidney_NN1 uptake_NN1 and_CC low_JJ MC1-R_NP1 receptor_NN1 numbers_NN2 per_II tumor_NN1 cell_NN1 ._. 
</s>
<s>
They_PPHS2 also_RR proposed_VVD that_CST clinicians_NN2 might_VM accept_VVI lower_JJR accuracy_NN1 of_IO a_AT1 monitor_NN1 ,_, in_II31 return_II32 for_II33 other_JJ advantages_NN2 such_II21 as_II22 ease_NN1 of_IO use_NN1 and_CC non-invasiveness_NN1 ._. 
</s>
<s>
Raters_NP1 were_VBDR trained_VVN and_CC their_APPGE rating_NN1 skill_NN1 was_VBDZ tested_VVN prior_II21 to_II22 data_NN collection_NN1 ,_, and_CC retested_VVD every_AT1 6_MC months_NNT2 throughout_II the_AT course_NN1 of_IO the_AT study_NN1 ._. 
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<s>
Must_VM be_VBI randomized_VVN controlled_JJ trial_NN1 ,_, controlled_VVD trial_NN1 ,_, prospective_JJ case_NN1 series_NN or_CC cohort_NN1 ._. 
</s>
<s>
Such_DA approaches_NN2 depend_VV0 ,_, however_RR ,_, on_II designing_VVG efficient_JJ mechanisms_NN2 through_II which_DDQ to_TO target_VVI mutant_NN1 p53_FO ,_, an_AT1 understanding_NN1 of_IO the_AT activities_NN2 and_CC function_NN1 of_IO the_AT many_DA2 different_JJ mutants_NN2 ,_, and_CC the_AT capacity_NN1 to_TO identify_VVI which_DDQ mutation_NN1 a_AT1 tumor_NN1 carries_VVZ (_( the_AT latter_DA likely_JJ to_TO be_VBI the_AT most_RGT easily_RR attainable_JJ goal_NN1 )_) ._. 
</s>
<s>
In_II31 view_II32 of_II33 these_DD2 considerations_NN2 ,_, comprehensive_JJ analyses_NN2 of_IO BACE1-/-_FU mice_NN2 should_VM help_VVI to_TO parse_VVI developmental_JJ versus_II adult_NN1 BACE1_FO null_JJ phenotypes_NN2 for_IF the_AT evaluation_NN1 of_IO risks_NN2 of_IO BACE1_FO inhibitors_NN2 ._. 
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<s>
The_AT size_NN1 of_IO each_DD1 ROI_NN1 was_VBDZ 200_MC mm2_FO ._. 
</s>
<s>
These_DD2 pre-analytical_JJ steps_NN2 or_CC a_AT1 combination_NN1 of_IO them_PPHO2 could_VM have_VHI led_VVN to_II cellular_JJ loss_NN1 or_CC cell_NN1 lysis_NN1 which_DDQ could_VM have_VHI resulted_VVN in_II lower_JJR chamber_NN1 counts_NN2 ._. 
</s>
<s>
There_EX was_VBDZ a_AT1 significant_JJ correlation_NN1 between_II NRS_NP1 scores_NN2 during_II the_AT CPT_NP1 and_CC change_VV0 in_II pain_NN1 tolerance_NN1 limit_NN1 immediately_RR after_II the_AT CPT_NP1 (_( r60_FO =_FO 0.397_MC ,_, P_ZZ1 =_FO 0.002_MC )_) ._. 
</s>
<s>
A_AT1 positive_JJ Hedges_NN2 '_NULL g_ZZ1 indicates_VVZ the_AT presence_NN1 of_IO more_RGR negative_JJ communication_NN1 attitudes_NN2 among_II CWS_NP1 than_CSN CWNS_NP1 ._. 
</s>
<s>
Acoustic_JJ recordings_NN2 were_VBDR made_VVN with_IW a_AT1 Shure_NN1 omnidirectional_JJ lapel_NN1 microphone_NN1 (_( MX393/O_NP1 )_) worn_VVN by_II the_AT participant_NN1 ._. 
</s>
<s>
Cell_NN1 Lines_NN2 and_CC Cell_NN1 Culture_NN1 Normal_JJ small_JJ airway_NN1 epithelial_JJ cells_NN2 (_( SAECs_NP2 )_) and_CC lung_NN1 cancer_NN1 cell_NN1 lines_NN2 were_VBDR purchased_VVN from_II ATCC_NP1 ._. 
</s>
<s>
All_DB patients_NN2 presented_VVN with_IW symptomatic_JJ obstructive_JJ jaundice_NN1 and_CC underwent_VVN percutaneously_RR biliary_JJ drainage_NN1 with_IW catheters_NN2 or_CC stents_NN2 ._. 
</s>
<s>
The_AT RAI_NN1 could_VM also_RR be_VBI applied_VVN in_II other_JJ dysregulated_JJ states_NN2 and_CC related_VVN to_II functional_JJ magnetic_JJ resonance_NN1 imaging_VVG data_NN acquired_VVN from_II a_AT1 variety_NN1 of_IO tasks_NN2 ._. 
</s>
<s>
However_RR ,_, the_AT cost_NN1 of_IO the_AT device_NN1 and_CC its_APPGE relative_JJ immobility_NN1 currently_RR discourages_VVZ it_PPH1 from_II being_VBG used_VVN outside_II eye_NN1 clinics_NN2 ,_, and_CC therefore_RR as_II a_AT1 component_NN1 of_IO a_AT1 tele-AMD_NP1 program_NN1 ._. 
</s>
<s>
The_AT main_JJ protector_NN1 of_IO dopaminergic_JJ neurons_NN2 against_II this_DD1 oxidative_JJ stress_NN1 is_VBZ the_AT dopamine_NN1 transporter_NN1 (_( DAT_DD1 )_) ._. 
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<s>
In_II 1940_MC ,_, the_AT webbed_JJ style_NN1 suspension_NN1 was_VBDZ replaced_VVN by_II a_AT1 padded_JJ style_NN1 suspension_NN1 ._. 
</s>
<s>
No_AT correlations_NN2 were_VBDR observed_VVN between_II the_AT individual_JJ CAES_NP2 group_NN1 threshold_NN1 shifts_NN2 and_CC maximum_JJ current_JJ levels_NN2 or_CC dynamic_JJ ranges_NN2 of_IO stimulation_NN1 ._. 
</s>
<s>
For_IF in_JJ21 vivo_JJ22 silencing_NN1 experiments_NN2 ,_, C57BL/6_FU mice_NN2 were_VBDR obtained_VVN from_II The_AT Jackson_NP1 Laboratory_NN1 ._. 
</s>
<s>
Given_VVN the_AT success_NN1 of_IO multidisciplinary_JJ pain_NN1 management_NN1 interventions_NN2 that_CST include_VV0 some_DD form_NN1 of_IO behavioral_JJ therapy_NN1 ,_, it_PPH1 would_VM seem_VVI logical_JJ that_CST behavioral_JJ intervention_NN1 would_VM be_VBI a_AT1 useful_JJ part_NN1 of_IO any_DD weaning_JJ program_NN1 to_TO help_VVI with_IW sleep_NN1 hygiene_NN1 ,_, anxiety/mood_NN1 symptoms_NN2 ,_, and_CC pain-related_JJ symptoms_NN2 that_CST may_VM occur_VVI during_II the_AT weaning_JJ period_NN1 ._. 
</s>
<s>
All_DB analyses_NN2 were_VBDR performed_VVN using_VVG R_ZZ1 version_NN1 3.0.2_MC (_( R_ZZ1 Development_NN1 Core_NN1 Team_NN1 ,_, http_NNU :_: //www.rproject.org/_JJ )_) ,_, with_IW inferential_JJ data_NN calculated_VVN with_IW the_AT complex_JJ survey_NN1 design_NN1 package_NN1 ,_, which_DDQ uses_VVZ the_AT Taylor_NP1 series_NN method_NN1 to_TO calculate_VVI properly_RR weighted_JJ variance_NN1 estimate_NN1 ._. 
</s>
<s>
Totally_RR dislocated_VVD IOLs_NN2 into_II the_AT posterior_JJ segment_NN1 of_IO the_AT eye_NN1 requiring_VVG pars_NN2 plana_NN1 vitrectomy_NN1 were_VBDR not_XX included_VVN ._. 
</s>
<s>
There_EX were_VBDR significant_JJ differences_NN2 across_II the_AT range_NN1 of_IO interventions_NN2 (_( low_JJ heterogeneity_NN1 )_) in_II total_NN1 ,_, general_NN1 ,_, social_JJ and_CC physical_JJ support_NN1 subscales_NN2 (_( anova_NN1 F_ZZ1 =_FO 103_MC ._. 
</s>
<s>
A_AT1 set_NN1 of_IO non-overlapping_JJ cells_NN2 spread_VV0 over_RP a_AT1 plane_NN1 ,_, e.g._REX blue_JJ cones_NN2 ,_, is_VBZ a_AT1 packing_NN1 and_CC with_IW a_AT1 coverage_NN1 ofless_JJ than_CSN 1_MC1 ._. 
</s>
<s>
The_AT first_MD major_JJ finding_NN1 of_IO our_APPGE work_NN1 was_VBDZ the_AT high_JJ fidelity_NN1 of_IO the_AT extraction_NN1 in_II the_AT formulations_NN2 of_IO the_AT pure_JJ contrast_NN1 materials_NN2 :_: tungsten_NN1 ,_, calcium_NN1 ,_, and_CC iodine_NN1 ._. 
</s>
<s>
The_AT participants_NN2 '_NULL demographic_JJ characteristics_NN2 are_VBR shown_VVN in_II Table_NN1 1_MC1 ._. 
</s>
<s>
From_II these_DD2 ,_, 24_MC categories_NN2 and_CC seven_MC metacategories_NN2 were_VBDR generated_VVN ._. 
</s>
<s>
Recognition_NN1 of_IO perioperative_JJ stroke_NN1 remains_VVZ a_AT1 major_JJ challenge_NN1 ._. 
</s>
<s>
K._NP1 Meador_NP1 has_VHZ received_VVN research_NN1 support_NN1 from_II the_AT NIH_NN1 ,_, the_AT Patient-Centered_JJ Outcomes_NN2 Research_VV0 Institute_NN1 ,_, UCB_NP1 Pharma_NP1 ,_, and_CC Sunovion_NN1 Pharmaceuticals_NN2 ,_, as_II31 well_II32 as_II33 travel_NN1 support_NN1 from_II UCB_NP1 Pharma_NP1 ._. 
</s>
<s>
On_II the_AT other_JJ hand_NN1 ,_, duration_NN1 discrimination_NN1 refers_VVZ to_II the_AT ability_NN1 to_TO discriminate_VVI the_AT smallest_JJT possible_JJ difference_NN1 in_II duration_NN1 (_( difference_NN1 limen_NN2 )_) which_DDQ usually_RR has_VHZ a_AT1 duration_NN1 similar_JJ to_II that_DD1 reported_VVD for_IF TOJ_NP1 ,_, thus_RR of_IO ca_VM ._. 
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<s>
Given_VVN the_AT existing_JJ link_NN1 between_II highly_RR penetrant_JJ CNVs_NP1 and_CC severe_JJ ASD_NN1 ,_, we_PPIS2 tested_VVD whether_CSW the_AT extreme_JJ patterns_NN2 of_IO DNA_NN1 methylation_NN1 in_II these_DD2 two_MC twins_NN2 were_VBDR associated_VVN with_IW the_AT presence_NN1 of_IO genomic_JJ alterations_NN2 ._. 
</s>
<s>
Longitudinal_JJ studies_NN2 in_II adults_NN2 have_VH0 shown_VVN that_CST bipolar_JJ disorder_NN1 is_VBZ a_AT1 lifelong_JJ illness_NN1 manifested_VVN by_II recurrent_JJ mood_NN1 episodes_NN2 ,_, but_CCB the_AT length_NN1 of_IO asymptomatic_JJ periods_NN2 is_VBZ highly_RR variable_JJ ,_, and_CC some_DD adults_NN2 with_IW bipolar_JJ disorder_NN1 may_VM have_VHI extended_VVN periods_NN2 without_IW recurrences_NN2 ._. 
</s>
<s>
Recently_RR ,_, US_NP1 features_NN2 of_IO papillary_JJ thyroid_JJ carcinoma_NN1 that_CST appear_VV0 to_TO be_VBI malignant_JJ in_II thyroid_JJ nodules_NN2 were_VBDR reported_VVN to_TO be_VBI associated_VVN with_IW recurrence_NN1 ._. 
</s>
<s>
M.W._NNU Financial_JJ activities_NN2 related_VVN to_II the_AT present_JJ article_NN1 :_: none_PN to_TO disclose_VVI ._. 
</s>
<s>
We_PPIS2 did_VDD not_XX conduct_VVI studies_NN2 of_IO neuropathic_JJ pain_NN1 using_VVG the_AT oral_JJ form_NN1 of_IO Meflo_NP1 ._. 
</s>
<s>
Finally_RR ,_, we_PPIS2 expected_VVD that_DD1 onset-to-treatment_NN1 (_( OTT_NP1 )_) time_VV0 would_VM be_VBI reduced_VVN when_CS the_AT stroke_NN1 physician_NN1 was_VBDZ centrally_RR located_VVN compared_VVN to_II when_RRQ the_AT stroke_NN1 physician_NN1 was_VBDZ not_XX centrally_RR located_VVN ._. 
</s>
<s>
GAPDH_NP1 was_VBDZ used_VVN as_II both_DB2 loading_VVG and_CC internal_JJ protein_NN1 control_NN1 to_TO confirm_VVI the_AT success_NN1 of_IO the_AT biotinylation_NN1 procedures_NN2 (_( Fig_NN1 ._. 
</s>
<s>
S3_FO )_) ._. 
</s>
<s>
Alternatively_RR ,_, factors_NN2 such_II21 as_II22 MDT-15_MC ,_, which_DDQ is_VBZ required_VVN to_TO transcribe_VVI fat-5_MC ,_, fat-6_MC ,_, and_CC fat-7_MC ,_, may_VM be_VBI required_VVN to_TO transcribe_VVI cytoprotective_JJ pathways_NN2 rather_CS21 than_CS22 promote_VVI anabolic_JJ metabolism_NN1 in_II a_AT1 pro-oxidative_JJ environment_NN1 ._. 
</s>
<s>
GDNF_NP1 and_CC the_AT anti-GDNF_JJ antibody_NN1 were_VBDR injected_VVN ._. 
</s>
<s>
Clinical_JJ implications_NN2 for_IF cediranib_NN1 in_II advanced_JJ cervical_JJ cancer_NN1 For_IF decades_NNT2 ,_, the_AT management_NN1 of_IO women_NN2 with_IW recurrent_JJ or_CC persistent_JJ cervical_JJ cancer_NN1 not_XX amenable_JJ to_II surgery_NN1 and_CC women_NN2 who_PNQS present_VV0 with_IW metastatic_JJ disease_NN1 has_VHZ constituted_VVN a_AT1 high_JJ unmet_JJ clinical_JJ need_NN1 ,_, with_IW platinum-based_JJ chemotherapy_NN1 being_VBG palliative_JJ and_CC associated_VVN with_IW shortlived_JJ responses_NN2 ,_, rapid_JJ deterioration_NN1 in_II quality_NN1 of_IO life_NN1 ,_, and_CC early_JJ death_NN1 (_( median_JJ overall_JJ survival_NN1 7-12_MCMC months_NNT2 )_) ._. 
</s>
<s>
However_RR ,_, the_AT groups_NN2 were_VBDR not_XX comparable_JJ in_II frequency_NN1 prior_II21 to_II22 randomisation_NN1 ._. 
</s>
<s>
Statistical_JJ analysis_NN1 :_: Eraly_RR ,_, Nievergelt_NP1 ,_, Maihofer_NP1 ,_, and_CC Barkauskas_NP2 ._. 
</s>
<s>
Without_IW adoption_NN1 of_IO common_JJ standards_NN2 ,_, health_NN1 information_NN1 exchange_NN1 will_VM remain_VVI limited_JJ in_II scope_NN1 and_CC functionality_NN1 ._. 
</s>
<s>
Accepted_VVN for_IF publication_NN1 13_MC August_NPM1 2013_MC Summary_NN1 Collagen_NN1 fibrils_NN2 become_VV0 resistant_JJ to_II cleavage_NN1 over_II time_NNT1 ._. 
</s>
<s>
The_AT primary_JJ endpoint_NN1 was_VBDZ incidence_NN1 of_IO ABT_NN1 ._. 
</s>
<s>
According_II21 to_II22 the_AT Office_NN1 of_IO the_AT National_JJ Coordinator_NN1 for_IF Health_NN1 Information_NN1 Technology_NN1 ,_, currently_RR there_EX are_VBR 3_MC key_JJ forms_NN2 of_IO health_NN1 information_NN1 exchange_NN1 ._. 
</s>
<s>
The_AT chi-squared_JJ test_NN1 was_VBDZ used_VVN for_IF group_NN1 comparisons_NN2 of_IO proportions_NN2 (_( sex_NN1 ,_, race_NN1 ,_, AON_NP1 history_NN1 )_) ._. 
</s>
<s>
Although_CS models_NN2 of_IO how_RGQ mammalian_JJ RIBEYE_NN1 assembles_VVZ have_VH0 been_VBN proposed_VVN based_VVN on_II yeast_NN1 two-hybrid_NN1 interactions_NN2 (_( Magupalli_NP1 et_RA21 al_RA22 ._. 
</s>
<s>
,_, 2008_MC )_) ,_, the_AT in_JJ21 vivo_JJ22 orientation_NN1 of_IO RIBEYE_NN1 within_II the_AT spherical_JJ structure_NN1 of_IO hair_NN1 cell_NN1 ribbons_NN2 is_VBZ not_XX known_VVN ._. 
</s>
<s>
Computed_JJ tomography_NN1 scans_NN2 of_IO the_AT orbit_NN1 were_VBDR performed_VVN at_II the_AT time_NNT1 of_IO the_AT blockade_NN1 and_CC 10_MC minutes_NNT2 after_II anesthetic_JJ injection_NN1 ._. 
</s>
<s>
The_AT profile_NN1 of_IO CYP_NP1 expression_NN1 and_CC cholesterol_NN1 metabolite_NN1 content_NN1 in_II the_AT brain_NN1 (_( gray_JJ matter_NN1 of_IO temporal_JJ lobe_NN1 )_) was_VBDZ the_AT opposite_JJ ,_, consistent_JJ with_IW the_AT role_NN1 of_IO CYP46A1_FO as_II the_AT enzyme_NN1 responsible_JJ for_IF the_AT majority_NN1 of_IO cholesterol_NN1 elimination_NN1 from_II this_DD1 organ_NN1 (_( Bjorkhem_NP1 et_RA21 al._RA22 ,_, 1998_MC )_) ._. 
</s>
<s>
It_PPH1 is_VBZ unclear_JJ whether_CSW surgery_NN1 can_VM similarly_RR accelerate_VVI the_AT growth_NN1 of_IO endometriosis_NN1 in_II later_JJR stages_NN2 or_CC of_IO deep_RR infiltrating_VVG endometriosis_NN1 ._. 
</s>
<s>
Its_APPGE first_MD hypothesis_NN1 postulates_VVZ that_CST CM-PST_NP1 is_VBZ more_RGR effective_JJ than_CSN CM_NNU in_II reducing_VVG depressive_NN1 symptoms_NN2 over_RG 12_MC weeks_NNT2 ._. 
</s>
<s>
Many_DA2 studies_NN2 support_VV0 the_AT finding_NN1 that_CST about_II one_MC1 third_MD of_IO childrenwho_NN1 stutter_NN1 also_RR exhibit_VV0 a_AT1 concomitant_JJ phonological_JJ disorder_NN1 (_( Byrd_NP1 ,_, Wolk_NP1 ,_, &;_NULL Davis_NP1 ,_, 2007_MC ;_; Wolk_NP1 ,_, Edwards_NP1 ,_, &Conture,;_NULL 1993_MC )_) ,_, and_CC approximately_RR 10%_NNU exhibit_VV0 a_AT1 concomitant_JJ language_NN1 disorder_NN1 (_( Arndt_NP1 &;_NULL Healey_NP1 ,_, 2001_MC ;_; Blood_NN1 &;_NULL Seider_NN1 ,_, 1981_MC )_) ._. 
</s>
<s>
Design_NN1 and_CC Setting_NN1 :_: A_ZZ1 prospective_JJ cohort_NN1 study_NN1 of_IO British_JJ civil_JJ servants_NN2 who_PNQS responded_VVD to_II a_AT1 self-administered_JJ questionnaire_NN1 in_II middle-age_NN1 and_CC at_II older_JJR ages_NN2 ,_, 21_MC years_NNT2 later_RRR ._. 
</s>
<s>
Exclusion_NN1 criteria_NN2 included_VVN (_( 1_MC1 )_) lumbar_NN1 spine_NN1 stenosis_NN1 on_II magnetic_JJ resonance_NN1 imaging_NN1 ;_; (_( 2_MC )_) use_NN1 of_IO exogenous_JJ steroid_NN1 ,_, including_II inhaled_JJ steroids_NN2 ,_, within_II the_AT past_JJ 6_MC months_NNT2 ;_; (_( 3_MC )_) history_NN1 of_IO any_DD lumbar_NN1 spine_NN1 surgery_NN1 including_II fusion_NN1 and_CC decompressive_JJ laminectomy_NN1 ;_; (_( 4_MC )_) adrenal_JJ disease_NN1 ,_, pituitary_JJ disease_NN1 ,_, or_CC other_JJ endocrinopathy_NN1 known_VVN to_TO impair_VVI the_AT HPA_NN1 axis_NN1 ;_; (_( 5_MC )_) end-stage_JJ liver_NN1 (_( Child-Pugh_NP1 classification_NN1 A_ZZ1 or_CC greater_JJR )_) or_CC kidney_NN1 disease_NN1 (_( creatinine_NN1 clearance_NN1 less_DAR than_CSN 30_MC mL/min_NNU )_) ;_; (_( 6_MC )_) use_NN1 of_IO any_DD medication_NN1 known_VVN to_TO interfere_VVI with_IW the_AT metabolism_NN1 of_IO triamcin_NN1 lone_JJ acetonide_NN1 ,_, including_VVG ,_, but_CCB not_XX limited_VVN to_II ,_, phenobarbital_NN1 ,_, phenytoin_NN1 ,_, itraconazole_NN1 ,_, rifampin_NN1 ,_, and_CC selected_JJ antiretroviral_JJ agents_NN2 ;_; (_( 7_MC )_) presence_NN1 of_IO a_AT1 psychiatric_JJ disorder_NN1 that_CST would_VM limit_VVI obtaining_VVG informed_JJ consent_NN1 or_CC impair_VV0 functioning_VVG in_II an_AT1 ambulatory_JJ care_NN1 environment_NN1 (_( eg_REX ,_, dementia_NN1 ,_, schizophrenia_NN1 ,_, severe_JJ depression_NN1 )_) ;_; and_CC (_( 8_MC )_) pregnancy_NN1 ._. 
</s>
<s>
The_AT grand-mean_JJ peak_NN1 MMN_NP1 latencies_NN2 were_VBDR identified_VVN from_II the_AT difference_NN1 waveforms_NN2 at_II F4_FO at_II 160_MC -_- 300_MC ms_NN1 from_II the_AT deviant-stimulus_JJ onset_NN1 separately_RR for_IF each_DD1 group_NN1 and_CC deviants_NN2 (_( Table_NN1 1_MC1 )_) ._. 
</s>
<s>
Notably_RR ,_, the_AT fibronectin-negative_JJ group_NN1 recruited_VVN under_II the_AT extended_JJ criteria_NN2 ,_, had_VHD rates_NN2 of_IO the_AT primary_JJ outcome_NN1 (_( death_NN1 or_CC preterm_VV0 birth_NN1 before_II 34_MC weeks_NNT2 )_) of_IO 13%_NNU (_( appendix_NN1 )_) ,_, some_DD three_MC times_II those_DD2 of_IO the_AT background_NN1 population_NN1 of_IO pregnant_JJ women_NN2 in_II the_AT UK_NP1 ._. 
</s>
<s>
We_PPIS2 sought_VVD to_TO identify_VVI all_DB trials_NN2 ,_, irrespective_II21 of_II22 whether_CSW a_AT1 trial_NN1 was_VBDZ ongoing_JJ or_CC completed_VVD ,_, published_VVN or_CC unpublished_JJ ,_, with_IW no_AT language_NN1 restrictions_NN2 ._. 
</s>
<s>
A_AT1 minimum_NN1 of_IO three_MC scans_NN2 of_IO the_AT central_JJ cornea_NN1 and_CC of_IO the_AT superior_JJ ,_, nasal_JJ ,_, inferior_JJ ,_, and_CC temporal_JJ limbus_NN1 were_VBDR collected_VVN ._. 
</s>
<s>
Moreover_RR ,_, NRP1_FO promotes_VVZ fibronectin_NN1 fibrillogenesis_NN1 in_II arterial_JJ endothelial_JJ cells_NN2 in_RR21 vitro_RR22 by_II regulating_VVG intracellular_JJ trafficking_NN1 of_IO activated_JJ a5p1_FO in_II a_AT1 mechanism_NN1 that_CST requires_VVZ the_AT NRP1_FO cytoplasmic_JJ domain_NN1 (_( Valdembri_NP1 et_RA21 al._RA22 ,_, 2009_MC )_) ._. 
</s>
<s>
Age_NN1 was_VBDZ evaluated_VVN as_II an_AT1 additional_JJ predictor_NN1 in_II each_DD1 multivariate_JJ model_NN1 to_TO adjust_VVI for_IF the_AT influence_NN1 of_IO age_NN1 on_II T1_FO and_CC T2_FO ._. 
</s>
<s>
These_DD2 studies_NN2 should_VM include_VVI an_AT1 early_JJ and_CC prospective_JJ assessment_NN1 of_IO CSF_NP1 antibody_NN1 titers_NN2 as_II a_AT1 possible_JJ prognostic_JJ biomarker_NN1 ._. 
</s>
<s>
They_PPHS2 first_MD showed_VVD in_II healthy_JJ volunteers_NN2 that_CST the_AT degree_NN1 of_IO left_JJ IFG_NN1 activity_NN1 in_II fMRI_NN2 could_VM be_VBI modulated_VVN by_II the_AT selection_NN1 demands_NN2 of_IO the_AT semantic_JJ task_NN1 with_IW a_AT1 higher_JJR activation_NN1 of_IO the_AT IFG_NN1 for_IF selective_JJ tasks_NN2 ._. 
</s>
<s>
Fourth_MD ,_, not_XX all_DB patients_NN2 underwent_VVD preoperative_JJ MR_NNB imaging_NN1 ._. 
</s>
<s>
For_IF "_" clinical_JJ inference_NN1 "_" ,_, we_PPIS2 have_VH0 to_TO specify_VVI the_AT "_" minimum_JJ chance_NN1 of_IO benefit_NN1 "_" (_( default_NN1 in_II E37_FO )_) and_CC the_AT "_" maximum_JJ risk_NN1 of_IO harm_NN1 "_" (_( default_NN1 in_II E36_FO )_) ._. 
</s>
<s>
However_RR ,_, even_CS21 though_CS22 it_PPH1 has_VHZ been_VBN demonstrated_VVN that_CST carbamylated_VVD albumin_NN1 may_VM predict_VVI mortality_NN1 in_II patients_NN2 with_IW kidney_NN1 failure_NN1 ,_, no_AT molecular_JJ mechanism_NN1 involving_VVG carbamylated_JJ albumin_NN1 has_VHZ been_VBN yet_RR proposed_VVN ._. 
</s>
<s>
General_JJ use_NN1 of_IO inpatient_NN1 administrative_JJ data_NN to_TO determine_VVI epidemiology_NN1 of_IO any_DD disease_NN1 is_VBZ likely_JJ to_TO provide_VVI a_AT1 lower_JJR estimate_NN1 ;_; however_RR ,_, we_PPIS2 were_VBDR able_JK to_TO validate_VVI estimates_NN2 of_IO recurrent_JJ respiratory_JJ papillomatosis_NN1 and_CC frequency_NN1 of_IO use_NN1 of_IO Cobla-tion_NN1 obtained_VVN from_II our_APPGE survey_NN1 using_VVG Hospital_NN1 Episode_NN1 Statistics_NN inpatient_NN1 data_NN due_II21 to_II22 high_JJ admission/intervention_NN1 rate_NN1 associated_VVN with_IW the_AT recurrent_JJ respiratory_JJ papillomatosis_NN1 condition_NN1 ._. 
</s>
<s>
Therefore_RR ,_, a_AT1 break_NN1 of_IO at_RR21 least_RR22 4_MC weeks_NNT2 was_VBDZ completed_VVN after_II evaluation_NN1 of_IO SRs_NP1 to_TO avoid_VVI recall_NN1 bias_NN1 for_IF the_AT assessment_NN1 of_IO FT_NNU reports_NN2 ._. 
</s>
<s>
In_II that_DD1 retrospective_JJ ,_, single-center_JJ study_NN1 on_II 1129_MC patients_NN2 who_PNQS underwent_VVD lung_NN1 resection_NN1 surgery_NN1 ,_, multivariate_JJ analysis_NN1 demonstrated_VVD an_AT1 independent_JJ association_NN1 between_II postoperative_JJ AKI_NN2 and_CC HE_PPHS1 S_VBZ use_NN1 (_( OR_CC ,_, 1.5_MC ;_; 95%_NNU CI_FO ,_, 1.1_MC '_NULL 2.1_MC )_) and_CC open_JJ procedures_NN2 ._. 
</s>
<s>
If_CS this_DD1 is_VBZ the_AT case_NN1 ,_, then_RT given_VVN the_AT early_JJ onset_NN1 of_IO most_DAT mental_JJ disorders_NN2 and_CC the_AT similarly_RR early_JJ etiopathogenesis_NN1 of_IO many_DA2 chronic_JJ physical_JJ conditions_NN2 ,_, 29_MC treatment_NN1 of_IO all_DB mental_JJ disorders_NN2 should_VM optimally_RR incorporate_VVI attention_NN1 to_II physical_JJ health_NN1 and_CC health_NN1 behaviors_NN2 ,_, with_IW this_DD1 parallel_JJ focus_NN1 on_II physical_JJ health_NN1 beginning_VVG as_RG early_RR in_II the_AT course_NN1 of_IO the_AT mental_JJ disorder_NN1 as_CSA possible_JJ ._. 
</s>
<s>
It_PPH1 is_VBZ possible_JJ that_CST some_DD of_IO the_AT children_NN2 who_PNQS completed_VVD Stage_NN1 1_MC1 did_VDD so_RG naturally_RR ._. 
</s>
<s>
NPC1_FO loss_NN1 impaired_VVD visual_JJ function_NN1 and_CC caused_VVD degeneration_NN1 of_IO OS_NP2 ,_, disruption_NN1 of_IO synaptic_JJ layers_NN2 ,_, and_CC accumulation_NN1 of_IO cholesterol_NN1 in_II the_AT RPE_NN1 ._. 
</s>
<s>
The_AT expression_NN1 of_IO Drp1_FO in_II the_AT gp120_FO +_FO AS-Drp1_JJ group_NN1 was_VBDZ lower_JJR than_CSN that_DD1 in_II the_AT gp120_FO +_FO MM-Drp1_JJ group_NN1 (_( P_ZZ1 =_FO 0.0009_MC ,_, 1-way_JJ ANOVA_NN1 ,_, n_ZZ1 =_FO 4_MC '_NULL 5_MC ;_; Fig._NN1 4_MC )_) ._. 
</s>
<s>
The_AT Antiallodynic_JJ Effect_NN1 of_IO Intrathecal_NP1 ROS_NP1 Scavenger_NN1 in_II Rats_NN2 with_IW Perineural_NP1 gp120_FO Neuropathic_JJ Pain_NN1 Previous_JJ evidence_NN1 shows_VVZ that_CST spinal_JJ ROS_NP1 scavenger_NN1 ,_, PBN_NP1 ,_, reduces_VVZ chronic_JJ pain_NN1 in_II animals_NN2 ._. 
</s>
<s>
Finally_RR ,_, the_AT current_JJ study_NN1 focused_VVN on_II adults_NN2 ,_, who_PNQS may_VM have_VHI a_AT1 long_JJ history_NN1 of_IO anticipation_NN1 of_IO stuttering_VVG which_DDQ may_VM have_VHI changed_VVN and_CC evolved_VVN throughout_II the_AT progression_NN1 of_IO stuttering_VVG ._. 
</s>
<s>
The_AT suggested_JJ maintenance_NN1 rate_NN1 is_VBZ 0.25_MC mL/kg_NNU per_II minute_NNT1 ,_, which_DDQ equals_VVZ 1050_MC mL_NNU per_II hour_NNT1 for_IF a_AT1 70-kg_JJ patient_NN1 ,_, with_IW subsequent_JJ directive_NN1 to_TO double_VVI the_AT maintenance_NN1 (_( greater_JJR than_CSN 2000_MC mL/h_FU )_) as_CSA needed_VVN ._. 
</s>
<s>
However_RR ,_, one_MC1 of_IO the_AT difficulties_NN2 in_II describing_VVG the_AT relevance_NN1 of_IO the_AT different_JJ constraints_NN2 on_II RAEs_NP2 is_VBZ the_AT obvious_JJ interaction_NN1 between_II the_AT different_JJ constraints_NN2 ._. 
</s>
<s>
Hg_FO from_II baseline_NN1 was_VBDZ the_AT respiratory_JJ depression_NN1 criterion_NN1 associated_VVN with_IW the_AT largest_JJT relative_JJ drop_NN1 in_II StO2_FO (_( 17.1%_FO )_) ._. 
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<s>
Finally_RR ,_, as_CSA a_AT1 standard_NN1 of_IO care_NN1 for_IF non-cancer_JJ SCS_NP1 ,_, all_DB subjects_NN2 had_VHD a_AT1 psychological_JJ evaluation_NN1 to_TO determine_VVI eligibility_NN1 prior_II21 to_II22 enrollment_NN1 ._. 
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<s>
All_DB participants_NN2 provided_CS written_VVN informed_JJ consent_NN1 ._. 
</s>
<s>
Several_DA2 different_JJ genetically_RR engineered_JJ mouse_NN1 mutants_NN2 have_VH0 been_VBN reported_VVN to_TO increase_VVI the_AT frequency_NN1 of_IO arteriovenous_JJ crossings_NN2 in_II the_AT retina_NN1 ,_, including_II some_DD affecting_VVG NRP1_FO (_( see_VV0 section_NN1 4.4.1_MC )_) ._. 
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<s>
There_EX was_VBDZ no_AT difference_NN1 on_II other_JJ covariates_NN2 including_II specimen_NN1 weight_NN1 and_CC adhesion_NN1 severity_NN1 ._. 
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<s>
In_II conclusion_NN1 ,_, our_APPGE data_NN indicate_VV0 that_CST a_AT1 pregnancy_NN1 after_II primary_JJ hernia_NN1 repair_NN1 is_VBZ associated_VVN with_IW an_AT1 increased_JJ risk_NN1 of_IO hernia_NN1 recurrence_NN1 requiring_VVG reoperation_NN1 ._. 
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<s>
Thus_RR ,_, this_DD1 is_VBZ the_AT first_MD adequately_RR powered_JJ randomized_JJ clinical_JJ trial_NN1 to_TO test_VVI in_II nonobese_NN1 humans_NN2 the_AT long-term_JJ effects_NN2 of_IO CR_NP1 on_II the_AT IGF-1_MC1 axis_NN1 and_CC other_JJ growth_NN1 factors_NN2 implicated_VVD in_II the_AT pathogenesis_NN1 of_IO cancer_NN1 ._. 
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<s>
This_DD1 is_VBZ a_AT1 reasonable_JJ way_NN1 to_TO decrease_VVI costs_NN2 in_II patients_NN2 who_PNQS present_VV0 for_IF routine_NN1 cancer_NN1 detection_NN1 using_VVG MRI_NN2 as_II a_AT1 complement_NN1 to_II biopsy_NN1 ;_; however_RR ,_, in_II patients_NN2 who_PNQS are_VBR postprostatectomy_NN1 or_CC postradiation_NN1 ,_, DCE_NP1 MRI_NP1 should_VM be_VBI used_VVN ,_, because_CS it_PPH1 may_VM be_VBI the_AT only_JJ way_NN1 to_TO detect_VVI recurrent_JJ disease_NN1 in_II these_DD2 patients_NN2 with_IW altered_JJ anatomy_NN1 in_II the_AT form_NN1 of_IO enhancement_NN1 within_II scar_NN1 tissue_NN1 ._. 
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<s>
Our_APPGE hypothesis_NN1 was_VBDZ that_CST the_AT extent_NN1 and_CC degree_NN1 of_IO SI_FW increases_VVZ with_IW sCJD_NNU progression_NN1 ._. 
</s>
<s>
This_DD1 time_NNT1 difference_NN1 from_II MC_NN1 detection_NN1 to_TO relapse_VVI reached_VVN statistical_JJ significance_NN1 (_( p_ZZ1 =_FO 0.0191_MC )_) ._. 
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<s>
We_PPIS2 also_RR reviewed_VVD the_AT recovery_NN1 data_NN for_IF xenon_NN1 versus_II propofol_NN1 ._. 
</s>
<s>
Self-assessment_NN1 of_IO skills_NN2 and_CC identification_NN1 of_IO supplemental_JJ sessions_NNT2 ;_; planning_VVG for_IF the_AT future_NN1 with_IW the_AT following_JJ supplemental_JJ sessions_NNT2 :_: Talking_VVG with_IW your_APPGE teenager_NN1 Taking_VVG care_NN1 of_IO you/marital_FU communication/guilt_NN1 ,_, grief_NN1 ,_, and_CC caregiver_VV0 Social_JJ skills_NN2 After_II high_JJ school_NN1 Sibling_NN1 issues_NN2 Pain_NN1 management_NN1 Sleep_NN1 session_NNT1 Memory_NN1 session_NNT1 The_AT 8_MC core_NN1 sessions_NNT2 and_CC as_RG many_DA2 as_CSA 4_MC supplemental_JJ sessions_NNT2 per_II family_NN1 were_VBDR provided_VVN throughout_II the_AT 6-month_JJ intervention_NN1 period_NN1 ._. 
</s>
<s>
The_AT short_JJ and_CC long_JJ duration_NN1 exercise_NN1 test_NN1 to_TO document_VVI channelopathy_NN1 as_CSA cause_NN1 of_IO hypokalemia_NN1 was_VBDZ planned_VVN ,_, but_CCB patient_NN1 did_VDD not_XX give_VVI consent_NN1 for_IF the_AT same_DA ._. 
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<s>
At_II initial_JJ visit_NN1 ,_, the_AT following_JJ variables_NN2 were_VBDR collected_VVN :_: demographic_JJ details_NN2 ,_, symptom_NN1 duration_NN1 ,_, site_NN1 of_IO onset_NN1 ,_, phenotype_NN1 ,_, riluzole_NN1 use_NN1 and_CC Amyotrophic_JJ Lateral_JJ Sclerosis_NN1 Functional_JJ Rating_NN1 Scale-Revised_NN1 (_( ALSFRS-R_NP1 )_) scores_NN2 ._. 
</s>
<s>
The_AT most_RGT common_JJ other_JJ diagnoses_NN2 in_II the_AT rule-in_NN1 zone_NN1 were_VBDR myocarditis_NN1 (_( n=4_FO )_) ,_, unstable_JJ angina_NN1 (_( n=4_FO )_) ,_, takotsubo_NN1 cardiomyopathy_NN1 (_( n=3_FO )_) ,_, heart_NN1 failure_NN1 (_( n=3_FO )_) ,_, arrhythmia_NN1 (_( n=3_FO )_) ,_, and_CC symptoms_NN2 of_IO unknown_JJ origin_NN1 (_( n=16_FO )_) ._. 
</s>
<s>
Participants_NN2 were_VBDR excluded_VVN if_CS they_PPHS2 had_VHD a_AT1 temperature_NN1 greater_JJR than_CSN 38_MC ._. 
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<s>
C_NP1 (_( 100.4_MC ._. 
</s>
<s>
F_ZZ1 )_) ,_, an_AT1 estimated_JJ glomerular_JJ filtration_NN1 rate_NN1 less_DAR than_CSN 60_MC mL/minute_FU per_II 1.73_MC m2_FO ,_, a_AT1 calculus_NN1 greater_JJR than_CSN 10_MC mm_NNU ,_, solitary_JJ kidney_NN1 ,_, transplanted_VVD kidney_NN1 ,_, history_NN1 of_IO ureteral_JJ stricture_NN1 ,_, known_VVN allergic_JJ reaction_NN1 to_II the_AT study_NN1 medication_NN1 ,_, or_CC current_JJ calcium_NN1 channel_NN1 blocker_NN1 or_CC a-blocker_NN1 use_NN1 or_CC hypotension_NN1 (_( systolic_JJ blood_NN1 pressure_NN1 less_DAR than_CSN 100_MC mm_NNU Hg_FO )_) ,_, or_CC if_CS they_PPHS2 were_VBDR pregnant_JJ or_CC planning_VVG pregnancy_NN1 ._. 
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<s>
Collectively_RR ,_, these_DD2 encouraging_JJ new_JJ findings_NN2 accentuate_VV0 an_AT1 important_JJ role_NN1 of_IO ER_NP1 stress_NN1 and_CC the_AT UPR_NN1 in_II governing_VVG the_AT longevity_NN1 and_CC function_NN1 of_IO hematopoietic_JJ progenitor/stem_NN1 cells_NN2 ._. 
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<s>
Using_VVG this_DD1 model_NN1 ,_, the_AT predicted_JJ risk_NN1 of_IO conversion_NN1 to_II laparotomy_NN1 with_IW traditional_JJ laparoscopy_NN1 compared_VVN with_IW robotic-assisted_JJ laparoscopy_NN1 was_VBDZ 5.4%_FO compared_VVN with_IW 0.8%_FO (_( P_NNU less_DAR than_CSN .001_MC )_) after_II adjusting_VVG for_IF all_DB other_JJ variables_NN2 in_II the_AT model_NN1 ._. 
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<s>
We_PPIS2 were_VBDR also_RR intrigued_VVN by_II the_AT very_JJ rapid_JJ DiM_JJ in_II cells_NN2 lacking_VVG Bcl-xL_JJ and_CC Mcl1_FO (_( Figure_NN1 S3F_FO )_) ._. 
</s>
<s>
Functional_JJ Oral_JJ Intake_NN1 Scale_NN1 (_( FOIS_NP1 )_) scores_NN2 and_CC percutaneous_JJ endoscopic_JJ gastrostomy_NN1 (_( PEG_NP1 )_) placements_NN2 were_VBDR compared_VVN at_II posttreatment_NN1 and_CC at_II 3_MC months_NNT2 ._. 
</s>
<s>
A_AT1 total_NN1 of_IO 5569_MC thyroid_JJ nodules_NN2 that_CST were_VBDR 10-19_MCMC mm_NNU on_II US_NP1 images_NN2 were_VBDR aspirated_VVN ._. 
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<s>
Recent_JJ T2_FO intensity_NN1 studies_NN2 involving_VVG early_JJ and_CC milder_JJR forms_NN2 of_IO MS_NN1 (_( Ceccarelli_NP1 et_RA21 al._RA22 ,_, 2009_MC ,_, 2010_MC ,_, 2011_MC )_) have_VH0 begun_VVN to_TO bridge_VVI gaps_NN2 in_II knowledge_NN1 regarding_II the_AT role_NN1 of_IO iron_NN1 deposition_NN1 in_II the_AT pathophysiology_NN1 of_IO the_AT disease_NN1 ._. 
</s>
<s>
We_PPIS2 hypothesized_VVD that_CST the_AT reason_NN1 for_IF the_AT restoration_NN1 seen_VVN in_II miR-7_MC inhibitory_JJ experiments_NN2 was_VBDZ due_II21 to_II22 an_AT1 upregulated_JJ the_AT presence_NN1 of_IO HAS2-produced_NN1 HA_UH ._. 
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<s>
Over_II the_AT last_MD 10_MC years_NNT2 we_PPIS2 have_VH0 seen_VVN and_CC treated_VVN seven_MC patients_NN2 with_IW mesh_NN1 erosions_NN2 into_II the_AT bladder_NN1 with_IW partial_JJ removal_NN1 of_IO the_AT mesh_NN1 via_II a_AT1 transvesical_JJ laparoscopic_JJ approach_NN1 ._. 
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<s>
Comparisons_NN2 in_II eligible_JJ studies_NN2 were_VBDR between_II the_AT intervention_NN1 group_NN1 and_CC either_RR a_AT1 usual_JJ care_NN1 or_CC control_NN1 group_NN1 ,_, and_CC studies_NN2 with_IW factorial_JJ designs_NN2 comparing_VVG more_DAR than_CSN one_MC1 intervention_NN1 were_VBDR also_RR included_VVN ._. 
</s>
<s>
A_AT1 pain_NN1 psychologist_NN1 is_VBZ a_AT1 therapist_NN1 with_IW very_RG specific_JJ training_NN1 and_CC experience_NN1 in_II the_AT treatment_NN1 of_IO pain_NN1 ._. 
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<s>
Inhibition_NN1 of_IO Complex_NN1 I_PPIS1 leads_VVZ to_II increased_JJ generation_NN1 of_IO ROS_NP1 ,_, decreased_VVD ATP_NN1 levels_NN2 ,_, and_CC induction_NN1 of_IO apoptosis_NN1 (_( Langston_NP1 and_CC Ballard_NP1 ,_, 1983_MC ,_, Li_NP1 et_RA21 al._RA22 ,_, 2003_MC and_CC Ramsay_NP1 and_CC Singer_NP1 ,_, 1986_MC )_) ,_, all_DB of_IO which_DDQ play_VV0 a_AT1 major_JJ role_NN1 in_II neurodegeneration_NN1 ._. 
</s>
<s>
Application_NN1 of_IO appropriate_JJ selection_NN1 criteria_NN2 would_VM be_VBI required_VVN ._. 
</s>
<s>
However_RR ,_, the_AT additional_JJ advantages_NN2 of_IO WGS_NP1 over_II current_JJ genomic_JJ diagnostic_JJ technologies_NN2 (_( targeted_VVD NGS_NP1 )_) for_IF ophthalmic_JJ disorders_NN2 are_VBR not_XX yet_RR fully_RR quantified_VVN ,_, because_CS formal_JJ comparative_JJ analyses_NN2 of_IO the_AT 2_MC techniques_NN2 have_VH0 not_XX been_VBN undertaken_VVN ._. 
</s>
<s>
Hence_RR in_II Italy_NP1 the_AT overall_JJ incidence_NN1 rate_NN1 of_IO AN_AT1 including_VVG less_RGR severe_JJ forms_NN2 might_VM be_VBI higher_JJR ._. 
</s>
<s>
Two_MC representative_JJ cases_NN2 with_IW high_JJ and_CC low_JJ staining_JJ intensity_NN1 of_IO SYK_NP1 ,_, phospho-SYK_NP1 ,_, and_CC phospho-a-tubulin_NN1 are_VBR shown_VVN in_II Figure_NN1 5H.Expression_FO of_IO Active_JJ SYK_NN1 Confers_VVZ Paclitaxel_NP1 Resistance_NN1 and_CC Increases_VVZ MAP1B_FO and_CC MAP4_FO Tyrosine_NP1 Phosphorylation_NN1 To_TO demonstrate_VVI whether_CSW activating_VVG the_AT SYK_NN1 pathway_NN1 is_VBZ sufficient_JJ to_TO confer_VVI paclitaxel_NN1 resistance_NN1 ,_, we_PPIS2 generated_VVD tetracycline-induc-ible_JJ SKOV3_FO cells_NN2 to_TO ectopically_RR express_VVI wild-type_JJ or_CC active_JJ SYK_NN1 mutant_NN1 (_( SYK-130E_FO )_) ,_, which_DDQ has_VHZ been_VBN shown_VVN to_TO have_VHI a_AT1 high_JJ basal_JJ kinase_NN1 activity_NN1 (_( Keshvara_NP1 et_RA21 al._RA22 ,_, 1997_MC )_) ._. 
</s>
<s>
A_AT1 weakness_NN1 concerning_II the_AT dose-response_JJ analysis_NN1 of_IO excised_JJ tissue_NN1 was_VBDZ that_DD1 cone_NN1 size_NN1 information_NN1 was_VBDZ only_RR available_JJ for_IF 37%_NNU of_IO treatments_NN2 ,_, and_CC we_PPIS2 did_VDD not_XX have_VHI information_NN1 on_II the_AT possibly_RR more_RGR descriptive_JJ measure_NN1 of_IO excision_NN1 depth_NN1 and_CC length_NN1 ._. 
</s>
<s>
Thereby_RR ,_, the_AT hs-cTnT_JJ 0-hour/1-hour_JJ algorithm_NN1 seemed_VVD to_TO be_VBI even_RR more_RGR complete_JJ and_CC more_RGR effective_JJ in_II the_AT early_JJ triage_NN1 of_IO acute_JJ chest_NN1 pain_NN1 patients_NN2 than_CSN other_JJ important_JJ emerging_JJ early_JJ triage_NN1 strategies_NN2 in_II similar_JJ study_NN1 populations_NN2 ._. 
</s>
<s>
Negative_JJ valence_NN1 emotional_JJ auditory_JJ stimuli_NN2 led_VVN to_II higher_JJR tinnitus_JJ loudness_NN1 ratings_NN2 in_II males_NN2 and_CC females_NN2 and_CC higher_JJR annoyance_NN1 ratings_NN2 in_II males_NN2 only_RR ;_; loudness_NN1 matches_NN2 of_IO tinnitus_NN1 remained_VVD unchanged_JJ ._. 
</s>
<s>
This_DD1 patient_NN1 was_VBDZ not_XX included_VVN in_II the_AT analysis_NN1 ._. 
</s>
<s>
The_AT surgeons_NN2 infiltrated_VVD the_AT site_NN1 of_IO skin_NN1 incision_NN1 with_IW normal_JJ saline_JJ combined_VVN with_IW adrenaline_NN1 ._. 
</s>
<s>
The_AT temporal_JJ increase_NN1 in_II early-onset_JJ disease_NN1 is_VBZ also_RR consistent_JJ with_IW the_AT temporal_JJ increase_NN1 in_II chronic_JJ hypertension_NN1 among_II pregnant_JJ women_NN2 ,_, which_DDQ is_VBZ more_RGR strongly_RR associated_VVN with_IW early-onset_NN1 as_II31 opposed_II32 to_II33 late-onset_JJ disease_NN1 ._. 
</s>
<s>
Using_VVG the_AT Nationwide_JJ Inpatient_NN1 Sample_NN1 ,_, Okumura_NP1 et_RA21 al_RA22 ._. 
</s>
<s>
showed_VVD that_DD1 case_NN1 mix-adjusted_NN1 hospital_NN1 charges_NN2 for_IF patients_NN2 with_IW complex_JJ congenital_JJ heart_NN1 disease_NN1 ,_, cystic_JJ fibrosis_NN1 ,_, sickle_NN1 cell_NN1 disease_NN1 ,_, or_CC spina_NN121 bifida_NN122 were_VBDR higher_JJR in_II pediatric_JJ hospitals_NN2 than_CSN in_II mixed_JJ or_CC adult_NN1 hospitals_NN2 ,_, but_CCB that_DD1 length_NN1 of_IO stay_NN1 was_VBDZ only_RR significantly_RR longer_JJR in_II pediatric_JJ hospitals_NN2 for_IF those_DD2 with_IW complex_JJ congenital_JJ heart_NN1 disease_NN1 and_CC cystic_JJ fibrosis_NN1 ._. 
</s>
<s>
A_AT1 block_NN1 randomization_NN1 within_II each_DD1 stratum_NN1 with_IW block_NN1 size_NN1 of_IO 10_MC was_VBDZ used_VVN ._. 
</s>
<s>
The_AT directionality_NN1 of_IO the_AT changes_NN2 from_II baseline_NN1 to_II month_NNT1 24_MC was_VBDZ similar_JJ between_II the_AT sham_NN1 and_CC ranibizumab_VV0 patients_NN2 ._. 
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<s>
Negative_JJ control_NN1 tests_NN2 are_VBR made_VVN with_IW saline_JJ and_CC positive_JJ control_NN1 tests_NN2 with_IW histamine_NN1 ._. 
</s>
<s>
Mooijaart_VV0 :_: conception_NN1 and_CC design_NN1 of_IO the_AT study_NN1 ._. 
</s>
<s>
Light_JJ microscopic_JJ images_NN2 were_VBDR used_VVN to_TO calculate_VVI the_AT area_NN1 occupied_VVN by_II Ap_NP1 immunoreactivity_NN1 ,_, and_CC the_AT cell_NN1 densities_NN2 of_IO GFAP-and_CC CD45-immunopositive_JJ reactions_NN2 by_II using_VVG the_AT software_NN1 Image-Pro_NN1 Plus_NN1 for_IF Windows_NP1 version_NN1 5.0_MC (_( Media_NN Cybernetics_NN2 ,_, Bethesda_NP1 ,_, MD_NNA )_) ._. 
</s>
<s>
Descriptive_JJ statistics_NN (_( means_NN and_CC range_NN1 )_) were_VBDR calculated_VVN for:gestational_FO age_NN1 ,_, sac_NN1 volume_NN1 ,_, and_CC serum_NN1 human_JJ chorionic_JJ gonadotropin_NN1 at_II treatment_NN1 ,_, days_NNT2 the_AT balloon_NN1 was_VBDZ kept_VVN in_II place_NN1 ,_, and_CC days_NNT2 until_CS human_JJ chorionic_JJ gonadotropin_NN1 returned_VVN to_II nonpregnant_JJ values_NN2 ._. 
</s>
<s>
HACA_NP1 are_VBR more_RGR frequently_RR observed_VVN in_II autoimmune_NN1 disease_NN1 patients_NN2 treated_VVN with_IW rituximab_NN1 as_CSA compared_VVN to_II lymphoma_NN1 patients_NN2 treated_VVN with_IW rituximab_NN1 ._. 
</s>
<s>
The_AT x2-test_NN1 was_VBDZ used_VVN to_TO compare_VVI the_AT categorical_JJ variables_NN2 ._. 
</s>
<s>
This_DD1 role_NN1 that_CST we_PPIS2 observed_VVD for_IF DCE_NP1 in_II the_AT TZ_NP1 may_VM relate_VVI to_II our_APPGE incorporation_NN1 of_IO morphologic_JJ criteria_NN2 for_IF assessing_VVG DCE_NP1 in_II the_AT TZ_NP1 lesion_NN1 that_CST are_VBR not_XX a_AT1 component_NN1 of_IO PI-RADSV2_NN1 ._. 
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<s>
University_NN1 of_IO Alabama_NP1 ,_, Birmingham_NP1 :_: M._NN1 Harrigan_NP1 ,_, A._NP1 Alexandrov_NP1 ,_, J._NP1 Rothrock_NP1 ,_, I._NP1 Lopez_NP1 ,_, D.Patterson_NP1 ,_, L._NP1 Cava_NP1 ,_, T._NP1 Taylor_NP1 ,_, L._NP1 Nelson_NP1 ,_, B._NP1 Casey_NP1 ,_, K._NP1 Albright_NP1 ,_, and_CC H._NP1 Walker_NP1 ._. 
</s>
<s>
As_CSA Boschloo_NP1 and_CC colleagues_NN2 noted_VVN ,_, in_II our_APPGE definition_NN1 of_IO persistent_JJ alcohol_NN1 dependence_NN1 ,_, we_PPIS2 included_VVD individuals_NN2 with_IW lifetime_NNT1 dependence_NN1 with_IW or_CC without_IW 12-month_JJ dependence_NN1 at_II baseline_NN1 and_CC assessed_VVD the_AT association_NN1 between_II drinking_VVG self-medication_NN1 among_II this_DD1 group_NN1 with_IW alcohol_NN1 dependence_NN1 at_II follow-up_NN1 ._. 
</s>
<s>
Case_NN1 families_NN2 were_VBDR asked_VVN to_TO nominate_VVI 1_MC1 or_CC more_DAR friends_NN2 or_CC nonbiological_JJ relatives_NN2 with_IW a_AT1 child_NN1 in_II the_AT same_DA age_NN1 range_NN1 as_CSA the_AT index_NN1 child_NN1 (_( 0-1_MCMC ,_, 2-3_MCMC ,_, 4-5_MCMC ,_, 6-7_MCMC ,_, 8-9_MCMC ,_, 10-11_MCMC ,_, 12-13_MCMC ,_, or_CC 14-15_MCMC years_NNT2 )_) as_CSA potential_JJ controls_NN2 ._. 
</s>
<s>
Although_CS x-ray_JJ mammography_NN1 is_VBZ well_RR established_VVN in_II both_DB2 curative_JJ mammography_NN1 as_II31 well_II32 as_II33 in_II x-ray_JJ mammography_NN1 screening_NN1 ,_, it_PPH1 has_VHZ known_VVN diagnostical_JJ limitations_NN2 ,_, especially_RR regarding_II the_AT sensitivity_NN1 of_IO tumor_NN1 detection_NN1 in_II dense_JJ breasts_NN2 ._. 
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<s>
Proponents_NN2 of_IO marijuana_NN1 suggest_VV0 that_CST it_PPH1 is_VBZ safer_JJR than_CSN ethanol_NN1 ._. 
</s>
<s>
Key_JJ Words_NN2 :_: autologous_JJ chondrocyte_NN1 implantation_NN1 ,_, articular_JJ cartilage_NN1 ,_, cartilage_NN1 defect_NN1 ,_, regeneration_NN1 techniques_NN2 Focal_JJ cartilage_NN1 defects_NN2 of_IO the_AT knee_NN1 are_VBR relatively_RR common_JJ and_CC may_VM increase_VVI the_AT risk_NN1 of_IO developing_JJ osteoarthritis_NN1 ._. 
</s>
<s>
These_DD2 yielded_VVN similar_JJ results_NN2 ,_, except_II21 for_II22 the_AT EQ-5D_JJ thermometer_NN1 in_II cognitively_RR impaired_VVD older_JJR persons_NN2 :_: A_AT1 cut-off_NN1 score_VV0 less_DAR than_CSN 70_MC and_CC excluding_VVG missing_JJ values_NN2 showed_VVD a_AT1 lower_JJR quality_NN1 of_IO life_NN1 in_II the_AT subgroup_NN1 with_IW apathy_NN1 compared_VVN with_IW the_AT subgroup_NN1 without_IW apathy_NN1 ._. 
</s>
<s>
The_AT rate_NN1 of_IO adherence_NN1 to_II the_AT manual_NN1 was_VBDZ 94%_NNU as_CSA measured_VVN by_II therapist_NN1 report_NN1 and_CC was_VBDZ 93%_NNU as_CSA measured_VVN by_II independent_JJ audit_NN1 ._. 
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<s>
Indeed_RR ,_, patients_NN2 with_IW node-negative_JJ stage_NN1 I_ZZ1 HER2-positive_JJ disease_NN1 could_VM be_VBI treated_VVN with_IW adjuvant_JJ chemotherapy_NN1 containing_VVG paclitaxel_NN1 and_CC trastuzumab_VV0 without_IW anthracycline_NN1 ,_, thanks_NN2 to_II a_AT1 lower_JJR underlying_JJ risk_NN1 of_IO recurrence_NN1 than_CSN women_NN2 with_IW more_RGR advanced_JJ stage_NN1 of_IO disease_NN1 &lsqb;_( 85_MC &rsqb;_) ._. 
</s>
<s>
Our_APPGE behavioral_JJ tests_NN2 revealed_VVD that_CST the_AT mechanical_JJ PWT_NP1 values_NN2 of_IO R-treated_JJ animals_NN2 at_II 0.5_MC and_CC 2_MC hours_NNT2 postinfusion_NN1 were_VBDR significantly_RR lower_JJR than_CSN the_AT basal_JJ level_NN1 and_CC were_VBDR clearly_RR lower_JJR than_CSN the_AT corresponding_JJ levels_NN2 in_II the_AT L_ZZ1 and_CC RL_NP1 groups_NN2 ._. 
</s>
<s>
Pulmonary_JJ embolism_NN1 and_CC venous_JJ thrombosis_NN1 are_VBR incidental_JJ findings_NN2 in_II up_RG21 to_RG22 26%_NNU of_IO oncologic_JJ patients_NN2 undergoing_VVG imaging_VVG sur-veillance.7_JJ As_CSA CT_NN1 protocols_NN2 in_II such_DA patients_NN2 are_VBR optimized_JJ forthe_NN1 detection_NN1 and_CC monitoring_NN1 of_IO neoplastic_JJ diseases_NN2 ,_, they_PPHS2 are_VBR often_RR suboptimal_JJ for_IF detecting_VVG pulmonary_JJ embolism_NN1 or_CC deep_RR venous_JJ thrombosis_NN1 ._. 
</s>
<s>
Universally_RR directing_VVG all_DB injured_JJ patients_NN2 to_II nontrauma_NN1 hospitals_NN2 risks_VVZ limiting_JJ access_NN1 to_II major_JJ trauma_NN1 centers_NN2 for_IF those_DD2 most_RRT likely_JJ to_TO benefit_VVI from_II such_DA care_NN1 ._. 
</s>
<s>
Following_VVG selection_NN1 of_IO operative_JJ cases_NN2 in_II adults_NN2 within_II 48_MC ?_? hours_NNT2 ,_, where_CS pupil_NN1 reactivity_NN1 data_NN were_VBDR missing_VVG but_CCB GCS_NP1 was_VBDZ 14_MC or_CC 15_MC ,_, we_PPIS2 assumed_VVD that_CST no_AT significant_JJ brainstem_NN1 compression/uncal_NN1 herniation_NN1 would_VM exist_VVI and_CC pupils_NN2 were_VBDR considered_VVN to_TO be_VBI both_RR reactive_JJ ._. 
</s>
<s>
Other_JJ neuropeptides_NN2 like_II substance_NN1 P_ZZ1 ,_, enkephalin_NN1 ,_, and_CC somatostatin_NN1 are_VBR also_RR present_JJ in_II the_AT SPF_NP1 ,_, but_CCB it_PPH1 is_VBZ unknown_JJ if_CS they_PPHS2 exist_VV0 in_II neurons_NN2 that_CST project_NN1 to_II auditory_JJ nuclei_NN2 ._. 
</s>
<s>
The_AT size_NN1 of_IO the_AT lipid_JJ droplet_NN1 changes_NN2 mostly_RR by_II alterations_NN2 in_II its_APPGE triglyceride_NN1 (_( TG_NP1 )_) content_NN1 ._. 
</s>
<s>
In_II this_DD1 report_NN1 the_AT phosphorylation_NN1 pattern_NN1 was_VBDZ investigated_VVN of_IO potential_JJ residues_NN2 (_( Ser-381_MC and_CC Ser-398_MC ;_; c.f._VV0 Fig._NN1 1_MC1 )_) ,_, outside_II the_AT region_NN1 outlined_VVN before_II (_( Blasic_NN1 et_RA21 al._RA22 ,_, 2014_MC )_) ,_, using_VVG site-specific_JJ anti-phospho-antibodies_NN2 ._. 
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<s>
Acknowledgments_NN2 This_DD1 project_NN1 was_VBDZ funded_VVN by_II a_AT1 Programme_NN1 Grant_NN1 from_II the_AT British_JJ Heart_NN1 Foundation_NN1 ._. 
</s>
<s>
Studies_NN2 in_II T-cells_NN2 revealed_VVD that_CST NRP1_FO binds_VVZ to_II active_JJ TGFb1_FO ,_, LAP_NN1 and_CC the_AT latent_JJ form_NN1 of_IO TGFb_NP1 that_CST consists_VVZ of_IO a_AT1 complex_NN1 between_II TGFp1_FO and_CC LAP_NN1 (_( Glinka_NP1 and_CC Prud_NP1 '_NULL homme_NN1 ,_, 2008_MC )_) ._. 
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CFH_NP1 is_VBZ also_RR known_VVN as_II AM_VBM binding_JJ protein_NN1 ._. 
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<s>
Of_IO interest_NN1 ,_, however_RR ,_, is_VBZ the_AT strong_JJ association_NN1 in_II the_AT literature_NN1 of_IO the_AT various_JJ markers_NN2 with_IW OSA_NP1 ,_, independent_JJ of_IO confounding_VVG factors_NN2 ._. 
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<s>
It_PPH1 is_VBZ possible_JJ that_CST delay_VV0 in_II the_AT anticipated_JJ IDB_NN1 resulted_VVN in_II less_RGR dramatic_JJ responses_NN2 in_II the_AT cross-over_NN1 group_NN1 ._. 
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<s>
List_NN1 of_IO CNVs_NP1 Used_VVD in_II the_AT Analyses_NN2 A_ZZ1 complete_JJ list_NN1 of_IO the_AT case_NN1 CNVs_NP1 greater_JJR than_CSN 500_MC kb_NNU (_( ADHD_NP1 and_CC ASD_NP1 )_) used_VVD in_II the_AT analyses_NN2 is_VBZ given_VVN in_II Table_NN1 S4_FO (_( available_JJ online_JJ )_) ._. 
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<s>
By_II ChIP_NN1 assay_NN1 ,_, we_PPIS2 found_VVD that_DD1 binding_NN1 of_IO SUZ12_FO and_CC EZH2_FO at_II IkBalpha_NP1 targets_NN2 was_VBDZ significantly_RR decreased_VVN in_II these_DD2 cells_NN2 (_( Figure6B_FO )_) ,_, concomitant_JJ witha_NN1 massive_JJ increase_NN1 in_II IkBalpha_NP1 target_NN1 gene_NN1 expression_NN1 (_( Figure_NN1 6C_FO )_) ._. 
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In_II the_AT majority_NN1 of_IO cases_NN2 ,_, an_AT1 anaesthetist_NN1 received_VVD the_AT report_NN1 of_IO AAGA_NN1 from_II the_AT patient_NN1 (_( Fig._NN1 2_MC )_) ._. 
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Myocytes_NN2 have_VH0 large_JJ intracellular_JJ calcium_NN1 stores_NN2 within_II the_AT SR_NN1 ._. 
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Radiation_NN1 and_CC concurrent_JJ chemotherapy_NN1 are_VBR also_RR often_RR used_VVN for_IF patients_NN2 who_PNQS are_VBR noted_VVN to_TO have_VHI positive_JJ margins_NN2 on_II pathology_NN1 after_II a_AT1 surgical_JJ resection_NN1 ._. 
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Rate_NN1 ratios_NN2 for_IF SIDS_NP2 were_VBDR calculated_VVN using_VVG a_AT1 cox-proportional_JJ hazards_NN2 model_NN1 ._. 
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<s>
Albeit_CS the_AT undeniable_JJ importance_NN1 of_IO a_AT1 study_NN1 reporting_VVG that_DD1 nutritional_JJ intake_NN1 can_VM modify_VVI the_AT rate_NN1 of_IO decline_NN1 of_IO visual_JJ acuity_NN1 in_II RP_NP1 ,_, the_AT Authors_NN2 themselves_PPX2 express_VV0 caution_NN1 in_II evaluating_VVG the_AT results_NN2 obtained_VVN ._. 
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All_DB authors_NN2 contributed_VVN to_II critical_JJ revision_NN1 of_IO the_AT manuscript_NN1 for_IF important_JJ intellectual_JJ content_NN1 ._. 
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<s>
Cutoff_VV0 points_NN2 for_IF sensitivity_NN1 and_CC specificity_NN1 were_VBDR determined_VVN using_VVG the_AT Youden_NN1 '_NULL s_ZZ1 Index_NN1 ._. 
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Very_RG little_DA1 is_VBZ known_VVN on_II how_RRQ amantadine_NN1 can_VM reduce_VVI neuroinflammation_NN1 ._. 
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<s>
Some_DD restoration_NN1 of_IO the_AT EZ_NN1 line_NN1 can_VM occur_VVI in_II other_JJ retinaldisorders_NN2 ,_, 14,15_MC but_CCB more_DAR hydroxychloroquine_NN1 cases_NN2 need_VV0 to_TO be_VBI monitored_VVN with_IW repetitive_JJ studies_NN2 to_TO verify_VVI the_AT potential_NN1 for_IF recovery_NN1 ._. 
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<s>
Identification_NN1 of_IO compounds_NN2 that_CST interact_VV0 specifically_RR with_IW SC_FO cells_NN2 and_CC decrease_VV0 outflow_NN1 resistance_NN1 will_VM also_RR give_VVI important_JJ insights_NN2 into_II cellular_JJ control_NN1 of_IO aqueous_JJ outflow_NN1 and_CC aid_NN1 in_II the_AT understanding_NN1 of_IO its_APPGE dysfunction_NN1 in_II glaucoma_NN1 ._. 
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The_AT remaining_JJ participant_NN1 ,_, who_PNQS presented_VVD with_IW severe_JJ stuttering_NN1 ,_, completed_VVD Stage_NN1 1_MC1 but_CCB had_VHD some_DD relapse_NN1 in_II Stage_NN1 2_MC and_CC demonstrated_VVD mild_JJ stuttering_VVG 12_MC months_NNT2 post-Stage_NN1 1_MC1 ._. 
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LEMD1_FO is_VBZ overexpressed_VVN in_II prostate_NN1 cancer_NN1 (_( Ghafouri-Fard_NP1 et_RA21 al._RA22 ,_, 2010_MC )_) and_CC anaplastic_JJ cell_NN1 lymphoma_NN1 (_( Matsuyama_NP1 et_RA21 al._RA22 ,_, 2011_MC )_) ._. 
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<s>
The_AT definition_NN1 of_IO open-angle_JJ glaucoma_NN1 '_NULL the_AT most_RGT common_JJ form_NN1 of_IO the_AT neuropathy_NN1 '_NULL is_VBZ degeneration_NN1 and_CC loss_NN1 of_IO retinal_JJ ganglion_NN1 cells_NN2 (_( RGCs_NP1 )_) and_CC their_APPGE axons_NN2 with_IW characteristic_JJ changes_NN2 in_II the_AT optic_NN1 nerve_NN1 head_NN1 and_CC the_AT visual_JJ field_NN1 (_( Kerrigan-Baumrind_NP1 et_RA21 al_RA22 ._. '_NULL 
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<s>
2000_MC ;_; Quigley_NP1 and_CC Green_JJ '_NULL 1979_MC ;_; Weinreb_NP1 and_CC Khaw_VV0 '_NULL 2004_MC )_) ._. 
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<s>
The_AT larger_JJR current_NN1 evoked_VVN by_II etomidate_NN1 plus_II GABA_NP1 in_II IL-1miu-treated_JJ neurons_NN2 could_VM result_VVI from_II either_RR an_AT1 increase_NN1 in_II the_AT number_NN1 of_IO GABAA_NN1 receptors_NN2 or_CC an_AT1 increase_NN1 in_II the_AT pharmacological_JJ sensitivity_NN1 of_IO the_AT receptors_NN2 ._. 
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In_II contrast_NN1 ,_, critical_JJ access_NN1 hospitals_NN2 had_VHD higher_JJR rates_NN2 of_IO readmission_NN1 within_II 30_MC days_NNT2 than_CSN non_FU '_NULL critical_JJ access_NN1 hospitals_NN2 (_( 14.7%_FO vs_II 13.3%_FO ;_; OR_CC ,_, 1.13_MC ;_; 95%_NNU CI_FO ,_, 1.08-1.18_MCMC ;_; P_NP1 less_DAR than_CSN .001_MC )_) ._. 
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First_MD ,_, administrative_JJ data_NN have_VH0 well-known_JJ limitations_NN2 for_IF assessing_VVG comorbid_JJ conditions_NN2 and_CC ascertaining_VVG complications_NN2 of_IO care_NN1 factors_NN2 ._. 
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To_TO further_RRR determine_VVI whether_CSW the_AT presynaptic_JJ and_CC post-synaptic_JJ transmissions_NN2 were_VBDR decreased_VVN by_II Meflo_NP1 ,_, paired-pulse_JJ facilitation_NN1 (_( PPF_NP1 )_) and_CC inward_JJ rectification_NN1 were_VBDR examined_VVN in_II ACC_NP1 neurons_NN2 in_II the_AT current_JJ study_NN1 ._. 
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<s>
Further_JJR development_NN1 of_IO family_NN1 and_CC community-based_JJ interventions_NN2 that_CST could_VM better_RRR target_VVI behaviour_NN1 during_II weekends_NNT2 may_VM be_VBI especially_RR important_JJ ._. 
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As_II such_DA ,_, it_PPH1 may_VM be_VBI that_CST the_AT signal_NN1 characteristics_NN2 need_VV0 to_TO be_VBI individualised_VVN to_TO account_VVI for_IF the_AT variance_NN1 in_II disease_NN1 and_CC the_AT state_NN1 of_IO the_AT patient_NN1 '_NULL s_ZZ1 residual_JJ retina_NN1 ._. 
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He_PPHS1 was_VBDZ not_XX on_II systemic_JJ immunosuppressive_JJ medications_NN2 and_CC pain_NN1 was_VBDZ not_XX a_AT1 major_JJ complaint_NN1 for_IF him_PPHO1 ._. 
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Results_NN2 '_NULL Lifetime_NNT1 and_CC 12-month_JJ prevalence_NN1 of_IO MDD_NP1 were_VBDR 11.0%_FO and_CC 7.5%_FO ,_, respectively_RR ._. 
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Inter-assay_JJ coefficient_NN1 of_IO variation_NN1 for_IF this_DD1 set_NN1 of_IO assays_NN2 is_VBZ 12.98%_FO ._. 
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<s>
Although_CS the_AT study_NN1 was_VBDZ not_XX designed_VVN to_TO detect_VVI efficacy_NN1 '_NULL some_DD improvement_NN1 in_II visual_JJ function_NN1 was_VBDZ noted_VVN on_II microperimetry_NN1 '_NULL perimetry_NN1 '_NULL and/or_CC ERG_VV0 in_II most_DAT of_IO the_AT study_NN1 eyes_NN2 following_VVG CD34+_FO cell_NN1 injection_NN1 ._. 
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<s>
The_AT scales_NN2 are_VBR ,_, however_RR ,_, intended_VVD to_TO be_VBI interpreted_VVN independently.18_FO The_AT Self_NN1 Care_NN1 Inventory_NN1 has_VHZ recently_RR been_VBN validated_VVN for_IF medical_JJ trainees_NN2 ._. 
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<s>
Whereas_CS the_AT groups_NN2 did_VDD not_XX differ_VVI with_II31 respect_II32 to_II33 disease_NN1 duration_NN1 ,_, there_EX was_VBDZ a_AT1 strong_JJ male_JJ predominance_NN1 in_II the_AT benign_JJ bvFTD_NNU phenocopy_NN1 syndrome_NN1 group_NN1 only_RR and_CC the_AT patients_NN2 in_II this_DD1 group_NN1 were_VBDR significantly_RR younger_JJR ._. 
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The_AT demographics_NN1 (_( e.g._REX ,_, male-to-female_JJ ratio_NN1 )_) and_CC baseline_NN1 characteristics_NN2 of_IO patients_NN2 included_VVN in_II the_AT CRYSTAL_NN1 study_NN1 are_VBR more_RGR representative_JJ of_IO those_DD2 with_IW CRVO_NN1 in_II the_AT general_NN1 population.15,16_FO In_II the_AT CRYSTAL_NN1 study_NN1 ,_, patients_NN2 had_VHD a_AT1 higher_JJR mean_JJ BCVA_NN1 score_NN1 than_CSN in_II CRUISE_NN1 (_( 53.0_MC vs._II 48.1_MC letters_NN2 )_) ._. 
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<s>
Potential_JJ reasons_NN2 for_IF an_AT1 absence_NN1 of_IO this_DD1 to_TO be_VBI expected_VVN negative_JJ relationship_NN1 with_IW time_NNT1 interval_NN1 might_VM be_VBI that_CST the_AT decrease_NN1 overall_NN1 is_VBZ rather_RG small_JJ (_( and_CC hence_RR variations_NN2 therein_RR are_VBR harder_JJR to_TO predict_VVI )_) and_CC that_CST the_AT variations_NN2 of_IO the_AT total_JJ time_NNT1 intervals_NN2 in_II the_AT current_JJ study_NN1 were_VBDR not_XX large_JJ enough_RR to_TO make_VVI an_AT1 effect_NN1 on_II the_AT decrease_NN1 visible_JJ ._. 
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<s>
Rather_RR ,_, adaptation_NN1 facilitates_VVZ a_AT1 robust_JJ ,_, temporary_JJ improvement_NN1 in_II SLS_NP1 time_NNT1 symmetry_NN1 either_RR at_II the_AT end_NN1 of_IO Adaptation_NN1 or_CC the_AT beginning_NN1 of_IO Postadaptation_NN1 (_( aftereffect_NN1 )_) ,_, depending_II21 on_II22 whether_CSW the_AT paretic_JJ or_CC nonparetic_JJ leg_NN1 is_VBZ perturbed_VVN ._. 
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Changes_NN2 of_IO the_AT optic_NN1 nerve_NN1 head_NN1 vessel_NN1 structure_NN1 are_VBR furthermore_RR common_JJ for_IF central_JJ neuropathies_NN2 such_II21 as_II22 multiple_JJ sclerosis_NN1 ._. 
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For_IF this_DD1 reason_NN1 ,_, a_AT1 new_JJ patented_JJ method_NN1 for_IF direct_JJ non-Cp_NN1 Cu_FO detection_NN1 in_II serum_NN1 through_II a_AT1 fluorescent_JJ probe_NN1 has_VHZ been_VBN set-up_NN1 ._. 
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<s>
However_RR ,_, echocardiographic_JJ and_CC MR_NNB images_NN2 were_VBDR analyzed_VVN and_CC reported_VVN by_II sites_NN2 and_CC not_XX by_II independent_JJ core_NN1 laboratories_NN2 ._. 
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<s>
Released_JJ AMC_NN1 was_VBDZ measured_VVN using_VVG a_AT1 Fluoroskan_JJ Ascent_NN1 fluorometer_NN1 (_( Thermo_NP1 Electron_NN1 ,_, Waltham_NP1 ,_, MA_NNA ,_, USA_NP1 )_) at_II an_AT1 excitation_NN1 wavelength_NN1 of_IO 390_MC nm_FU and_CC an_AT1 emission_NN1 wavelength_NN1 of_IO 460_MC nm_FU ._. 
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<s>
Insights_NN2 into_II post-ED_JJ clinical_JJ progress_NN1 are_VBR ,_, in_RR21 general_RR22 ,_, of_IO value_NN1 for_IF practice-based_JJ learning_NN1 and_CC improvement_NN1 ,_, whether_CSW for_IF interns_NN2 and_CC residents_NN2 ,_, or_CC for_IF those_DD2 who_PNQS are_VBR already_RR attending_VVG physicians_NN2 ._. 
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Lipopolysaccharide_NN1 was_VBDZ used_VVN to_TO induce_VVI microglial_JJ activation_NN1 ,_, a_AT1 critical_JJ component_NN1 of_IO neuroinflammation_NN1 ._. 
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Now_RT ,_, many_DA2 states_NN2 are_VBR expanding_VVG Medicaid_JJ coverage_NN1 to_TO include_VVI previously_RR ineligible_JJ adults_NN2 ._. 
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<s>
Cross-sectional_JJ analysis_NN1 at_II 24_MC months_NNT2 showed_VVD no_AT significant_JJ differences_NN2 in_II overall_JJ bowel_NN1 bother_VV0 between_II the_AT treatment_NN1 groups_NN2 (_( 74_MC Gy_JJ vs_II 60_MC Gy_NP1 ,_, ptrend=0-64_FO ;_; 74_MC Gy_JJ vs_II 57_MC Gy_NP1 ,_, ptrend=0*59_FO ;_; appendix_NN1 p_ZZ1 3_MC )_) ._. 
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<s>
No_AT evidence_NN1 of_IO effect_NN1 modification_NN1 (_( nonsignificant_JJ interactions_NN2 ,_, data_NN not_XX shown_VVN )_) was_VBDZ found_VVN and_CC so_RR effect_VV0 modifiers_NN2 were_VBDR not_XX considered_VVN further_RRR ._. 
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Adjusted_JJ model_NN1 2_MC included_VVD variables_NN2 from_II the_AT first_MD model_NN1 as_II31 well_II32 as_II33 lifestyle_NN1 variables_NN2 of_IO smoking_JJ status_NN1 &lsqb;_( 33_MC &rsqb;_) ,_, alcohol_NN1 intake_NN1 &lsqb;_( 34_MC &rsqb;_) ,_, employment_NN1 status_NN1 &lsqb;_( 35_MC &rsqb;_) ,_, and_CC physical_JJ activity_NN1 &lsqb;_( 36_MC &rsqb;_) ._. 
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<s>
Incident_NN1 PD_NP1 cases_NN2 were_VBDR identified_VVN either_RR through_II follow-up_JJ interviews_NN2 or_CC record_NN1 linkage_NN1 analysis_NN1 with_IW hospital_NN1 discharge_NN1 and_CC PD_NP1 outpatient_NN1 registries_NN2 ._. 
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Indeed_RR ,_, U46619_FO caused_VVN a_AT1 dose-_NN1 and_CC time-dependent_JJ stimulation_NN1 of_IO ERK_NP1 phosphorylation_NN1 (_( Figures_VVZ 6A_FO ,_, B_ZZ1 )_) ._. 
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In_RR21 addition_RR22 ,_, these_DD2 findings_NN2 suggest_VV0 CSP_NP1 duration_NN1 may_VM be_VBI used_VVN to_TO assist_VVI in_II the_AT differential_JJ diagnosis_NN1 of_IO AdSD_NP1 ,_, and_CC provides_VVZ the_AT foundation_NN1 for_IF future_JJ studies_NN2 in_II cortical_JJ excitability_NN1 in_II this_DD1 population_NN1 which_DDQ may_VM lead_VVI to_II novel_JJ treatment_NN1 protocols_NN2 that_CST target_NN1 and_CC facilitate_VV0 balance_NN1 in_II cortical_JJ excitability_NN1 ._. 
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Samples_NN2 were_VBDR drawn_VVN immediately_RR after_II moving_VVG the_AT cage_NN1 (_( within_II 20_MC sec_NNU )_) to_TO minimize_VVI the_AT effect_NN1 of_IO stress_NN1 ._. 
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Class_NN1 membership_NN1 probabilities_NN2 from_II subjects_NN2 displaying_VVG v1.0_FO quit_VV0 success_NN1 scores_NN2 in_II the_AT top_JJ tercile_NN1 were_VBDR compared_VVN to_II those_DD2 of_IO subjects_NN2 displaying_VVG v1.0_FO scores_VVZ in_II the_AT lowest_JJT tercile_NN1 by_II t_ZZ1 test_NN1 ._. 
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We_PPIS2 have_VH0 an_AT1 important_JJ role_NN1 in_II educating_VVG all_DB medical_JJ students_NN2 as_II31 well_II32 as_II33 the_AT future_JJ pediatric_JJ clinical_JJ and_CC research_NN1 workforce_NN1 ._. 
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All_DB analyses_NN2 were_VBDR carried_VVN out_RP by_II applying_VVG the_AT selected_JJ and_CC fixed_JJ scanning_NN1 settings_NN2 obtained_VVN from_II the_AT primary_JJ evaluation_NN1 results_NN2 ._. 
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Regional_JJ Topologic_JJ Organization_NN1 of_IO the_AT Structural_JJ Connectome_NN1 We_PPIS2 identified_VVD the_AT brain_NN1 regions_NN2 that_CST showed_VVD significant_JJ between-group_JJ differences_NN2 in_II at_RR21 least_RR22 one_MC1 nodal_JJ metric_JJ (_( P_NNU less_DAR than_CSN .05_MC ,_, corrected_VVN for_IF false-discovery_JJ rate_NN1 )_) ._. 
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The_AT other_JJ study_NN1 did_VDD not_XX find_VVI any_DD steroid_NN1 and_CC lowest_RRT in_II the_AT group_NN1 receiving_VVG the_AT least_RGT potent_JJ steroid_NN1 ,_, responders_NN2 ._. 
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Unadjusted_JJ Associations_NN2 Between_II School_NN1 Mobility_NN1 and_CC Subsequent_JJ Peer_NN1 Difficulties_NN2 School_NN1 mobility_NN1 was_VBDZ significantly_RR associated_VVN with_IW bully_NN1 status_NN1 (_( OR_CC =_FO 1.47_MC ;_; 95%_NNU CI_FO =_FO 1.02-2.14_MCMC )_) ,_, bully_VV0 victimization_NN1 (_( OR_CC =_FO 1.26_MC ;_; 95%_NNU CI_FO =_FO 1.01-1.59_MCMC )_) and_CC negative_JJ friendship_NN1 score_NN1 (_( b_ZZ1 =_FO 0.50_MC ;_; 95%_NNU CI_FO =_FO 0.29-0.72_MCMC )_) ._. 
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If_CS there_EX was_VBDZ a_AT1 pattern_NN1 in_II number_NN1 of_IO interval_NN1 cancers_NN2 with_IW time_NNT1 on_II task_NN1 ,_, then_RT this_DD1 may_VM provide_VVI evidence_NN1 of_IO a_AT1 vigilance_NN1 decrement_NN1 ._. 
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Our_APPGE results_NN2 in_II both_DB2 groups_NN2 compare_VV0 favourably_RR with_IW a_AT1 meta-analysis_NN1 of_IO the_AT effects_NN2 of_IO CBT_NP1 that_DD1 estimate_NN1 proportions_NN2 of_IO patients_NN2 with_IW remissions_NN2 of_IO around_RG 50%_NNU ._. 
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The_AT recurrence-free_JJ interval_NN1 was_VBDZ recorded_VVN as_II the_AT time_NNT1 between_II metastasectomy_NN1 and_CC subsequent_JJ tumor_NN1 recurrence_NN1 or_CC the_AT date_NN1 of_IO last_MD follow-up_NN1 ._. 
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The_AT primary_JJ goal_NN1 of_IO this_DD1 study_NN1 was_VBDZ to_TO compare_VVI the_AT frequency_NN1 with_IW which_DDQ SSEPs_NN2 were_VBDR obtained_VVN with_IW that_DD1 for_IF TcMEPs_NN2 in_II children_NN2 younger_JJR than_CSN 6_MC years_NNT2 ._. 
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Intermolecular_JJ disulfide_NN1 bridges_NN2 can_VM form_VVI between_II a_AT1 chains_NN2 of_IO each_DD1 monomer_NN1 ,_, creating_VVG Hp_NN1 polymers_NN2 ._. 
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<s>
Methods_NN2 We_PPIS2 conducted_VVD a_AT1 secondary_JJ analysis_NN1 of_IO national_JJ DHS_NP2 data_NN from_II nine_MC countries_NN2 on_II the_AT association_NN1 between_II place_NN1 and_CC attendance_NN1 at_II birth_NN1 ,_, and_CC maternal_JJ complications_NN2 during_II delivery_NN1 with_IW reported_JJ early_JJ neonatal_JJ mortality_NN1 ._. 
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Therefore_RR ,_, therapeutic_JJ intervention_NN1 through_II dietary_JJ supplementation_NN1 of_IO DHA_NP1 has_VHZ potential_JJ to_TO improve_VVI the_AT recovery_NN1 process_NN1 in_II patient-athletes_NN2 after_II brain_NN1 injury_NN1 ._. 
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Control_VV0 connectivity_NN1 was_VBDZ greater_JJR between_II the_AT midcingulate_NN1 seed_NN1 point_NN1 and_CC the_AT ventral_JJ attention_NN1 network_NN1 ,_, a_AT1 '_NULL bottom-up_JJ '_NULL attentional_JJ network_NN1 ._. 
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First_MD ,_, we_PPIS2 used_VVD the_AT weights_NN2 that_CST were_VBDR computed_VVN to_TO be_VBI optimal_JJ for_IF predicting_VVG lifespan_NN1 at_II exam_NN1 1_MC1 ,_, when_CS the_AT mean_JJ age_NN1 of_IO the_AT cohort_NN1 was_VBDZ 34.5_MC years_NNT2 (_( Fig._NN1 1_MC1 ,_, bottom_NN1 )_) ._. 
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When_CS analyzing_VVG miR-223_MC ,_, they_PPHS2 demonstrated_VVD that_CST the_AT use_NN1 of_IO either_RR EDTA_NP1 or_CC citrate_JJ tubes_NN2 resulted_VVN in_II slightly_RR elevated_JJ miRNA_NN1 levels_NN2 ._. 
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Six_MC male_JJ piglets_NN2 (_( mean_JJ age_NN1 of_IO 13_MC weeks_NNT2 and_CC mean_JJ weight_NN1 of_IO 39_MC kg_NNU )_) underwent_VVD experiments_NN2 under_II general_JJ anesthesia_NN1 in_II a_AT1 supine_JJ position_NN1 ._. 
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For_IF DCE-MRI_NN1 ,_, no_AT elevated_JJ parametric_JJ maps_NN2 of_IO permeability_NN1 were_VBDR found_VVN in_II human_JJ ischemic_JJ stroke.29_FO The_AT difference_NN1 between_II our_APPGE results_NN2 and_CC those_DD2 of_IO previous_JJ studies_NN2 can_VM not_XX be_VBI explained_VVN by_II either_RR the_AT different_JJ time_NNT1 of_IO onset_NN1 or_CC differences_NN2 in_II the_AT employed_JJ kinetic_JJ model_NN1 since_CS we_PPIS2 did_VDD not_XX find_VVI an_AT1 association_NN1 between_II time_NNT1 of_IO onset_NN1 and_CC stroke_VV0 Ktrans_NN2 values_NN2 and_CC used_VVD a_AT1 unidirectional_JJ 2-compartment_JJ model_NN1 as_RR21 well_RR22 ._. 
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The_AT calibration_NN1 phase_NN1 ,_, performed_VVN at_II both_RR sessions_NNT2 ,_, consisted_VVN in_II fixating_VVG 9_MC positions_NN2 on_II the_AT screen_NN1 located_VVN in_II the_AT corners_NN2 ,_, the_AT center_NN1 ,_, and_CC the_AT extremities_NN2 on_II the_AT horizontal_JJ and_CC vertical_JJ middle_JJ lines_NN2 ._. 
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Also_RR ,_, in_II the_AT study_NN1 by_II Ho_NP1 et_RA21 al._RA22 ,_, about_II one-third_MF of_IO the_AT patients_NN2 had_VHD general_JJ anesthesia_NN1 ,_, whereas_CS all_DB patients_NN2 in_II the_AT current_JJ study_NN1 had_VHD regional_JJ anesthesia_NN1 ._. 
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This_DD1 suggests_VVZ that_CST neuromuscular_JJ exercise_NN1 may_VM be_VBI the_AT best_JJT type_NN1 of_IO exercise_NN1 for_IF pain_NN1 relief_NN1 in_II those_DD2 with_IW varus_NN1 thrust_NN1 (_( 4_MC )_) ._. 
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EVALUATION_NN1 TOOLS_NN2 AND_CC OUTCOMES_NN2 IN_II NEUROMUSCULAR_JJ EXERCISE_NN1 TRIALS_NN2 From_II the_AT patient_NN1 '_NULL s_ZZ1 perspective_NN1 ,_, it_PPH1 is_VBZ most_RGT important_JJ to_TO evaluate_VVI the_AT effect_NN1 from_II exercise_NN1 on_II perceived_JJ pain_NN1 and_CC functional_JJ limitations_NN2 ._. 
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CAF_NP1 was_VBDZ significantly_RR superior_JJ to_II BUN_NN1 and_CC eGFR_NN1 ,_, since_CS the_AT latter_DA ones_NN2 were_VBDR no_AT more_RGR associated_JJ with_IW GL_NP1 when_CS adjusted_VVN for_IF CAF_NN1 levels_NN2 ._. 
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Western_JJ perioperative_JJ neurologic_JJ scale_NN1 The_AT Western_JJ perioperative_JJ neurologic_JJ scale_NN1 was_VBDZ designed_VVN to_TO detect_VVI neurologic_JJ deficits_NN2 after_II cardiac_JJ surgery_NN1 ._. 
</s>
<s>
For_REX21 example_REX22 ,_, if_CS we_PPIS2 increase_VV0 from_II 0.005_MC to_II 0.05_MC (_( by_II changing_VVG E36_FO to_II 5_MC )_) ,_, the_AT "_" clinical_JJ inference_NN1 "_" changes_NN2 to_II "_" possibly_RR beneficial_JJ "_" ._. 
</s>
<s>
For_IF persistent_JJ thrombocytopenia_NN1 ,_, the_AT next_MD cycle_NN1 was_VBDZ delayed_VVN until_CS platelets_NN2 had_VHD recovered_VVN to_II at_RR21 least_RR22 100_MC x_ZZ1 109_MC cells_NN2 per_II L_ZZ1 and_CC chemotherapy_NN1 doses_NN2 were_VBDR reduced_VVN to_II 80%_NNU ,_, maintaining_VVG this_DD1 dose_NN1 reduction_NN1 for_IF subsequent_JJ cycles_NN2 ._. 
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<s>
The_AT four_MC patients_NN2 with_IW a_AT1 BRCA2_FO gene_NN1 mutation_NN1 underwent_VVD MR_NNB mammography_NN1 for_IF early_JJ detection_NN1 in_II high-risk_JJ patients_NN2 (_( n=2_FO )_) ,_, suspected_JJ recurrence_NN1 (_( n=1_FO )_) and_CC proven_JJ breast_NN1 cancer_NN1 (_( n=1_FO )_) ._. 
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<s>
They_PPHS2 reasoned_VVD ,_, mainly_RR by_II linking_VVG symptoms_NN2 to_II lesions_NN2 identified_VVN by_II dissection_NN1 ,_, that_CST disorders_NN2 could_VM be_VBI caused_VVN by_II focal_JJ lesions_NN2 to_II cortical_JJ network_NN1 nodes_NN2 or_CC the_AT white_JJ matter_NN1 links_VVZ between_II them_PPHO2 ._. 
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<s>
If_CS using_VVG telemedicine_NN1 ,_, generate_VV0 telemedicine_NN1 set-up_NN1 duration_NN1 ._. 
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<s>
This_DD1 lends_VVZ credence_NN1 to_II our_APPGE findings_NN2 that_CST 1_MC1 mM_NNU propofol-fed_JJ flies_NN2 are_VBR not_XX merely_RR sleeping_JJ and_CC should_VM not_XX be_VBI roused_VVN by_II vibratory_JJ stimuli_NN2 as_CSA these_DD2 tissue_NN1 levels_NN2 are_VBR predicted_VVN to_TO produce_VVI surgical_JJ plane_NN1 of_IO propofol_NN1 anesthesia_NN1 ._. 
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<s>
The_AT median_JJ time_NNT1 between_II the_AT ILD_NN1 diagnosis_NN1 and_CC the_AT PET_NN1 scan_NN1 was_VBDZ 13_MC months_NNT2 (_( range_NN1 ;_; 34-119_MCMC )_) ._. 
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<s>
We_PPIS2 note_VV0 that_CST these_DD2 findings_NN2 apply_VV0 to_II optimization_NN1 of_IO care_NN1 for_IF the_AT entire_JJ region_NN1 and_CC do_VD0 not_XX focus_VVI on_II the_AT performance_NN1 of_IO isolated_JJ hospitals_NN2 in_II the_AT region_NN1 ._. 
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<s>
Discussion_NN1 Data_NN that_CST have_VH0 the_AT potential_JJ to_TO inform_VVI our_APPGE knowledge_NN1 base_NN1 about_II how_RGQ school-age_JJ children_NN2 and_CC adolescents_NN2 who_PNQS stutter_VV0 (_( S-Only_JJ )_) differ_VV0 from_II Stuttering_VVG plus_II Language_NN1 Disordered_JJ (_( S_ZZ1 +_FO LD_NP1 )_) peers_NN2 are_VBR presented_VVN in_II the_AT current_JJ study_NN1 ._. 
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<s>
Delirium_NN1 occurs_VVZ in_RP almost_RR half_DB of_IO surgical_JJ patients_NN2 over_II the_AT age_NN1 of_IO 65.3_MC Surgery_NN1 has_VHZ also_RR been_VBN observed_VVN to_TO increase_VVI risk_NN1 of_IO persistent_JJ and/or_CC progressive_JJ cognitive_JJ impairment_NN1 ,_, however_RR ._. 
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<s>
Agreement_NN1 between_II respondents_NN2 and_CC the_AT different_JJ scales_NN2 was_VBDZ assessed_VVN using_VVG kappa_NN1 (_( k_ZZ1 )_) statistics_NN ._. 
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<s>
So_RG far_RR only_RR some_DD recent_JJ retrospective_JJ or_CC small_JJ prospective_JJ studies_NN2 have_VH0 called_VVN attention_NN1 to_II the_AT high_JJ prevalence_NN1 of_IO postoperative_JJ pain_NN1 after_II otorhinolaryngologic_JJ surgery_NN1 ._. 
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<s>
This_DD1 adds_VVZ to_II the_AT evidence_NN1 previously_RR offered_VVN ,_, demonstrating_VVG that_DD1 primary_JJ conservative_JJ management_NN1 of_IO tumours_NN2 of_IO this_DD1 size_NN1 leads_VVZ to_II superior_JJ clinical_JJ outcomes_NN2 in_II31 terms_II32 of_II33 facial_JJ nerve_NN1 and_CC hearing_VVG preservation_NN1 ._. 
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<s>
Allodynia_NN1 to_TO brush_VVI :_: scored_VVN nil_PN1 ,_, mild_JJ ,_, moderate_JJ ,_, or_CC severe_JJ ._. 
</s>
<s>
That_REX21 is_REX22 ,_, respondents_NN2 who_PNQS only_RR knewPWS_VVZ as_CSA acquaintances_NN2 were_VBDR not_XX significantly_RR different_JJ in_II reported_JJ affective_JJ reactions_NN2 from_II those_DD2 without_IW familiarity_NN1 withPWS_NN2 ._. 
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<s>
Conclusions_NN2 Given_VVN the_AT high_JJ prevalence_NN1 and_CC impact_NN1 of_IO trauma_NN1 on_II pediatric_JJ patients_NN2 ,_, families_NN2 ,_, and_CC providers_NN2 ,_, it_PPH1 is_VBZ essential_JJ that_CST pediatric_JJ healthcare_NN1 networks_NN2 integrate_VV0 a_AT1 trauma-informed_JJ care_NN1 approach_NN1 into_II delivery_NN1 of_IO medical_JJ care_NN1 ._. 
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<s>
Quantification_NN1 of_IO the_AT total_JJ amount_NN1 of_IO NCX3_FO (_( intact_JJ plus_II fragmented_JJ )_) showed_VVD that_CST there_EX were_VBDR no_AT significant_JJ differences_NN2 between_II any_DD tauopathy_NN1 and_CC control_NN1 brain_NN1 following_VVG normalization_NN1 to_TO NSE_VVI (_( Fig._NN1 3B_FO )_) ._. 
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<s>
III_MC ,_, respiratory_JJ failure_NN1 prior_II21 to_II22 primary_JJ PCI_NP1 ,_, the_AT average_NN1 of_IO TIMI_JJ risk_NN1 score_NN1 ,_, and_CC the_AT incidence_NN1 of_IO high_JJ TIMI_JJ risk_NN1 score_NN1 were_VBDR similar_JJ between_II groups_NN2 ._. 
</s>
<s>
ACR_NP1 Appropriateness_NN1 Criteria_NN2 Nasal_JJ Cavity_NN1 and_CC Paranasal_NP1 Sinus_NP1 Cancers_NN2 Supporting_VVG documents_NN2 For_IF additional_JJ information_NN1 on_II the_AT Appropriateness_NN1 Criteria_NN2 methodology_NN1 and_CC other_JJ supporting_JJ documents_NN2 go_VV0 to_II www_NNU ._. 
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<s>
Advances_NN2 in_II CT_NN1 in_II recent_JJ years_NNT2 have_VH0 focused_VVN in_RR21 part_RR22 on_II reduced_JJ radiation_NN1 dose_NN1 ,_, an_AT1 important_JJ topic_NN1 for_IF the_AT years_NNT2 to_TO come_VVI ._. 
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<s>
DBT_NP1 worked_VVD with_IW continuous_JJ x-ray_JJ tube_NN1 motion_NN1 ,_, taking_VVG 15_MC projections_NN2 over_II a_AT1 15-degree_JJ angular_JJ range_NN1 ._. 
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<s>
In_II the_AT Bogalusa_NP1 Heart_NN1 Study_NN1 of_IO 5-to_MC 10-yr-old_JJ obese_JJ children_NN2 ,_, 58%_NNU of_IO the_AT population_NN1 had_VHD one_MC1 risk_NN1 factor_NN1 for_IF cardiovascular_JJ disease_NN1 and_CC 25%_NNU had_VHD two_MC or_CC more_RRR ._. 
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<s>
AMOSS_NP1 was_VBDZ approved_VVN by_II the_AT Human_JJ Research_NN1 Ethics_NN Committee_NN1 of_IO The_AT University_NN1 of_IO New_NP1 South_NP1 Wales_NP1 ,_, Australia_NP1 (_( Reference_NN1 07313_MC )_) and_CC multiple_JJ other_JJ ethical_JJ and_CC site_NN1 governance_NN1 reviews_NN2 ._. 
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<s>
MiRNAs_NN2 with_IW cycle_NN1 thresholds_NN2 (_( CTs_NN2 )_) greater_JJR than_CSN 35_MC were_VBDR excluded_VVN from_II further_JJR analysis_NN1 ._. 
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<s>
Results_NN2 We_PPIS2 obtained_VVD aggregated_JJ screening_NN1 data_NN for_IF 5_MC 243_MC 658_MC women_NN2 screened_VVN between_II April_NPM1 1_MC1 ,_, 2003_MC ,_, and_CC March_NPM1 31_MC ,_, 2007_MC ._. 
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<s>
Further_JJR investigations_NN2 are_VBR needed_VVN to_TO establish_VVI the_AT link_NN1 between_II increased_JJ hippocampal_JJ zinc_NN1 levels_NN2 and_CC the_AT age-associated_JJ memory_NN1 deficits_NN2 and_CC how_RGQ dietary_JJ zinc_NN1 supplementation_NN1 affects_VVZ the_AT hippocampal_JJ zinc_NN1 levels_NN2 and_CC plasticity_NN1 ._. 
</s>
<s>
The_AT mean_JJ (_( SD_NP1 )_) difference_NN1 between_II the_AT two_MC methods_NN2 was_VBDZ 0.003_MC (_( 0.86_MC )_) ,_, and_CC Table_NN1 2_MC and_CC Figure_NN1 1D_NNU show_VV0 a_AT1 good_JJ linearity_NN1 fit_NN1 ._. 
</s>
<s>
To_TO determine_VVI whether_CSW these_DD2 changes_NN2 were_VBDR associated_VVN with_IW altered_JJ collagen_NN1 content_NN1 ,_, we_PPIS2 undertook_VVD circular_JJ polarization_NN1 microscopic_JJ imaging_NN1 of_IO the_AT aortic_JJ wall_NN1 of_IO 15-month-old_JJ mice_NN2 ._. 
</s>
<s>
Theresa_NP1 A._NP1 Guise_NN1 1Division_FO of_IO Endocrinology_NP1 ,_, Indiana_NP1 University_NN1 School_NN1 of_IO Medicine_NN1 ,_, Indianapolis_NP1 ,_, IN_II 46202_MC ,_, USA_NP1 2Division_FO of_IO Endocrinology_NP1 ,_, University_NN1 of_IO Virginia_NP1 School_NN1 of_IO Medicine_NN1 ,_, Charlottesville_NP1 ,_, VA_FW 22903_MC ,_, USA_NP1 3Center_FO for_IF Computational_JJ Biology_NN1 and_CC Bioinformatics_NP1 ,_, Indiana_NP1 University_NN1 ,_, Indianapolis_NP1 ,_, IN_II 46202_MC ,_, USA_NP1 4Division_FO of_IO Metabolism_NN1 ,_, Endocrinology_NP1 and_CC Diabetes_NN1 ,_, University_NN1 of_IO Michigan_NP1 ,_, Ann_NP1 Arbor_NP1 ,_, MI_NP1 48105_MC ,_, USA_NP1 5Department_FO of_IO Biochemistry_NP1 and_CC Molecular_JJ Biology_NN1 ,_, Indiana_NP1 University_NN1 School_NN1 of_IO Medicine_NN1 ,_, Indianapolis_NP1 ,_, IN_II 46202_MC ,_, USA_NP1 6Richard_FO L._NP1 Roudebush_NP1 VA_FW Medical_JJ Center_NN1 ,_, Indianapolis_NP1 ,_, IN_II 46202_MC ,_, USA_NP1 Correspondence_NN1 :_: tguise@iu.edu_FO http_NNU :_: Highlights_VVZ TGF-b_NN1 inhibition_NN1 decreases_VVZ prometastatic_JJ genes_NN2 and_CC PMEPA1_FO inhibits_VVZ TGF-b_NN1 signaling_VVG by_II a_AT1 non-proteasomal_JJ mechanism_NN1 Clinically_RR ,_, low_JJ PMEPA1_FO correlates_VVZ with_IW poor_JJ metastasis-free_JJ survival_NN1 PMEPA1_FO knockdown_NN1 increases_VVZ prostate_NN1 cancer_NN1 bone_NN1 metastases_VVZ in_II a_AT1 mouse_NN1 model_NN1 SUMMARY_NN1 Transforming_VVG growth_NN1 factor-b_NN1 (_( TGF-b_NP1 )_) regulates_VVZ the_AT expression_NN1 of_IO genes_NN2 supporting_VVG breast_NN1 cancer_NN1 cells_NN2 in_II bone_NN1 ,_, but_CCB little_DA1 is_VBZ known_VVN about_II prostate_NN1 cancer_NN1 bone_NN1 metastases_NN2 and_CC TGF-b_NP1 ._. 
</s>
<s>
Because_CS the_AT only_RR two_MC cases_NN2 of_IO Ebola_NP1 virus_NN1 -_- infected_JJ patients_NN2 in_II the_AT United_NP1 States_NP1 were_VBDR the_AT result_NN1 of_IO evacuation_NN1 efforts_NN2 ,_, this_DD1 represents_VVZ a_AT1 very_RG rare_JJ situation_NN1 ._. 
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<s>
In_II VE_NP1 ,_, KP_NP1 resulted_VVD in_II increased_JJ elbow_NN1 extension_NN1 without_IW compensatory_JJ trunk_NN1 movement_NN1 in_II the_AT mild_JJ subgroup_NN1 ._. 
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<s>
In_II third-generation_JJ ACI_NN2 ,_, scaffolds_NN2 are_VBR biodegradable_JJ ,_, noncytotoxic_JJ ,_, and_CC mechanically_RR pliable_JJ ._. 
</s>
<s>
These_DD2 facilities_NN2 also_RR include_VV0 43_MC specialist_JJ eating_NN1 disorders_NN2 services_NN2 with_IW dedicated_JJ inpatients_NN2 beds_NN2 ,_, also_RR located_VVN in_II general_JJ hospitals_NN2 ._. 
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<s>
The_AT first_MD group_NN1 of_IO 177_MC patients_NN2 (_( July_NPM1 2002_MC to_II June_NPM1 2003_MC )_) did_VDD not_XX receive_VVI vitamin_NN1 C_ZZ1 supplementation_NN1 ,_, whereas_CS the_AT second_MD group_NN1 of_IO 215_MC patients_NN2 (_( July_NPM1 2003_MC to_II June_NPM1 2004_MC )_) received_VVD vitamin_NN1 C_ZZ1 supplementation_NN1 ._. 
</s>
<s>
A_AT1 third_MD question_NN1 is_VBZ whether_CSW suicide_NN1 is_VBZ sufficiently_RR common_JJ in_II the_AT highest-risk_JJ stratum_NN1 and_CC available_JJ interventions_NN2 sufficiently_RR powerful_JJ to_TO make_VVI targeted_VVN post-hospital_JJ interventions_NN2 efficient_JJ compared_VVN to_II alternative_JJ ways_NN2 of_IO deploying_VVG the_AT same_DA clinical_JJ resources_NN2 ._. 
</s>
<s>
Author_NN1 contributions_NN2 were_VBDR as_CSA follows_VVZ :_: Study_NN1 concept_NN1 and_CC design_NN1 :_: De_NP1 Waal_NP1 ,_, Gussekloo_NP1 ,_, Van_NP1 der_NP1 Mast_NP1 ._. 
</s>
<s>
Stained_JJ tissues_NN2 were_VBDR mounted_VVN on_II glass_NN1 slides_VVZ with_IW Fluoro-Gel_NP1 mounting_VVG media_NN (_( Electron_NN1 Microscopy_NN1 Sciences_NN2 ,_, Hatfield_NP1 ,_, PA_NP1 )_) ._. 
</s>
<s>
The_AT mechanism_NN1 of_IO this_DD1 neurologic_JJ deterioration_NN1 is_VBZ not_XX fully_RR understood_VVN ,_, but_CCB appears_VVZ to_TO be_VBI related_VVN to_TO dosage_VVI since_CS a_AT1 high_JJ starting_NN1 dose_NN1 could_VM increase_VVI the_AT risk_NN1 of_IO rapid_JJ chelator-induced_JJ paradoxical_JJ worsening_JJ ._. 
</s>
<s>
The_AT findings_NN2 confirmed_VVD this_DD1 suspicion_NN1 ,_, suggesting_VVG that_DD1 ulceration_NN1 may_VM be_VBI driven_VVN by_II systemic_JJ inflammation_NN1 ,_, but_CCB higher_JJR vitamin_NN1 D_ZZ1 levels_NN2 were_VBDR independently_RR protective_JJ for_IF ulceration_NN1 ._. 
</s>
<s>
By_II the_AT end_NN1 of_IO the_AT 42-month_JJ follow-up_JJ period_NN1 ,_, the_AT reduced_JJ mortality_NN1 in_II the_AT participating_JJ hospitals_NN2 was_VBDZ no_RR21 longer_RR22 significant_JJ (_( .0.1_MC percentage_NN1 points_NN2 ;_; 95%_NNU CI_FO ,_, .0.6_MC to_II 0.3_MC )_) ._. 
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<s>
Finally_RR ,_, a_AT1 trim-and-fill_JJ method_NN1 was_VBDZ used_VVN to_TO determine_VVI whether_CSW there_EX were_VBDR any_DD missing_JJ studies_NN2 ._. 
</s>
<s>
Both_DB2 the_AT 3D_NNU GMM_NP1 and_CC its_APPGE more_RGR clinically_RR implementable_JJ threshold_NN1 plane_NN1 derivative_NN1 yielded_VVD similar_JJ results_NN2 ,_, with_IW higher_JJR than_CSN 90%_NNU accuracy_NN1 at_II matched_JJ SECT_NN1 attenuation_NN1 levels_NN2 of_IO 50_MC HU_NP1 and_CC greater_JJR ._. 
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<s>
For_IF that_DD1 purpose_NN1 ,_, the_AT bottom_NN1 of_IO the_AT optic_NN1 nerve_NN1 head_NN1 is_VBZ formed_VVN by_II the_AT LC_NP1 as_II a_AT1 sieve-like_JJ structure_NN1 ._. 
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<s>
In_RR21 addition_RR22 ,_, the_AT false-negative_JJ rate_NN1 for_IF mpMRI_NN2 remains_VVZ approximately_RR 5%_NNU ._. 
</s>
<s>
The_AT first_MD author_NN1 randomised_VVN the_AT participants_NN2 to_II an_AT1 intervention_NN1 group_NN1 or_CC a_AT1 control_NN1 group_NN1 by_II a_AT1 concealed_JJ allocation_NN1 procedure_NN1 ._. 
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<s>
It_PPH1 is_VBZ also_RR appropriate_JJ for_IF the_AT specialist_NN1 to_TO forgo_VVI or_CC delay_VVI the_AT internal_JJ gynecologic_JJ component_NN1 of_IO the_AT examination_NN1 of_IO an_AT1 adolescent_JJ patient_NN1 (_( as_CSA described_VVN in_II further_JJR detail_NN1 below_RL )_) or_CC in_II cases_NN2 where_RRQ the_AT patient_NN1 makes_VVZ informed_JJ refusal_NN1 ,_, can_VM not_XX tolerate_VVI the_AT examination_NN1 ,_, or_CC is_VBZ near_II the_AT end_NN1 oflife_NN1 ._. 
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<s>
The_AT delivery_NN1 frequency_NN1 was_VBDZ 0.1_MC Hz_NNU ,_, slightly_RR shifting_VVG the_AT stimulation_NN1 point_NN1 in_BCL21 order_BCL22 to_TO avoid_VVI stimuli_NN2 habituation_NN1 and_CC skin_NN1 lesions_NN2 ._. 
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<s>
Robustness_NN1 of_IO the_AT Treatment_NN1 Effect_NN1 Treatment_NN1 Effect_NN1 According_II21 to_II22 More_RGR Precise_JJ Determination_NN1 of_IO Duration_NN1 of_IO Diabetic_JJ Macular_NP1 Edema_NP1 ._. 
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<s>
All_DB statistical_JJ analyses_NN2 were_VBDR completed_VVN using_VVG SAS_NP1 Enterprise_NN1 Guide_NN1 7.1_MC software_NN1 ._. 
</s>
<s>
More_RGR recently_RR ,_, Carlsson_NP1 et_RA21 al_RA22 ._. 
</s>
<s>
evaluating_VVG 667_MC miRNA_NN1 ,_, found_VVD nine_MC miRNAs_NN2 that_CST consistently_RR differ_VV0 between_II malignant_JJ prostate_NN1 tissues_NN2 and_CC the_AT adjacent_JJ normal_JJ tissue_NN1 from_II each_DD1 case_NN1 ._. 
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<s>
Janie_NP1 Corley_NP1 ,_, Leone_NNU1 C.A._NP1 Craig_NP1 ,_, Geraldine_NP1 M._NN1 McNeill_NP1 :_: food_NN1 frequency_NN1 data_NN analysis_NN1 ,_, critical_JJ revision_NN1 of_IO manuscript_NN1 for_IF intellectual_JJ content_NN1 ._. 
</s>
<s>
Cortical_JJ Stimulation_NN1 Programming_NN1 Three_MC electrode_NN1 contacts_NN2 along_II one_MC1 edge_NN1 of_IO the_AT lead_NN1 were_VBDR configured_VVN as_CSA anodes_NN2 ,_, and_CC 3_MC contacts_NN2 on_II the_AT opposite_JJ edge_NN1 were_VBDR programmed_VVN as_CSA cathodes_NN2 ._. 
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<s>
Of_IO note_NN1 ,_, further_JJR subset_NN1 analysis_NN1 of_IO the_AT less_DAR than_CSN 35%_NNU and_CC more_DAR than_CSN 85%_NNU perfusion_NN1 reduction_NN1 categories_NN2 into_II individual_JJ groups_NN2 was_VBDZ limited_VVN by_II small_JJ sample_NN1 sizes_NN2 (_( 11_MC patients_NN2 in_II the_AT ,_, 35%_NNU group_NN1 and_CC seven_MC in_II the_AT .85%_FO group_NN1 )_) ._. 
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<s>
These_DD2 findings_NN2 taken_VVN together_RL suggest_VV0 that_CST the_AT CAT_NN1 assess_VV0 some_DD underlying_JJ dimensions_NN2 of_IO the_AT construct_NN1 communication_NN1 attitudes_NN2 that_CST is_VBZ not_XX assessed_VVN in_II the_AT KiddyCAT_NN1 ._. 
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<s>
In_II our_APPGE study_NN1 ,_, nearly_RR 40%_NNU of_IO patients_NN2 lost_VVD consciousness_NN1 for_IF less_DAR than_CSN 10_MC minutes_NNT2 ,_, and_CC another_DD1 21.0%_FO lost_JJ consciousness_NN1 for_IF 10_MC to_II 60_MC minutes_NNT2 ,_, with_IW subsequent_JJ witnessed_VVD recovery_NN1 of_IO alertness_NN1 during_II the_AT prehospital_JJ phase_NN1 ._. 
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<s>
In_II many_DA2 other_JJ assays_NN2 ,_, this_DD1 information_NN1 would_VM be_VBI lost_VVN to_II the_AT dominant_JJ signal_NN1 of_IO the_AT clonal_JJ expansions_NN2 ._. 
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<s>
We_PPIS2 thank_VV0 Dr._NNB Philipp_NP1 Elbert_NP1 and_CC Dr._NNB Richard_NP1 Dahler_NP1 for_IF proofreading_VVG the_AT manuscript_NN1 ._. 
</s>
<s>
The_AT brainstems_NN2 were_VBDR sectioned_VVN through_II their_APPGE entire_JJ rostrocaudal_JJ axis_NN1 at_II 50-m_NNU on_II a_AT1 cryostat_NN1 and_CC 16_MC spaced_JJ series_NN of_IO sections_NN2 were_VBDR obtained_VVN (_( sections_NN2 sampled_VVD every_AT1 800_MC m_NNU )_) ._. 
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<s>
Votavova_NP1 et_RA21 al_RA22 ._. 
</s>
<s>
similarly_RR compared_VVN a_AT1 GPC_NP1 method_NN1 to_II the_AT High_JJ Pure_JJ RNA_NN1 Paraffin_NN1 Kit_NN1 (_( Roche_NP1 )_) and_CC demonstrated_VVD lower_JJR Ct_NN1 values_NN2 of_IO beta-2_MC microglobulin_NN1 (_( B2M_FO )_) when_RRQ miRNA_NN1 was_VBDZ extracted_VVN from_II formalin-fixed_JJ paraffin-embedded_JJ tissue_NN1 (_( FFPE_NP1 )_) by_II the_AT commercial_JJ kit_NN1 ._. 
</s>
<s>
Although_CS fluctuations_NN2 in_II choroidal_JJ thickness_NN1 may_VM not_XX be_VBI mechanistic_JJ in_II31 terms_II32 of_II33 the_AT cause_NN1 of_IO vision_NN1 loss_NN1 in_II migraine_NN1 (_( see_VV0 Sections_NN2 5._MC 1_MC1 and_CC 5._MC 2_MC )_) ,_, it_PPH1 may_VM reflect_VVI a_AT1 vascular_JJ dysregulation_NN1 in_II migraine_NN1 that_CST could_VM explain_VVI why_RRQ the_AT retina_NN1 is_VBZ susceptible_JJ to_II glaucoma_NN1 development_NN1 in_II some_DD migraine_NN1 sufferers_NN2 ._. 
</s>
<s>
The_AT term_NN1 tendon_NN1 pathology_NN1 will_VM be_VBI used_VVN to_TO indicate_VVI abnormal_JJ imaging_NN1 or_CC histopathology_NN1 without_IW reference_NN1 to_II pain_NN1 ._. 
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<s>
Figure_NN1 3_MC gives_VVZ a_AT1 further_JJR breakdown_NN1 of_IO these_DD2 47_MC articles_NN2 in_II31 terms_II32 of_II33 year_NNT1 ,_, topic_NN1 ,_, and_CC journal_NN1 ._. 
</s>
<s>
Interestingly_RR ,_, 2_MC macrocyclic_JJ GBCAs-gadoterate_JJ meglumine_NN1 and_CC gadoteridol_VV0 '_NULL present_VV0 a_AT1 much_RR faster_JJR clearance_NN1 (_( 20-30_MCMC days_NNT2 )_) ._. 
</s>
<s>
Because_II21 of_II22 the_AT relatively_RR small_JJ percentage_NN1 of_IO nonwhite_NN1 students_NN2 in_II Vermont_NP1 during_II the_AT time_NNT1 period_NN1 of_IO this_DD1 study_NN1 ,_, the_AT minimum_JJ cell_NN1 size_NN1 restriction_NN1 of_IO 10_MC prevented_VVD us_PPIO2 from_II searching_VVG for_IF effects_NN2 of_IO race_NN1 ._. 
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<s>
The_AT twitch_NN1 force_NN1 elicited_VVN by_II the_AT Mmax_NN1 stimulus_NN1 was_VBDZ greater_JJR immediately_RR after_II the_AT protocol_NN1 but_CCB was_VBDZ then_RT reduced_VVN ._. 
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<s>
The_AT mechanisms_NN2 underlying_VVG the_AT increased_JJ risk_NN1 of_IO hyponatremia_NN1 in_II some_DD TBI_JJ patients_NN2 remain_VV0 unclear_JJ to_II date_NN1 ._. 
</s>
<s>
Gastroesophageal_JJ reflux_NN1 disease_NN1 (_( GERD_NP1 )_) was_VBDZ one_MC1 of_IO the_AT most_RGT common_JJ gastrointestinal_JJ diseases_NN2 in_II Europe_NP1 and_CC the_AT United_NP1 States_NP1 with_IW prevalence_NN1 rates_NN2 of_IO 10%_NNU to_II 25%_NNU in_II population-based_NN1 studies.9,10_FO Reports_VVZ from_II many_DA2 other_JJ regions_NN2 have_VH0 also_RR demonstrated_VVN an_AT1 increase_NN1 in_II the_AT prevalence_NN1 of_IO GERD_NN1 ._. 
</s>
<s>
Walcott_NP1 et_NP1 al11_FO identified_VVN a_AT1 greater_JJR mortality_NN1 associated_VVN with_IW faster_JJR time_NNT1 to_II surgery_NN1 ,_, but_CCB the_AT study_NN1 was_VBDZ limited_VVN to_II patients_NN2 with_IW ASDH_NN1 but_CCB limited_JJ additional_JJ structural_JJ brain_NN1 injury_NN1 ._. 
</s>
<s>
The_AT optimal_JJ use_NN1 of_IO pan-CT_NN1 in_II patients_NN2 with_IW blunt_JJ trauma_NN1 remains_VVZ unknown_JJ ._. 
</s>
<s>
Three_MC different_JJ age_NN1 groups_NN2 (_( n_ZZ1 =_FO 5/group_FU )_) were_VBDR imaged_VVN to_TO assess_VVI microglia_NN1 motility_NN1 and_CC in_JJ21 vivo_JJ22 morphology_NN1 in_II the_AT somatosensory_JJ cortex_NN1 ._. 
</s>
<s>
The_AT clinician_NN1 can_VM begin_VVI to_TO implement_VVI other_JJ planes_NN2 of_IO external_JJ stimulus_NN1 to_TO facilitate_VVI recruitment_NN1 of_IO the_AT surrounding_JJ musculature_NN1 as_II31 well_II32 as_II33 place_NN1 the_AT arm_NN1 at_II various_JJ angles_NN2 of_IO both_DB2 elevation_NN1 and_CC external_JJ rotation_NN1 ._. 
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<s>
Table_NN1 5_MC presents_VVZ the_AT standardized_JJ and_CC unstandardized_JJ coefficients_NN2 of_IO beliefs_NN2 about_II PWS_NP2 and_CC the_AT control_NN1 variables_NN2 from_II the_AT SUR_NP1 results_NN2 for_CS sympathy/social_FU distancing_NN1 ._. 
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<s>
At_II 12_MC months_NNT2 following_RA the_AT original_JJ IDM_NP1 +_FO CMM_NP1 treatment_NN1 ,_, primary_JJ outcome_NN1 data_NN on_II 22_MC of_IO the_AT original_JJ 29_MC (_( 76%_NNU )_) subjects_NN2 in_II this_DD1 cohort_NN1 were_VBDR available_JJ ._. 
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<s>
Increasing_VVG the_AT stimulus_NN1 by_II a_AT1 further_JJR 5_MC dB_NNU confirmed_VVD the_AT reflex_JJ growth_NN1 ._. 
</s>
<s>
Proteins_NN2 were_VBDR transferred_VVN electrically_RR from_II the_AT gel_NN1 onto_II a_AT1 0.45_MC |_NULL xm_NNU nitrocellulose_NN1 membrane_NN1 (_( Millipore_NP1 ,_, Temecula_NP1 ,_, CA_NP1 ,_, USA_NP1 )_) by_II the_AT semidry_JJ electro-transfer_JJ method_NN1 ._. 
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<s>
Currently_RR ,_, the_AT dominant_JJ mode_NN1 of_IO PA_NN1 and_CC SB_NP1 environmental_JJ assessment_NN1 is_VBZ centered_VVN on_II combining_VVG GIS_NN2 and_CC accelerometer_JJR data_NN -_- focusing_VVG on_II specific_JJ a_JJ21 priori_JJ22 locations_NN2 such_II21 as_II22 the_AT home_NN1 or_CC work_VV0 address_NN1 and_CC extracting_VVG environmental_JJ variables_NN2 from_II GIS_NN2 for_IF those_DD2 locations_NN2 using_VVG a_AT1 buffer_NN1 (_( 3_MC )_) ._. 
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<s>
In_II the_AT PARTNER_NN1 trial_NN1 ,_, women_NN2 had_VHD greater_JJR benefit_NN1 from_II TAVR_NN1 with_IW BE_VBI valve_NN1 compared_VVN with_IW men_NN2 ._. 
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<s>
Written_VVN informed_JJ consent_NN1 was_VBDZ obtained_VVN from_II all_DB parents_NN2 and_CC participants_NN2 more_DAR than_CSN 16_MC years_NNT2 of_IO age_NN1 ,_, and_CC informed_JJ assent_NN1 from_II participants_NN2 less_DAR than_CSN 16_MC years_NNT2 of_IO age_NN1 ,_, after_CS a_AT1 detailed_JJ description_NN1 of_IO the_AT study_NN1 had_VHD been_VBN given_VVN ._. 
</s>
<s>
We_PPIS2 found_VVD that_CST perceived_VVD trustworthiness_NN1 is_VBZ important_JJ in_II therapeutic_JJ encounters_NN2 as_CSA it_PPH1 helps_VVZ to_TO negotiate_VVI tensions_NN2 with_II31 respect_II32 to_II33 subjective_JJ pain_NN1 symptoms_NN2 ,_, addiction_NN1 ,_, and_CC prescription_NN1 opioid_NN1 use_NN1 ._. 
</s>
<s>
It_PPH1 is_VBZ important_JJ to_TO understand_VVI ,_, however_RRQV that_CST the_AT relative_JJ importance_NN1 ,_, mechanisms_NN2 and_CC functions_NN2 of_IO the_AT various_JJ PRPH2/RDS_FU oligomers_NN2 are_VBR not_XX understood_VVN ,_, and_CC given_VVN the_AT differences_NN2 in_II distribution_NN1 of_IO complex_JJ type_NN1 between_II rods_NN2 and_CC cones_NN2 ,_, the_AT function_NN1 of_IO individual_JJ types_NN2 of_IO PRPH2/RDS_FU complexes_NN2 remains_VVZ of_IO great_JJ interest_NN1 ._. 
</s>
<s>
Although_CS the_AT present_JJ results_NN2 showed_VVD that_CST stimulus-presentation_JJ condition_NN1 had_VHD an_AT1 impact_NN1 on_II the_AT ERP_NN1 amplitudes_NN2 ,_, they_PPHS2 did_VDD not_XX fully_RR contradict_VVI the_AT finding_NN1 by_II Amenedo_NP1 and_CC Escera_NP1 (_( 2000_MC )_) who_PNQS found_VVD that_CST the_AT magnitude_NN1 of_IO the_AT MMN_NP1 was_VBDZ proportional_JJ to_II a_AT1 difference_NN1 between_II standards_NN2 and_CC deviants_NN2 ._. 
</s>
<s>
The_AT SMOG_NN1 and_CC GFOG_VV0 scores_NN2 were_VBDR consistently_RR higher_JJR than_CSN the_AT FKGL_NP1 score_NN1 ,_, in_II31 keeping_II32 with_II33 previous_JJ reports_NN2 ._. 
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<s>
For_IF that_DD1 purpose_NN1 ligand-based_NN1 affinity_NN1 chromatography_NN1 can_VM be_VBI exploited_VVN ,_, which_DDQ also_RR can_VM be_VBI employed_VVN to_TO purify_VVI GPCRs_NP1 from_II native_JJ sources_NN2 (_( Reilander_NP1 et_RA21 al._RA22 ,_, 1991_MC )_) ._. 
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<s>
In_II fact_NN1 ,_, only_RR the_AT provision_NN1 of_IO verbal_JJ contingencies_NN2 for_IF unambiguous_JJ stuttering_VVG during_II practice_NN1 sessions_NNT2 was_VBDZ associated_VVN with_IW treatment_NN1 duration_NN1 and_CC this_DD1 was_VBDZ in_II the_AT opposite_JJ direction_NN1 to_II expectations_NN2 ._. 
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<s>
Finally_RR ,_, a_AT1 total_NN1 of_IO 2380_MC pregnant_JJ women_NN2 aged_II 21_MC -_- 38_MC years_NNT2 were_VBDR recruited_VVN from_II hospitalized_JJ and_CC outpatient_NN1 women_NN2 in_II our_APPGE hospital_NN1 ._. 
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<s>
We_PPIS2 did_VDD not_XX address_VVI test_NN1 performance_NN1 for_IF differentiating_VVG perforated_JJ from_II nonperforated_JJ appendicitis_NN1 ,_, nor_CC did_VDD we_PPIS2 look_VVI at_II specific_JJ US_NP1 features_NN2 ._. 
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<s>
A_AT1 cursory_JJ review_NN1 of_IO the_AT past_JJ 30_MC years_NNT2 of_IO literature_NN1 demonstrates_VVZ several_DA2 discrete_JJ evolutions_NN2 in_II the_AT operative_JJ treatment_NN1 of_IO hernia_NN1 ._. 
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<s>
The_AT hypothesis_NN1 tested_VVD here_RL is_VBZ that_CST PDS_NP2 participants_NN2 have_VH0 a_AT1 backward_JJ masking_NN1 deficit_NN1 compared_VVN with_IW the_AT RDS_NN2 participants_NN2 ._. 
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<s>
Over_II the_AT same_DA period_NN1 ,_, age-standardised_JJ adult_NN1 prevalence_NN1 of_IO diabetes_NN1 at_RR21 least_RR22 doubled_VVN for_IF men_NN2 in_II 120_MC countries_NN2 and_CC for_IF women_NN2 in_II 87_MC countries_NN2 ,_, with_IW a_AT1 posterior_JJ probability_NN1 of_IO 0.887_MC or_CC higher_JJR ._. 
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<s>
Similarly_RR ,_, we_PPIS2 found_VVD the_AT level_NN1 of_IO NR1_FO protein_NN1 to_TO be_VBI significantly_RR reduced_VVN in_II C_NP1 carriers_NN2 with_IW schizophrenia_NN1 relative_II21 to_II22 C_NP1 carrier_NN1 controls_NN2 (_( P=0.025_FO ;_; Figure_NN1 3c_FO )_) ._. 
</s>
<s>
Marco_NP1 Lezzerini_NP1 and_CC Yelena_NP1 Budovskaya_NP1 Swammerdam_NP1 Institute_NN1 for_IF Life_NN1 Sciences_NN2 ,_, University_NN1 of_IO Amsterdam_NP1 ,_, Amsterdam_NP1 ,_, The_AT Netherlands_NP1 Correspondence_NN1 Yelena_NP1 Budovskaya_NP1 ,_, Swammerdam_NP1 Institute_NN1 for_IF Life_NN1 Sciences_NN2 ,_, University_NN1 of_IO Amsterdam_NP1 ,_, Science_NN1 Park_NN1 904_MC ,_, Amsterdam_NP1 1098_MC XH_NP1 ,_, The_AT Netherlands_NP1 ._. 
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<s>
Similarly_RR ,_, 015_MC ,_, an_AT1 investigational_JJ participant_NN1 with_IW moderate_JJ aphasia_NN1 returned_VVN at_II 8_MC months_NNT2 posttreatment_NN1 ,_, whereas_CS the_AT control_NN1 participant_NN1 005_MC returned_VVD at_II 20_MC months_NNT2 posttreatment_NN1 ._. 
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<s>
Obesity_NN1 causes_VVZ adverse_JJ effects_NN2 on_II health_NN1 in_II childhood_NN1 ,_, which_DDQ perpetuate_VV0 and_CC amplify_VV0 the_AT metabolic_JJ disturbances_NN2 in_II adulthood_NN1 ,_, thereby_RR leading_VVG to_II a_AT1 high_JJ risk_NN1 of_IO mortality_NN1 ._. 
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<s>
At_II the_AT heart_NN1 of_IO this_DD1 debate_NN1 are_VBR the_AT proponents_NN2 and_CC critics_NN2 of_IO the_AT competency-based_JJ education_NN1 movement_NN1 ,_, with_IW provocative_JJ arguments_NN2 for_IF both_DB2 breaking_VVG down_RP performance_NN1 into_II observable_JJ competencies_NN2 and_CC considering_VVG performance_NN1 as_II a_AT1 global_JJ phenomenon_NN1 or_CC sum_NN1 that_CST may_VM be_VBI incompletely_RR measured_VVN even_RR by_II accurately_RR assessing_VVG its_APPGE parts_NN2 ._. 
</s>
<s>
Schwrzler_NP1 et_RA21 al_RA22 and_CC Kollen_NP1 et_RA21 al_RA22 attributed_VVD the_AT increased_JJ PTD_NP1 rate_NN1 to_II increased_JJ twinning_NN1 in_II the_AT blastocyst_NN1 group_NN1 and_CC potential_JJ patient_JJ selection_NN1 bias_NN1 ._. 
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<s>
Notably_RR ,_, while_CS genome_NN1 sequencing_NN1 of_IO 20_MC treated_VVD MM_NNU tumors_NN2 did_VDD not_XX identify_VVI any_DD proteasome_JJ PSMB5_FO mutations_NN2 ,_, this_DD1 initial_JJ genomic_JJ analysis_NN1 of_IO MM_NNU did_VDD identify_VVI two_MC mutations_NN2 in_II XBP1_FO (_( Chapman_NP1 et_RA21 al._RA22 ,_, 2011_MC )_) ,_, both_RR in_II treatment-refractory_JJ tumors_NN2 (_( Figure_NN1 2F_RA )_) ._. 
</s>
<s>
Keywords_NN2 :_: airway_NN1 management_NN1 ;_; airway_NN1 resistance_NN1 ;_; intrinsic_JJ peep_NN1 ;_; one-lung_JJ ventilation_NN1 ._. 
</s>
<s>
A_AT1 negative_JJ result_NN1 does_VDZ not_XX necessary_JJ rule_NN1 out_RP LSCD_NP1 ._. 
</s>
<s>
The_AT xMAP_NN1 assays_NN2 are_VBR done_VDN in_II 96-well_JJ microplate_NN1 format_NN1 according_II21 to_II22 the_AT protocol_NN1 provided_VVN by_II EMD_NP1 Millipore_NP1 (_( Billerica_NP1 ,_, MA_NNA ,_, USA_NP1 )_) ._. 
</s>
<s>
No_AT other_JJ potential_JJ conflict_NN1 of_IO interest_NN1 relevant_JJ to_II this_DD1 article_NN1 was_VBDZ reported_VVN ._. 
</s>
<s>
Hierarchical_JJ nesting_NN1 means_VVZ containing_VVG another_DD1 entire_JJ network_NN1 within_II a_AT1 node_NN1 or_CC vertex_NN1 ._. 
</s>
<s>
All_DB analyses_NN2 were_VBDR conducted_VVN using_VVG SPSS_NP1 statistical_JJ software_NN1 ,_, version_NN1 22.0_MC (_( SPSS_NP1 Inc_JJ )_) ._. 
</s>
<s>
Of_IO note_NN1 ,_, IOP_VV0 results_NN2 were_VBDR impacted_VVN by_II treatment_NN1 as_CSA 86%_NNU ,_, 23%_NNU and_CC 0%_NNU of_IO POAG_NP1 ,_, OH_UH ,_, and_CC control_NN1 subjects_NN2 were_VBDR using_VVG topical_JJ IOP-lowering_JJ agents_NN2 ._. 
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<s>
Kind_RR21 of_RR22 like_CS they_PPHS2 don_VV0 '_NULL t_ZZ1 trust_VV0 you_PPY anymore_RR ._. 
</s>
<s>
Study_NN1 Design_NN1 :_: Randomised_JJ single-blinded_NN1 controlled_VVD trial_NN1 ._. 
</s>
<s>
The_AT maxillary_JJ sinus_NN1 can_VM be_VBI divided_VVN into_II 2_MC portions_NN2 by_II the_AT imaginary_JJ Ohngren_NN1 line_NN1 ,_, drawn_VVN from_II the_AT medial_JJ canthus_NN1 to_II the_AT angle_NN1 of_IO the_AT mandible_NN1 ._. 
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<s>
Then_RT ,_, the_AT scores_NN2 obtained_VVN by_II the_AT parents_NN2 in_II the_AT CISS_NN1 questionnaire_NN1 were_VBDR correlated_VVN with_IW those_DD2 in_II the_AT RSDS_NP1 ._. 
</s>
<s>
Many_DA2 of_IO the_AT current_JJ resources_NN2 used_VMK to_TO determine_VVI the_AT competency_NN1 of_IO our_APPGE interns_NN2 may_VM be_VBI used_VVN ,_, without_IW any_DD need_NN1 to_TO develop_VVI elaborate_JJ new_JJ programs_NN2 ._. 
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<s>
This_DD1 is_VBZ the_AT first_MD evidence_NN1 for_IF the_AT involvement_NN1 of_IO the_AT '_NULL hate_NN1 circuit_NN1 '_NULL in_II depression_NN1 and_CC suggests_VVZ a_AT1 potential_JJ reappraisal_NN1 of_IO the_AT key_JJ neural_JJ circuitry_NN1 involved_VVD ._. 
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<s>
Smaller_JJR distances_NN2 indicate_VV0 disorders_NN2 that_CST are_VBR closer_RRR together_RL ;_; larger_JJR distances_NN2 indicate_VV0 disorders_NN2 further_RRR apart_RL ._. 
</s>
<s>
SS_NP1 ,_, RDM_NP1 ,_, RAS_NP2 ,_, PLH_NP1 ,_, DAP_NP1 ,_, NKR_NP1 ,_, JSJ_NP1 ,_, and_CC DCL_MC contributed_VVD to_II the_AT acquisition_NN1 of_IO data_NN and_CC reviewed_VVD the_AT manuscript_NN1 ._. 
</s>
<s>
Instead_RR ,_, multiple_JJ assessment_NN1 methods_NN2 that_CST are_VBR well_RR integrated_VVN into_II education_NN1 curricula_NN2 provide_VV0 the_AT most_RGT valid_JJ information_NN1 ._. 
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<s>
Statistical_JJ Analyses_NN2 Both_DB2 studies_NN2 were_VBDR designed_VVN to_TO use_VVI a_JJ21 priori_JJ22 planned_JJ comparisons_NN2 for_IF the_AT primary_JJ analyses_NN2 ,_, using_VVG SPSS_NP1 (_( SPSS_NP1 ,_, Inc._JJ )_) or_CC SAS_NP1 (_( SAS_NP1 Institute_NN1 ,_, Inc_JJ ,_, Cary_NP1 ,_, NC_NP1 )_) general_JJ linear_JJ models_NN2 procedures_NN2 for_IF analysis_NN1 of_IO variance_NN1 (_( ANOVA_NP1 )_) ,_, with_IW post_JJ21 hoc_JJ22 T_ZZ1 tests_NN2 as_CSA warranted_VVN by_II ANOVA_NP1 ._. 
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<s>
Anticoagulation_NN1 was_VBDZ recommended_VVN to_TO be_VBI continued_VVN for_IF 60_MC days_NNT2 ,_, unless_CS complications_NN2 occurred_VVD ._. 
</s>
<s>
With_IW this_DD1 technique_NN1 ,_, you_PPY can_VM reduce_VVI the_AT wound-healing_JJ process_NN1 and_CC minimise_VVI the_AT postoperative_JJ side-effects_NN2 ,_, which_DDQ makes_VVZ it_PPH1 possible_JJ for_IF the_AT wound_NN1 to_TO heal_VVI fully_RR and_CC for_IF the_AT patient_JJ to_TO wear_VVI the_AT sound_NN1 processor_NN1 over_II the_AT wound_NN1 without_IW problems_NN2 ._. 
</s>
<s>
The_AT "_" need_NN1 for_IF transplantation_NN1 "_" was_VBDZ recorded_VVN as_II a_AT1 binary_JJ variable_NN1 ,_, where_CS 0_MC =low_FO and_CC 1_MC1 =medium_FO ,_, high_JJ ._. 
</s>
<s>
Although_CS the_AT findings_NN2 of_IO this_DD1 study_NN1 suggest_VV0 a_AT1 significant_JJ relationship_NN1 among_II the_AT robotic_JJ platform_NN1 ,_, high-volume_JJ surgeons_NN2 ,_, and_CC lower_JJR odds_NN2 of_IO conversion_NN1 to_II laparotomy_NN1 ,_, these_DD2 results_NN2 are_VBR not_XX intended_VVN to_TO define_VVI medical_JJ policies_NN2 or_CC surgical_JJ privileging_NN1 ._. 
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<s>
The_AT primary_JJ aim_NN1 of_IO the_AT present_JJ review_NN1 was_VBDZ therefore_RR to_TO evaluate_VVI evidence_NN1 regarding_II the_AT potential_JJ impact_NN1 of_IO the_AT 7-day_JJ HFI_NN2 on_II ovarian_JJ activity_NN1 ,_, contraceptive_JJ effectiveness_NN1 ,_, and_CC adverse_JJ effects_NN2 ._. 
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<s>
A_AT1 random_JJ sample_NN1 of_IO 225_MC recorded_JJ sessions_NNT2 (_( 25%_NNU )_) were_VBDR then_RT audited_VVN and_CC independently_RR rated_VVN for_IF integrity_NN1 to_II protocol_NN1 by_II a_AT1 doctorate-level_JJ trainee_NN1 in_II clinical_JJ psychology_NN1 ._. 
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<s>
A_AT1 sensitivity_NN1 analysis_NN1 excluding_II subjects_NN2 with_IW greatest_JJT progression_NN1 (_( greater_JJR than_CSN 100_MC units_NN2 of_IO change_NN1 )_) did_VDD not_XX alter_VVI the_AT result_NN1 ._. 
</s>
<s>
The_AT average_JJ PPT_NP1 across_II the_AT 2_MC repetitions_NN2 and_CC 4_MC sites_NN2 was_VBDZ used_VVN for_IF further_JJR analysis_NN1 as_II a_AT1 measure_NN1 of_IO widespread_JJ PPT_NP1 ._. 
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<s>
This_DD1 approach_NN1 entails_VVZ serial_JJ CPX_NP1 testing_NN1 before_II and_CC after_CS the_AT implementation_NN1 of_IO a_AT1 given_JJ intervention_NN1 ._. 
</s>
<s>
In_II patients_NN2 who_PNQS underwent_VVD preoperative_JJ standard_JJ breast_NN1 MRI_NN2 ,_, axillary_JJ ultrasound_NN1 is_VBZ only_RR required_VVN in_II31 case_II32 of_II33 suspicious_JJ nodal_JJ findings_NN2 on_II MRI_NP1 ._. 
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<s>
Publication_NN1 bias_NN1 There_EX was_VBDZ a_AT1 moderate_JJ visual_JJ asymmetry_NN1 in_II the_AT funnel_NN1 plot_NN1 ,_, as_CSA shown_VVN in_II Fig._NN1 4_MC ._. 
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<s>
On_II the_AT other_JJ hand_NN1 ,_, there_EX are_VBR numerous_JJ studies_NN2 suggesting_VVG that_DD1 adaptation_NN1 to_II standard_JJ frequency_NN1 allocation_NN1 tables_NN2 may_VM take_VVI a_AT1 long_JJ time_NNT1 or_CC may_VM even_RR be_VBI incomplete_JJ despite_II months_NNT2 or_CC years_NNT2 of_IO experience_NN1 (_( Fu_NP1 et_RA21 al_RA22 ._. 
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<s>
(_( 2002_MC )_) ,_, Svirsky_NP1 et_RA21 al_RA22 ._. 
</s>
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(_( 2004a_FO )_) ,_, Francart_NP1 et_RA21 al_RA22 ._. 
</s>
<s>
(_( 2008_MC )_) ,_, Sagi_NP1 et_RA21 al_RA22 ._. 
</s>
<s>
(_( 2010_MC )_) ,_, Svirsky_NP1 et_RA21 al_RA22 ._. 
</s>
<s>
(_( 2012_MC )_) )_) ._. 
</s>
<s>
A_AT1 comparison_NN1 between_II the_AT wt_NN1 homingendonuclease_NN1 I-AniI_NN1 (_( inducing_VVG a_AT1 DSB_NP1 )_) and_CC a_AT1 nicking_JJ variant_NN1 of_IO I-Anil_NP1 showed_VVD lower_JJR HR_NNU ratios_NN2 for_IF the_AT nicking_JJ nuclease_NN1 by_II a_AT1 factor_NN1 4_MC to_II 6_MC and_CC also_RR lower_JJR mutation_NN1 rate_NN1 by_II a_AT1 factor_NN1 of_IO 150_MC ._. 
</s>
<s>
It_PPH1 is_VBZ notable_JJ that_CST the_AT 2_MC genes_NN2 implicated_VVD by_II our_APPGE studies_NN2 ,_, TNK2_FO and_CC TNR_NP1 ,_, were_VBDR each_DD1 more_DAR than_CSN 1000_MC amino_NN1 acids_NN2 in_II length_NN1 ,_, raising_VVG potential_JJ concern_NN1 that_CST they_PPHS2 would_VM be_VBI discovered_VVN to_TO harbor_VVI rare_JJ damaging_JJ variation_NN1 by_II chance_NN1 because_II21 of_II22 their_APPGE large_JJ size_NN1 ._. 
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<s>
INTRODUCTION_NN1 Background_NN1 Mass_NN1 methanol_NN1 poisonings_NN2 represent_VV0 a_AT1 challenge_NN1 for_IF health_NN1 care_NN1 providers_NN2 throughout_II the_AT world_NN1 because_II21 of_II22 the_AT distillation_NN1 and_CC consumption_NN1 of_IO illicit_JJ alcohol_NN1 ._. 
</s>
<s>
This_DD1 interpretation_NN1 receives_VVZ some_DD support_NN1 from_II the_AT relatively_RR poor_JJ early_JJ performance_NN1 of_IO the_AT transgenic_JJ groups_NN2 on_II the_AT spatial_JJ memory_NN1 and_CC NMTS_NP1 tasks_NN2 ._. 
</s>
<s>
Discussion_NN1 Cricoid_NN1 pressure_NN1 is_VBZ a_AT1 technique_NN1 used_VMK to_TO occlude_VVI the_AT oesophagus_NN1 by_II compressing_VVG it_PPH1 between_II the_AT cricoid_JJ cartilage_NN1 and_CC cervical_JJ vertebrae_NN2 ._. 
</s>
<s>
Data_NN were_VBDR extracted_VVN for_IF all_DB cases_NN2 and_CC controls_VVZ on_II all_DB inpatient_NN1 and_CC outpatient_NN1 diagnoses_VVZ with_IW principal_JJ or_CC comorbid_JJ diagnoses_NN2 of_IO alcohol_NN1 or_CC drug_NN1 abuse_NN1 or_CC dependence_NN1 ,_, depression_NN1 and_CC related_JJ mood_NN1 disorders_NN2 ,_, and_CC any_DD psychiatric_JJ disorder_NN1 (_( Author_NN1 Table_NN1 1_MC1 )_) ._. 
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<s>
Even_CS21 though_CS22 a_AT1 large_JJ volume_NN1 of_IO information_NN1 has_VHZ been_VBN collected_VVN about_II managing_NN1 and_CC treating_VVG septic_JJ patient_NN1 ,_, the_AT lack_NN1 of_IO knowledge_NN1 about_II the_AT diagnostic_JJ criteria_NN2 for_IF sepsis_NN1 by_II emergency_NN1 teams_NN2 is_VBZ one_MC1 of_IO the_AT greatest_JJT factors_NN2 limiting_VVG its_APPGE adequate_JJ treatment_NN1 ._. 
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<s>
From_II 3_MC years_NNT2 of_IO age_NN1 ,_, during_II the_AT winter_NNT1 months_NNT2 ,_, papular_JJ lesions_NN2 were_VBDR noticed_VVN on_II the_AT legs_NN2 ,_, which_DDQ resolved_VVD leaving_VVG atrophic_JJ scars_NN2 (_( Fig._NN1 3d_NNU )_) ._. 
</s>
<s>
We_PPIS2 do_VD0 not_XX expect_VVI the_AT rise_NN1 in_II the_AT use_NN1 of_IO portable_JJ devices_NN2 to_TO affect_VVI the_AT estimated_JJ levels_NN2 and_CC trends_NN2 because_CS their_APPGE higher_JJR use_NN1 in_II population-based_JJ research_NN1 is_VBZ partly_RR due_II21 to_II22 increasing_JJ similarity_NN1 between_II their_APPGE measurements_NN2 and_CC those_DD2 in_II laboratory-based_JJ tests_NN2 ,_, 47_MC ,_, 48_MC facilitated_VVD by_II more_RGR advanced_JJ technologies_NN2 and_CC better_JJR standardisation_NN1 ._. 
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<s>
Next_MD ,_, the_AT committee_NN1 would_VM discover_VVI if_CSW a_AT1 consensus_NN1 existed_VVD ,_, through_II a_AT1 quick_JJ verbal_JJ polling_NN1 of_IO all_DB committee_NN1 members_NN2 present_NN1 ._. 
</s>
<s>
The_AT reoperation_NN1 rate_NN1 was_VBDZ 15.2%_FO with_IW adjustable_JJ suture_NN1 and_CC 10.4%_FO with_IW conventional_JJ suture_NN1 technique_NN1 (_( p=0.045_FO ,_, Table_NN1 4_MC ,_, Figure_NN1 1_MC1 )_) ._. 
</s>
<s>
In_II human_JJ pre-B_JJ ALL_DB ,_, however_RR ,_, negative_JJ control_NN1 of_IO Erk_NN1 is_VBZ constitutively_RR active_JJ (_( Figure_NN1 11_MC )_) ._. 
</s>
<s>
The_AT HORTIS_NN1 investigators_NN2 also_RR reported_VVN a_AT1 significant_JJ benefit_NN1 of_IO hyperbaric_JJ oxygen_NN1 in_II patients_NN2 with_IW bowel_NN1 bother_VV0 ,_, a_AT1 group_NN1 of_IO symptoms_NN2 that_CST include_VV0 faecal_JJ incontinence_NN1 ,_, faecal_JJ urgency_NN1 ,_, and_CC pain_NN1 ._. 
</s>
<s>
Longitudinal_JJ studies_NN2 have_VH0 found_VVN that_CST individuals_NN2 diagnosed_VVN with_IW ASD_NP1 rarely_RR move_VV0 off_RP the_AT spectrum_NN1 (_( but_CCB see_VV0 Fein_NP1 et_NP1 al.8_FO )_) ,_, although_CS improvement_NN1 in_II symptoms_NN2 is_VBZ often_RR observed_VVN between_II childhood_NN1 and_CC adolescence/_NN1 adulthood_NN1 (_( for_IF review_NN1 ,_, see_VV0 Matson_NP1 and_CC Horovitz_NP1 )_) ._. 
</s>
<s>
MiR-34a_FO ,_, a_AT1 pro-ageing_JJ microRNA_NN1 ,_, was_VBDZ reported_VVN to_TO be_VBI upregulated_VVN in_II C._NP1 elegans_NP1 ageing_JJ and_CC also_RR was_VBDZ found_VVN to_TO be_VBI upregulated_VVN in_II late_JJ passage_NN1 endothelial_JJ cells_NN2 as_II31 well_II32 as_II33 in_II heart_NN1 and_CC spleen_NN1 of_IO 8month_FO old_JJ mice_NN2 compared_VVN to_II 1_MC1 month_NNT1 old_JJ mice_NN2 similar_JJ to_II the_AT study_NN1 of_IO Boon_NN1 et_RA21 al_RA22 ._. 
</s>
<s>
(_( Boon_NN1 et_RA21 al._RA22 ,_, 2013_MC ;_; Ito_NP1 et_RA21 al._RA22 ,_, 2010_MC )_) ._. 
</s>
<s>
Written_JJ permission_NN1 to_TO participate_VVI is_VBZ obtained_VVN from_II parents_NN2 or_CC legal_JJ guardians.24_FO Institutional_JJ review_NN1 board_NN1 approval_NN1 was_VBDZ waived_VVN because_CS we_PPIS2 used_VVD data_NN from_II a_AT1 deidentified_JJ public-use_JJ data_NN set_VV0 ._. 
</s>
